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  1. Article ; Online: Olanzapine for chemotherapy-induced nausea and vomiting control - Authors' reply.

    Bajpai, Jyoti / Pawar, Akash / Kapu, Venkatesh / Prabhash, Kumar

    The Lancet. Oncology

    2024  Volume 25, Issue 5, Page(s) e177

    MeSH term(s) Humans ; Olanzapine/adverse effects ; Olanzapine/therapeutic use ; Nausea/chemically induced ; Nausea/drug therapy ; Vomiting/chemically induced ; Vomiting/drug therapy ; Vomiting/prevention & control ; Antiemetics/therapeutic use ; Antineoplastic Agents/adverse effects ; Benzodiazepines/adverse effects ; Benzodiazepines/therapeutic use
    Chemical Substances Olanzapine (N7U69T4SZR) ; Antiemetics ; Antineoplastic Agents ; Benzodiazepines (12794-10-4)
    Language English
    Publishing date 2024-05-02
    Publishing country England
    Document type Letter
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(24)00195-5
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5696: Show issues Location:
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    Zs.MO 460: Show issues

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  2. Article: Treatment of advanced nonsmall cell lung cancer: First line, maintenance and second line - Indian consensus statement update.

    Prabhash, Kumar

    South Asian journal of cancer

    2018  Volume 8, Issue 1, Page(s) 1–17

    Abstract: The management of advanced nonsmall cell lung cancer (NSCLC) patients is becoming increasingly complex with the identification of driver mutations/rearrangements and development/availability of appropriate targeted therapies. In 2017, an expert group of ... ...

    Abstract The management of advanced nonsmall cell lung cancer (NSCLC) patients is becoming increasingly complex with the identification of driver mutations/rearrangements and development/availability of appropriate targeted therapies. In 2017, an expert group of medical oncologists with expertise in treating lung cancer used data from published literature and experience to arrive at practical consensus recommendations on treatment of advanced NSCLC for use by the community oncologists. This was published subsequently in the Indian Journal of Cancer with a plan to be updated annually. The present document is an update to the 2017 document.
    Language English
    Publishing date 2018-08-13
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 2719571-5
    ISSN 2278-4306 ; 2278-330X
    ISSN (online) 2278-4306
    ISSN 2278-330X
    DOI 10.4103/sajc.sajc_227_18
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  3. Article ; Online: Exploring key genes and pathways associated with sex differences in autism spectrum disorder: integrated bioinformatic analysis.

    Nautiyal, Himani / Jaiswar, Akanksha / Jha, Prabhash Kumar / Dwivedi, Shubham

    Mammalian genome : official journal of the International Mammalian Genome Society

    2024  

    Abstract: Autism spectrum disorder (ASD) is a heterogenous neurodevelopmental disorder marked by functional abnormalities in brain that causes social and linguistic difficulties. The incidence of ASD is more prevalent in males compared to females, but the ... ...

    Abstract Autism spectrum disorder (ASD) is a heterogenous neurodevelopmental disorder marked by functional abnormalities in brain that causes social and linguistic difficulties. The incidence of ASD is more prevalent in males compared to females, but the underlying mechanism, as well as molecular indications for identifying sex-specific differences in ASD symptoms remain unknown. Thus, impacting the development of personalized strategy towards pharmacotherapy of ASD. The current study employs an integrated bioinformatic approach to investigate the genes and pathways uniquely associated with sex specific differences in autistic individuals. Based on microarray dataset (GSE6575) extracted from the gene expression omnibus, the dysregulated genes between the autistic and the neurotypical individuals for both sexes were identified. Gene set enrichment analysis was performed to ascertain biological activities linked to the dysregulated genes. Protein-protein interaction network analysis was carried out to identify hub genes. The identified hub genes were examined to determine their functions and involvement in the associated pathways using Enrichr. Additionally, hub genes were validated from autism-associated databases and the potential small molecules targeting the hub genes were identified. The present study utilized whole blood transcriptomic gene expression analysis data and identified 2211 and 958 differentially expressed unique genes in males and females respectively. The functional enrichment analysis revealed that male hub genes were functionally associated with RNA polymerase II mediated transcriptional regulation whereas female hub genes were involved in intracellular signal transduction and cell migration. The top male hub genes exhibited functional enrichment in tyrosine kinase signalling pathway. The pathway enrichment analysis of male hub genes indicates the enrichment of papillomavirus infection. Female hub genes were enriched in androgen receptor signalling pathway and functionally enriched in focal adhesion specific excision repair. Identified drug like candidates targeting these genes may serve as a potential sex specific therapeutics. Wortmannin for males, 5-Fluorouracil for females had the highest scores. Targeted and sex-specific pharmacotherapies may be created for the management of ASD. The current investigation identifies sex-specific molecular signatures derived from whole blood which may serve as a potential peripheral sex-specific biomarkers for ASD. The study also uncovers the possible pharmacological interventions against the selected genes/pathway, providing support in development of therapeutic strategies to mitigate ASD. However, experimental proofs on biological systems are warranted.
    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1058547-3
    ISSN 1432-1777 ; 0938-8990
    ISSN (online) 1432-1777
    ISSN 0938-8990
    DOI 10.1007/s00335-024-10036-5
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    Zs.A 3489: Show issues Location:
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  4. Article ; Online: Superpixel based robust reversible data hiding scheme exploiting Arnold transform with DCT and CA

    Prabhash Kumar Singh / Biswapati Jana / Kakali Datta

    Journal of King Saud University: Computer and Information Sciences, Vol 34, Iss 7, Pp 4402-

    2022  Volume 4420

    Abstract: The emergence of data hiding schemes was to provide multimedia security besides the sharing of information in a confidential manner. Since then, various techniques have cropped up to meet the objective of secured data communication using multimedia ... ...

    Abstract The emergence of data hiding schemes was to provide multimedia security besides the sharing of information in a confidential manner. Since then, various techniques have cropped up to meet the objective of secured data communication using multimedia documents. In this paper, a novel data hiding approach has been designed to exploit the superpixel of the image to identify the nature of the blocks for embedding data using spatial and transform domain techniques such as Cellular Automata (CA) and Discrete Cosine Transform (DCT) respectively. In addition, an Arnold transform is used to provide a blanket of security through a random selection of blocks via sharable keys. The proposed technique obtains YCbCr color model of an RGB image to use superpixel on only the Y color component. Thereafter, the acquired labeled image of superpixel is partitioned into (8×8) blocks which are to be categorised as homogeneous and heterogeneous blocks. Based on the categorization, DCT and CA are applied for the embedding of the secret data in the Cb and Cr color components. The experimental results and its comparison with state-of-the-art schemes uphold the effectiveness of the demonstrated scheme. Various analysis have been conducted to showcase the degree of robustness, imperceptibility, and visual quality attained by the proposed scheme.
    Keywords Data hiding ; Superpixel ; Cellular Automata ; DCT ; Arnold Transform ; Electronic computers. Computer science ; QA75.5-76.95
    Subject code 004
    Language English
    Publishing date 2022-07-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Treatment of advanced nonsmall cell lung cancer: First line, maintenance and second line – Indian consensus statement update

    Prabhash, Kumar

    South Asian Journal of Cancer

    2019  Volume 08, Issue 01, Page(s) 1–17

    Abstract: The management of advanced nonsmall cell lung cancer (NSCLC) patients is becoming increasingly complex with the identification of driver mutations/rearrangements and development/availability of appropriate targeted therapies. In 2017, an expert group of ... ...

    Abstract The management of advanced nonsmall cell lung cancer (NSCLC) patients is becoming increasingly complex with the identification of driver mutations/rearrangements and development/availability of appropriate targeted therapies. In 2017, an expert group of medical oncologists with expertise in treating lung cancer used data from published literature and experience to arrive at practical consensus recommendations on treatment of advanced NSCLC for use by the community oncologists. This was published subsequently in the Indian Journal of Cancer with a plan to be updated annually. The present document is an update to the 2017 document.
    Keywords Consensus statement ; driver mutations ; nonsmall cell lung cancer ; targeted therapies
    Language English
    Publishing date 2019-01-01
    Publisher Thieme Medical and Scientific Publishers Pvt. Ltd.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2719571-5
    ISSN 2278-4306 ; 2278-330X ; 2278-4306
    ISSN (online) 2278-4306
    ISSN 2278-330X ; 2278-4306
    DOI 10.4103/sajc.sajc_227_18
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  6. Article ; Online: Analysis of Outcomes With Addition of Immunotherapy to Chemoradiation Therapy for Non-Small Cell Lung Cancer.

    Kapoor, Akhil / Prabhash, Kumar

    JAMA oncology

    2021  Volume 8, Issue 1, Page(s) 168

    MeSH term(s) Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/radiotherapy ; Chemoradiotherapy ; Humans ; Immunologic Factors ; Immunotherapy ; Lung Neoplasms/radiotherapy
    Chemical Substances Immunologic Factors
    Language English
    Publishing date 2021-11-03
    Publishing country United States
    Document type Letter ; Comment
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2021.5608
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  7. Article ; Online: Gefitinib vs Gefitinib Plus Pemetrexed and Carboplatin Chemotherapy in EGFR-Variant Lung Cancer-Long-Term Results of a Randomized Clinical Trial.

    Noronha, Vanita / Patil, Vijay / Menon, Nandini / Shah, Minit / Chougule, Anuradha / Peelay, Zoya / Prabhash, Kumar

    JAMA oncology

    2024  

    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Journal Article
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2024.0584
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  8. Article ; Online: Differential clinicopathological features, treatments and outcomes in patients with Exon 19 deletion and Exon 21 L858R EGFR mutation-positive adenocarcinoma non-small-cell lung cancer.

    Batra, Ullas / Biswas, Bivas / Prabhash, Kumar / Krishna, M Vamshi

    BMJ open respiratory research

    2023  Volume 10, Issue 1

    Abstract: The most common oncogenic driver in non-small-cell lung cancer (NSCLC) is the epidermal growth factor receptor ( ...

    Abstract The most common oncogenic driver in non-small-cell lung cancer (NSCLC) is the epidermal growth factor receptor (
    MeSH term(s) Humans ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Protein Kinase Inhibitors/therapeutic use ; Mutation ; Adenocarcinoma/drug therapy ; Adenocarcinoma/genetics ; ErbB Receptors/genetics ; ErbB Receptors/therapeutic use ; Exons/genetics
    Chemical Substances Protein Kinase Inhibitors ; ErbB Receptors (EC 2.7.10.1) ; EGFR protein, human (EC 2.7.10.1)
    Language English
    Publishing date 2023-06-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2736454-9
    ISSN 2052-4439 ; 2052-4439
    ISSN (online) 2052-4439
    ISSN 2052-4439
    DOI 10.1136/bmjresp-2022-001492
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  9. Article ; Online: Reply to D.-C. Mo et al.

    Patil, Vijay Maruti / Noronha, Vanita / Prabhash, Kumar / Bhattacharjee, Atanu

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2023  Volume 41, Issue 9, Page(s) 1791

    Language English
    Publishing date 2023-01-20
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.22.02741
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    Zs.A 1847: Show issues Location:
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    Zs.MO 650: Show issues

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  10. Article ; Online: Virtual oncology conferences - The new normal?

    Munshi, Anusheel / Agarwal, Jai Prakash / Prabhash, Kumar

    Journal of cancer research and therapeutics

    2022  Volume 18, Issue 6, Page(s) 1832–1833

    MeSH term(s) Humans ; Medical Oncology
    Language English
    Publishing date 2022-11-22
    Publishing country India
    Document type Letter
    ZDB-ID 2187633-2
    ISSN 1998-4138 ; 0973-1482
    ISSN (online) 1998-4138
    ISSN 0973-1482
    DOI 10.4103/jcrt.JCRT_496_20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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