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  1. Article ; Online: Anomalous aortic origin of right coronary artery from left coronary cusp: a management conundrum: a case report.

    Arun Kumar, Pramukh / Patel, Boskey / Dasari, Mahati / Bhattad, Pradnya Brijmohan / Prabhu, Sushmita / Hadley, Michelle

    Journal of medical case reports

    2023  Volume 17, Issue 1, Page(s) 191

    Abstract: Background: Coronary artery anomalies are characterized by an abnormality in the course or origin of three main coronary arteries. There needs to be more scientific evidence to promptly treat coronary artery anomalies with poorly understood prognostic ... ...

    Abstract Background: Coronary artery anomalies are characterized by an abnormality in the course or origin of three main coronary arteries. There needs to be more scientific evidence to promptly treat coronary artery anomalies with poorly understood prognostic implications, especially anomalous aortic origin of the right coronary artery from the left coronary cusp.
    Case presentation: A 58-year-old Caucasian female presented multiple times over 6 months with atypical chest discomfort and palpitations. The treadmill exercise test demonstrated exercise-induced non-sustained ventricular tachycardia. A coronary angiogram revealed no obstructive coronary artery disease and an anomalous aortic origin of the right coronary artery from the left coronary cusp with an interarterial course. She was managed conservatively with medications, despite persistent recurrent symptoms.
    Conclusion: It is essential to identify subtle symptoms and insidious onset of anomalous aortic origin of the right coronary artery symptoms as seen in our patient, which can contribute to significant morbidity. There are discrepancies in existing guidelines between different cardiovascular societies in managing selected subgroups of patients with anomalous aortic origin of the right coronary artery who do not have high-risk features, but continue to remain symptomatic.
    MeSH term(s) Humans ; Female ; Middle Aged ; Aorta ; Coronary Artery Disease ; Coronary Angiography ; Exercise Test
    Language English
    Publishing date 2023-05-10
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2269805-X
    ISSN 1752-1947 ; 1752-1947
    ISSN (online) 1752-1947
    ISSN 1752-1947
    DOI 10.1186/s13256-023-03921-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Neurosarcoidosis Presenting as Normal Pressure Hydrocephalus in a Patient with Pulmonary Sarcoidosis.

    Prabhu, Sushmita / Kumar, Pramukh Arun / Kumar, Sumukh Arun / Dasari, Mahati / Mishra, Ajay K / Donaghy, Justin

    Journal of community hospital internal medicine perspectives

    2023  Volume 13, Issue 1, Page(s) 33–36

    Abstract: A gentleman in his early 50's with past medical history significant for biopsy confirmed pulmonary sarcoidosis presented with acute onset confusion, gait disturbance and bowel/urinary incontinence. Brain imaging was consistent with normal pressure ... ...

    Abstract A gentleman in his early 50's with past medical history significant for biopsy confirmed pulmonary sarcoidosis presented with acute onset confusion, gait disturbance and bowel/urinary incontinence. Brain imaging was consistent with normal pressure hydrocephalus and CSF studies supported the suspicion of neurosarcoidosis. He received treatment with a prolonged course of steroids with good effect. We discuss a rare case of normal pressure hydrocephalus as a presenting feature of neurosarcoidosis and the rationale of starting empiric treatment for probable diagnosis of the same.
    Language English
    Publishing date 2023-01-10
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2616884-4
    ISSN 2000-9666
    ISSN 2000-9666
    DOI 10.55729/2000-9666.1136
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Use of inflammatory markers as predictor for mechanical ventilation in COVID-19 patients with stages IIIb-V chronic kidney disease?

    Shanmugavel Geetha, Harinivaas / Prabhu, Sushmita / Sekar, Abinesh / Gogtay, Maya / Singh, Yuvaraj / Mishra, Ajay K / Abraham, George M / Martin, Suzanne

    World journal of virology

    2023  Volume 12, Issue 5, Page(s) 286–295

    Abstract: Background: Studies have shown elevated C-reactive protein (CRP) to predict mechanical ventilation (MV) in patients with coronavirus disease 2019 (COVID-19). Its utility is unknown in patients with chronic kidney disease (CKD), who have elevated ... ...

    Abstract Background: Studies have shown elevated C-reactive protein (CRP) to predict mechanical ventilation (MV) in patients with coronavirus disease 2019 (COVID-19). Its utility is unknown in patients with chronic kidney disease (CKD), who have elevated baseline CRP levels due to chronic inflammation and reduced renal clearance.
    Aim: To assess whether an association exists between elevated inflammatory markers and MV rate in patients with stages IIIb-V CKD and COVID-19.
    Methods: We conducted a retrospective cohort study on patients with COVID-19 and stages IIIb-V CKD. The primary outcome was the rate of invasive MV, the rate of noninvasive MV, and the rate of no MV. Statistical analyses used unpaired
    Results: 290 were screened, and 118 met the inclusion criteria. CRP, D-dimer, and ferritin were significantly different among the three groups. On univariate analysis for invasive MV (IMV), CRP had an odds ratio (OR)-5.44; ferritin, OR-2.8; LDH, OR-7.7; D-dimer, OR-3.9, (
    Conclusion: Our results demonstrate a positive correlation between CRP, ferritin, and D-dimer levels and MV and NIMV rates in CKD patients. The AUROC demonstrates a good sensitivity for CRP levels in detecting the need for MV in patients with stages IIIb-V CKD. This may be because of the greater magnitude of increased inflammation due to COVID-19 itself compared with increased inflammation and reduced clearance due to CKD alone.
    Language English
    Publishing date 2023-11-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2829019-7
    ISSN 2220-3249
    ISSN 2220-3249
    DOI 10.5501/wjv.v12.i5.286
    Database MEDical Literature Analysis and Retrieval System OnLINE

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