LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Zurück zur letzten Suche Suchhistorie
Erweiterte Suche

Ihre letzten Suchen

  1. AU="Prabhu S. Arunachalam"
  2. AU="Crețu, Oana Iulia"
  3. AU="Kim, Y G"
  4. AU=Lejuste Florian
  5. AU="Xavier-Carvalho, Caroline"
  6. AU="Lamb, Keith"
  7. AU="Şenbabaoğlu, Yasin"
  8. AU="Papaparaskeva, Kleo" AU="Papaparaskeva, Kleo"
  9. AU="Hanmer, Stuart B"
  10. AU="de Graaf, Gimon"
  11. AU=Bryan Nathan S
  12. AU="Bhatia, Chitra"
  13. AU="Neufeld, Niko"
  14. AU="Martínez-Cruz, Nayeli"
  15. AU="Joffe, Marshall M"
  16. AU="Wilunda, Calistus"
  17. AU="Das, Partha Pratim"
  18. AU="Staiano, Leopoldo"
  19. AU="Tibbatts, Clare"
  20. AU="Bandeira, Igor D"
  21. AU="Papathanassiou, Dimitri"
  22. AU="Mazurek, Camille"
  23. AU="Jenkinson, Crispin"
  24. AU="Hernández-Huérfano, Emilio Ernesto"
  25. AU="Conowall, Peter"
  26. AU="Nesan, Daniel"
  27. AU="Ueda, Takashi"
  28. AU="Yuan, Jiacheng"
  29. AU="Kahama, C B"
  30. AU="D’Alessio, Roberto"
  31. AU="Reuhl, Kenneth"
  32. AU="Seeleman, Conny"
  33. AU="Delaquis, Pascal"
  34. AU="Bommineni, Gopal R"
  35. AU="Kuhn, Cynthia M."
  36. AU="Olson, Jason C"
  37. AU="Buchholz, V."
  38. AU="Urquhart, Bradley L"
  39. AU="Ezaki, Kazune"
  40. AU="Choi, Jong Hyun"
  41. AU="Xie, Qiaowei"
  42. AU=Rojas-Marte G AU=Rojas-Marte G
  43. AU="Belli, A"
  44. AU="Moolman, M Charl"
  45. AU="Mazzoni, Stefania"
  46. AU=Stryjewski Martin E
  47. AU=Vallon Volker AU=Vallon Volker
  48. AU="Knowland, K E"
  49. AU="Beker, M. G."

Suchergebnis

Treffer 1 - 4 von insgesamt 4

Suchoptionen

  1. Artikel ; Online: A molecular atlas of innate immunity to adjuvanted and live attenuated vaccines, in mice

    Audrey Lee / Madeleine K. D. Scott / Florian Wimmers / Prabhu S. Arunachalam / Wei Luo / Christopher B. Fox / Mark Tomai / Purvesh Khatri / Bali Pulendran

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Band 13

    Abstract: Adjuvants provide additional impetus for the immune response to vaccination regimens, however their modes of activity and impact on particular compartments of the immune response are currently not well understood. Here the authors perform high resolution ...

    Abstract Adjuvants provide additional impetus for the immune response to vaccination regimens, however their modes of activity and impact on particular compartments of the immune response are currently not well understood. Here the authors perform high resolution assessment of the immune response to a well-established vaccination model and show innate immune transcriptomic and epigenomic alterations of innate cells in the lymph nodes following vaccination.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  2. Artikel ; Online: Durability of immune responses to mRNA booster vaccination against COVID-19

    Prabhu S. Arunachalam / Lilin Lai / Hady Samaha / Yupeng Feng / Mengyun Hu / Harold Sai-yin Hui / Bushra Wali / Madison Ellis / Meredith E. Davis-Gardner / Christopher Huerta / Kareem Bechnak / Sarah Bechnak / Matthew Lee / Matthew B. Litvack / Cecilia Losada / Alba Grifoni / Alessandro Sette / Veronika I. Zarnitsyna / Nadine Rouphael /
    Mehul S. Suthar / Bali Pulendran

    The Journal of Clinical Investigation, Vol 133, Iss

    2023  Band 10

    Abstract: Background Maintaining durable immunity following vaccination represents a major challenge, but whether mRNA booster vaccination improves durability is unknown.Methods We measured antibody responses in 55 healthy adults, who received a booster dose of ... ...

    Abstract Background Maintaining durable immunity following vaccination represents a major challenge, but whether mRNA booster vaccination improves durability is unknown.Methods We measured antibody responses in 55 healthy adults, who received a booster dose of the Pfizer-BioNTech or Moderna vaccine against SARS-CoV-2 and calculated the half-life of the antibody titers. We also measured memory B and T cell responses in a subset of 28 participants. In 13 volunteers who received a second booster vaccine, we measured serum antibody titers and memory B and T cell responses.Results The booster (third immunization) dose at 6 to 10 months increased the half-life of the serum–neutralizing antibody (nAb) titers to 76 days from 56 to 66 days after the primary 2-dose vaccination. A second booster dose (fourth immunization) a year after the primary vaccination further increased the half-life to 88 days. However, despite this modestly improved durability in nAb responses against the ancestral (WA.1) strain, there was a loss of neutralization capacity against the Omicron subvariants BA.2.75.2, BQ.1.1, and XBB.1.5 (48-, 71-, and 66-fold drop in titers, respectively, relative to the WA.1 strain). Although only 45% to 65% of participants demonstrated a detectable nAb titer against the newer variants after the booster (third dose), the response declined to below the detection limit in almost all individuals by 6 months. In contrast, booster vaccination induced antigen-specific memory B and T cells that persisted for at least 6 months.Conclusion The durability of serum antibody responses improves only marginally following booster immunizations with the Pfizer-BioNTech or Moderna mRNA vaccines.
    Schlagwörter Vaccines ; Medicine ; R
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2023-05-01T00:00:00Z
    Verlag American Society for Clinical Investigation
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  3. Artikel ; Online: A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates

    Payton A.-B. Weidenbacher / Mrinmoy Sanyal / Natalia Friedland / Shaogeng Tang / Prabhu S. Arunachalam / Mengyun Hu / Ozan S. Kumru / Mary Kate Morris / Jane Fontenot / Lisa Shirreff / Jonathan Do / Ya-Chen Cheng / Gayathri Vasudevan / Mark B. Feinberg / Francois J. Villinger / Carl Hanson / Sangeeta B. Joshi / David B. Volkin / Bali Pulendran /
    Peter S. Kim

    Nature Communications, Vol 14, Iss 1, Pp 1-

    2023  Band 13

    Abstract: Abstract While the rapid development of COVID-19 vaccines has been a scientific triumph, the need remains for a globally available vaccine that provides longer-lasting immunity against present and future SARS-CoV-2 variants of concern (VOCs). Here, we ... ...

    Abstract Abstract While the rapid development of COVID-19 vaccines has been a scientific triumph, the need remains for a globally available vaccine that provides longer-lasting immunity against present and future SARS-CoV-2 variants of concern (VOCs). Here, we describe DCFHP, a ferritin-based, protein-nanoparticle vaccine candidate that, when formulated with aluminum hydroxide as the sole adjuvant (DCFHP-alum), elicits potent and durable neutralizing antisera in non-human primates against known VOCs, including Omicron BQ.1, as well as against SARS-CoV-1. Following a booster ~one year after the initial immunization, DCFHP-alum elicits a robust anamnestic response. To enable global accessibility, we generated a cell line that can enable production of thousands of vaccine doses per liter of cell culture and show that DCFHP-alum maintains potency for at least 14 days at temperatures exceeding standard room temperature. DCFHP-alum has potential as a once-yearly (or less frequent) booster vaccine, and as a primary vaccine for pediatric use including in infants.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2023-04-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  4. Artikel ; Online: The C3/465 glycan hole cluster in BG505 HIV-1 envelope is the major neutralizing target involved in preventing mucosal SHIV infection.

    Tysheena P Charles / Samantha L Burton / Prabhu S Arunachalam / Christopher A Cottrell / Leigh M Sewall / Venkata S Bollimpelli / Sailaja Gangadhara / Antu K Dey / Andrew B Ward / George M Shaw / Eric Hunter / Rama R Amara / Bali Pulendran / Marit J van Gils / Cynthia A Derdeyn

    PLoS Pathogens, Vol 17, Iss 2, p e

    2021  Band 1009257

    Abstract: Stabilized HIV-1 envelope (Env) trimers elicit tier 2 autologous neutralizing antibody (nAb) responses in immunized animals. We previously demonstrated that BG505 SOSIP.664.T332N gp140 (BG505 SOSIP) immunization of rhesus macaques (RM) provided robust ... ...

    Abstract Stabilized HIV-1 envelope (Env) trimers elicit tier 2 autologous neutralizing antibody (nAb) responses in immunized animals. We previously demonstrated that BG505 SOSIP.664.T332N gp140 (BG505 SOSIP) immunization of rhesus macaques (RM) provided robust protection against autologous intra-vaginal simian-human immunodeficiency virus (SHIV) challenge that was predicted by high serum nAb titers. Here, we show that nAb in these protected RM targeted a glycan hole proximal to residue 465 in gp120 in all cases. nAb also targeted another glycan hole at residues 241/289 and an epitope in V1 at varying frequencies. Non-neutralizing antibodies directed at N611-shielded epitopes in gp41 were also present but were more prevalent in RM with low nAb titers. Longitudinal analysis demonstrated that nAb broadened in some RM during sequential immunization but remained focused in others, the latter being associated with increases in nAb titer. Thirty-eight monoclonal antibodies (mAbs) isolated from a protected RM with an exceptionally high serum neutralization titer bound to the trimer in ELISA, and four of the mAbs potently neutralized the BG505 Env pseudovirus (PV) and SHIV. The four neutralizing mAbs were clonally related and targeted the 465 glycan hole to varying degrees, mimicking the serum. The data demonstrate that the C3/465 glycan hole cluster was the dominant neutralization target in high titer protected RM, despite other co-circulating neutralizing and non-neutralizing specificities. The isolation of a neutralizing mAb family argues that clonotype expansion occurred during BG505 SOSIP immunization, leading to high titer, protective nAb and setting a desirable benchmark for HIV vaccines.
    Schlagwörter Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 630
    Sprache Englisch
    Erscheinungsdatum 2021-02-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

Zum Seitenanfang