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  1. AU="Prachayasittikul, Veda"
  2. AU="Fernando Garces"
  3. AU="Capderou, Sami"
  4. AU="Carolina Loch"
  5. AU="Matus Gonzalez, Andrea"
  6. AU="Roy, Antara"
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  11. AU="Alagappan, Annamalai"
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  14. AU="Zi-Lan Wang"
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  18. AU="Joseph R. Francica"
  19. AU="Stringer, Kathleen A."
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  21. AU="Sznitman, Raphael"
  22. AU="Philippe Ciais"
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  1. Article: Effects of barakol from

    Wongsawatkul, Orapin / Buachan, Paiwan / Jaisin, Yamaratee / Busarakumtragul, Panaree / Chainakul, Sunan / Watanapokasin, Ramida / Prachayasittikul, Veda / Prachayasittikul, Supaluk / Ruchirawat, Somsak / Prachayasittikul, Virapong

    Heliyon

    2024  Volume 10, Issue 3, Page(s) e24694

    Abstract: Management of neuroblastoma is challenging because of poor response to drugs, chemotherapy resistance, high relapse, and treatment failures. Doxorubicin is a potent anticancer drug commonly used for neuroblastoma treatment. However, doxorubicin induces ... ...

    Abstract Management of neuroblastoma is challenging because of poor response to drugs, chemotherapy resistance, high relapse, and treatment failures. Doxorubicin is a potent anticancer drug commonly used for neuroblastoma treatment. However, doxorubicin induces considerable toxicities, particularly those caused by oxidative-related damage. To minimize drug-induced adverse effects, the combined use of anticancer drugs with natural-derived compounds possessing antioxidant properties has become an interesting treatment strategy. Barakol is a major compound found in
    Language English
    Publishing date 2024-01-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e24694
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Anticancer activity and QSAR study of sulfur-containing thiourea and sulfonamide derivatives

    Pingaew, Ratchanok / Prachayasittikul, Veda / Worachartcheewan, Apilak / Thongnum, Anusit / Prachayasittikul, Supaluk / Ruchirawat, Somsak / Prachayasittikul, Virapong

    Heliyon. 2022 Aug., v. 8, no. 8 p.e10067-

    2022  

    Abstract: Sulfur-containing compounds are considered as attractive pharmacophores for discovery of new drugs regarding their versatile properties to interact with various biological targets. Quantitative structure-activity relationship (QSAR) modeling is one of ... ...

    Abstract Sulfur-containing compounds are considered as attractive pharmacophores for discovery of new drugs regarding their versatile properties to interact with various biological targets. Quantitative structure-activity relationship (QSAR) modeling is one of well-recognized in silico tools for successful drug discovery. In this work, a set of 38 sulfur-containing derivatives (Types I-VI) were evaluated for their in vitro anticancer activities against 6 cancer cell lines. In vitro findings indicated that compound 13 was the most potent cytotoxic agent toward HuCCA-1 cell line (IC₅₀ = 14.47 μM). Compound 14 exhibited the most potent activities against 3 investigated cell lines (i.e., HepG2, A549, and MDA-MB-231: IC₅₀ range = 1.50-16.67 μM). Compound 10 showed the best activity for MOLT-3 (IC₅₀ = 1.20 μM) whereas compound 22 was noted for T47D (IC₅₀ = 7.10 μM). Subsequently, six QSAR models were built using multiple linear regression (MLR) algorithm. All constructed QSAR models provided reliable predictive performance (training sets: Rₜᵣ range = 0.8301-0.9636 and RMSEₜᵣ = 0.0666-0.2680; leave-one-out cross validation sets: RCV range = 0.7628-0.9290 and RMSECV = 0.0926-0.3188). From QSAR modeling, chemical properties such as mass, polarizability, electronegativity, van der Waals volume, octanol-water partition coefficient, as well as frequency/presence of C-N, F-F, and N-N bonds in the molecule are essential key predictors for anticancer activities of the compounds. In summary, a series of promising fluoro-thiourea derivatives (10, 13, 14, 22) were suggested as potential molecules for future development as anticancer agents. Key structure-activity knowledge obtained from the QSAR modeling was suggested to be advantageous for suggesting the effective rational design of the related sulfur-containing anticancer compounds with improved bioactivities and properties.
    Keywords algorithms ; antineoplastic activity ; cell lines ; computer simulation ; cytotoxicity ; drugs ; neoplasm cells ; quantitative structure-activity relationships ; regression analysis ; thiourea ; van der Waals forces ; Sulfonamide ; Anticancer activity ; QSAR
    Language English
    Dates of publication 2022-08
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2022.e10067
    Database NAL-Catalogue (AGRICOLA)

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  3. Article: Anticancer activity and QSAR study of sulfur-containing thiourea and sulfonamide derivatives.

    Pingaew, Ratchanok / Prachayasittikul, Veda / Worachartcheewan, Apilak / Thongnum, Anusit / Prachayasittikul, Supaluk / Ruchirawat, Somsak / Prachayasittikul, Virapong

    Heliyon

    2022  Volume 8, Issue 8, Page(s) e10067

    Abstract: Sulfur-containing compounds are considered as attractive pharmacophores for discovery of new drugs regarding their versatile properties to interact with various biological targets. Quantitative structure-activity relationship (QSAR) modeling is one of ... ...

    Abstract Sulfur-containing compounds are considered as attractive pharmacophores for discovery of new drugs regarding their versatile properties to interact with various biological targets. Quantitative structure-activity relationship (QSAR) modeling is one of well-recognized
    Language English
    Publishing date 2022-08-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2022.e10067
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Promising 8-Aminoquinoline-Based Metal Complexes in the Modulation of SIRT1/3-FOXO3a Axis against Oxidative Damage-Induced Preclinical Neurons.

    Ruankham, Waralee / Songtawee, Napat / Prachayasittikul, Veda / Worachartcheewan, Apilak / Suwanjang, Wilasinee / Pingaew, Ratchanok / Prachayasittikul, Virapong / Prachayasittikul, Supaluk / Phopin, Kamonrat

    ACS omega

    2023  Volume 8, Issue 49, Page(s) 46977–46988

    Abstract: The discovery of novel bioactive molecules as potential multifunctional neuroprotective agents has clinically drawn continual interest due to devastating oxidative damage in the pathogenesis and progression of neurodegenerative diseases. Synthetic 8- ... ...

    Abstract The discovery of novel bioactive molecules as potential multifunctional neuroprotective agents has clinically drawn continual interest due to devastating oxidative damage in the pathogenesis and progression of neurodegenerative diseases. Synthetic 8-aminoquinoline antimalarial drug is an attractive pharmacophore in drug development and chemical modification owing to its wide range of biological activities, yet the underlying molecular mechanisms are not fully elucidated in preclinical models for oxidative damage. Herein, the neuroprotective effects of two 8-aminoquinoline-uracil copper complexes were investigated on the hydrogen peroxide-induced human neuroblastoma SH-SY5Y cells. Both metal complexes markedly restored cell survival, alleviated apoptotic cascades, maintained antioxidant defense, and prevented mitochondrial function by upregulating the sirtuin 1 (SIRT1)/3-FOXO3a signaling pathway. Intriguingly,
    Language English
    Publishing date 2023-11-30
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c06764
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Discovery of Novel Naphthoquinone-Chalcone Hybrids as Potent FGFR1 Tyrosine Kinase Inhibitors: Synthesis, Biological Evaluation, and Molecular Modeling.

    Leechaisit, Ronnakorn / Mahalapbutr, Panupong / Boonsri, Pornthip / Karnchanapandh, Kun / Rungrotmongkol, Thanyada / Prachayasittikul, Veda / Prachayasittikul, Supaluk / Ruchirawat, Somsak / Prachayasittikul, Virapong / Pingaew, Ratchanok

    ACS omega

    2023  Volume 8, Issue 36, Page(s) 32593–32605

    Abstract: This work presents a flexible synthesis of 10 novel naphthoquinone-chalcone derivatives ( ...

    Abstract This work presents a flexible synthesis of 10 novel naphthoquinone-chalcone derivatives (
    Language English
    Publishing date 2023-08-30
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c03176
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Rational design of novel sirtuin 1 activators via structure-activity insights from application of QSAR modeling.

    Pratiwi, Reny / Prachayasittikul, Veda / Prachayasittikul, Supaluk / Nantasenamat, Chanin

    EXCLI journal

    2019  Volume 18, Page(s) 207–222

    Abstract: Sirtuin 1 (SIRT1) enzyme regulates major cell activities, and its activation offers lucrative therapeutic potentials for aging diseases including Alzheimer's disease (AD). Regarding the global aging society, continual attention has been given to various ... ...

    Abstract Sirtuin 1 (SIRT1) enzyme regulates major cell activities, and its activation offers lucrative therapeutic potentials for aging diseases including Alzheimer's disease (AD). Regarding the global aging society, continual attention has been given to various chemical scaffolds as a source for the discovery of novel SIRT1 activators since the discovery of the pioneer activator, resveratrol. Understanding structure-activity relationship (SAR) is essential for screening, designing as well as improving the properties of drugs. In this study, an
    Language English
    Publishing date 2019-04-05
    Publishing country Germany
    Document type Journal Article
    ISSN 1611-2156
    ISSN 1611-2156
    DOI 10.17179/excli2019-1274
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: P-glycoprotein transporter in drug development.

    Prachayasittikul, Veda / Prachayasittikul, Virapong

    EXCLI journal

    2016  Volume 15, Page(s) 113–118

    Language English
    Publishing date 2016-02-12
    Publishing country Germany
    Document type Journal Article
    ISSN 1611-2156
    ISSN 1611-2156
    DOI 10.17179/excli2015-768
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Investigations on Anticancer and Antimalarial Activities of Indole-Sulfonamide Derivatives and

    Pingaew, Ratchanok / Mandi, Prasit / Prachayasittikul, Veda / Thongnum, Anusit / Prachayasittikul, Supaluk / Ruchirawat, Somsak / Prachayasittikul, Virapong

    ACS omega

    2021  Volume 6, Issue 47, Page(s) 31854–31868

    Abstract: A library of 44 indole-sulfonamide derivatives ( ...

    Abstract A library of 44 indole-sulfonamide derivatives (
    Language English
    Publishing date 2021-11-18
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.1c04552
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Discovery of Anilino-1,4-naphthoquinones as Potent EGFR Tyrosine Kinase Inhibitors: Synthesis, Biological Evaluation, and Comprehensive Molecular Modeling.

    Mahalapbutr, Panupong / Leechaisit, Ronnakorn / Thongnum, Anusit / Todsaporn, Duangjai / Prachayasittikul, Veda / Rungrotmongkol, Thanyada / Prachayasittikul, Supaluk / Ruchirawat, Somsak / Prachayasittikul, Virapong / Pingaew, Ratchanok

    ACS omega

    2022  Volume 7, Issue 21, Page(s) 17881–17893

    Abstract: Epidermal growth factor receptor (EGFR) has been recognized as one of the attractive targets for anticancer drug development. Herein, a set of anilino-1,4-naphthoquinone derivatives ( ...

    Abstract Epidermal growth factor receptor (EGFR) has been recognized as one of the attractive targets for anticancer drug development. Herein, a set of anilino-1,4-naphthoquinone derivatives (
    Language English
    Publishing date 2022-05-18
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.2c01188
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Coriander (Coriandrum sativum): A promising functional food toward the well-being

    Prachayasittikul, Veda / Somsak Ruchirawat / Supaluk Prachayasittikul / Virapong Prachayasittikul

    Food research international. 2017,

    2017  

    Abstract: Coriandrum sativum (C. sativum) or coriander is one of the most popularly used spices in culinary worldwide, and its medicinal values has been recognized since ancient time. C. sativum contains bioactive phytochemicals that are accounted for a wide range ...

    Abstract Coriandrum sativum (C. sativum) or coriander is one of the most popularly used spices in culinary worldwide, and its medicinal values has been recognized since ancient time. C. sativum contains bioactive phytochemicals that are accounted for a wide range of biological activities including antioxidant, anticancer, neuroprotective, anxiolytic, anticonvulsant, analgesic, migraine-relieving, hypolipidemic, hypoglycemic, hypotensive, antimicrobial, and antiinflammatory activities. The major compound, linalool, abundantly found in seeds is remarked for its abilities to modulate many key pathogenesis pathways of diseases. Apart from the modulating effects, the potent antioxidant property of the C. sativum provides a key mechanism behind its protective effects against neurodegenerative diseases, cancer, and metabolic syndrome. This review shed light on comprehensive aspects regarding the therapeutic values of the C. sativum, which indicate its significance of being a promising functional food for promoting the well-being in the era of aging and lifestyle-related diseases.
    Keywords analgesics ; anticonvulsants ; anti-inflammatory activity ; antioxidant activity ; antioxidants ; Coriandrum sativum ; functional foods ; linalool ; metabolic syndrome ; neoplasms ; neurodegenerative diseases ; pathogenesis ; phytopharmaceuticals ; protective effect ; seeds ; spices ; tranquilizers
    Language English
    Size p. .
    Publishing place Elsevier Ltd
    Document type Article
    Note Pre-press version
    ZDB-ID 1111695-x
    ISSN 1873-7145 ; 0963-9969
    ISSN (online) 1873-7145
    ISSN 0963-9969
    DOI 10.1016/j.foodres.2017.11.019
    Database NAL-Catalogue (AGRICOLA)

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