Article ; Online: Carbazole-based semicarbazones and hydrazones as multifunctional anti-Alzheimer agents.
Journal of biomolecular structure & dynamics
2021 Volume 40, Issue 20, Page(s) 10278–10299
Abstract: With the aim to combat a multi-faceted neurodegenerative Alzheimer's disease (AD), a series of carbazole-based semicarbazide and hydrazide derivatives were designed, synthesized and assessed for their cholinesterase (ChE) inhibitory, antioxidant and ... ...
Abstract | With the aim to combat a multi-faceted neurodegenerative Alzheimer's disease (AD), a series of carbazole-based semicarbazide and hydrazide derivatives were designed, synthesized and assessed for their cholinesterase (ChE) inhibitory, antioxidant and biometal chelating activity. Among them, ( |
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MeSH term(s) | Humans ; Cholinesterase Inhibitors/pharmacology ; Cholinesterase Inhibitors/chemistry ; Acetylcholinesterase/chemistry ; Semicarbazones/pharmacology ; Hydrazones ; Molecular Docking Simulation ; Carbazoles/pharmacology ; Carbazoles/chemistry ; Chelating Agents/pharmacology ; Chelating Agents/chemistry ; Antioxidants/pharmacology ; Antioxidants/chemistry ; Alzheimer Disease/drug therapy ; Structure-Activity Relationship |
Chemical Substances | Cholinesterase Inhibitors ; Acetylcholinesterase (EC 3.1.1.7) ; hydrazinecarbothioamide ; Semicarbazones ; Hydrazones ; Carbazoles ; Chelating Agents ; Antioxidants |
Language | English |
Publishing date | 2021-07-02 |
Publishing country | England |
Document type | Journal Article ; Research Support, Non-U.S. Gov't |
ZDB-ID | 49157-3 |
ISSN | 1538-0254 ; 0739-1102 |
ISSN (online) | 1538-0254 |
ISSN | 0739-1102 |
DOI | 10.1080/07391102.2021.1942212 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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