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Book ; Online ; E-Book: MicroRNA in Human Infectious Diseases

Prajapati, Vijay Kumar / Ojha, Rupal

2024

Language	English
Size	1 online resource (346 pages)
Edition	1st ed.
Publisher	Elsevier Science & Technology
Publishing place	San Diego
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	0-323-99662-0 ; 9780323996617 ; 978-0-323-99662-4 ; 0323996612
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book ; Online ; E-Book: Translational Bioinformatics

Donev, Rossen / Prajapati, Vijay Kumar

2024

Author's details	Rossen Donev and Vijay Kumar Prajapati
Keywords	Bioinformatics
Subject code	570.285
Language	English
Size	1 online resource (522 pages)
Edition	First edition.
Publisher	Zoe Kruze
Publishing place	San Diego, CA
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	0-443-19349-5 ; 0-443-19348-7 ; 978-0-443-19349-1 ; 978-0-443-19348-4
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book ; Online ; E-Book: System vaccinology

Prajapati, Vijay Kumar

the history, the translational challenges and the future

2022

Abstract: Emergence of new and deadly infectious diseases is significantly deteriorating the human health. Development of vaccine by the scientist has become an important weapon to control the spread of infectious diseases as well as to improve the life expectancy ...

Author's details	edited by Vijay Kumar Prajapati
Abstract	Emergence of new and deadly infectious diseases is significantly deteriorating the human health. Development of vaccine by the scientist has become an important weapon to control the spread of infectious diseases as well as to improve the life expectancy at global level in 20th-21st Century. This book will provide the in-depth knowledge of vaccine history, and development of new strategies to design efficacious and safe vaccine molecule. This book will cover the development of system vaccinology and their applications revolutionize the vaccine discovery. This will provide a resource for the basic and clinical researcher working to human life expectancy by their vaccine experiments and clinical trials. My purpose to write this book to educate the students and researchers with modern development in the field of vaccinology and empowering the researcher with new tools and methodology for developing potential and immunogenic vaccines. This book will be helpful to solve the curiosity of science and medical background students related with vaccinology and will be helpful to devise a new vaccine molecule to control the spread of new and emerging pathogens. Systems biology is a rapidly expanding research discipline aiming to integrate multifaceted datasets generated using state-of-the-art high- throughput technologies such as arrays and next-generation sequencing. Combined with sophisticated computational analysis we are able to interrogate host responses to infections and vaccination on a systems level, thus generating important new hypotheses and discovering unknown associations between immunological parameters.
Keywords	Vaccines/History ; Vaccines/Research
Subject code	615.372
Language	English
Size	1 online resource (xvi, 420 pages) :, colour illustrations
Publisher	Academic Press is an imprint of Elsevier
Publishing place	London, United Kingdom
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	9780323897860 ; 9780323859417 ; 032389786X ; 0323859410
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: From genome to clinic: The power of translational bioinformatics in improving human health.

Singh, Satyendra / Pandey, Anurag Kumar / Prajapati, Vijay Kumar

Advances in protein chemistry and structural biology

2024 Volume 139, Page(s) 1–25

Abstract: Translational bioinformatics (TBI) has transformed healthcare by providing personalized medicine and tailored treatment options by integrating genomic data and clinical information. In recent years, TBI has bridged the gap between genome and clinical ... ...

Abstract	Translational bioinformatics (TBI) has transformed healthcare by providing personalized medicine and tailored treatment options by integrating genomic data and clinical information. In recent years, TBI has bridged the gap between genome and clinical data because of significant advances in informatics like quantum computing and utilizing state-of-the-art technologies. This chapter discusses the power of translational bioinformatics in improving human health, from uncovering disease-causing genes and variations to establishing new therapeutic techniques. We discuss key application areas of bioinformatics in clinical genomics, such as data sources and methods used in translational bioinformatics, the impact of translational bioinformatics on human health, and how machine learning and artificial intelligence are being used to mine vast amounts of data for drug development and precision medicine. We also look at the problems, constraints, and ethical concerns connected with exploiting genomic data and the future of translational bioinformatics and its potential impact on medicine and human health. Ultimately, this chapter emphasizes the great potential of translational bioinformatics to alter healthcare and enhance patient outcomes.
MeSH term(s)	Humans ; Artificial Intelligence ; Computing Methodologies ; Quantum Theory ; Computational Biology ; Genomics
Language	English
Publishing date	2024-02-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2473077-4
ISSN	1876-1631 ; 1876-1623
ISSN (online)	1876-1631
ISSN	1876-1623
DOI	10.1016/bs.apcsb.2023.11.010
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Article: Exploring actinomycetes natural products to identify potential multi-target inhibitors against

Singh, Satyendra / Prajapati, Vijay Kumar

3 Biotech

2022 Volume 12, Issue 9, Page(s) 235

Abstract: Visceral leishmaniasis (VL) is a neglected tropical disease that mainly affects the poor population of the Indian, African, and South American subcontinent. The increasing resistance to antimonial and miltefosine and frequent toxicity of amphotericin B ... ...

Abstract	Visceral leishmaniasis (VL) is a neglected tropical disease that mainly affects the poor population of the Indian, African, and South American subcontinent. The increasing resistance to antimonial and miltefosine and frequent toxicity of amphotericin B drives an urgent need to develop an anti-leishmanial drug with excellent efficacy and safety profile. In this study, three sequential docking protocols (HTVS, SP, and XP) were performed to screen the secondary metabolites (
Language	English
Publishing date	2022-08-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2600522-0
ISSN	2190-5738 ; 2190-572X
ISSN (online)	2190-5738
ISSN	2190-572X
DOI	10.1007/s13205-022-03304-1
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Article ; Online: Technological advancements in viral vector designing and optimization for therapeutic applications.

Singh, Satyendra / Pandey, Anurag Kumar / Malemnganba, Takhellambam / Prajapati, Vijay Kumar

Advances in protein chemistry and structural biology

2024 Volume 139, Page(s) 57–87

Abstract: Viral vector engineering is critical to the advancement of several sectors of biotechnology, gene therapy, and vaccine development. These vectors were produced from viruses, were employed to deliver therapeutic genes or to alter biological processes. The ...

Abstract	Viral vector engineering is critical to the advancement of several sectors of biotechnology, gene therapy, and vaccine development. These vectors were produced from viruses, were employed to deliver therapeutic genes or to alter biological processes. The potential for viral vectors to improve the precision, safety, and efficiency of therapeutic interventions has boosted their demand. The dynamic interplay between technological advancements and computational tools in establishing the landscape of viral vector engineering and vector optimization for therapeutic reasons is discussed in this chapter. It also emphasizes the importance of in silico techniques in maximizing vector potential for therapeutics and many phases of viral vector engineering, from genomic analysis to computer modelling and advancements to improve precise gene delivery. High-throughput screening propels the expedited process of vector selection, and computational techniques to analyze complex omics data to further enhance vector capabilities have been discussed. As in silico models reveal insights into off-target effects and integration sites, vector safety (biodistribution and toxicity) remains a crucial part and bridges the gap between preclinical and clinical investigations. Despite the limitations, this chapter depicts a future in which technology and computing merge to catapult viral vector therapy into an era of boundless possibilities.
MeSH term(s)	Tissue Distribution ; Computer Simulation ; Genetic Therapy ; Genomics ; High-Throughput Screening Assays
Language	English
Publishing date	2024-02-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2473077-4
ISSN	1876-1631 ; 1876-1623
ISSN (online)	1876-1631
ISSN	1876-1623
DOI	10.1016/bs.apcsb.2023.11.013
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Article: Exploring actinomycetes natural products to identify potential multi-target inhibitors against Leishmania donovani

Singh, Satyendra / Prajapati, Vijay Kumar

3 Biotech. 2022 Sept., v. 12, no. 9

2022

Abstract	Visceral leishmaniasis (VL) is a neglected tropical disease that mainly affects the poor population of the Indian, African, and South American subcontinent. The increasing resistance to antimonial and miltefosine and frequent toxicity of amphotericin B drives an urgent need to develop an anti-leishmanial drug with excellent efficacy and safety profile. In this study, three sequential docking protocols (HTVS, SP, and XP) were performed to screen the secondary metabolites (n = 6519) from the actinomycetes source against five key proteins involved in the metabolic pathway of Leishmania donovani. Those proteins were adenine phosphoribosyltransferase (PDB ID: 1QB7), trypanothione reductase (PDB ID: 2JK6), N-myristoyl transferase (PDB ID: 2WUU), pteridine reductase (PDB ID: 2XOX), and MAP kinase (PDB ID: 4QNY). Although the binding energy of top ligands was predicted using the MM-GBSA module of the Schrödinger suite. SP and XP docking mode resulted in 55 multi-targeted ligands against L donovani. MM-GBSA analysis selected the top 18 ligands with good-binding affinity and the binding-free energy for four proteins, as mentioned earlier, when compared with the miltefosine, paromomycin, and a reference ligand selected for each target. Finally, molecular dynamics simulation, post-MD-binding-free energy (MM-PBSA), and principal component analysis (PCA) proposed three best ligands (Adenosine pentaphosphate, Atetra P, and GDP-4-keto-6-deoxymannose) qualifying the above screening parameters and confirmed as a potential drug candidate to fight against Leishmania donovani parasites.
Keywords	Leishmania donovani ; adenine phosphoribosyltransferase ; adenosine ; amphotericin B ; antileishmanials ; biochemical pathways ; energy ; ligands ; mitogen-activated protein kinase ; molecular dynamics ; oxidoreductases ; principal component analysis ; secondary metabolites ; toxicity ; tropical diseases ; visceral leishmaniasis
Language	English
Dates of publication	2022-09
Size	p. 235.
Publishing place	Springer International Publishing
Document type	Article
ZDB-ID	2600522-0
ISSN	2190-5738 ; 2190-572X
ISSN (online)	2190-5738
ISSN	2190-572X
DOI	10.1007/s13205-022-03304-1
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The interplay between circadian clock and viral infections: A molecular perspective.

Kalita, Elora / Panda, Mamta / Prajapati, Vijay Kumar

Advances in protein chemistry and structural biology

2023 Volume 137, Page(s) 293–330

Abstract: The circadian clock influences almost every aspect of mammalian behavioral, physiological and metabolic processes. Being a hierarchical network, the circadian clock is driven by the central clock in the brain and is composed of several peripheral tissue- ... ...

Abstract	The circadian clock influences almost every aspect of mammalian behavioral, physiological and metabolic processes. Being a hierarchical network, the circadian clock is driven by the central clock in the brain and is composed of several peripheral tissue-specific clocks. It orchestrates and synchronizes the daily oscillations of biological processes to the environment. Several pathological events are influenced by time and seasonal variations and as such implicate the clock in pathogenesis mechanisms. In context with viral infections, circadian rhythmicity is closely associated with host susceptibility, disease severity, and pharmacokinetics and efficacies of antivirals and vaccines. Leveraging the circadian molecular mechanism insights has increased our understanding of clock infection biology and proposes new avenues for viral diagnostics and therapeutics. In this chapter, we address the molecular interplay between the circadian clock and viral infections and discuss the importance of chronotherapy as a complementary approach to conventional medicines, emphasizing the significance of virus-clock studies.
MeSH term(s)	Animals ; Circadian Clocks ; Virus Diseases ; Antiviral Agents/therapeutic use ; Brain ; Mammals
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2023-02-25
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2473077-4
ISSN	1876-1631 ; 1876-1623
ISSN (online)	1876-1631
ISSN	1876-1623
DOI	10.1016/bs.apcsb.2023.02.009
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Article ; Online: Cognizance of posttranslational modifications in vaccines: A way to enhanced immunogenicity.

Ojha, Rupal / Prajapati, Vijay Kumar

Journal of cellular physiology

2021 Volume 236, Issue 12, Page(s) 8020–8034

Abstract: Vaccination is a significant advancement or preventative strategy for controlling the spread of various severe infectious and noninfectious diseases. The purpose of vaccination is to stimulate or activate the immune system by injecting antigens, i.e., ... ...

Abstract	Vaccination is a significant advancement or preventative strategy for controlling the spread of various severe infectious and noninfectious diseases. The purpose of vaccination is to stimulate or activate the immune system by injecting antigens, i.e., either whole microorganisms or using the pathogen's antigenic part or macromolecules. Over time, researchers have made tremendous efforts to reduce vaccine side effects or failure by developing different strategies combining with immunoinformatic and molecular biology. These newly designed vaccines are composed of single or several antigenic molecules derived from a pathogenic organism. Although, whole-cell vaccines are still in use against various diseases but due to their ineffectiveness, other vaccines like DNA-based, RNA-based, and protein-based vaccines, with the addition of immunostimulatory agents, are in the limelight. Despite this, many researchers escape the most common fundamental phenomenon of protein posttranslational modifications during the development of vaccines, which regulates protein functional behavior, evokes immunogenicity and stability, etc. The negligence about post translational modification (PTM) during vaccine development may affect the vaccine's efficacy and immune responses. Therefore, it becomes imperative to consider these modifications of macromolecules before finalizing the antigenic vaccine construct. Here, we have discussed different types of posttranslational/transcriptional modifications that are usually considered during vaccine construct designing: Glycosylation, Acetylation, Sulfation, Methylation, Amidation, SUMOylation, Ubiquitylation, Lipidation, Formylation, and Phosphorylation. Based on the available research information, we firmly believe that considering these modifications will generate a potential and highly immunogenic antigenic molecule against communicable and noncommunicable diseases compared to the unmodified macromolecules.
MeSH term(s)	Adjuvants, Immunologic/pharmacology ; Animals ; Antigens/immunology ; Humans ; Immunogenicity, Vaccine/immunology ; Vaccination/methods ; Vaccine Development ; Vaccines/immunology
Chemical Substances	Adjuvants, Immunologic ; Antigens ; Vaccines
Language	English
Publishing date	2021-06-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	3116-1
ISSN	1097-4652 ; 0021-9541
ISSN (online)	1097-4652
ISSN	0021-9541
DOI	10.1002/jcp.30483
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Article ; Online: Design of inhibitor peptide sequences based on the interfacial knowledge of the protein G-IgG crystallographic complex and their binding studies with IgG.

Tanwar, Neetu / Ojha, Rupal / Aggarwal, Soumya / Prajapati, Vijay Kumar / Munde, Manoj

European biophysics journal : EBJ

2024 Volume 53, Issue 3, Page(s) 159–170

Abstract: Protein-protein interactions (PPI) have emerged as valuable targets in medicinal chemistry due to their key roles in important biological processes. The modulation of PPI by small peptides offers an excellent opportunity to develop drugs against human ... ...

Abstract	Protein-protein interactions (PPI) have emerged as valuable targets in medicinal chemistry due to their key roles in important biological processes. The modulation of PPI by small peptides offers an excellent opportunity to develop drugs against human diseases. Here, we exploited the knowledge of the binding interface of the IgG-protein G complex (PDB:1FCC) for designing peptides that can inhibit these complexes. Herein, we have designed several closely related peptides, and the comparison of results from experiments and computational studies indicated that all the peptides bind close to the expected binding site on IgG and the complexes are stable. A minimal sequence consisting of 11 amino acids (P5) with binding constants in the range of 100 nM was identified. We propose that the main affinity differences across the series of peptides arose from the presence of polar amino acid residues. Further, the molecular dynamic studies helped to understand the dynamic properties of complexes in terms of flexibility of residues and structural stability at the interface. The ability of P5 to compete with the protein G in recognizing IgG can help in the detection and purification of antibodies. Further, it can serve as a versatile tool for a better understanding of protein-protein interactions.
MeSH term(s)	Humans ; Peptides/chemistry ; Amino Acid Sequence ; Binding Sites ; Amino Acids/metabolism ; Immunoglobulin G/chemistry ; Immunoglobulin G/metabolism ; Protein Binding ; Thermodynamics
Chemical Substances	Peptides ; Amino Acids ; Immunoglobulin G
Language	English
Publishing date	2024-03-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	283671-3
ISSN	1432-1017 ; 0175-7571
ISSN (online)	1432-1017
ISSN	0175-7571
DOI	10.1007/s00249-024-01704-0
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