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  1. Article ; Online: EQuIP India: The National Cancer Grid quality improvement competency training initiative.

    Vallath, Nandini / Pramesh, C S

    Indian journal of cancer

    2023  Volume 60, Issue 2, Page(s) 149–151

    MeSH term(s) Humans ; Quality Improvement ; Neoplasms/epidemiology ; Neoplasms/therapy ; India/epidemiology
    Language English
    Publishing date 2023-08-02
    Publishing country India
    Document type Editorial
    ZDB-ID 410194-7
    ISSN 1998-4774 ; 0019-509X
    ISSN (online) 1998-4774
    ISSN 0019-509X
    DOI 10.4103/ijc.ijc_427_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 581: Show issues Location:
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  2. Article ; Online: Virtual oncology research-different models and lessons learned.

    Ranganathan, P / Pramesh, C S

    Current opinion in supportive and palliative care

    2022  Volume 16, Issue 3, Page(s) 117–122

    Abstract: Purpose of review: The COVID-19 pandemic posed several challenges to cancer research including halting of trials, reduced recruitment and protocol violations related to inflexible processes followed in clinical trials. Researchers adopted innovative ... ...

    Abstract Purpose of review: The COVID-19 pandemic posed several challenges to cancer research including halting of trials, reduced recruitment and protocol violations related to inflexible processes followed in clinical trials. Researchers adopted innovative measures to mitigate these problems and continue studies without compromising their quality. This review collates these adaptations that could well continue after the pandemic.
    Recent findings: The COVID-19 pandemic forced researchers globally to adopt innovative measures to overcome the challenges of the pandemic. These included protocol amendments to adjust to the pandemic and travel restrictions, and increased use of digital technologies. 'Virtual' clinical trials were conducted increasingly with adaptations in ethics and regulatory approvals, patient recruitment and consenting, study interventions and delivery of study medications, trial assessments, and monitoring. Many of these adaptations are safe and feasible, without compromising study quality and data integrity. Although these may not be universally applicable in all types of research, they bring many benefits including more diverse patient participation, less burden on patients for study procedures and reduced resources to conduct trials.
    Summary: The COVID-19 pandemic has affected cancer research adversely; however, learnings from the pandemic and adaptations from researchers are likely to improve the efficiency of clinical research beyond the pandemic.
    MeSH term(s) COVID-19/epidemiology ; Humans ; Medical Oncology ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2022-07-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2633726-5
    ISSN 1751-4266 ; 1751-4258
    ISSN (online) 1751-4266
    ISSN 1751-4258
    DOI 10.1097/SPC.0000000000000605
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6946: Show issues Location:
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  3. Article ; Online: Choosing Wisely in a time of resource constraints.

    Born, Karen B / Levinson, Wendy / Pramesh, C S / Kerr, Eve A

    BMJ (Clinical research ed.)

    2024  Volume 385, Page(s) q166

    Language English
    Publishing date 2024-04-12
    Publishing country England
    Document type Editorial
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.q166
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Virtual clinical trials.

    Ranganathan, Priya / Aggarwal, Rakesh / Pramesh, C S

    Perspectives in clinical research

    2023  Volume 14, Issue 4, Page(s) 203–206

    Abstract: Virtual clinical trials refer to clinical trials that take advantage of digital technologies, including computer and mobile device apps, web-based tools, and remote monitoring devices, for one or more of the trial processes, such as participant ... ...

    Abstract Virtual clinical trials refer to clinical trials that take advantage of digital technologies, including computer and mobile device apps, web-based tools, and remote monitoring devices, for one or more of the trial processes, such as participant recruitment, counseling, informed consent, measurement of endpoints, and/or adverse event monitoring, to obviate or reduce the need for participant visits to the trial site. The advantages of such trials may include higher recruitment rates, better compliance, lower dropout rates, reduction in time for trial completion, and lower costs. The use of such trials increased manifold during the COVID-19 pandemic and is likely to continue in the future.
    Language English
    Publishing date 2023-03-08
    Publishing country India
    Document type Journal Article
    ZDB-ID 2593231-7
    ISSN 2229-5488 ; 2229-3485
    ISSN (online) 2229-5488
    ISSN 2229-3485
    DOI 10.4103/picr.picr_184_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The COVID-19 Pandemic and Cancer Surgery.

    Pramesh, C S / Badwe, Rajendra Achyut

    Indian journal of surgical oncology

    2021  Volume 12, Issue Suppl 2, Page(s) 229–231

    Language English
    Publishing date 2021-11-04
    Publishing country India
    Document type Editorial
    ZDB-ID 2568289-1
    ISSN 0976-6952 ; 0975-7651
    ISSN (online) 0976-6952
    ISSN 0975-7651
    DOI 10.1007/s13193-021-01461-y
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  6. Article: Research studies on screening tests.

    Aggarwal, Rakesh / Ranganathan, Priya / Pramesh, C S

    Perspectives in clinical research

    2022  Volume 13, Issue 3, Page(s) 168–171

    Abstract: Screening tests are done to diagnose asymptomatic disease in apparently healthy people with the aim to reduce mortality and morbidity from the disease. Certain criteria need to be fulfilled before we adopt population-level screening for any disease. ... ...

    Abstract Screening tests are done to diagnose asymptomatic disease in apparently healthy people with the aim to reduce mortality and morbidity from the disease. Certain criteria need to be fulfilled before we adopt population-level screening for any disease. Several biases exist in evaluating screening studies, and the ideal study design would be a randomized trial with hard endpoints such as mortality and morbidity.
    Language English
    Publishing date 2022-06-30
    Publishing country India
    Document type Journal Article
    ZDB-ID 2593231-7
    ISSN 2229-5488 ; 2229-3485
    ISSN (online) 2229-5488
    ISSN 2229-3485
    DOI 10.4103/picr.picr_111_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Equivalence trials.

    Ranganathan, Priya / Pramesh, C S / Aggarwal, Rakesh

    Perspectives in clinical research

    2022  Volume 13, Issue 2, Page(s) 114–117

    Abstract: In an equivalence trial, researchers aim to show that a new intervention is more or less similar to an existing standard of care, i.e., the two are "equivalent". In this article, we discuss some aspects of the design, analysis, interpretation and ... ...

    Abstract In an equivalence trial, researchers aim to show that a new intervention is more or less similar to an existing standard of care, i.e., the two are "equivalent". In this article, we discuss some aspects of the design, analysis, interpretation and reporting of equivalence trials.
    Language English
    Publishing date 2022-04-06
    Publishing country India
    Document type Journal Article
    ZDB-ID 2593231-7
    ISSN 2229-5488 ; 2229-3485
    ISSN (online) 2229-5488
    ISSN 2229-3485
    DOI 10.4103/picr.picr_55_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Common pitfalls in statistical analysis: Measures of agreement.

    Ranganathan, Priya / Pramesh, C S / Aggarwal, Rakesh

    Perspectives in clinical research

    2022  Volume 8, Issue 4, Page(s) 187–191

    Abstract: Agreement between measurements refers to the degree of concordance between two (or more) sets of measurements. Statistical methods to test agreement are used to assess inter-rater variability or to decide whether one technique for measuring a variable ... ...

    Abstract Agreement between measurements refers to the degree of concordance between two (or more) sets of measurements. Statistical methods to test agreement are used to assess inter-rater variability or to decide whether one technique for measuring a variable can substitute another. In this article, we look at statistical measures of agreement for different types of data and discuss the differences between these and those for assessing correlation.
    Language English
    Publishing date 2022-03-31
    Publishing country India
    Document type Journal Article
    ZDB-ID 2593231-7
    ISSN 2229-5488 ; 2229-3485
    ISSN (online) 2229-5488
    ISSN 2229-3485
    DOI 10.4103/picr.PICR_123_17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Non-inferiority trials.

    Ranganathan, Priya / Pramesh, C S / Aggarwal, Rakesh

    Perspectives in clinical research

    2022  Volume 13, Issue 1, Page(s) 54–57

    Abstract: Studies sometimes aim to show that a new intervention is not substantially worse than the existing standard of care while offering some benefits, for example, lower cost, decreased toxicity, or easier administration. Such studies are called non- ... ...

    Abstract Studies sometimes aim to show that a new intervention is not substantially worse than the existing standard of care while offering some benefits, for example, lower cost, decreased toxicity, or easier administration. Such studies are called non-inferiority (NI) trials. In this article, we look at some aspects of NI trials.
    Language English
    Publishing date 2022-01-06
    Publishing country India
    Document type Journal Article
    ZDB-ID 2593231-7
    ISSN 2229-5488 ; 2229-3485
    ISSN (online) 2229-5488
    ISSN 2229-3485
    DOI 10.4103/picr.picr_245_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The "Weekday Effect"-Does It Impact Esophageal Cancer Surgery Outcomes?

    Jiwnani, Sabita / Pramesh, C S / Ranganathan, Priya

    Journal of gastrointestinal cancer

    2022  Volume 54, Issue 3, Page(s) 970–977

    Abstract: Background: Increased 30-day mortality rates have been reported in patients undergoing elective surgery later compared with earlier in the week. However, these reports have been conflicting for esophageal surgery. We conducted a study to assess the ... ...

    Abstract Background: Increased 30-day mortality rates have been reported in patients undergoing elective surgery later compared with earlier in the week. However, these reports have been conflicting for esophageal surgery. We conducted a study to assess the differences in outcomes of patients undergoing surgery for esophageal cancer earlier in the week (Tuesday) versus later (Friday).
    Methods: This retrospective analysis of a prospectively maintained database included patients with esophageal cancer who underwent esophageal resection in a tertiary cancer center between 1 January 2005 and 31 December 2017. We compared patients operated on Tuesdays versus Fridays. The primary outcome was a composite of major morbidity (defined as Clavien-Dindo grade 3 or more) and/or mortality. Secondary outcomes included duration of post-operative ventilation, and length of ICU and hospital stay.
    Results: Among 1300 patients included, 733 were operated on a Tuesday and 567 on a Friday. Patient and surgery characteristics were similar in the two groups. The primary outcome (composite of major morbidity and mortality) was 23.6% in the Tuesday group versus 26.3% in the Friday group. Mortality was similar in the two groups (6.0%). Multivariable logistic regression analysis showed that the day of surgery was not a predictor of major morbidity or mortality.
    Conclusions: In patients undergoing esophagectomy at tertiary care high volume cancer center, there was no difference in major morbidity and mortality whether the surgery was performed early in the week (Tuesday) or closer to the weekend (Friday).
    MeSH term(s) Humans ; Retrospective Studies ; Time Factors ; Elective Surgical Procedures ; Esophageal Neoplasms/surgery ; Hospital Mortality ; Esophagectomy ; Treatment Outcome ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology
    Language English
    Publishing date 2022-08-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2452514-5
    ISSN 1941-6636 ; 1559-0739 ; 1941-6628 ; 1537-3649
    ISSN (online) 1941-6636 ; 1559-0739
    ISSN 1941-6628 ; 1537-3649
    DOI 10.1007/s12029-022-00855-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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