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  1. AU="Pramudo, Setyo G"
  2. AU="Riddle, Austin"

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  1. Article ; Online: Longitudinal proteomic profiling of the inflammatory response in dengue patients.

    Garishah, Fadel Muhammad / Boahen, Collins K / Vadaq, Nadira / Pramudo, Setyo G / Tunjungputri, Rahajeng N / Riswari, Silvita Fitri / van Rij, Ronald P / Alisjahbana, Bachti / Gasem, Muhammad Hussein / van der Ven, André J A M / de Mast, Quirijn

    PLoS neglected tropical diseases

    2023  Volume 17, Issue 1, Page(s) e0011041

    Abstract: Background: The immunopathogenesis of dengue virus (DENV) infection remains incompletely understood. To increase our understanding of inflammatory response in non-severe dengue, we assessed longitudinal changes in the inflammatory proteome in patients ... ...

    Abstract Background: The immunopathogenesis of dengue virus (DENV) infection remains incompletely understood. To increase our understanding of inflammatory response in non-severe dengue, we assessed longitudinal changes in the inflammatory proteome in patients with an acute DENV infection.
    Methods: Using a multiplex proximity extension assay (PEA), we measured relative levels of 368 inflammatory markers in plasma samples from hospitalized patients with non-severe DENV infection in the acute (n = 43) and convalescence (n = 35) phase of the infection and samples of healthy controls (n = 10).
    Results: We identified 203 upregulated and 39 downregulated proteins in acute versus convalescent plasma samples. The upregulated proteins had a strong representation of interferon (IFN) and IFN-inducible effector proteins, cytokines (e.g. IL-10, IL-33) and cytokine receptors, chemokines, pro-apoptotic proteins (e.g. granzymes) and endothelial markers. A number of differentially expressed proteins (DEPs) have not been reported in previous studies. Functional network analysis highlighted a central role for IFNγ, IL-10, IL-33 and chemokines. We identified different novel associations between inflammatory proteins and circulating concentrations of the endothelial glycocalyx disruption surrogate marker syndecan-1. Conclusion: This unbiased proteome analysis provides a comprehensive insight in the inflammatory response in DENV infection and its association with glycocalyx disruption.
    MeSH term(s) Humans ; Interleukin-10 ; Interleukin-33 ; Dengue ; Proteome ; Proteomics ; Cytokines/metabolism ; Chemokines
    Chemical Substances Interleukin-10 (130068-27-8) ; Interleukin-33 ; Proteome ; Cytokines ; Chemokines
    Language English
    Publishing date 2023-01-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2429704-5
    ISSN 1935-2735 ; 1935-2735
    ISSN (online) 1935-2735
    ISSN 1935-2735
    DOI 10.1371/journal.pntd.0011041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Characteristics, attitudes, and the odds for positive attitude toward clinical trial: A study on Indonesian COVID-19 vaccine trial participants.

    Maharani, Nani / Gustriawanto, Nuvi / Nency, Yetty M / Mahati, Endang / Yeremia, Glenn F / Anantyo, Dimas T / Hapsari, Rebriarina / Mulyono, Mulyono / Pramudo, Setyo G / Farhanah, Nur

    Perspectives in clinical research

    2023  Volume 14, Issue 4, Page(s) 194–202

    Abstract: Aims: This study was performed to understand the Indonesian population's characteristics and the factors that contribute to a more positive attitude toward participation in a clinical trial.: Methods: A cross-sectional survey was conducted involving ... ...

    Abstract Aims: This study was performed to understand the Indonesian population's characteristics and the factors that contribute to a more positive attitude toward participation in a clinical trial.
    Methods: A cross-sectional survey was conducted involving 402 COVID-19 vaccine trial participants in Semarang, Indonesia, utilizing self-reporting questionnaires consisting of questions related to socio-demographic characteristics and statements in a 5-scaled Likert Scale to assess the attitude toward vaccine trial. The odds for positive attitude were analyzed using Ordinal Logistic Regression to obtain the odd-ratio and 95% confidence interval. The
    Results: Most of the respondents were adults aged 22-64-year-old (89.30%), males (63.68%), married (77.61%), worked as an employee (59.70%), obtained information about the clinical trial from the Public Health Service (41.29%), had a low education level (40.80%), a low monthly income level (68.41%), with no previous participation in a clinical trial (90.80%). All respondents showed a good attitude toward the trial, with low education level, nonemployment status, fewer or no previous participation in clinical trials, and getting the information from the public health centers were the main predictors for better attitude toward vaccine trials.
    Conclusion: There was a positive attitude toward vaccine trials in the Indonesian population. The positive attitude could be driven by having a low education level, nonemployment status, fewer or no previous participation in the clinical trial, and getting information from public health centers.
    Language English
    Publishing date 2023-09-11
    Publishing country India
    Document type Journal Article
    ZDB-ID 2593231-7
    ISSN 2229-5488 ; 2229-3485
    ISSN (online) 2229-5488
    ISSN 2229-3485
    DOI 10.4103/picr.picr_71_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Effect of oseltamivir phosphate versus placebo on platelet recovery and plasma leakage in adults with dengue and thrombocytopenia; a phase 2, multicenter, double-blind, randomized trial.

    Tunjungputri, Rahajeng N / Riswari, Silvita Fitri / Pramudo, Setyo G / Kuntjoro, Lydia / Alisjahbana, Bachti / Nugraha, Harry Galuh / van der Ven, Andre / Gasem, Muhammad Hussein / de Mast, Quirijn

    PLoS neglected tropical diseases

    2022  Volume 16, Issue 1, Page(s) e0010051

    Abstract: Background: Thrombocytopenia, bleeding and plasma leakage are major complications of dengue. Activation of endogenous sialidases with desialylation of platelets and endothelial cells may underlie these complications. We aimed to assess the effects of ... ...

    Abstract Background: Thrombocytopenia, bleeding and plasma leakage are major complications of dengue. Activation of endogenous sialidases with desialylation of platelets and endothelial cells may underlie these complications. We aimed to assess the effects of the neuraminidase inhibitor oseltamivir on platelet recovery and plasma leakage in dengue.
    Methods: We performed a phase 2, double-blind, multicenter, randomized trial in adult dengue patients with thrombocytopenia (<70,000/μl) and a duration of illness ≤ 6 days. Oseltamivir phosphate 75mg BID or placebo were given for a maximum of five days. Primary outcomes were the time to platelet recovery (≥ 100,000/μl) or discharge from hospital and the course of measures of plasma leakage.
    Results: A total of 70 patients were enrolled; the primary outcome could be assessed in 64 patients (31 oseltamivir; 33 placebo). Time to platelet count ≥100,000/μl (n = 55) or discharge (n = 9) were similar in the oseltamivir and placebo group (3.0 days [95% confidence interval, 2.7 to 3.3] vs. 2.9 days [2.5 to 3.3], P = 0.055). The kinetics of platelet count and parameters of plasma leakage (gall bladder thickness, hematocrit, plasma albumin, syndecan-1) were also similar between the groups.
    Discussion: In this trial, adjunctive therapy with oseltamivir phosphate had no effect on platelet recovery or plasma leakage parameters.
    Trial registration: ISRCTN35227717.
    MeSH term(s) Adolescent ; Adult ; Antiviral Agents ; Blood Platelets ; Dengue/drug therapy ; Double-Blind Method ; Female ; Humans ; Male ; Oseltamivir ; Young Adult
    Chemical Substances Antiviral Agents ; Oseltamivir (20O93L6F9H)
    Language English
    Publishing date 2022-01-07
    Publishing country United States
    Document type Clinical Trial, Phase II ; Journal Article ; Multicenter Study ; Randomized Controlled Trial
    ZDB-ID 2429704-5
    ISSN 1935-2735 ; 1935-2735
    ISSN (online) 1935-2735
    ISSN 1935-2735
    DOI 10.1371/journal.pntd.0010051
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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