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  1. Article ; Online: A Component-Resolved Therapeutic Vaccine for Cockroach Allergy Made of Per a 9 and Transforming Growth Factor-β Homologue, an Immunosuppressive Protein of

    Prangtaworn, Pannathee / Mahasongkram, Kodchakorn / Saeung, Atiporn / Chaisri, Urai / Seesuay, Watee / Reamtong, Onrapak / Tungtrongchitr, Anchalee / Chaicumpa, Wanpen / Sookrung, Nitat

    Frontiers in immunology

    2021  Volume 12, Page(s) 676558

    Abstract: Allergen-specific-immunotherapy (ASIT) can cause long-term resolution of allergic diseases, reduces drug use and chances of new allergen sensitization. Nevertheless, therapeutic vaccine and data on ASIT efficacy for cockroach (CR) allergy are relatively ... ...

    Abstract Allergen-specific-immunotherapy (ASIT) can cause long-term resolution of allergic diseases, reduces drug use and chances of new allergen sensitization. Nevertheless, therapeutic vaccine and data on ASIT efficacy for cockroach (CR) allergy are relatively scarce. In this study, efficacy and mechanism of a novel intranasal vaccine consisting of liposome (L)-entrapped mixture of American CR (
    MeSH term(s) Administration, Intranasal ; Allergens/blood ; Allergens/immunology ; Animals ; Arginine Kinase/blood ; Arginine Kinase/immunology ; Brugia malayi/immunology ; Dendritic Cells/immunology ; Desensitization, Immunologic/methods ; Disease Models, Animal ; Hypersensitivity/blood ; Hypersensitivity/immunology ; Hypersensitivity/parasitology ; Hypersensitivity/prevention & control ; Immunoglobulin E/blood ; Immunoglobulin E/immunology ; Immunoglobulin G/blood ; Immunoglobulin G/immunology ; Immunosuppressive Agents/immunology ; Insect Proteins/immunology ; Liposomes ; Male ; Mice ; Mice, Inbred BALB C ; Periplaneta/immunology ; T-Lymphocytes, Regulatory/immunology ; Transforming Growth Factor beta/blood ; Transforming Growth Factor beta/immunology ; Treatment Outcome ; Vaccines/administration & dosage ; Vaccines/immunology
    Chemical Substances Allergens ; Immunoglobulin G ; Immunosuppressive Agents ; Insect Proteins ; Liposomes ; Transforming Growth Factor beta ; Vaccines ; Immunoglobulin E (37341-29-0) ; Arginine Kinase (EC 2.7.3.3) ; Per a 9 allergen, Periplaneta americana (EC 2.7.3.3.)
    Language English
    Publishing date 2021-05-31
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.676558
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Immune Response after SARS-CoV-2 Infection with Residual Post-COVID Symptoms.

    Pongkunakorn, Tanyaporn / Manosan, Thamonwan / Surawit, Apinya / Ophakas, Suphawan / Mongkolsucharitkul, Pichanun / Pumeiam, Sureeporn / Suta, Sophida / Pinsawas, Bonggochpass / Sookrung, Nitat / Saelim, Nawannaporn / Mahasongkram, Kodchakorn / Prangtaworn, Pannathee / Tungtrongchitr, Anchalee / Tangjittipokin, Watip / Mangmee, Suthee / Boonnak, Kobporn / Narkdontri, Tassanee / Teerawattanapong, Nipaporn / Wanitphadeedecha, Rungsima /
    Mayurasakorn, Korapat

    Vaccines

    2023  Volume 11, Issue 9

    Abstract: Many patients develop post-acute COVID syndrome (long COVID (LC)). We compared the immune response of LC and individuals with post-COVID full recovery (HC) during the Omicron pandemic. Two hundred ninety-two patients with confirmed COVID infections from ... ...

    Abstract Many patients develop post-acute COVID syndrome (long COVID (LC)). We compared the immune response of LC and individuals with post-COVID full recovery (HC) during the Omicron pandemic. Two hundred ninety-two patients with confirmed COVID infections from January to May 2022 were enrolled. We observed anti-SARS-CoV-2 receptor-binding domain immunoglobulin G, surrogate virus neutralization test, T cell subsets, and neutralizing antibodies against Wuhan, BA.1, and BA.5 viruses (NeuT). NeuT was markedly reduced against BA.1 and BA.5 in HC and LC groups, while antibodies were more sustained with three doses and an updated booster shot than ≤2-dose vaccinations. The viral neutralization ability declined at >84-days after COVID-19 onset (PC) in both groups. PD1-expressed central and effector memory CD4
    Language English
    Publishing date 2023-08-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11091413
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Tregitope-linked Refined Allergen Vaccines for Immunotherapy in Cockroach Allergy.

    Prangtaworn, Pannathee / Chaisri, Urai / Seesuay, Watee / Mahasongkram, Kodchakorn / Onlamoon, Nattawat / Reamtong, Onrapak / Tungtrongchitr, Anchalee / Indrawattana, Nitaya / Chaicumpa, Wanpen / Sookrung, Nitat

    Scientific reports

    2018  Volume 8, Issue 1, Page(s) 15480

    Abstract: Allergen-specific immunotherapy (AIT) facilitates long-term resolution of allergic morbidity resulting in reduced drug use and increased refractoriness to new sensitization. AIT effectiveness has been demonstrated in seasonal and perennial allergies, and ...

    Abstract Allergen-specific immunotherapy (AIT) facilitates long-term resolution of allergic morbidity resulting in reduced drug use and increased refractoriness to new sensitization. AIT effectiveness has been demonstrated in seasonal and perennial allergies, and insect stings. However, data and studies in AIT relative to cockroach (CR) allergy are relatively scarce. In this study, mice allergic to American CR (Periplaneta americana) were treated with a liposome (L)-entrapped vaccine made of mouse Tregitope289-Per a 9 of the CR, Tregitope167-Per a 9, or Per a 9 alone - or placebo. Allergic mice that received an individual vaccine intranasally had reduced Th2 response, reduced lung inflammation, and reduced respiratory tissue remodeling. However, only L-Tregitope289-Per a 9 and L-Tregitope167-Per a 9 induced expression of immunosuppressive cytokine genes (IL-10, TGF-β, and IL-35 for L-Tregitope289-Per a 9, and IL-10 and TGF-β for L-Tregitope167-Per a 9) and increment of idoleamine-2,3-dioxygenase 1 (IDO1), indicating that these vaccines caused allergic disease suppression and reversal of respiratory tissue remodeling via generation of regulatory lymphocytes. Liposome entrapped-recombinant Per a 9 (L-Per a 9) did not cause upregulation of immunosuppressive cytokine genes and IDO1 increment; rather, L-Per a 9 induced high expression of IFN-γ in lungs of treated mice, which resulted in mitigation of allergic manifestations. This study provides compelling evidence that both liposome-entrapped vaccines made of single refined major allergen alone and single refined major allergen linked with Tregitopes are effective for reducing allergen-mediated respiratory tissue inflammation and remodeling, but through different mechanisms.
    MeSH term(s) Administration, Intranasal ; Allergens/immunology ; Animals ; Capsid Proteins/immunology ; Cells, Cultured ; Cytokines/metabolism ; Desensitization, Immunologic/methods ; Disease Models, Animal ; Epitopes, T-Lymphocyte/immunology ; Humans ; Hypersensitivity/immunology ; Male ; Mice ; Mice, Inbred BALB C ; Periplaneta ; T-Lymphocytes, Regulatory/immunology ; Vaccines/immunology
    Chemical Substances Allergens ; Capsid Proteins ; Cytokines ; Epitopes, T-Lymphocyte ; Vaccines
    Language English
    Publishing date 2018-10-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-018-33680-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Immune response after SARS-CoV-2 infection with residual post COVID symptoms

    Pongkunakorn, Tanyaporn / Manosan, Thamonwan / Surawit, Apinya / Ophakas, Suphawan / Mongkolsucharitkul, Pichanun / Pumiem, Sureeporn / Suta, Sophida / Pinsawas, Bonggochpass / Sookrung, Nitat / Saelim, Nawannaporn / Mahasongkram, Kodchakorn / Prangtaworn, Pannathee / Tungtrongchitr, Anchalee / Tangjittipokin, Watip / Boonnak, Kobporn / Narkdontri, Tassanee / Teerawattanapong, Nipaporn / Jongkaewwattana, Anan / Mayurasakorn, Korapat

    medRxiv

    Abstract: BACKGROUND In a number of patients, post-acute COVID syndrome develops after acute infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Long COVID [LC]). Here, we examined the immune responses and clinical characteristics of ... ...

    Abstract BACKGROUND In a number of patients, post-acute COVID syndrome develops after acute infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Long COVID [LC]). Here, we examined the immune responses and clinical characteristics of individuals with LC compared to age- and gender-matched healthy recovered COVID individuals (HC) during the Omicron pandemic. Immune responses following BNT162b2 (Pfizer) booster are also determined. METHODS This retrospective cohort study included 292 patients (LC, 158; HC, 134) confirmed to have SARS-CoV-2 infection from January to August 2022. We determined anti-SARS-CoV-2 receptor-binding domain immunoglobulin G (anti-RBD IgG), surrogate virus neutralization test (sVNT), T-cell subsets, and neutralization of wild-type, BA.1 and BA.5. A subset of patients was voluntarily recruited for booster vaccination with BNT162b2 vaccine and immunogenicity was assessed 4weeks after vaccination. RESULTS Cycle thresholds were higher in the HC group than in the LC group (20.7 vs. 19.7; P<0.039). Anti-RBD IgG was higher at ≤56 days after COVID-19 onset (PC) in 3-dose vaccines compared with 2-dose vaccines in the LC group (P=0.02) and after 57-84 days PC in 3-dose vaccines in the HC group (P<0.001). The sVNT in LC was significantly high against Wuhan and sVNT was 30% lower against the Omicron than the Wuhan. sVNT was relatively sustained in 3-dose vaccines than ≤ 2-dose vaccines. sVNT in the HC group reached its peak at 57-84 days PC as compared with the LC group. CONCLUSIONS These findings imply that LC produced increased neutralizing antibody responses than those with HC. During the Omicron pandemic, immunity after LC has still waned; therefore, a booster vaccine may be needed after 2-3 months from last infection. (ClinicalTrials.gov number, NCT05484700)
    Keywords covid19
    Language English
    Publishing date 2022-10-10
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2022.10.10.22280762
    Database COVID19

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  5. Article ; Online: Programmed genome editing of the omega-1 ribonuclease of the blood fluke,

    Ittiprasert, Wannaporn / Mann, Victoria H / Karinshak, Shannon E / Coghlan, Avril / Rinaldi, Gabriel / Sankaranarayanan, Geetha / Chaidee, Apisit / Tanno, Toshihiko / Kumkhaek, Chutima / Prangtaworn, Pannathee / Mentink-Kane, Margaret M / Cochran, Christina J / Driguez, Patrick / Holroyd, Nancy / Tracey, Alan / Rodpai, Rutchanee / Everts, Bart / Hokke, Cornelis H / Hoffmann, Karl F /
    Berriman, Matthew / Brindley, Paul J

    eLife

    2019  Volume 8

    Abstract: CRISPR/Cas9-based genome editing has yet to be reported in species of the Platyhelminthes. We tested this approach by targeting omega-1 (ω1) ... ...

    Abstract CRISPR/Cas9-based genome editing has yet to be reported in species of the Platyhelminthes. We tested this approach by targeting omega-1 (ω1) of
    MeSH term(s) Animals ; Base Sequence ; CRISPR-Cas Systems/genetics ; Cell Line ; Chromosomes/genetics ; DNA Repair/genetics ; Exons/genetics ; Gene Editing ; Gene Expression Regulation ; Genetic Loci ; Granuloma/pathology ; Homologous Recombination/genetics ; Humans ; Inflammation/pathology ; Lung/parasitology ; Lung/pathology ; Mice ; Mutation/genetics ; Ovum/enzymology ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Ribonucleases/genetics ; Schistosoma mansoni/enzymology ; Schistosoma mansoni/genetics ; Th2 Cells/immunology ; Transgenes
    Chemical Substances RNA, Messenger ; Ribonucleases (EC 3.1.-)
    Language English
    Publishing date 2019-01-15
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.41337
    Database MEDical Literature Analysis and Retrieval System OnLINE

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