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Article ; Online: Review: Dietary cation-anion difference to prevent hypocalcemia with emphasis on over-acidification in prepartum dairy cows.

Melendez, Pedro / Chelikani, Prasanth K

Animal : an international journal of animal bioscience

2022 Volume 16, Issue 10, Page(s) 100645

Abstract: Hypocalcemia remains a common metabolic disorder of dairy cattle; therefore, an efficient prevention is still challenging. Among the various prevention strategies for hypocalcemia is the use of anionic compounds to induce a mild metabolic acidosis during ...

Abstract	Hypocalcemia remains a common metabolic disorder of dairy cattle; therefore, an efficient prevention is still challenging. Among the various prevention strategies for hypocalcemia is the use of anionic compounds to induce a mild metabolic acidosis during the prepartum period. Acid-base status can be readily assessed through urine pH. Accordingly, a target urine pH during the prepartum period between 6.0 and 6.8 has been recommended for Holstein cows; however, in several countries, including the US, certain nutritional strategies are still focused on benchmarking the urine pH to below 6.0. Unfortunately, over-acidification can have no advantages and/or detrimental effects on both the dam and her offspring. In this review, updated information regarding the use of anionic diets on prepartum dairy cows and the potential negative impact of such diets on both cow and calf performance are discussed. There is an urgent need for studies that will elucidate the pathophysiological mechanisms by which very acidotic diets may impact the well-being and productive efficiency of dairy cows, and the transgenerational effects of such diets on offspring performance and survival.
MeSH term(s)	Animal Feed/analysis ; Animals ; Anions/metabolism ; Anions/pharmacology ; Cations/metabolism ; Cations/pharmacology ; Cattle ; Diet/veterinary ; Dietary Supplements ; Female ; Hydrogen-Ion Concentration ; Hypocalcemia/metabolism ; Hypocalcemia/prevention & control ; Hypocalcemia/veterinary ; Lactation/physiology ; Milk/metabolism ; Postpartum Period
Chemical Substances	Anions ; Cations
Language	English
Publishing date	2022-10-03
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2257920-5
ISSN	1751-732X ; 1751-7311
ISSN (online)	1751-732X
ISSN	1751-7311
DOI	10.1016/j.animal.2022.100645
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Article ; Online: Does PYY mediate resolution of diabetes following bariatric surgery?

Chelikani, Prasanth K

EBioMedicine

2019 Volume 40, Page(s) 5–6

MeSH term(s)	Animals ; Bariatric Surgery/methods ; Diabetes Mellitus/metabolism ; Diabetes Mellitus/surgery ; Humans ; Peptide YY/metabolism
Chemical Substances	Peptide YY (106388-42-5)
Language	English
Publishing date	2019-01-20
Publishing country	Netherlands
Document type	Letter
ZDB-ID	2851331-9
ISSN	2352-3964
ISSN (online)	2352-3964
DOI	10.1016/j.ebiom.2019.01.034
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Article: Low Protein Diets and Energy Balance: Mechanisms of Action on Energy Intake and Expenditure.

Pezeshki, Adel / Chelikani, Prasanth K

Frontiers in nutrition

2021 Volume 8, Page(s) 655833

Abstract: Low protein diets are associated with increased lifespan and improved cardiometabolic health primarily in rodents, and likely improve human health. There is strong evidence that moderate to severe reduction in dietary protein content markedly influences ... ...

Abstract	Low protein diets are associated with increased lifespan and improved cardiometabolic health primarily in rodents, and likely improve human health. There is strong evidence that moderate to severe reduction in dietary protein content markedly influences caloric intake and energy expenditure, which is often followed by a decrease in body weight and adiposity in animal models. While the neuroendocrine signals that trigger hyperphagic responses to protein restriction are better understood, there is accumulating evidence that increased sympathetic flux to brown adipose tissue, fibroblast growth factor-21 and serotonergic signaling are important for the thermogenic effects of low protein diets. This mini-review specifically focuses on the effect of low protein diets with variable carbohydrate and lipid content on energy intake and expenditure, and the underlying mechanisms of actions by these diets. Understanding the mechanisms by which protein restriction influences energy balance may unveil novel approaches for treating metabolic disorders in humans and improve production efficiency in domestic animals.
Language	English
Publishing date	2021-05-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2021.655833
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Article ; Online: Controlled Photochemical Synthesis of Substituted Isoquinoline-1,3,4(2

Reddy, Mandapati Bhargava / Prasanth, Kesavan / Anandhan, Ramasamy

Organic letters

2022 Volume 24, Issue 20, Page(s) 3674–3679

Abstract: We report a controlled radical cyclization cascade of isoquinoline-1,3,4( ... ...

Abstract	We report a controlled radical cyclization cascade of isoquinoline-1,3,4(2
Language	English
Publishing date	2022-05-12
Publishing country	United States
Document type	Journal Article
ISSN	1523-7052
ISSN (online)	1523-7052
DOI	10.1021/acs.orglett.2c01296
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Review: Dietary cation-anion difference to prevent hypocalcemia with emphasis on over-acidification in prepartum dairy cows

Melendez Retamal, Pedro / Chelikani, Prasanth K.

animal. 2022 Oct., v. 16, no. 10 p.100645-

2022

Abstract	Hypocalcemia remains a common metabolic disorder of dairy cattle; therefore, an efficient prevention is still challenging. Among the various prevention strategies for hypocalcemia is the use of anionic compounds to induce a mild metabolic acidosis during the prepartum period. Acid-base status can be readily assessed through urine pH. Accordingly, a target urine pH during the prepartum period between 6.0 and 6.8 has been recommended for Holstein cows; however, in several countries, including the US, certain nutritional strategies are still focused on benchmarking the urine pH to below 6.0. Unfortunately, over-acidification can have no advantages and/or detrimental effects on both the dam and her offspring. In this review, updated information regarding the use of anionic diets on prepartum dairy cows and the potential negative impact of such diets on both cow and calf performance are discussed. There is an urgent need for studies that will elucidate the pathophysiological mechanisms by which very acidotic diets may impact the well-being and productive efficiency of dairy cows, and the transgenerational effects of such diets on offspring performance and survival.
Keywords	Holstein ; acidosis ; calves ; cows ; dairy cattle ; dietary cation anion difference ; hypocalcemia ; pH ; prepartum period ; progeny ; urine ; Anionic diets ; Metabolic acidosis ; Milk fever ; Peripartum
Language	English
Dates of publication	2022-10
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2257920-5
ISSN	1751-732X ; 1751-7311
ISSN (online)	1751-732X
ISSN	1751-7311
DOI	10.1016/j.animal.2022.100645
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Plant leaf proteins for food applications: Opportunities and challenges

Anoop, A. A. / Pillai, Prasanth K. S. / Nickerson, Michael / Ragavan, K. V.

Comprehensive Reviews in Food Science and Food Safety. 2023 Jan., v. 22, no. 1 p.473-501

2023

Abstract: Plant‐based proteins are gaining a lot of attention for their health benefits and are considered as an alternative to animal proteins for developing sustainable food systems. Against the backdrop, ensuring a healthy diet supplemented with good quality ... ...

Abstract	Plant‐based proteins are gaining a lot of attention for their health benefits and are considered as an alternative to animal proteins for developing sustainable food systems. Against the backdrop, ensuring a healthy diet supplemented with good quality protein will be a massive responsibility of governments across the globe. Increasing the yield of food crops has its limitations, including low acceptance of genetically modified crops, land availability for cultivation, and the need for large quantities of agrochemicals. It necessitates the sensible use of existing resources and farm output to derive the proteins. On average, the protein content of plant leaves is similar to that of milk, which can be efficiently tapped for food applications across the globe. There has been limited research on utilizing plant leaf proteins for food product development over the years, which has not been fruitful. However, the current global food production scenario has pushed some leading economies to reconsider the scope of plant leaf proteins with dedicated efforts. It is evident from installing pilot‐scale demonstration plants for protein extraction from agro‐food residues to cater to the protein demand with product formulation. The present study thoroughly reviews the opportunities and challenges linked to the production of plant leaf proteins, including its nutritional aspects, extraction and purification strategies, anti‐nutritional factors, functional and sensory properties in food product development, and finally, its impact on the environment. Practical Application: Plant leaf proteins are one of the sustainable and alternative source of proteins. It can be produced in most of the agroclimatic conditions without requiring much agricultural inputs. It's functional properties are unique and finds application in novel food product formulations.
Keywords	agrochemicals ; animals ; environmental impact ; farms ; food production ; food safety ; healthy diet ; leaves ; milk ; novel foods ; product development ; protein content
Language	English
Dates of publication	2023-01
Size	p. 473-501.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	2185829-9
ISSN	1541-4337
ISSN	1541-4337
DOI	10.1111/1541-4337.13079
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Article ; Online: Quinazolinones/Benzothiadiazines as Amidyl/Aminyl Radical Precursors for Controlled Cascade Cyclization via Photocatalyzed PCET.

Bhargava Reddy, Mandapati / Prasanth, Kesavan / Neerathilingam, Nalladhambi / Anandhan, Ramasamy

Organic letters

2022 Volume 24, Issue 44, Page(s) 8158–8163

Abstract: Quinazolinones/benzothiadiazines were used as amidyl/aminyl radical precursors for cascade cyclizations via a photoredox-catalyzed proton-coupled electron transfer (PCET) process for the first time. A controlled synthesis of isoindole-fused ... ...

Abstract	Quinazolinones/benzothiadiazines were used as amidyl/aminyl radical precursors for cascade cyclizations via a photoredox-catalyzed proton-coupled electron transfer (PCET) process for the first time. A controlled synthesis of isoindole-fused quinazolinones/benzothiadiazines was carried out via quinazolinone amidyl/benzothiadiazine aminyl radical addition to the C-C triple bond under mild conditions. This transition-metal-free method provides an efficient and broad substrate scope for the synthesis of isoindole-fused quinazolinones/benzothiadiazines with step economy and atom efficiency.
Language	English
Publishing date	2022-10-27
Publishing country	United States
Document type	Journal Article
ISSN	1523-7052
ISSN (online)	1523-7052
DOI	10.1021/acs.orglett.2c03222
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Article ; Online: Plant leaf proteins for food applications: Opportunities and challenges.

Anoop, A A / Pillai, Prasanth K S / Nickerson, Michael / Ragavan, K V

Comprehensive reviews in food science and food safety

2022 Volume 22, Issue 1, Page(s) 473–501

Abstract: Plant-based proteins are gaining a lot of attention for their health benefits and are considered as an alternative to animal proteins for developing sustainable food systems. Against the backdrop, ensuring a healthy diet supplemented with good quality ... ...

Abstract	Plant-based proteins are gaining a lot of attention for their health benefits and are considered as an alternative to animal proteins for developing sustainable food systems. Against the backdrop, ensuring a healthy diet supplemented with good quality protein will be a massive responsibility of governments across the globe. Increasing the yield of food crops has its limitations, including low acceptance of genetically modified crops, land availability for cultivation, and the need for large quantities of agrochemicals. It necessitates the sensible use of existing resources and farm output to derive the proteins. On average, the protein content of plant leaves is similar to that of milk, which can be efficiently tapped for food applications across the globe. There has been limited research on utilizing plant leaf proteins for food product development over the years, which has not been fruitful. However, the current global food production scenario has pushed some leading economies to reconsider the scope of plant leaf proteins with dedicated efforts. It is evident from installing pilot-scale demonstration plants for protein extraction from agro-food residues to cater to the protein demand with product formulation. The present study thoroughly reviews the opportunities and challenges linked to the production of plant leaf proteins, including its nutritional aspects, extraction and purification strategies, anti-nutritional factors, functional and sensory properties in food product development, and finally, its impact on the environment. Practical Application: Plant leaf proteins are one of the sustainable and alternative source of proteins. It can be produced in most of the agroclimatic conditions without requiring much agricultural inputs. It's functional properties are unique and finds application in novel food product formulations.
MeSH term(s)	Animals ; Crops, Agricultural ; Plant Proteins/analysis ; Plants, Genetically Modified ; Dietary Supplements ; Plant Leaves/chemistry
Chemical Substances	Plant Proteins
Language	English
Publishing date	2022-12-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2185829-9
ISSN	1541-4337 ; 1541-4337
ISSN (online)	1541-4337
ISSN	1541-4337
DOI	10.1111/1541-4337.13079
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Article: Neuroprotection by Cerebrolysin and Citicoline Through the Upregulation of Brain-Derived Neurotrophic Factor (BDNF) Expression in the Affected Neural Cells: A Preliminary Clue Obtained Through an In Vitro Study.

P, Anandan / Rengarajan, Santhanam / Venkatachalam, Sankar / Pattabi, Sasikumar / Jones, Sumathi / K, Prabhu / Krishna, Vani / Prasanth, Krishna

Cureus

2024 Volume 16, Issue 2, Page(s) e54665

Abstract: Objectives: Citicoline and cerebrolysin are two unique yet contentious medications because of inconsistencies in efficacy as well as the mystery surrounding their mode of action. The current study aimed to re-validate the neuroprotective benefits of ... ...

Abstract	Objectives: Citicoline and cerebrolysin are two unique yet contentious medications because of inconsistencies in efficacy as well as the mystery surrounding their mode of action. The current study aimed to re-validate the neuroprotective benefits of these medications and investigate the possible molecular mechanism. Methods: Neuro-2A cells were exposed to tert-butyl hydroperoxide, a consistent in vitro model of neuronal damage caused by oxidative stress. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, acridine orange/ethidium bromide (AO-EtBr) staining, and phase-view examinations were utilized to evaluate cell survival and cytotoxicity. Real-time reverse transcription-polymerase chain reaction (RT-PCR)-based gene expression studies were conducted. Key finding: Observations revealed that these two medications had modest but considerable neuroprotective effects. While the majority of the genes' expressions remained unchanged, cerebrolysin upregulated Neuregulin 1, and both upregulated brain-derived neurotrophic factor (BDNF) expression. Conclusion: The findings of the current study may be the first to suggest that citicoline and cerebrolysin may increase host cells' defense mechanisms (secretion neurotrophic factors) rather than carrying nutrients for cell survival. Because of its simplicity, the current study can readily be repeated to learn more about these two disputed medications for treating ischemic stroke.
Language	English
Publishing date	2024-02-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.54665
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Article: Dietary whey and egg proteins interact with inulin fiber to modulate energy balance and gut microbiota in obese rats

Avirineni, Bharath S. / Singh, Arashdeep / Zapata, Rizaldy C. / Phillips, Caleb D. / Chelikani, Prasanth K.

Journal of nutritional biochemistry. 2022 Jan., v. 99

2022

Abstract: Diets supplemented with protein and fiber are well known to reduce food intake and weight gain; however, less is known about the combined effects of protein and prebiotic fiber on energy balance and gut microbiota composition. We compared effects of ... ...

Abstract	Diets supplemented with protein and fiber are well known to reduce food intake and weight gain; however, less is known about the combined effects of protein and prebiotic fiber on energy balance and gut microbiota composition. We compared effects of diets containing high egg or whey protein with cellulose or prebiotic (inulin) fiber on energy balance, gut microbiota, hormones, and metabolites. Male obese rats (n=8/group) were allocated to four diets: Egg albumen+Cellulose (EC), Egg albumen+Inulin (EI), Whey protein+Cellulose (WC), and Whey protein+Inulin (WI). Results revealed that diet-induced hypophagia was transient with EC and prolonged with EI and WI, compared to WC. Importantly, CCK-1 receptor antagonist (Devazepide) attenuated the hypophagic effects of EC, EI, and WI. Further, EC, EI and WI decreased respiratory quotient, energy expenditure, weight and adiposity gains, and improved glycemia, relative to WC. Propranolol (β₁-β₂-receptor blocker) attenuated diet-induced changes in energy expenditure. Transcript abundance of thermogenic markers in brown adipose tissue, plasma hormones, and metabolites especially acyl-carnitines and glycerophospholipids, were differentially altered by diets. Diet explained 25% of compositional differences in cecal microbiomes, but diets with same fiber type did not differ. Microbiota differing between groups also strongly correlated with gut hormones and metabolites. Species most strongly correlated to a marker for butyrate production were in highest abundance in inulin diets. Together, these findings indicate that inulin enriched diets containing egg or whey protein improved energy balance, decreased adiposity, and modulated gut microbiota and metabolites, with CCK signaling partly mediating the satiety effects of diets.
Keywords	adiposity ; antagonists ; blood glucose ; brown adipose tissue ; butyrates ; cellulose ; digestive system ; eggs ; energy expenditure ; food intake ; glycerophospholipids ; intestinal microorganisms ; inulin ; males ; metabolites ; microbiome ; prebiotics ; propranolol ; respiratory quotient ; satiety ; undereating ; weight gain ; whey ; whey protein
Language	English
Dates of publication	2022-01
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	1014929-6
ISSN	1873-4847 ; 0955-2863
ISSN (online)	1873-4847
ISSN	0955-2863
DOI	10.1016/j.jnutbio.2021.108860
Database	NAL-Catalogue (AGRICOLA)

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