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  1. AU="Pratima Verma"
  2. AU="Nomaguchi, Masako"
  3. AU="Hutson, Alan D"
  4. AU="Jarvis, Deborah"
  5. AU="Yilmaz, Sevdican Ustun"
  6. AU="Kreisel, Wolfgang"
  7. AU="Tracy R. Nichols, Ph.D."
  8. AU="Hellal, Faycel"
  9. AU="Steffen Koschmieder"
  10. AU="Hsin-Hui Yu"
  11. AU="Watanabe, Sadanori"
  12. AU="Swarts, Benjamin M"
  13. AU="Zang, Trinity"
  14. AU="Almayahi, Basim A"
  15. AU="Lupke, Madeleine"
  16. AU="Tweed, Conor"

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  1. Artikel ; Online: Analyzing the potential benefits and use cases of ChatGPT as a tool for improving the efficiency and effectiveness of business operations

    Rohit Raj / Arpit Singh / Vimal Kumar / Pratima Verma

    BenchCouncil Transactions on Benchmarks, Standards and Evaluations, Vol 3, Iss 3, Pp 100140- (2023)

    2023  

    Abstract: The study addresses the potential benefits for companies of adopting ChatGPT, a popular chatbot built on a large-scale transformer-based language model known as a generative pre-trained transformer (GPT). Chatbots like ChatGPT may improve customer ... ...

    Abstract The study addresses the potential benefits for companies of adopting ChatGPT, a popular chatbot built on a large-scale transformer-based language model known as a generative pre-trained transformer (GPT). Chatbots like ChatGPT may improve customer service, handle several client inquiries at once, and save operational costs. Moreover, ChatGPT may automate regular processes like order tracking and billing, allowing human employees to focus on more complex and strategic responsibilities. Nevertheless, before deploying ChatGPT, enterprises must carefully analyze its use cases and restrictions, as well as its strengths and disadvantages. ChatGPT, for example, requires training data that is particular to the business domain and might produce erroneous and ambiguous findings. The study identifies areas of deployment of ChatGPT's possible benefits in enterprises by drawing on the literature that is currently accessible on ChatGPT, massive language models, and artificial intelligence. Then, using the PSI (Preference Selection Index) and COPRAS (Complex Proportional Assessment) approaches, potential advantages are taken into account and prioritized. By highlighting current trends and possible advantages in the industry, this editorial seeks to provide insight into the present state of employing ChatGPT in enterprises and research. ChatGPT may also learn biases from training data and create replies that reinforce those biases. As a result, enterprises must train and fine-tune ChatGPT to specific operations, set explicit boundaries and limitations for its use, and implement appropriate security measures to avoid malicious input. The study highlights the research gap in the dearth of literature by outlining ChatGPT's potential benefits for businesses, analyzing its strengths and limits, and offering insights into how organizations might use ChatGPT's capabilities to enhance their operations.
    Schlagwörter ChatGPT ; benefits ; business ; efficiency ; automation ; Science ; Q ; Engineering (General). Civil engineering (General) ; TA1-2040
    Thema/Rubrik (Code) 650
    Sprache Englisch
    Erscheinungsdatum 2023-09-01T00:00:00Z
    Verlag KeAi Communications Co. Ltd.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Current Perspective on the Membrane-Damaging Action of Thermostable Direct Hemolysin, an Atypical Bacterial Pore-forming Toxin

    Pratima Verma / Kausik Chattopadhyay

    Frontiers in Molecular Biosciences, Vol

    2021  Band 8

    Abstract: Thermostable direct hemolysin (TDH) is the major virulence determinant of the gastroenteric bacterial pathogen Vibrio parahaemolyticus. TDH is a membrane-damaging pore-forming toxin (PFT). TDH shares remarkable structural similarity with the actinoporin ... ...

    Abstract Thermostable direct hemolysin (TDH) is the major virulence determinant of the gastroenteric bacterial pathogen Vibrio parahaemolyticus. TDH is a membrane-damaging pore-forming toxin (PFT). TDH shares remarkable structural similarity with the actinoporin family of eukaryotic PFTs produced by the sea anemones. Unlike most of the PFTs, it exists as tetramer in solution, and such assembly state is crucial for its functionality. Although the structure of the tetrameric assembly of TDH in solution is known, membrane pore structure is not available yet. Also, the specific membrane-interaction mechanisms of TDH, and the exact role of any receptor(s) in such process, still remain unclear. In this mini review, we discuss some of the unique structural and physicochemical properties of TDH, and their implications for the membrane-damaging action of the toxin. We also present our current understanding regarding the membrane pore-formation mechanism of this atypical bacterial PFT.
    Schlagwörter pore-forming toxin ; thermostable direct hemolysin ; membranes ; actinoporins ; oligomer ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 612
    Sprache Englisch
    Erscheinungsdatum 2021-07-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Prevalence of hemoglobinopathies in different regions and castes of Uttar Pradesh, India -A hospital based study

    Pratima Verma

    Asian Journal of Medical Sciences, Vol 6, Iss 5, Pp 21-

    2015  Band 25

    Abstract: Background: Thalasemia and other hemoglobinopathies are found in all the states of India and their prevalence is quite variable. In Uttar Pradesh very few studies are found which explore the spectrum of hemoglobinopathies. There is no such study which ... ...

    Abstract Background: Thalasemia and other hemoglobinopathies are found in all the states of India and their prevalence is quite variable. In Uttar Pradesh very few studies are found which explore the spectrum of hemoglobinopathies. There is no such study which identifies the geographic distribution of high-risk communities with frequencies of hemoglobinopathies. Aim: Present study was carried out to determine the prevalence of hemoglobinopathies in different regions and castes of Uttar-Pradesh (UP) state. Materials and Methods: This is a preliminary community based cross-sectional, hospital based study, conducted at King George’s Medical University, Lucknow, Uttar- Pradesh. Subjects aged between 18 to 65 years were enrolled for sampling. The anticoagulated blood was used for performing CBC (complete blood count), and hemoglobin electrophoresis to measure hemoglobinopathies. Results: The present study revealed higher(28/194;19.5%,p<0.05) prevalence of hemoglobinopathies in Lucknow district as compared to other districts of Uttar-Pradesh and Brahmin caste having high frequency (33/112;29.5%) followed by Jaiswal (3/13;23.1%) and Arora (2/9;22.2%). Conclusion: The data regarding prevalence and distribution can be useful in prevention and management of various hemoglobinopathies which play a vital role in the hospital blood bank as well as in the formulation of transfusion policies.
    Schlagwörter hemoglobinopathies ; thalassemia ; prevalence ; Medicine ; R
    Thema/Rubrik (Code) 360
    Sprache Englisch
    Erscheinungsdatum 2015-04-01T00:00:00Z
    Verlag Manipal College of Medical Sciences, Pokhara
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Comparative DNA Methylome of Phytoplasma Associated Retrograde Metamorphosis in Sesame ( Sesamum indicum L.)

    Pratima Verma / Amrita Singh / Supriya Purru / Kangila Venkataramana Bhat / Suman Lakhanpaul

    Biology, Vol 11, Iss 7, p

    2022  Band 954

    Abstract: Phytoplasma-associated diseases such as phyllody and little leaf are critical threats to sesame cultivation worldwide. The mechanism of the dramatic conversion of flowers to leafy structures leading to yield losses and the drastic reduction in leaf size ... ...

    Abstract Phytoplasma-associated diseases such as phyllody and little leaf are critical threats to sesame cultivation worldwide. The mechanism of the dramatic conversion of flowers to leafy structures leading to yield losses and the drastic reduction in leaf size due to Phytoplasma infection remains yet to be identified. Cytosine methylation profiles of healthy and infected sesame plants studied using Whole Genome Bisulfite Sequencing (WGBS) and Quantitative analysis of DNA methylation with the real-time PCR (qAMP) technique revealed altered DNA methylation patterns upon infection. Phyllody was associated with global cytosine hypomethylation, though predominantly in the CHH (where H = A, T or C) context. Interestingly, comparable cytosine methylation levels were observed between healthy and little leaf-affected plant samples in CG, CHG and CHH contexts. Among the different genomic fractions, the highest number of differentially methylated Cytosines was found in the intergenic regions, followed by promoter, exonic and intronic regions in decreasing order. Further, most of the differentially methylated genes were hypomethylated and were mainly associated with development and defense-related processes. Loci for STOREKEEPER protein-like, a DNA-binding protein and PP2-B15, an F-Box protein, responsible for plugging sieve plates to maintain turgor pressure within the sieve tubes were found to be hypomethylated by WGBS, which was confirmed by methylation-dependent restriction digestion and qPCR. Likewise, serine/threonine-protein phosphatase-7 homolog, a positive regulator of cryptochrome signaling involved in hypocotyl and cotyledon growth and probable O-methyltransferase 3 locus were determined to be hypermethylated. Phytoplasma infection-associated global differential methylation as well as the defense and development-related loci reported here for the first time significantly elucidate the mechanism of phytoplasma-associated disease development.
    Schlagwörter Sesamum indicum L ; DNA methylation ; Whole Genome Bisulfite Sequencing (WGBS) ; phytoplasma ; phyllody ; little leaf and McrBC ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2022-06-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Early and Effective Diagnosis of Sepsis Using Flow Cytometry

    Pratima Verma / Anurag Singh / Rashmi Kushwaha / Geeta Yadav / Shailendra P. Verma / Uma S. Singh / Himanshu D. Reddy / Avinash Agarwal

    Journal of Laboratory Physicians, Vol 15, Iss 02, Pp 230-

    2023  Band 236

    Abstract: Objective Sepsis is a major global health issue due to its high death and morbidity rates. To avoid the negative effects of sepsis and decrease mortality, it is vital to diagnose and treat it as soon as possible. Blood cultures can take up to 2 days to ... ...

    Abstract Objective Sepsis is a major global health issue due to its high death and morbidity rates. To avoid the negative effects of sepsis and decrease mortality, it is vital to diagnose and treat it as soon as possible. Blood cultures can take up to 2 days to give result, and they are not always reliable. According to recent studies, neutrophil CD64 expression might be a sensitive and specific option for assessing sepsis. This study aimed to evaluate the diagnostic performance of a flow cytometry analysis for the expression of neutrophil CD64 in sepsis and its comparison with other standard tests in a tertiary care center. Materials and Methods Prospective analysis on 40 blood samples from suspected sepsis patients admitted to intensive care units with criteria for the systemic inflammatory response syndrome on presentation was performed for expression of neutrophil CD64, C-reactive protein, procalcitonin, and complete blood count. Ten healthy volunteers were also enrolled in this prospective study. The laboratory results were compared in different groups. Results The neutrophil CD64 had the highest diagnostic value to differentiate between patients of sepsis and nonsepsis groups with a sensitivity of 100% (95% confidence interval [CI]: 77.19–100%) and 100% (95% CI: 55.32–86.83%); specificity of 90.00% (95% CI: 59.58–99.49%) and 87.24% (95% CI: 66.69–99.61%); and likelihood ratio of 10.00 and 7.84, respectively. Conclusion The neutrophil CD64 expression provides a more sensitive, specific, and novel marker for the early detection of sepsis in critically ill patients.
    Schlagwörter cd64 ; sepsis ; biomarker ; flow cytometry ; intensive care unit ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2023-06-01T00:00:00Z
    Verlag Thieme Medical and Scientific Publishers Pvt. Ltd.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Torn ties and waning morale

    Binod Kumar Rajak / Rohit Raj / Vimal Kumar / Punam Singh / Pratima Verma / Seema Mahlawat / Sumanjeet Singh / K. Vidyullatha Reddy

    Social Sciences and Humanities Open, Vol 8, Iss 1, Pp 100732- (2023)

    Unravelling the link between family incivility, employee engagement and perceived supervisor support

    2023  

    Abstract: The present study extends family stress to the work domain and explains how family stressors impact job outcomes. The investigation examines the relationship between family incivility (FI), employee engagement (EE), and perceived supervisor support (PSS) ...

    Abstract The present study extends family stress to the work domain and explains how family stressors impact job outcomes. The investigation examines the relationship between family incivility (FI), employee engagement (EE), and perceived supervisor support (PSS) in the context of government school teachers in the Indian subcontinent. The examination uses a time-lag method, collecting data in two phases. The first phase collected demographic and independent variable data, while the second phase collected moderator and dependent variable data after a three-week gap. The data analysis revealed that FI harms EE, supporting previous research on the detrimental effects of incivility on job outcomes. Additionally, the study found that PSS plays a moderating role in reducing the negative effect of FI on EE. The findings of this study have important implications for managing work-family conflict and promoting work-life balance. Organizations should prioritize creating a supportive work environment that addresses family-related stressors and provides resources for employees to manage FI effectively. Supervisors play a critical role in supporting employees facing FI, and training programs on emotion management and human psychology can enhance their supportive skills. While this study is limited to the Indian subcontinent, it has implications across sectors for effectively managing family-related stress. The study contributes to the literature on FI, EE, and PSS, expanding our understanding of the impact of incivility in the home domain on job outcomes. Future research can explore additional variables, such as peer incivility and co-worker support, to better understand the relationships between these constructs.
    Schlagwörter Family incivility ; Employee engagement ; Perceived supervisor support ; Moderation ; Time-lag study ; History of scholarship and learning. The humanities ; AZ20-999 ; Social sciences (General) ; H1-99
    Thema/Rubrik (Code) 360
    Sprache Englisch
    Erscheinungsdatum 2023-01-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: The rs2070895 (-250G/A) Single Nucleotide Polymorphism in Hepatic Lipase (HL) Gene and the Risk of Coronary Artery Disease in North Indian Population

    Pratima Verma / Dileep Kumar Verma / Rishi Sethi / Shraddha Singh / Akhilesh Krishna

    Journal of Clinical and Diagnostic Research, Vol 10, Iss 8, Pp GC01-GC

    A Case-Control Study

    2016  Band 06

    Abstract: Introduction: Several Single Nucleotide Polymorphisms (SNPs) in lipid transport genes have been shown to be associated with Coronary Artery Disease (CAD). The Hepatic Lipase (HL) glycoprotein is a key component that catalyzes the hydrolysis of ... ...

    Abstract Introduction: Several Single Nucleotide Polymorphisms (SNPs) in lipid transport genes have been shown to be associated with Coronary Artery Disease (CAD). The Hepatic Lipase (HL) glycoprotein is a key component that catalyzes the hydrolysis of triglycerides and phospholipids in all major classes of lipoproteins. Aim: We studied whether the HL gene-250G/A polymorphism affect blood lipid level and the CAD in a North Indian population. Materials and Methods: A total number of 477 subjects were enrolled in the study after approval of the Institutional Ethics Committee. Out of 477 subjects, 233 were with coronary artery disease as study group and 244 subjects without coronary artery disease as control group. All subjects recruited with matched ethnicity in age group of 40-70 years. Blood samples were collected in EDTA vials and genomic DNA was extracted from blood using the phenol-chloroform method. Lipid profile was estimated by using a commercially available kit. Polymorphisms in the HL (-250 G/A) gene were analysed by using restriction fragment length polymorphism-polymerase chain reaction (PCR-RFLP) method. The effect of this polymorphism on plasma lipids, lipoproteins and coronary artery disease was determined. Results: In Human Hepatic Lipase (LIPC)-250G/A genotype, the frequencies of GG, GA and AA genotype in CAD group was 80.69%, 15.45% and 3.86%, respectively; in the control group, the corresponding frequencies were 90.16%, 9.02% and 0.82%, respectively. A significant difference was found in the genotype (LIPC-250G/A) distribution between the two groups. Further logistic regression analysis indicated that the GA and AA genotypes in SNP-250G/A were significantly associated with CAD in all genetic models (In codominant model- GA vs. GG, OR=1.91, 95% CI=1. 09-3.37, p=0. 03 and AA vs. GG, OR= 5.26, 95% CI= 1.10-24.60, p=0.04; in dominant modelGA+AA vs. GG, OR=2.19, p=0.004 and in recessive model- AA vs. GG+GA, OR=5.26, p=0.04 whereas, A allele at nucleotide -250G/A in the LIPC gene had an association with ...
    Schlagwörter hl activity ; lipc gene ; low density lipoprotein ; polymorphisms ; hdl-c ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2016-08-01T00:00:00Z
    Verlag JCDR Research and Publications Private Limited
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    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Oral contraceptive pills decrease pulmonary airway resistance in healthy north Indian women

    Pradeep Kumar / Shraddha Singh / Uma Singh / Pratima Verma

    Indian Journal of Medical Sciences, Vol 65, Iss 2, Pp 64-

    2011  Band 68

    Abstract: Objectives: Oral contraceptive pills (OCPs) are hormonal pills used by females to prevent conception; they are a combination of estrogen and progestin. There is, however, compelling evidence that throughout the reproductive life of a woman, her airways ... ...

    Abstract Objectives: Oral contraceptive pills (OCPs) are hormonal pills used by females to prevent conception; they are a combination of estrogen and progestin. There is, however, compelling evidence that throughout the reproductive life of a woman, her airways are subject to the influence of the cyclical variations in sex hormones which occur in relation to circadian rhythms. The present study has been designed to investigate the effects of OCPs on airway resistance in terms of spirometric parameters in OCP users and nonusers. Materials and Methods: A total of 100 women (age: 20-40 years) ware selected for the present study. The subjects were provided with a one-month supply of OCPs. The constituents per tablet of MALA-N used were levonorgestrel 0.15 mg and ethinylestradiol 0.03 mg. Peak expiratory flow rate (PEFR), forced expiratory flow in expiring 25-75% air (FEF 25-75), forced expiratory volume percentage in one second (FEV1% or FEV1/FVC), forced vital capacity (FVC), and forced expiratory volume in one second (FEV1) were recorded. Results: In our study, the FEF 25-75and PEFR increased significantly in OCP users, showing that these hormone pills decrease the resistance offered by small bronchioles.
    Schlagwörter Airways resistance ; oral contraceptive pills ; Indian women ; Medicine (General) ; R5-920 ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2011-01-01T00:00:00Z
    Verlag Medknow Publications
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  9. Artikel ; Online: A new method for spectrophotometric determination of benzene in air

    Pratima Verma / V.K. Gupta

    Environment International, Vol 10, Iss 4, Pp 279-

    1984  Band 283

    Abstract: A new spectrophotometric method for the determination of benzene in air is described. The method is based upon the nitration of benzene to m-dinitrobenzene and subsequent reduction to m-phenylenediamine. m-Phenylenediamine is determined by diazotization- ... ...

    Abstract A new spectrophotometric method for the determination of benzene in air is described. The method is based upon the nitration of benzene to m-dinitrobenzene and subsequent reduction to m-phenylenediamine. m-Phenylenediamine is determined by diazotization-coupling reaction. α-Naphthol is used as a coupling reagent. Beer's law is obeyed in the range of 10–80 μg of m-dinitribenzene per 25 mL sample. The dye shows a wavelength of maximum absorption at 530 nm. The dye is stable for ∼ 30 h. Toluene, the major interferent, can be separated. Beer's law, sensitivity, reproducibility, and other reaction conditions such as time, temperature, and acidity were studied. Formation of stable dye is the main advantage of the method over the butanone method for benzene, in which the colored complex is stable for only 5 min. It is possible to determine traces of benzene (0.05–0.30 μg/mL) by extracting the azo dye in 10 mL iso-amyl alcohol; this also increases the stability of the dye up to 42 h.
    Schlagwörter Environmental sciences ; GE1-350
    Thema/Rubrik (Code) 540
    Sprache Englisch
    Erscheinungsdatum 1984-01-01T00:00:00Z
    Verlag Elsevier
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