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  1. Article ; Online: Development of Distillation Sensors for Spirit Beverages Production Monitoring Based on Impedance Spectroscopy Measurement and Partial Least-Squares Regression.

    Zeng, Liming / Pernet, Arnaud / Cléroux, Marilyn / Bach, Benoît / Froidevaux, Lucas / Preda, Ioana

    ACS omega

    2023  Volume 8, Issue 17, Page(s) 15323–15333

    Abstract: During spirit beverages production, the distillate is divided into three parts: the head, the heart, and the tail. Acetaldehyde and ethanol are two key markers which allow the correct separation of distillate. Being toxic, the elimination of the head ... ...

    Abstract During spirit beverages production, the distillate is divided into three parts: the head, the heart, and the tail. Acetaldehyde and ethanol are two key markers which allow the correct separation of distillate. Being toxic, the elimination of the head part, which contains a high concentration of acetaldehyde, is crucial to guarantee the consumer's health and security. Plus, the tail should be separated from the heart based on ethanol concentration. Nowadays, online or in-line sensors for acetaldehyde monitoring during distillation do not exist, and the online sensors for alcohol monitoring, based on density measurement, remain expensive for producers. In this work, we demonstrate the development of distillation monitoring sensors based on electrical impedance spectroscopy (EIS) measurements, combined with PLS-R (partial least-squares regression) modeling. Four types of sensors are proposed and tested with wine-based distillates. Using PLS-R, the best correlations were found for one electrode, named "SpotsSym". With an
    Language English
    Publishing date 2023-04-17
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c00481
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Review of Technologies and Materials Used in High-Voltage Film Capacitors.

    Gnonhoue, Olatoundji Georges / Velazquez-Salazar, Amanda / David, Éric / Preda, Ioana

    Polymers

    2021  Volume 13, Issue 5

    Abstract: High-voltage capacitors are key components for circuit breakers and monitoring and protection devices, and are important elements used to improve the efficiency and reliability of the grid. Different technologies are used in high-voltage capacitor ... ...

    Abstract High-voltage capacitors are key components for circuit breakers and monitoring and protection devices, and are important elements used to improve the efficiency and reliability of the grid. Different technologies are used in high-voltage capacitor manufacturing process, and at all stages of this process polymeric films must be used, along with an encapsulating material, which can be either liquid, solid or gaseous. These materials play major roles in the lifespan and reliability of components. In this paper, we present a review of the different technologies used to manufacture high-voltage capacitors, as well as the different materials used in fabricating high-voltage film capacitors, with a view to establishing a bibliographic database that will allow a comparison of the different technologies.
    Language English
    Publishing date 2021-02-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym13050766
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Soluble, dimeric HLA DR4-peptide chimeras: an approach for detection and immunoregulation of human type-1 diabetes.

    Preda, Ioana / McEvoy, Robert C / Lin, Marvin / Bona, Constantin A / Rapaport, Robert / Brumeanu, Teodor D / Casares, Sofia

    European journal of immunology

    2005  Volume 35, Issue 9, Page(s) 2762–2775

    Abstract: Still there are no effective methods to predict or cure type 1 diabetes (T1D) in humans. Soluble, dimeric MHC class II-peptide (DEF) chimeras have potential for both early diagnosis and immunospecific therapy. DEF chimeras prevent and reverse diabetes in ...

    Abstract Still there are no effective methods to predict or cure type 1 diabetes (T1D) in humans. Soluble, dimeric MHC class II-peptide (DEF) chimeras have potential for both early diagnosis and immunospecific therapy. DEF chimeras prevent and reverse diabetes in mice by stimulating antigen-specific type 1 T regulatory cell (Tr1)-like cells. We also showed that diabetes could be predicted by changes in the phenotype of autoreactive CD4 T cells in peripheral blood. Herein, we demonstrated that human DEF (HLA-DR*0401/Fcgamma1) chimeras expressing peptides of beta-cell antigens stimulate Tr1-like cells in blood of patients with T1D, non-diabetic relatives, and controls. Furthermore, the specific and stable binding of DEF chimeras to cognate TCR and CD4 coreceptor allowed quantification and phenotyping of autoreactive CD4 T cells in non-stimulated blood by FACS. Our results indicate that (1) autoreactive CD4 T cells to GAD65 autoantigen are commonly present in humans expressing diabetes-susceptible HLA-DR*0401 molecules; (2) these autoreactive T cells undergo avidity maturation upon encountering the self antigen early in life; (3) the disease is associated with an imbalance between autoreactive CD4+CD25+ and CD4+CD69+ T cells specific for GAD65. Based on this, we propose a model to explain the kinetics of autoreactive CD4 T cells in blood during the natural history of T1D.
    MeSH term(s) Adolescent ; Adult ; Antigens, CD/immunology ; Antigens, Differentiation, T-Lymphocyte/immunology ; CD4-Positive T-Lymphocytes/immunology ; Child ; Child, Preschool ; Diabetes Mellitus, Type 1/diagnosis ; Diabetes Mellitus, Type 1/immunology ; Diabetes Mellitus, Type 1/therapy ; Dimerization ; Female ; Flow Cytometry ; Glutamate Decarboxylase/immunology ; HLA-DR4 Antigen/immunology ; Humans ; Immunophenotyping ; Isoenzymes/immunology ; Lectins, C-Type ; Male ; Middle Aged ; Receptors, Interleukin-2/immunology ; Recombinant Fusion Proteins/immunology
    Chemical Substances Antigens, CD ; Antigens, Differentiation, T-Lymphocyte ; CD69 antigen ; HLA-DR4 Antigen ; Isoenzymes ; Lectins, C-Type ; Receptors, Interleukin-2 ; Recombinant Fusion Proteins ; Glutamate Decarboxylase (EC 4.1.1.15) ; glutamate decarboxylase 2 (EC 4.1.1.15)
    Language English
    Publishing date 2005-09
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.200526158
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 489: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 85: Show issues

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  4. Article: Immunokinetics of autoreactive CD4 T cells in blood: a reporter for the "hit-and-run" autoimmune attack on pancreas and diabetes progression.

    George, Sunil K / Preda, Ioana / Avagyan, Serine / McEvoy, Robert C / Rapaport, Robert / Brumeanu, Teodor-Doru / Casares, Sofia

    Journal of autoimmunity

    2004  Volume 23, Issue 2, Page(s) 151–160

    Abstract: Little is known about the fate of autoreactive CD4 T cells in blood. Using a mouse model for spontaneous autoimmune diabetes we demonstrated that the status of the autoimmune process in pancreas could be pictured through the frequency and phenotype of ... ...

    Abstract Little is known about the fate of autoreactive CD4 T cells in blood. Using a mouse model for spontaneous autoimmune diabetes we demonstrated that the status of the autoimmune process in pancreas could be pictured through the frequency and phenotype of autoreactive CD4 T cells in the blood. Early during the prediabetic stage, the frequency of these cells in blood decreased as a consequence of their recruitment in the pancreas. This was followed by an imbalance between CD4(+)CD25(+) and CD4(+)CD69(+) T cells in the pancreas that was mirrored in the phenotype of autoreactive T cells in the blood. Waves of activated CD4(+)CD69(+) T cells in blood preceded the disease onset suggesting that the autoimmune attack on pancreas is a discontinuous "hit-and-run" rather than a continuous process. Tracking autoreactive CD4 T cells in blood may help in identifying prediabetic humans and monitoring the disease progression during therapeutic interventions.
    MeSH term(s) Animals ; Antigens, CD ; Antigens, Differentiation, T-Lymphocyte ; Autoimmunity ; Blood Cells/immunology ; CD4-Positive T-Lymphocytes/immunology ; Diabetes Complications/etiology ; Diabetes Complications/immunology ; Diabetes Mellitus/immunology ; Disease Models, Animal ; Disease Progression ; Immunophenotyping ; Kinetics ; Lectins, C-Type ; Lymphocyte Count ; Mice ; Mice, Knockout ; Mice, Transgenic ; Pancreatic Diseases/etiology ; Pancreatic Diseases/immunology ; Receptors, Interleukin-2 ; T-Lymphocytes/transplantation
    Chemical Substances Antigens, CD ; Antigens, Differentiation, T-Lymphocyte ; CD69 antigen ; Lectins, C-Type ; Receptors, Interleukin-2
    Language English
    Publishing date 2004-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 639452-8
    ISSN 0896-8411
    ISSN 0896-8411
    DOI 10.1016/j.jaut.2004.06.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2368: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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