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  1. Article ; Online: Scedosporium apiospermum

    Figueroa, Rocio / Martinez-Calle, Nicolas / Prescott, Katie / Bishton, Mark

    EJHaem

    2020  Volume 1, Issue 2, Page(s) 418–419

    Language English
    Publishing date 2020-10-26
    Publishing country United States
    Document type Journal Article
    ISSN 2688-6146
    ISSN (online) 2688-6146
    DOI 10.1002/jha2.121
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: COVID-19

    Prescott, Katie / Baxter, Elaine / Lynch, Christopher / Jassal, Simran / Bashir, Amreen / Gray, James

    How prepared are front line healthcare workers in England?

    2020  

    Abstract: National efforts are underway to prepare the UK National Health Service (NHS) for the COVID-19 pandemic; however, the efficacy of these interventions is unknown. In view of this, a cross-sectional survey of front-line healthcare workers (HCWs) at two ... ...

    Abstract National efforts are underway to prepare the UK National Health Service (NHS) for the COVID-19 pandemic; however, the efficacy of these interventions is unknown. In view of this, a cross-sectional survey of front-line healthcare workers (HCWs) at two large acute NHS hospital trusts in England was undertaken to assess their confidence and perceived level of preparedness for the virus. The survey found that there has been moderate success in readying HCWs to manage COVID-19, but that more still needs to be done, particularly in relation to educating HCWs about laboratory diagnostics.
    Keywords covid19
    Language English
    Publishing date 2020-06-01
    Publishing country uk
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: TGFβ pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis.

    Cammareri, Patrizia / Vincent, David F / Hodder, Michael C / Ridgway, Rachel A / Murgia, Claudio / Nobis, Max / Campbell, Andrew D / Varga, Julia / Huels, David J / Subramani, Chithra / Prescott, Katie L H / Nixon, Colin / Hedley, Ann / Barry, Simon T / Greten, Florian R / Inman, Gareth J / Sansom, Owen J

    Cell death and differentiation

    2017  Volume 24, Issue 10, Page(s) 1681–1693

    Abstract: Recent studies have suggested increased plasticity of differentiated cells within the intestine to act both as intestinal stem cells (ISCs) and tumour-initiating cells. However, little is known of the processes that regulate this plasticity. Our previous ...

    Abstract Recent studies have suggested increased plasticity of differentiated cells within the intestine to act both as intestinal stem cells (ISCs) and tumour-initiating cells. However, little is known of the processes that regulate this plasticity. Our previous work has shown that activating mutations of Kras or the NF-κB pathway can drive dedifferentiation of intestinal cells lacking Apc. To investigate this process further, we profiled both cells undergoing dedifferentiation in vitro and tumours generated from these cells in vivo by gene expression analysis. Remarkably, no clear differences were observed in the tumours; however, during dedifferentiation in vitro we found a marked upregulation of TGFβ signalling, a pathway commonly mutated in colorectal cancer (CRC). Genetic inactivation of TGFβ type 1 receptor (Tgfbr1/Alk5) enhanced the ability of Kras
    MeSH term(s) Animals ; Carcinogenesis/genetics ; Cell Proliferation/genetics ; Cell Transformation, Neoplastic/genetics ; Gene Expression Regulation, Neoplastic/genetics ; Genes, ras/genetics ; MAP Kinase Signaling System ; Mice, Inbred C57BL ; Mice, Transgenic ; Mutation/genetics ; NF-kappa B/metabolism ; Transforming Growth Factor beta/genetics ; Transforming Growth Factor beta/metabolism ; Wnt Signaling Pathway/genetics
    Chemical Substances NF-kappa B ; Transforming Growth Factor beta
    Language English
    Publishing date 2017-06-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 1225672-9
    ISSN 1476-5403 ; 1350-9047
    ISSN (online) 1476-5403
    ISSN 1350-9047
    DOI 10.1038/cdd.2017.92
    Database MEDical Literature Analysis and Retrieval System OnLINE

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