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  1. Article: Open Letter to the President of the National Academy of Sciences.

    Pressman, Peter

    Dose-response : a publication of International Hormesis Society

    2022  Volume 20, Issue 3, Page(s) 15593258221127577

    Language English
    Publishing date 2022-09-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2440820-7
    ISSN 1559-3258
    ISSN 1559-3258
    DOI 10.1177/15593258221127577
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Early Detection of Incipient Alzheimer Pathology: Time Is of the Essence.

    Barkhof, Frederik / Pressman, Peter S

    Neurology

    2021  Volume 96, Issue 14, Page(s) 647–648

    MeSH term(s) Aged ; Alzheimer Disease/diagnosis ; Amyloid beta-Peptides ; Early Diagnosis ; Humans ; Positron-Emission Tomography ; tau Proteins
    Chemical Substances Amyloid beta-Peptides ; tau Proteins
    Language English
    Publishing date 2021-03-02
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000011739
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  3. Article ; Online: Significant shifts in preclinical and clinical neurotoxicology: a review and commentary.

    Pressman, Peter / Clemens, Roger / Hayes, A Wallace

    Toxicology mechanisms and methods

    2022  Volume 33, Issue 3, Page(s) 173–182

    Abstract: The ever-expanding prevalence of adverse neurotoxic reactions of the brain in response to therapeutic and recreational drugs, dietary supplements, environmental hazards, cosmetic ingredients, a spectrum of herbals, health status, and environmental ... ...

    Abstract The ever-expanding prevalence of adverse neurotoxic reactions of the brain in response to therapeutic and recreational drugs, dietary supplements, environmental hazards, cosmetic ingredients, a spectrum of herbals, health status, and environmental stressors continues to prompt the development of novel cell-based assays to better determine neurotoxic hazard. Neurotoxicants may cause direct and epigenetic damage to the nervous tissue and alter the chemistry, structure, or normal activity of the nervous system. In severe neurotoxicity due to exposure to physical or psychosocial toxicants, neurons are disrupted or killed, and a consistent pattern of clinical neural dysfunction appears.
    MeSH term(s) Humans ; Neurotoxicity Syndromes/etiology ; Neurons
    Language English
    Publishing date 2022-08-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2081252-8
    ISSN 1537-6524 ; 1537-6516 ; 1051-7235
    ISSN (online) 1537-6524
    ISSN 1537-6516 ; 1051-7235
    DOI 10.1080/15376516.2022.2109228
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  4. Article: Delirium Following Anticholinergic Use in Hospitalized Patients With Dementia.

    Hale, Elijah W / Macchi, Zachary A / Pressman, Peter S

    The Neurohospitalist

    2022  Volume 13, Issue 2, Page(s) 153–155

    Abstract: We sought to explore rates of delirium amongst hospitalized patients with dementia following orders for anticholinergic medications. We hypothesized that patients receiving anticholinergic medications would have higher rates of delirium than similar, ... ...

    Abstract We sought to explore rates of delirium amongst hospitalized patients with dementia following orders for anticholinergic medications. We hypothesized that patients receiving anticholinergic medications would have higher rates of delirium than similar, unexposed patients. We performed a retrospective chart review of 23 031 hospitalized individuals with Alzheimer's disease, vascular dementia, or unspecified dementia from 2011-2018. Rates of delirium diagnosis and haloperidol orders following anticholinergic administration were compared to patients with dementia without anticholinergic orders. Significant differences in rates of delirium and orders for haloperidol were observed between exposed and unexposed groups, with delirium having a relative risk of 2.3 and orders for haloperidol having a relative risk of 10.4. The number needed to harm for anticholinergic exposure was 5.45 for delirium and 7.09 for haloperidol. The identified difference suggests that inpatient use of anticholinergic medications may increase the risk of delirium in hospitalized patients with dementia. Despite this risk, our review suggests that anticholinergic administration is common during hospital stays among patients with dementia. Anticholinergic use may be a modifiable risk factor for delirium prevention, which could improve inpatient management of patients with dementia.
    Language English
    Publishing date 2022-10-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2629083-2
    ISSN 1941-8752 ; 1941-8744
    ISSN (online) 1941-8752
    ISSN 1941-8744
    DOI 10.1177/19418744221135914
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  5. Article ; Online: The absence of genotoxicity of a mixture of aloin A and B and a commercial aloe gel beverage.

    Hayes, A Wallace / Clemens, Roger A / Pressman, Peter

    Toxicology mechanisms and methods

    2022  Volume 32, Issue 5, Page(s) 385–394

    Abstract: Aloe products are increasingly valued as ingredients in food supplements and as flavoring agents. The ... ...

    Abstract Aloe products are increasingly valued as ingredients in food supplements and as flavoring agents. The global
    MeSH term(s) Aloe/toxicity ; Beverages ; DNA Damage ; Emodin/analogs & derivatives ; Emodin/analysis ; Emodin/toxicity ; Plant Extracts/toxicity
    Chemical Substances Plant Extracts ; Emodin (KA46RNI6HN) ; alloin (W41H6S09F4)
    Language English
    Publishing date 2022-01-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2081252-8
    ISSN 1537-6524 ; 1537-6516 ; 1051-7235
    ISSN (online) 1537-6524
    ISSN 1537-6516 ; 1051-7235
    DOI 10.1080/15376516.2021.2023828
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  6. Article ; Online: A Call for Perspective and Precision in Research Design and Conclusions Drawn From Preclinical Data.

    Pressman, Peter / Clemens, Roger A / Hayes, Andrew W

    American journal of clinical oncology

    2021  Volume 45, Issue 3, Page(s) 134–135

    MeSH term(s) Humans ; Research Design
    Language English
    Publishing date 2021-10-18
    Publishing country United States
    Document type Letter
    ZDB-ID 604536-4
    ISSN 1537-453X ; 0277-3732
    ISSN (online) 1537-453X
    ISSN 0277-3732
    DOI 10.1097/COC.0000000000000889
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  7. Article ; Online: Distinguishing Behavioral Variant Frontotemporal Dementia From Primary Psychiatric Disorders: A Review of Recently Published Consensus Recommendations From the Neuropsychiatric International Consortium for Frontotemporal Dementia.

    Pressman, Peter S / Matlock, Daniel / Ducharme, Simon

    The Journal of neuropsychiatry and clinical neurosciences

    2021  Volume 33, Issue 2, Page(s) 152–156

    Abstract: The behavioral variant of frontotemporal dementia (bvFTD) is the second most common cause of dementia for individuals <65 years old, but accurate diagnosis is often delayed for several years. While previous criteria have increased the ability of ... ...

    Abstract The behavioral variant of frontotemporal dementia (bvFTD) is the second most common cause of dementia for individuals <65 years old, but accurate diagnosis is often delayed for several years. While previous criteria have increased the ability of diagnosticians to distinguish between bvFTD and other neurocognitive disorders such as Alzheimer's disease, distinguishing bvFTD from a primary psychiatric disorder (PPD) has been more challenging. In early 2020, the Neuropsychiatric International Consortium for Frontotemporal Dementia published the first consensus recommendations to help clinicians distinguish between bvFTD and PPD. These recommendations were produced by a consortium of 45 scientists and clinicians from more than 15 different countries, who explored aspects of history taking, neuropsychological assessments, clinical scales, neuroimaging, CSF and serum biomarkers, and genetics. A multidisciplinary approach is encouraged throughout. In this article, the authors also review those consensus recommendations and highlight use of novel tests and techniques. Additionally, they indicate where further research is needed, including methods to assess the dissemination and implementation of these recommendations. In this way, future efforts by clinicians and researchers alike to improve accurate recognition of bvFTD are encouraged, thereby expanding opportunities for improved guidance and management.
    MeSH term(s) Alzheimer Disease/diagnosis ; Consensus ; Diagnosis, Differential ; Frontotemporal Dementia/diagnosis ; Humans ; Mental Disorders/diagnosis ; Neuroimaging ; Neuropsychological Tests
    Language English
    Publishing date 2021-01-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1036340-3
    ISSN 1545-7222 ; 0895-0172
    ISSN (online) 1545-7222
    ISSN 0895-0172
    DOI 10.1176/appi.neuropsych.20090238
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  8. Article: Δ

    Pressman, Peter / Hayes, A Wallace / Hoeng, Julia / Latino, Diogo A R S / Mazurov, Anatoly / Schlage, Walter K / Rana, Azhar

    Journal of clinical medicine

    2024  Volume 13, Issue 6

    Abstract: In this overview, we seek to appraise recent experimental and observational studies investigating THC and its potential role as adjunctive therapy in various medical illnesses. Recent clinical trials are suggestive of the diverse pharmacologic potentials ...

    Abstract In this overview, we seek to appraise recent experimental and observational studies investigating THC and its potential role as adjunctive therapy in various medical illnesses. Recent clinical trials are suggestive of the diverse pharmacologic potentials for THC but suffer from small sample sizes, short study duration, failure to address tolerance, little dose variation, ill-defined outcome measures, and failure to identify and/or evaluate confounds, all of which may constitute significant threats to the validity of most trials. However, the existing work underscores the potential therapeutic value of THC and, at the same time, calls attention to the critical need for better-designed protocols to fully explore and demonstrate safety and efficacy. In the most general sense, the present brief review illuminates some intriguing findings about THC, along with the basic threats to the validity of the research that supports those findings. The intent is to highlight existing generic weaknesses in the existing randomized controlled trial literature and, most importantly, provide guidance for improved clinical research.
    Language English
    Publishing date 2024-03-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13061540
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  9. Article ; Online: RUTIN, a widely consumed flavonoid, that commonly induces hormetic effects.

    Calabrese, Edward J / Pressman, Peter / Hayes, A Wallace / Dhawan, Gaurav / Kapoor, Rachna / Agathokleous, Evgenios / Calabrese, Vittorio

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

    2024  Volume 187, Page(s) 114626

    Abstract: Rutin is a flavonoid present in numerous fruits and vegetables and therefore widely consumed by humans. It is also a popular dietary supplement of 250-500 mg/day. There is considerable consumer interest in rutin due to numerous reports in the biomedical ... ...

    Abstract Rutin is a flavonoid present in numerous fruits and vegetables and therefore widely consumed by humans. It is also a popular dietary supplement of 250-500 mg/day. There is considerable consumer interest in rutin due to numerous reports in the biomedical literature of its multi-system chemo-preventive properties. The present paper provides the first assessment of rutin-induced hormetic concentration/dose responses, their quantitative features and mechanistic basis, along with their biological, biomedical, clinical, and public health implications. The findings indicate that rutin-induced hormetic dose responses are widespread, being reported in numerous biological models and cell types for a wide range of endpoints. Of critical importance is that the optimal hormetic findings shown in in vitro systems are currently not achievable for human populations due to low gastrointestinal tract bioavailability. These findings have the potential to strengthen future experimental studies with rutin, particularly concerning study design parameters.
    MeSH term(s) Humans ; Hormesis ; Rutin/pharmacology ; Flavonoids/pharmacology ; Models, Biological ; Vegetables
    Chemical Substances Rutin (5G06TVY3R7) ; Flavonoids
    Language English
    Publishing date 2024-03-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 782617-5
    ISSN 1873-6351 ; 0278-6915
    ISSN (online) 1873-6351
    ISSN 0278-6915
    DOI 10.1016/j.fct.2024.114626
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  10. Article ; Online: Flavonoids commonly induce hormetic responses.

    Calabrese, Edward J / Hayes, A Wallace / Pressman, Peter / Dhawan, Gaurav / Kapoor, Rachna / Agathokleous, Evgenios / Calabrese, Vittorio

    Archives of toxicology

    2024  Volume 98, Issue 4, Page(s) 1237–1240

    Abstract: The present paper provides a new perspective of previously published findings by Siwak (Food Chem 141:1227-1241, 2013) which showed that 15 structurally diverse flavonoids reduced toxicity (i.e., enhanced cell viability) from hypochlorite using the MTT ... ...

    Abstract The present paper provides a new perspective of previously published findings by Siwak (Food Chem 141:1227-1241, 2013) which showed that 15 structurally diverse flavonoids reduced toxicity (i.e., enhanced cell viability) from hypochlorite using the MTT assay within a pre-conditioning experimental protocol, with each agent showing a similar biphasic concentration response relationship. We use this Commentary to point out that each of the concentration response relationships are consistent with the hormetic dose response. The paper of Siwak (Food Chem 141:1227-1241, 2013) is unique in that it provides a comparison of a relatively large number of agents using the identical experimental protocol.
    MeSH term(s) Hormesis ; Flavonoids/toxicity ; Cell Survival ; Dose-Response Relationship, Drug
    Chemical Substances Flavonoids
    Language English
    Publishing date 2024-02-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 124992-7
    ISSN 1432-0738 ; 0340-5761
    ISSN (online) 1432-0738
    ISSN 0340-5761
    DOI 10.1007/s00204-024-03684-8
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