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  1. Article ; Online: Proton Image-guided Radiation Assignment for Therapeutic Escalation via Selection of locally advanced head and neck cancer patients [PIRATES]: A Phase I safety and feasibility trial of MRI-guided adaptive particle radiotherapy.

    van Dijk, Lisanne V / Frank, Steven J / Yuan, Ying / Gunn, Brandon / Moreno, Amy C / Mohamed, Abdallah S R / Preston, Kathryn E / Qing, Yun / Spiotto, Michael T / Morrison, William H / Lee, Anna / Phan, Jack / Garden, Adam S / Rosenthal, David I / Langendijk, Johannes A / Fuller, Clifton D

    Clinical and translational radiation oncology

    2021  Volume 32, Page(s) 35–40

    Abstract: Introduction: Radiation dose-escalation for head and neck cancer (HNC) patients aiming to improve cure rates is challenging due to the increased risk of unacceptable treatment-induced toxicities. With "Proton Image-guided Radiation Assignment for ... ...

    Abstract Introduction: Radiation dose-escalation for head and neck cancer (HNC) patients aiming to improve cure rates is challenging due to the increased risk of unacceptable treatment-induced toxicities. With "Proton Image-guided Radiation Assignment for Therapeutic Escalation via Selection of locally advanced head and neck cancer patients" (PIRATES), we present a novel treatment approach that is designed to facilitate dose-escalation while minimizing the risk of dose-limiting toxicities for locally advanced HPV-negative HNC patients. The aim of this Phase I trial is to assess the safety & feasibility of PIRATES approach.
    Methods: The PIRATES protocol employs a multi-faceted dose-escalation approach to minimize the risk of dose-limiting toxicities (DLTs): 1) sparing surrounding normal tissue from extraneous dose with intensity-modulated proton therapy, 2) mid-treatment hybrid hyper-fractionation for radiobiologic normal tissue sparing; 3) Magnetic Resonance Imaging (MRI) guided mid-treatment boost volume adaptation, and 4) iso-effective restricted organ-at-risk dosing to mucosa and bone tissues.The time-to-event Bayesian optimal interval (TITE-BOIN) design is employed to address the challenge of the long DLT window of 6 months and find the maximum tolerated dose. The primary endpoint is unacceptable radiation-induced toxicities (Grade 4, mucositis, dermatitis, or Grade 3 myelopathy, osteoradionecrosis) occurring within 6 months following radiotherapy. The second endpoint is
    Discussion: The PIRATES dose-escalation approach is designed to provide a safe avenue to intensify local treatment for HNC patients for whom therapy with conventional radiation dose levels is likely to fail. PIRATES aims to minimize the radiation damage to the tissue
    Language English
    Publishing date 2021-11-11
    Publishing country Ireland
    Document type Journal Article
    ISSN 2405-6308
    ISSN (online) 2405-6308
    DOI 10.1016/j.ctro.2021.11.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Longitudinal diffusion and volumetric kinetics of head and neck cancer magnetic resonance on a 1.5T MR-Linear accelerator hybrid system: A prospective R-IDEAL Stage 2a imaging biomarker characterization/ pre-qualification study.

    El-Habashy, Dina M / Wahid, Kareem A / He, Renjie / McDonald, Brigid / Rigert, Jillian / Mulder, Samuel J / Lim, Tze Yee / Wang, Xin / Yang, Jinzhong / Ding, Yao / Naser, Mohamed A / Ng, Sweet Ping / Bahig, Houda / Salzillo, Travis C / Preston, Kathryn E / Abobakr, Moamen / Shehata, Mohamed A / Elkhouly, Enas A / Alagizy, Hagar A /
    Hegazy, Amira H / Mohammadseid, Mustefa / Terhaard, Chris / Philippens, Marielle / Rosenthal, David I / Wang, Jihong / Lai, Stephen Y / Dresner, Alex / Christodouleas, John C / Mohamed, Abdallah Sherif Radwan / Fuller, Clifton D

    medRxiv : the preprint server for health sciences

    2023  

    Abstract: Objectives: We aim to characterize the serial quantitative apparent diffusion coefficient (ADC) changes of the target disease volume using diffusion-weighted imaging (DWI) acquired weekly during radiation therapy (RT) on a 1.5T MR-Linac and correlate ... ...

    Abstract Objectives: We aim to characterize the serial quantitative apparent diffusion coefficient (ADC) changes of the target disease volume using diffusion-weighted imaging (DWI) acquired weekly during radiation therapy (RT) on a 1.5T MR-Linac and correlate these changes with tumor response and oncologic outcomes for head and neck squamous cell carcinoma (HNSCC) patients as part of a programmatic R-IDEAL biomarker characterization effort.
    Methods: Thirty patients with pathologically confirmed HNSCC who received curative-intent RT at the University of Texas MD Anderson Cancer Center, were included in this prospective study. Baseline and weekly Magnetic resonance imaging (MRI) (weeks 1-6) were obtained, and various ADC parameters (mean, 5
    Results: There was an overall significant rise in all ADC parameters during different time points of RT compared to baseline values for both gross primary disease volume (GTV-P) and gross nodal disease volumes (GTV-N). The increased ADC values for GTV-P were statistically significant only for primary tumors achieving complete remission (CR) during RT. RPA identified GTV-P ΔADC 5
    Conclusion: Assessment of ADC kinetics at regular intervals throughout RT seems to be correlated with RT response. Further studies with larger cohorts and multi-institutional data are needed for validation of ΔADC as a model for prediction of response to RT.
    Language English
    Publishing date 2023-05-05
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.05.04.23289527
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Long-term patient reported outcomes following radiation therapy for oropharyngeal cancer: cross-sectional assessment of a prospective symptom survey in patients ≥65 years old.

    Eraj, Salman A / Jomaa, Mona K / Rock, Crosby D / Mohamed, Abdallah S R / Smith, Blaine D / Smith, Joshua B / Browne, Theodora / Cooksey, Luke C / Williams, Bowman / Temple, Brandi / Preston, Kathryn E / Aymard, Jeremy M / Gross, Neil D / Weber, Randal S / Hessel, Amy C / Ferrarotto, Renata / Phan, Jack / Sturgis, Erich M / Hanna, Ehab Y /
    Frank, Steven J / Morrison, William H / Goepfert, Ryan P / Lai, Stephen Y / Rosenthal, David I / Mendoza, Tito R / Cleeland, Charles S / Hutcheson, Kate A / Fuller, Clifton D / Garden, Adam S / Gunn, G Brandon

    Radiation oncology (London, England)

    2017  Volume 12, Issue 1, Page(s) 150

    Abstract: Background: Given the potential for older patients to experience exaggerated toxicity and symptoms, this study was performed to characterize patient reported outcomes in older patients following definitive radiation therapy (RT) for oropharyngeal cancer ...

    Abstract Background: Given the potential for older patients to experience exaggerated toxicity and symptoms, this study was performed to characterize patient reported outcomes in older patients following definitive radiation therapy (RT) for oropharyngeal cancer (OPC).
    Methods: Cancer-free head and neck cancer survivors (>6 months since treatment completion) were eligible for participation in a questionnaire-based study. Participants completed the MD Anderson Symptom Inventory-Head and Neck module (MDASI-HN). Those patients ≥65 years old at treatment for OPC with definitive RT were included. Individual and overall symptom severity and clinical variables were analyzed.
    Results: Of the 79 participants analyzed, 82% were male, 95% white, 41% T3/4 disease, 39% RT alone, 27% induction chemotherapy, 52% concurrent, and 18% both, and 96% IMRT. Median age at RT was 71 yrs. (range: 65-85); median time from RT to MDASI-HN was 46 mos. (2/3 > 24 mos.). The top 5 MDASI-HN items rated most severe in terms of mean (±SD) ratings (0-10 scale) were dry mouth (3.48 ± 2.95), taste (2.81 ± 3.29), swallowing (2.59 ± 2.96), mucus in mouth/throat (2.04 ± 2.68), and choking (1.30 ± 2.38) reported at moderate-severe levels (≥5) by 35, 29, 29, 18, and 13%, respectively. Thirty-nine % reported none (0) or no more than mild (1-4) symptoms across all 22 MDASI-HN symptoms items, and 38% had at least one item rated as severe (≥7). Hierarchical cluster analysis resulted in 3 patient groups: 1) ~65% with ranging from none to moderate symptom burden, 2) ~35% with moderate-severe ratings for a subset of classically RT-related symptoms (e.g. dry mouth, mucus, swallowing) and 3) 2 pts. with severe ratings of most items.
    Conclusions: The overall long-term symptom burden seen in this older OPC cohort treated with modern standard therapy was largely favorable, yet a higher symptom group (~35%) with a distinct pattern of mostly local and classically RT-related symptoms was identified.
    Language English
    Publishing date 2017-09-09
    Publishing country England
    Document type Journal Article
    ISSN 1748-717X
    ISSN (online) 1748-717X
    DOI 10.1186/s13014-017-0878-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Correction to: Long-term patient reported outcomes following radiation therapy for oropharyngeal cancer: cross-sectional assessment of a prospective symptom survey in patients ≥65 years old.

    Eraj, Salman A / Jomaa, Mona K / Rock, Crosby D / Mohamed, Abdallah S R / Smith, Blaine D / Smith, Joshua B / Browne, Theodora / Cooksey, Luke C / Williams, Bowman / Temple, Brandi / Preston, Kathryn E / Aymard, Jeremy M / Gross, Neil D / Weber, Randal S / Hessel, Amy C / Ferrarotto, Renata / Phan, Jack / Sturgis, Erich M / Hanna, Ehab Y /
    Frank, Steven J / Morrison, William H / Goepfert, Ryan P / Lai, Stephen Y / Rosenthal, David I / Mendoza, Tito R / Cleeland, Charles S / Hutcheson, Kate A / Fuller, Clifton D / Garden, Adam S / Brandon Gunn, G

    Radiation oncology (London, England)

    2017  Volume 12, Issue 1, Page(s) 186

    Abstract: In the original publication [1] the name of author Jeremy M. Aymard was spelled wrong. The original article was updated to rectify this error. ...

    Abstract In the original publication [1] the name of author Jeremy M. Aymard was spelled wrong. The original article was updated to rectify this error.
    Language English
    Publishing date 2017-11-23
    Publishing country England
    Document type Published Erratum
    ISSN 1748-717X
    ISSN (online) 1748-717X
    DOI 10.1186/s13014-017-0921-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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