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  1. Article ; Online: Heat-Related Emergency Department Visits - United States, May-September 2023.

    Vaidyanathan, Ambarish / Gates, Abigail / Brown, Claudia / Prezzato, Emily / Bernstein, Aaron

    MMWR. Morbidity and mortality weekly report

    2024  Volume 73, Issue 15, Page(s) 324–329

    Abstract: Unprecedented heat waves can affect all persons, but some are more sensitive to the effects of heat, including children and adults with underlying health conditions, pregnant women, and outdoor workers. Many regions of the United States experienced ... ...

    Abstract Unprecedented heat waves can affect all persons, but some are more sensitive to the effects of heat, including children and adults with underlying health conditions, pregnant women, and outdoor workers. Many regions of the United States experienced record-breaking high temperatures in 2023, with populations exposed to extremely high temperatures for prolonged periods. CDC examined emergency department (ED) visits associated with heat-related illness (HRI) from the National Syndromic Surveillance Program and compared daily HRI ED visit rates during the warm-season months (May-September) of 2023 with those during 2018-2022. In the 2023 warm-season months, daily HRI ED visit rates peaked in several regions and remained elevated for a prolonged duration. More males than females sought care in EDs for HRI, especially males aged 18-64 years. CDC issued multiple public health alerts using the Epidemic Information Exchange system to bring attention to increases in ED utilization for HRI. Deaths and illnesses associated with heat exposure are a continuing public health concern as climate change results in longer, hotter, and more frequent episodes of extreme heat. Near real-time monitoring of weather conditions and adverse health outcomes can guide public health practitioners' timing of risk communication and implementation of prevention measures associated with extreme heat.
    MeSH term(s) Pregnancy ; Adult ; Child ; Male ; Humans ; United States/epidemiology ; Female ; Hot Temperature ; Emergency Service, Hospital ; Emergency Room Visits ; Extreme Heat/adverse effects ; Seasons ; Heat Stress Disorders/epidemiology
    Language English
    Publishing date 2024-04-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 412775-4
    ISSN 1545-861X ; 0149-2195
    ISSN (online) 1545-861X
    ISSN 0149-2195
    DOI 10.15585/mmwr.mm7315a1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Opportunities to monitor disparities in asthma and other respiratory diseases using public health data.

    Sircar, Kanta / Hagen, Melissa Briggs / Prezzato, Emily / Hsu, Joy

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2023  Volume 131, Issue 6, Page(s) 683–684

    MeSH term(s) Humans ; Public Health ; Asthma/epidemiology ; Respiratory Tract Diseases ; Health Status Disparities
    Language English
    Publishing date 2023-05-16
    Publishing country United States
    Document type Editorial
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2023.09.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Racial and Ethnic Disparities in Multisystem Inflammatory Syndrome in Children in the United States, March 2020 to February 2021.

    Stierman, Bryan / Abrams, Joseph Y / Godfred-Cato, Shana E / Oster, Matthew E / Meng, Lu / Yip, Luke / Patel, Pragna / Balachandran, Neha / Prezzato, Emily / Pierce, Timmy / Hsu, Katherine K / Burns, Meagan / Peterson Pompa, Xandy / Lauro, Priscilla / Hartley, Amanda / Jones, Cassandra / Gretsch, Stephanie / Reid, Heather / Lim, Sarah /
    Campbell, Angela P / Belay, Ermias D

    The Pediatric infectious disease journal

    2021  Volume 40, Issue 11, Page(s) e400–e406

    Abstract: Background: The incidence of multisystem inflammatory syndrome in children (MIS-C) varies by race and ethnicity. This study assessed whether disparities in MIS-C in the United States by race and ethnicity exceed known disparities in coronavirus disease ... ...

    Abstract Background: The incidence of multisystem inflammatory syndrome in children (MIS-C) varies by race and ethnicity. This study assessed whether disparities in MIS-C in the United States by race and ethnicity exceed known disparities in coronavirus disease 2019 (COVID-19) incidence.
    Methods: We compared the distribution of race and ethnicity among patients with MIS-C (<21 years of age, termed children) with onset March 2020 to February 2021 to that of children with COVID-19 and in the general population. Analysis was restricted to 369 counties with high completeness of race and ethnicity reporting for MIS-C and COVID-19. For each racial and ethnic group, observed numbers of patients with MIS-C were compared with expected numbers (observed/expected ratio) in children with COVID-19 and in the general population within these counties.
    Results: Compared with children in the general population, MIS-C was more frequent among Hispanic (139% of expected) and non-Hispanic Black children (183%) and less frequent among non-Hispanic White (64%) and non-Hispanic Asian children (48%). Compared with children with COVID-19, MIS-C was more frequent in non-Hispanic Black children (207% of expected) and less frequent in non-Hispanic White children (68%); however, frequency was not different among Hispanic (102%) and non-Hispanic Asian (74%) children.
    Conclusions: Disparities in MIS-C by race and ethnicity exist, even after controlling for COVID-19 disparities and geographic variations. The high proportion of MIS-C among Hispanic children and low proportion among non-Hispanic Asian children align with COVID-19 rates, while the high proportion among non-Hispanic Black children and low proportion among non-Hispanic White children are not explainable by COVID-19 rates.
    MeSH term(s) Adolescent ; Adult ; COVID-19/complications ; COVID-19/epidemiology ; COVID-19/etiology ; COVID-19/history ; COVID-19/virology ; Child ; Child, Preschool ; Ethnicity/statistics & numerical data ; Female ; History, 21st Century ; Humans ; Incidence ; Infant ; Male ; Public Health Surveillance ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome/epidemiology ; Systemic Inflammatory Response Syndrome/etiology ; Systemic Inflammatory Response Syndrome/history ; United States/epidemiology ; United States/ethnology ; Young Adult
    Language English
    Publishing date 2021-08-11
    Publishing country United States
    Document type Historical Article ; Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 392481-6
    ISSN 1532-0987 ; 0891-3668
    ISSN (online) 1532-0987
    ISSN 0891-3668
    DOI 10.1097/INF.0000000000003294
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Trends in Geographic and Temporal Distribution of US Children With Multisystem Inflammatory Syndrome During the COVID-19 Pandemic.

    Belay, Ermias D / Abrams, Joseph / Oster, Matthew E / Giovanni, Jennifer / Pierce, Timmy / Meng, Lu / Prezzato, Emily / Balachandran, Neha / Openshaw, John J / Rosen, Hilary E / Kim, Moon / Richardson, Gillian / Hand, Julie / Tobin-D'Angelo, Melissa / Wilson, Siri / Hartley, Amanda / Jones, Cassandra / Kolsin, Jonathan / Mohamed, Hani /
    Colles, Zachary / Hammett, Teresa / Patel, Pragna / Stierman, Bryan / Campbell, Angela P / Godfred-Cato, Shana

    JAMA pediatrics

    2021  Volume 175, Issue 8, Page(s) 837–845

    Abstract: Importance: Multiple inflammatory syndrome in children (MIS-C) occurs in association with the COVID-19 pandemic.: Objective: To describe the clinical characteristics and geographic and temporal distribution of the largest cohort of patients with MIS- ... ...

    Abstract Importance: Multiple inflammatory syndrome in children (MIS-C) occurs in association with the COVID-19 pandemic.
    Objective: To describe the clinical characteristics and geographic and temporal distribution of the largest cohort of patients with MIS-C in the United States to date.
    Design, setting, and participants: Cross-sectional analysis was conducted on clinical and laboratory data collected from patients with MIS-C. The analysis included patients with illness onset from March 2020 to January 2021 and met MIS-C case definition.
    Main outcomes and measures: Geographic and temporal distribution of MIS-C was compared with that of COVID-19 nationally, by region, and level of urbanicity by county. Clinical and laboratory findings and changes over time were described by age group and by presence or absence of preceding COVID-19.
    Results: A total of 1733 patients with MIS-C were identified; 994 (57.6%) were male and 1117 (71.3%) were Hispanic or non-Hispanic Black. Gastrointestinal symptoms, rash, and conjunctival hyperemia were reported by 53% (n = 931) to 67% (n = 1153) of patients. A total of 937 patients (54%) had hypotension or shock, and 1009 (58.2%) were admitted for intensive care. Cardiac dysfunction was reported in 484 patients (31.0%), pericardial effusion in 365 (23.4%), myocarditis in 300 (17.3%), and coronary artery dilatation or aneurysms in 258 (16.5%). Patients aged 0 to 4 years had the lowest proportion of severe manifestations, although 171 patients (38.4%) had hypotension or shock and 197 (44.3%) were admitted for intensive care. Patients aged 18 to 20 years had the highest proportions with myocarditis (17 [30.9%]), pneumonia (20 [36.4%]), acute respiratory distress syndrome (10 [18.2%]), and polymerase chain reaction positivity (39 [70.9%]). These older adolescents also had the highest proportion reporting preceding COVID-19-like illness (63%). Nationally, the first 2 MIS-C peaks followed the COVID-19 peaks by 2 to 5 weeks. The cumulative MIS-C incidence per 100 000 persons younger than 21 years was 2.1 and varied from 0.2 to 6.3 by state. Twenty-four patients (1.4%) died.
    Conclusions and relevance: In this cross-sectional study of a large cohort of patients with MIS-C, 2 peaks that followed COVID-19 peaks by 2 to 5 weeks were identified. The geographic and temporal association of MIS-C with the COVID-19 pandemic suggested that MIS-C resulted from delayed immunologic responses to SARS-CoV-2 infection. The clinical manifestations varied by age and by presence or absence of preceding COVID-19.
    MeSH term(s) Adolescent ; COVID-19/epidemiology ; Child ; Child, Preschool ; Critical Care/statistics & numerical data ; Cross-Sectional Studies ; Female ; Hospitalization/statistics & numerical data ; Humans ; Incidence ; Infant ; Infant, Newborn ; Male ; Pandemics ; Retrospective Studies ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome/epidemiology ; United States/epidemiology ; Young Adult
    Language English
    Publishing date 2021-04-05
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 2701223-2
    ISSN 2168-6211 ; 2168-6203
    ISSN (online) 2168-6211
    ISSN 2168-6203
    DOI 10.1001/jamapediatrics.2021.0630
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: COVID-19-Associated Multisystem Inflammatory Syndrome in Children - United States, March-July 2020.

    Godfred-Cato, Shana / Bryant, Bobbi / Leung, Jessica / Oster, Matthew E / Conklin, Laura / Abrams, Joseph / Roguski, Katherine / Wallace, Bailey / Prezzato, Emily / Koumans, Emilia H / Lee, Ellen H / Geevarughese, Anita / Lash, Maura K / Reilly, Kathleen H / Pulver, Wendy P / Thomas, Deepam / Feder, Kenneth A / Hsu, Katherine K / Plipat, Nottasorn /
    Richardson, Gillian / Reid, Heather / Lim, Sarah / Schmitz, Ann / Pierce, Timmy / Hrapcak, Susan / Datta, Deblina / Morris, Sapna Bamrah / Clarke, Kevin / Belay, Ermias

    MMWR. Morbidity and mortality weekly report

    2020  Volume 69, Issue 32, Page(s) 1074–1080

    Abstract: In April 2020, during the peak of the coronavirus disease 2019 (COVID-19) pandemic in Europe, a cluster of children with hyperinflammatory shock with features similar to Kawasaki disease and toxic shock syndrome was reported in England* (1). The patients' ...

    Abstract In April 2020, during the peak of the coronavirus disease 2019 (COVID-19) pandemic in Europe, a cluster of children with hyperinflammatory shock with features similar to Kawasaki disease and toxic shock syndrome was reported in England* (1). The patients' signs and symptoms were temporally associated with COVID-19 but presumed to have developed 2-4 weeks after acute COVID-19; all children had serologic evidence of infection with SARS-CoV-2, the virus that causes COVID-19 (1). The clinical signs and symptoms present in this first cluster included fever, rash, conjunctivitis, peripheral edema, gastrointestinal symptoms, shock, and elevated markers of inflammation and cardiac damage (1). On May 14, 2020, CDC published an online Health Advisory that summarized the manifestations of reported multisystem inflammatory syndrome in children (MIS-C), outlined a case definition,
    MeSH term(s) Adolescent ; COVID-19 ; Child ; Child, Preschool ; Coronavirus Infections/complications ; Coronavirus Infections/epidemiology ; Female ; Humans ; Male ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/epidemiology ; Systemic Inflammatory Response Syndrome/epidemiology ; Systemic Inflammatory Response Syndrome/virology ; United States/epidemiology
    Keywords covid19
    Language English
    Publishing date 2020-08-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 412775-4
    ISSN 1545-861X ; 0149-2195
    ISSN (online) 1545-861X
    ISSN 0149-2195
    DOI 10.15585/mmwr.mm6932e2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: COVID-19-Associated Multisystem Inflammatory Syndrome in Children - United States, March-July 2020

    Godfred-Cato, Shana / Bryant, Bobbi / Leung, Jessica / Oster, Matthew E / Conklin, Laura / Abrams, Joseph / Roguski, Katherine / Wallace, Bailey / Prezzato, Emily / Koumans, Emilia H / Lee, Ellen H / Geevarughese, Anita / Lash, Maura K / Reilly, Kathleen H / Pulver, Wendy P / Thomas, Deepam / Feder, Kenneth A / Hsu, Katherine K / Plipat, Nottasorn /
    Richardson, Gillian / Reid, Heather / Lim, Sarah / Schmitz, Ann / Pierce, Timmy / Hrapcak, Susan / Datta, Deblina / Morris, Sapna Bamrah / Clarke, Kevin / Belay, Ermias

    MMWR Morb Mortal Wkly Rep

    Abstract: In April 2020, during the peak of the coronavirus disease 2019 (COVID-19) pandemic in Europe, a cluster of children with hyperinflammatory shock with features similar to Kawasaki disease and toxic shock syndrome was reported in England* (1). The patients' ...

    Abstract In April 2020, during the peak of the coronavirus disease 2019 (COVID-19) pandemic in Europe, a cluster of children with hyperinflammatory shock with features similar to Kawasaki disease and toxic shock syndrome was reported in England* (1). The patients' signs and symptoms were temporally associated with COVID-19 but presumed to have developed 2-4 weeks after acute COVID-19; all children had serologic evidence of infection with SARS-CoV-2, the virus that causes COVID-19 (1). The clinical signs and symptoms present in this first cluster included fever, rash, conjunctivitis, peripheral edema, gastrointestinal symptoms, shock, and elevated markers of inflammation and cardiac damage (1). On May 14, 2020, CDC published an online Health Advisory that summarized the manifestations of reported multisystem inflammatory syndrome in children (MIS-C), outlined a case definition,† and asked clinicians to report suspected U.S. cases to local and state health departments. As of July 29, a total of 570 U.S. MIS-C patients who met the case definition had been reported to CDC. A total of 203 (35.6%) of the patients had a clinical course consistent with previously published MIS-C reports, characterized predominantly by shock, cardiac dysfunction, abdominal pain, and markedly elevated inflammatory markers, and almost all had positive SARS-CoV-2 test results. The remaining 367 (64.4%) of MIS-C patients had manifestations that appeared to overlap with acute COVID-19 (2-4), had a less severe clinical course, or had features of Kawasaki disease.§ Median duration of hospitalization was 6 days; 364 patients (63.9%) required care in an intensive care unit (ICU), and 10 patients (1.8%) died. As the COVID-19 pandemic continues to expand in many jurisdictions, clinicians should be aware of the signs and symptoms of MIS-C and report suspected cases to their state or local health departments; analysis of reported cases can enhance understanding of MIS-C and improve characterization of the illness for early detection and treatment.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #695725
    Database COVID19

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