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  1. Book: Molecular and cell biology of pain

    Price, Theodore J. / Dussor, Gregory

    (Progress in molecular biology and translational science ; 131)

    2015  

    Author's details ed. by Theodore J. Price ; Gregory Dussor
    Series title Progress in molecular biology and translational science ; 131
    Collection
    Keywords Pain ; Pain/Treatment ; Schmerzforschung
    Subject Schmerz
    Subject code 616.0472
    Language English
    Size XVIII, 630, [7] Bl. : Ill., graph. Darst.
    Edition 1. ed.
    Publisher Elsevier AP
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT018599802
    ISBN 978-0-12-801389-2 ; 9780128014325 ; 0-12-801389-3 ; 0128014326
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Uc I Zs 357 -131- verfügbar in Königswinter Königswinter

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  2. Article ; Online: Commentary on: Conserved transcriptional programming across sex and species after peripheral nerve injury predicts treatments for neuropathic pain.

    Lesnak, Joseph B / Price, Theodore J

    British journal of pharmacology

    2023  Volume 180, Issue 20, Page(s) 2603–2604

    MeSH term(s) Humans ; Peripheral Nerve Injuries/drug therapy ; Neuralgia/drug therapy ; Hyperalgesia
    Language English
    Publishing date 2023-07-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 80081-8
    ISSN 1476-5381 ; 0007-1188
    ISSN (online) 1476-5381
    ISSN 0007-1188
    DOI 10.1111/bph.16189
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Tiam1 creates a painful link between dendritic spine remodeling and NMDA receptors.

    Davis, Olivia C / Price, Theodore J

    Neuron

    2023  Volume 111, Issue 13, Page(s) 1993–1995

    Abstract: Dendritic spine remodeling in the dorsal horn is associated with many chronic pain models. Li et al. demonstrate that Tiam1 links Rac1-mediated spine changes to NMDA receptor activity to promote behavioral signs of chronic pain in rodents. ...

    Abstract Dendritic spine remodeling in the dorsal horn is associated with many chronic pain models. Li et al. demonstrate that Tiam1 links Rac1-mediated spine changes to NMDA receptor activity to promote behavioral signs of chronic pain in rodents.
    MeSH term(s) Humans ; Receptors, N-Methyl-D-Aspartate/metabolism ; Chronic Pain ; Dendritic Spines/metabolism ; Signal Transduction ; Neurons/metabolism ; rac1 GTP-Binding Protein/metabolism
    Chemical Substances Receptors, N-Methyl-D-Aspartate ; rac1 GTP-Binding Protein (EC 3.6.5.2)
    Language English
    Publishing date 2023-07-06
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2023.06.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: RNA isoform expression landscape of the human dorsal root ganglion (DRG) generated from long read sequencing.

    Arendt-Tranholm, Asta / Mwirigi, Juliet M / Price, Theodore J

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Splicing is a post-transcriptional RNA processing mechanism that enhances genomic complexity by creating multiple isoforms from the same gene. Diversity in splicing in the mammalian nervous system is associated with neuronal development, synaptic ... ...

    Abstract Splicing is a post-transcriptional RNA processing mechanism that enhances genomic complexity by creating multiple isoforms from the same gene. Diversity in splicing in the mammalian nervous system is associated with neuronal development, synaptic function and plasticity, and is also associated with diseases of the nervous system ranging from neurodegeneration to chronic pain. We aimed to characterize the isoforms expressed in the human peripheral nervous system, with the goal of creating a resource to identify novel isoforms of functionally relevant genes associated with somatosensation and nociception. We used long read sequencing (LRS) to document isoform expression in the human dorsal root ganglia (hDRG) from 3 organ donors. Isoforms were validated
    Language English
    Publishing date 2023-11-01
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.10.28.564535
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: MNK1 and MNK2 expression in the human dorsal root and trigeminal ganglion.

    Shiers, Stephanie / Sahn, James J / Price, Theodore J

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Mitogen activated protein kinase interacting kinases (MNK) 1 and 2 are serine/threonine protein kinases that play an important role in translation of mRNAs through their phosphorylation of the RNA 5’-cap binding protein, eukaryotic translation ... ...

    Abstract Mitogen activated protein kinase interacting kinases (MNK) 1 and 2 are serine/threonine protein kinases that play an important role in translation of mRNAs through their phosphorylation of the RNA 5’-cap binding protein, eukaryotic translation initiation factor (eIF) 4E. These kinases are downstream targets for mitogen activated protein kinases (MAPKs), extracellular activity regulated protein kinase (ERK) and p38. MNKs have been implicated in the sensitization of peripheral nociceptors of the dorsal root and trigeminal ganglion (DRG and TG) using transgenic mouse lines and through the use of specific inhibitors of MNK1 and MNK2. While specific knockout of the
    Language English
    Publishing date 2023-01-04
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.01.04.522773
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Neuroimmune Mechanisms Underlying Post-acute Sequelae of SARS-CoV-2 (PASC) Pain, Predictions from a Ligand-Receptor Interactome.

    Lesnak, Joseph B / Mazhar, Khadijah / Price, Theodore J

    Current rheumatology reports

    2023  Volume 25, Issue 9, Page(s) 169–181

    Abstract: Purpose of review: Individuals with post-acute sequelae of SARS-CoV-2 (PASC) complain of persistent musculoskeletal pain. Determining how COVID-19 infection produces persistent pain would be valuable for the development of therapeutics aimed at ... ...

    Abstract Purpose of review: Individuals with post-acute sequelae of SARS-CoV-2 (PASC) complain of persistent musculoskeletal pain. Determining how COVID-19 infection produces persistent pain would be valuable for the development of therapeutics aimed at alleviating these symptoms.
    Recent findings: To generate hypotheses regarding neuroimmune interactions in PASC, we used a ligand-receptor interactome to make predictions about how ligands from PBMCs in individuals with COVID-19 communicate with dorsal root ganglia (DRG) neurons to induce persistent pain. In a structured literature review of -omics COVID-19 studies, we identified ligands capable of binding to receptors on DRG neurons, which stimulate signaling pathways including immune cell activation and chemotaxis, the complement system, and type I interferon signaling. The most consistent finding across immune cell types was an upregulation of genes encoding the alarmins S100A8/9 and MHC-I. This ligand-receptor interactome, from our hypothesis-generating literature review, can be used to guide future research surrounding mechanisms of PASC-induced pain.
    MeSH term(s) Humans ; SARS-CoV-2 ; Neuroimmunomodulation ; COVID-19/complications ; Ligands ; Disease Progression ; Musculoskeletal Pain
    Chemical Substances Ligands
    Language English
    Publishing date 2023-06-10
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2057357-1
    ISSN 1534-6307 ; 1523-3774
    ISSN (online) 1534-6307
    ISSN 1523-3774
    DOI 10.1007/s11926-023-01107-8
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    Zs.A 5531: Show issues Location:
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  7. Article ; Online: MNK1 and MNK2 Expression in the Human Dorsal Root and Trigeminal Ganglion.

    Shiers, Stephanie / Sahn, James J / Price, Theodore J

    Neuroscience

    2023  Volume 515, Page(s) 96–107

    Abstract: Mitogen activated protein kinase interacting kinases (MNK) 1 and 2 are serine/threonine protein kinases that play an important role in translation of mRNAs through their phosphorylation of the RNA 5'-cap binding protein, eukaryotic translation initiation ...

    Abstract Mitogen activated protein kinase interacting kinases (MNK) 1 and 2 are serine/threonine protein kinases that play an important role in translation of mRNAs through their phosphorylation of the RNA 5'-cap binding protein, eukaryotic translation initiation factor (eIF) 4E. These kinases are downstream targets for mitogen activated protein kinases (MAPKs), extracellular activity regulated protein kinase (ERK) and p38. MNKs have been implicated in the sensitization of peripheral nociceptors of the dorsal root and trigeminal ganglion (DRG and TG) using transgenic mouse lines and through the use of specific inhibitors of MNK1 and MNK2. While specific knockout of the Mknk1 gene suggests that it is the key isoform for regulation of nociceptor excitability and nociceptive behaviors in mice, both MKNK1 and MKNK2 genes are expressed in the DRG and TG of mice and humans based on RNA sequencing experiments. Single cell sequencing in mice suggests that Mknk1 and Mknk2 may be expressed in different populations of nociceptors. We sought to characterize mRNA expression in human DRG and TG (N = 3 ganglia for both DRG and TG) for both MNK1 and MNK2. Our results show that both genes are expressed by nearly all neurons in both human ganglia with expression in other cell types as well. Our findings provide evidence that MNK1 and MNK2 are expressed by human nociceptors of males and females and suggest that efforts to pharmacologically target MNKs for pain would likely be translatable due its conserved expression in both species.
    MeSH term(s) Animals ; Female ; Humans ; Male ; Mice ; Eukaryotic Initiation Factor-4E/metabolism ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Mitogen-Activated Protein Kinase Kinases/metabolism ; Mitogen-Activated Protein Kinases/metabolism ; Phosphorylation ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/metabolism ; Spinal Nerve Roots/metabolism ; Trigeminal Ganglion/metabolism
    Chemical Substances Eukaryotic Initiation Factor-4E ; Intracellular Signaling Peptides and Proteins ; Mitogen-Activated Protein Kinase Kinases (EC 2.7.12.2) ; Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; MKNK1 protein, human (EC 2.7.1.-) ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; MKNK2 protein, human (EC 2.7.11.1)
    Language English
    Publishing date 2023-02-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 196739-3
    ISSN 1873-7544 ; 0306-4522
    ISSN (online) 1873-7544
    ISSN 0306-4522
    DOI 10.1016/j.neuroscience.2023.01.039
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    Zs.A 1215: Show issues Location:
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  8. Article: Translation regulation and pain special issue editorial for neurobiology of pain.

    Price, Theodore J

    Neurobiology of pain (Cambridge, Mass.)

    2018  Volume 4, Page(s) 1

    Language English
    Publishing date 2018-05-30
    Publishing country United States
    Document type Editorial
    ISSN 2452-073X
    ISSN 2452-073X
    DOI 10.1016/j.ynpai.2018.05.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Vinorelbine causes a neuropathic pain-like state in mice via STING and MNK1 signaling associated with type I interferon induction.

    Franco-Enzástiga, Úrzula / Natarajan, Keerthana / David, Eric T / Patel, Krish / Ravirala, Abhira / Price, Theodore J

    iScience

    2024  Volume 27, Issue 2, Page(s) 108808

    Abstract: Type I interferons (IFNs) increase the excitability of dorsal root ganglia (DRGs) neurons via MNK-eIF4E signaling to promote pain sensitization in mice. Activation of stimulator of interferon response cGAMP interactor 1 (STING) signaling is pivotal for ... ...

    Abstract Type I interferons (IFNs) increase the excitability of dorsal root ganglia (DRGs) neurons via MNK-eIF4E signaling to promote pain sensitization in mice. Activation of stimulator of interferon response cGAMP interactor 1 (STING) signaling is pivotal for type I IFN induction. We hypothesized that vinorelbine, a chemotherapeutic and activator of STING, would cause a neuropathic pain-like state in mice via STING signaling in DRG neurons associated with IFN production. Vinorelbine caused tactile allodynia and grimacing in wild-type (WT) mice and increased
    Language English
    Publishing date 2024-01-08
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2024.108808
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Sex-differences in prostaglandin signaling: a semi-systematic review and characterization of PTGDS expression in human sensory neurons.

    Shen, Breanna Q / Sankaranarayanan, Ishwarya / Price, Theodore J / Tavares-Ferreira, Diana

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 4670

    Abstract: There is increasing evidence of sex differences in underlying mechanisms causing pain in preclinical models, and in clinical populations. There are also important disconnects between clinical pain populations and the way preclinical pain studies are ... ...

    Abstract There is increasing evidence of sex differences in underlying mechanisms causing pain in preclinical models, and in clinical populations. There are also important disconnects between clinical pain populations and the way preclinical pain studies are conducted. For instance, osteoarthritis pain more frequently affects women, but most preclinical studies have been conducted using males in animal models. The most widely used painkillers, nonsteroidal anti-inflammatory drugs (NSAIDs), act on the prostaglandin pathway by inhibiting cyclooxygenase (COX) enzymes. The purpose of this study was to analyze the preclinical and clinical literature on the role of prostaglandins and COX in inflammation and pain. We aimed to specifically identify studies that used both sexes and investigate whether any sex-differences in the action of prostaglandins and COX inhibition had been reported, either in clinical or preclinical studies. We conducted a PubMed search and identified 369 preclinical studies and 100 clinical studies that matched our inclusion/exclusion criteria. Our analysis shows that only 17% of preclinical studies on prostaglandins used both sexes and, out of those, only 19% analyzed or reported data separated by sex. In contrast, 79% of the clinical studies analyzed used both sexes. However, only 6% of those reported data separated by sex. Interestingly, 14 out of 15 preclinical studies and 5 out of 6 clinical studies that analyzed data separated by sex have identified sex-differences. This builds on the increasing evidence of sex-differences in prostaglandin signaling and the importance of sex as a biological variable in data analysis. The preclinical literature identifies a sex difference in prostaglandin D
    MeSH term(s) Animals ; Female ; Humans ; Male ; Cyclooxygenase 2 ; Pain ; Prostaglandins/metabolism ; Sensory Receptor Cells/metabolism ; Sex Characteristics
    Chemical Substances Cyclooxygenase 2 (EC 1.14.99.1) ; Prostaglandins ; PTGDS protein, human (EC 5.3.-)
    Language English
    Publishing date 2023-03-22
    Publishing country England
    Document type Systematic Review ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-31603-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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