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Article: Supplementation with the Symbiotic Formulation Prodefen

Méndez-Albiñana, Pablo / Martínez-González, Ángel / Camacho-Rodríguez, Laura / Ferreira-Lazarte, Álvaro / Villamiel, Mar / Rodrigues-Díez, Raquel / Balfagón, Gloria / García-Redondo, Ana B / Prieto-Nieto, Mª Isabel / Blanco-Rivero, Javier

Antioxidants (Basel, Switzerland)

2022 Volume 11, Issue 4

Abstract: In recent years, gut dysbiosis has been related to some peripheral vascular alterations linked to hypertension. In this work, we explore whether gut dysbiosis is related to vascular innervation dysfunction and altered nitric oxide (NO) production in the ... ...

Abstract	In recent years, gut dysbiosis has been related to some peripheral vascular alterations linked to hypertension. In this work, we explore whether gut dysbiosis is related to vascular innervation dysfunction and altered nitric oxide (NO) production in the superior mesenteric artery, one of the main vascular beds involved in peripheral vascular resistance. For this purpose, we used spontaneously hypertensive rats, either treated or not with the commercial synbiotic formulation Prodefen
Language	English
Publishing date	2022-03-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox11040680
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Article: Clinico-Pathological Features, Outcomes and Impacts of COVID-19 Pandemic on Patients with Early-Onset Colorectal Cancer: A Single-Institution Experience.

Martinez-Perez, Daniel / Viñal, David / Peña-Lopez, Jesús / Jimenez-Bou, Diego / Ruiz-Gutierrez, Iciar / Martinez-Recio, Sergio / Alameda-Guijarro, María / Rueda-Lara, Antonio / Martin-Montalvo, Gema / Ghanem, Ismael / Custodio, Ana Belén / Trilla-Fuertes, Lucia / Gamez-Pozo, Angelo / Barbachano, Antonio / Rodriguez-Cobos, Javier / Bustamante-Madrid, Pilar / Fernandez-Barral, Asuncion / Burgos, Aurora / Prieto-Nieto, Maria Isabel /

Pastrian, Laura Guerra / González-Sancho, José Manuel / Muñoz, Alberto / Feliu, Jaime / Rodríguez-Salas, Nuria

Cancers

2023 Volume 15, Issue 17

Abstract: Background: The rising incidence of colorectal cancer (CRC) among young patients is alarming. We aim to characterize the clinico-pathological features and outcomes of patients with early-onset CRC (EOCRC), as well as the impacts of COVID-19 pandemic.: ...

Abstract	Background: The rising incidence of colorectal cancer (CRC) among young patients is alarming. We aim to characterize the clinico-pathological features and outcomes of patients with early-onset CRC (EOCRC), as well as the impacts of COVID-19 pandemic. Methods: We included all patients with pathologically confirmed diagnoses of CRC at Hospital Universitario La Paz from October 2016 to December 2021. The EOCRC cut-off age was 50 years old. Results: A total of 1475 patients diagnosed with CRC were included, eighty (5.4%) of whom had EOCRC. Significant differences were found between EOCRC and later-onset patients regarding T, N stage and metastatic presentation at diagnosis; perineural invasion; tumor budding; high-grade tumors; and signet ring cell histology, with all issues having higher prevalence in the early-onset group. More EOCRC patients had the RAS/ BRAF wild type. Chemotherapy was administered more frequently to patients with EOCRC. In the metastatic setting, the EOCRC group presented a significantly longer median OS. Regarding the COVID-19 pandemic, more patients with COVID-19 were diagnosed with metastatic disease (61%) in the year after the lockdown (14 March 2020) than in the pre-pandemic EOCRC group (29%). Conclusions: EOCRC is diagnosed at a more advanced stage and with worse survival features in localized patients. More patients with EOCRC were diagnosed with metastatic disease in the year after the COVID-19 pandemic lockdown. The long-term consequences of COVID-19 are yet to be determined.
Language	English
Publishing date	2023-08-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15174242
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Article ; Online: ΔNp73 status in peritoneal and ovarian dissemination of appendicular adenocarcinoids (goblet cells).

Prieto-Nieto, M I / Pastor, D / Rodríguez-Cobos, J / Pérez, J P / Méndez, C / Palacios, E / Arranz-Alvarez, M / Santos-López, J / Cano-Vega, M / Viñal, D / Rodríguez, N / Domínguez, G

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

2019 Volume 21, Issue 10, Page(s) 1432–1439

Abstract: Introduction: Goblet cell carcinoma (GCC) is an appendicular neoplasia representing less than 5% of all appendicular tumors, found in 0.3-0.9% of the appendectomies, 35-58% of all appendicular neoplasms, and less than 14% of malign appendix tumors. The ... ...

Abstract	Introduction: Goblet cell carcinoma (GCC) is an appendicular neoplasia representing less than 5% of all appendicular tumors, found in 0.3-0.9% of the appendectomies, 35-58% of all appendicular neoplasms, and less than 14% of malign appendix tumors. The most frequent clinical presentation is abdominal pain associated with a picture of acute appendicitis. Materials and methods: We present 3 clinical cases of appendix GCC, 2 subjected to cytoreductory surgery plus intraperitoneal hyperthermic chemotherapy and a third, who is currently receiving neoadjuvant treatment with a good response to chemotherapy and who will be offered the same treatment as the first two patients. Given the unpredictable behavior of these tumors, the use of molecular markers could help us to predict their behavior and prognosis. In this context, the TP73 gene would make an interesting putative marker. ∆Np73 has been described as overexpressed in a great variety of tumor types including colon cancer and this up-regulation is associated with a poor prognosis. To evidence its role in this malignancy, we evaluate here the status of ∆Np73 in the primary tumor and normal counterpart tissues, in the metastatic implants and in healthy areas of the peritoneum from the appendicular GCC patients. In addition, we checked the expression levels of this p73 variant in the tumor and normal tissue of 26 patients with colon cancer. Results: Remarkably, 2 patients showed significant ∆Np73 down-regulation in both the primary tumor and the implants. Case 1 presented a fourfold decrease of levels in the primary tumor and 20-fold decrease in the implants. Case 2 showed a seven- and fourfold down-regulation in the primary tumor and implants, respectively. However, Case 3 showed an up-regulation of 53- and threefold in the primary tumor and implants, respectively. Conclusion: Goblet cell carcinoma of the appendix is very rate. It tends to seed throughout the peritoneum, making aggressive surgical cytoreduction and chemotherapy viable treatment options. Investigation into the molecular basis of these tumors may improve the diagnosis, prognosis and therapeutic decisions regarding these patients. ∆Np73 seems a good candidate for further analysis in longer series.
MeSH term(s)	Adenocarcinoma/chemistry ; Adenocarcinoma/secondary ; Adenocarcinoma/therapy ; Appendiceal Neoplasms/chemistry ; Appendiceal Neoplasms/pathology ; Appendiceal Neoplasms/therapy ; Biomarkers, Tumor/analysis ; Colon/chemistry ; Colonic Neoplasms/chemistry ; Cytoreduction Surgical Procedures ; Down-Regulation ; Female ; Goblet Cells/chemistry ; Humans ; Hyperthermia, Induced ; Male ; Middle Aged ; Ovarian Neoplasms/chemistry ; Ovarian Neoplasms/secondary ; Peritoneal Neoplasms/chemistry ; Peritoneal Neoplasms/secondary ; Peritoneum/chemistry ; Tumor Protein p73/analysis
Chemical Substances	Biomarkers, Tumor ; Tumor Protein p73 ; delta Np73 protein, human
Language	English
Publishing date	2019-04-25
Publishing country	Italy
Document type	Case Reports ; Journal Article
ZDB-ID	2397359-6
ISSN	1699-3055 ; 1699-048X
ISSN (online)	1699-3055
ISSN	1699-048X
DOI	10.1007/s12094-019-02091-1
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Article: Inflammatory pseudotumour of the spleen associated with splenic tuberculosis.

Prieto-Nieto, Maria Isabel / Pérez-Robledo, Juan Pedro / Díaz-San Andrés, Beatriz / Nistal, Manuel / Rodríguez-Montes, José Antonio

World journal of gastrointestinal surgery

2014 Volume 6, Issue 12, Page(s) 248–252

Abstract: Inflammatory pseudotumor (IPT) of the spleen is an uncommon entity with an uncertain aetiology. Inflammatory pseudotumors present diagnostic difficulties because the clinical and radiological findings tend to suggest a malignancy. The symptoms include ... ...

Abstract	Inflammatory pseudotumor (IPT) of the spleen is an uncommon entity with an uncertain aetiology. Inflammatory pseudotumors present diagnostic difficulties because the clinical and radiological findings tend to suggest a malignancy. The symptoms include weight loss, fever, and abdominal pain. Most cases of splenic IPT present solitary relatively large well circumscribed masses on imaging. The diagnosis in the majority of the cases is made after histopathologic study of splenectomy specimens. The IPTs that occur in the spleen and liver are typically associated with Epstein-Barr virus. Thirty-seven percent of all new cases of active tuberculosis infection are extrapulmonary tuberculosis and tuberculous lymphadenitis the most commonly occurring form of extrapulmonary tuberculosis. We report the case of an inflammatory pseudotumor of the spleen associated with splenic tuberculous lymphadenitis in a 50-year-old female patient who was preoperatively diagnosed with a malignant spleen tumour based on her history of breast of carcinoma.
Language	English
Publishing date	2014-12-07
Publishing country	United States
Document type	Case Reports
ZDB-ID	2573700-4
ISSN	1948-9366
ISSN	1948-9366
DOI	10.4240/wjgs.v6.i12.248
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Article ; Online: Cutaneous bronchobiliary fistula treated with Tissucol sealant.

Prieto-Nieto, M I / Pérez-Robledo, J P / Alvarez-Luque, A / Suz, J I Acitores / Torres, J Novo

Cardiovascular and interventional radiology

2011 Volume 34 Suppl 2, Page(s) S232–5

Abstract: Bronchobiliary fistula is a rare and is an uncommon but severe complication of hydatid disease of the liver. Treatment has traditionally been surgical resection, but embolization and stent placement have been described. The invasive method seems to be a ... ...

Abstract	Bronchobiliary fistula is a rare and is an uncommon but severe complication of hydatid disease of the liver. Treatment has traditionally been surgical resection, but embolization and stent placement have been described. The invasive method seems to be a key component of patient treatment. We describe a case of a 58-year-old woman who, 25 years before, had undergone surgery for a hydatid cyst. A total cystectomy without previous puncture or parasite extraction was carried out. The lower aspect of the cyst was found to be completely perforated over the biliary duct. During the postoperative course, the patient had subphrenic right-sided pleural effusion and biliary fistula that subsided with medical treatment. Afterward, the patient came to the outpatient area of our hospital complaining of leakage of purulent exudate through the cutaneous opening, pain located on the right hypochondrium radiating to the right hemithorax, malaise, fever, chronic cough, and occasional vomiting of bile. Fistulography revealed an anfractuous cavity communicating with a residual cystic cavity on the right hepatic lobe. We observed communication with the intrahepatic canaliculi. Computed tomographic scan revealed a fistulous tract on the anterior liver border through the abdominal wall. There were no posttreatment complications. The patient is asymptomatic.
MeSH term(s)	Biliary Fistula/diagnostic imaging ; Biliary Fistula/therapy ; Bronchial Fistula/diagnostic imaging ; Bronchial Fistula/therapy ; Catheters ; Contrast Media/administration & dosage ; Cutaneous Fistula/diagnostic imaging ; Cutaneous Fistula/therapy ; Echinococcosis, Hepatic/surgery ; Female ; Fibrin Tissue Adhesive/administration & dosage ; Follow-Up Studies ; Humans ; Middle Aged ; Postoperative Complications/diagnostic imaging ; Postoperative Complications/therapy ; Tissue Adhesives ; Tomography, X-Ray Computed
Chemical Substances	Contrast Media ; Fibrin Tissue Adhesive ; Tissue Adhesives
Language	English
Publishing date	2011-02
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	603082-8
ISSN	1432-086X ; 0342-7196 ; 0174-1551
ISSN (online)	1432-086X
ISSN	0342-7196 ; 0174-1551
DOI	10.1007/s00270-010-9807-0
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Article: Acute appendicitis-like symptoms as initial presentation of ovarian vein thrombosis.

Prieto-Nieto, M I / Perez-Robledo, J P / Rodriguez-Montes, J A / Garci-Sancho-Martin, L

Annals of vascular surgery

2004 Volume 18, Issue 4, Page(s) 481–483

Abstract: Postpartum ovarian vein thrombosis is a rare condition, with an incidence rate being 1/600 deliveries. It most often arises in the right ovarian vein. A 33-year-old patient who had had normal vaginal delivery presented with fever, pain in the right iliac ...

Abstract	Postpartum ovarian vein thrombosis is a rare condition, with an incidence rate being 1/600 deliveries. It most often arises in the right ovarian vein. A 33-year-old patient who had had normal vaginal delivery presented with fever, pain in the right iliac fossa, and leukocytosis on the sixth day after delivery. An antibiotic course was instituted but 3 days later symptoms reappeared. Diagnosis of acute appendicitis was made. At surgery through a McBurney incision, a woody tumoration consistent with ovarian vein thrombosis was found. Anticoagulation therapy with heparin and antibiotics were instituted. Phlebography and color Doppler sonography confirmed the presence of thrombosis of both the common femoral iliac and inferior vena cava. Fribrolysis with urokinase was performed. The patient has remained stable and symptom-free over a 4-year follow-up. Ovarian vein thrombosis typically presents with symptoms suggestive of acute appendicitis, as was the case in our patient. Color Doppler sonography is the favored diagnostic procedure, with CT being a supplementary tool. Surgery is not necessary and treatment consists of anticoagulants and antibiotics. Even though postpartum ovarian vein thrombosis is rare, early recognition of the condition is of paramount importance to institute the adequate treatment and avoid potential serious sequelae.
MeSH term(s)	Adult ; Appendicitis/etiology ; Female ; Humans ; Ovarian Diseases/diagnosis ; Ovarian Diseases/epidemiology ; Ovarian Diseases/etiology ; Ovary/blood supply ; Puerperal Disorders/complications ; Tomography, X-Ray Computed ; Ultrasonography, Doppler, Color ; Venous Thrombosis/diagnosis ; Venous Thrombosis/epidemiology ; Venous Thrombosis/etiology
Language	English
Publishing date	2004-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1027366-9
ISSN	1615-5947 ; 0890-5096
ISSN (online)	1615-5947
ISSN	0890-5096
DOI	10.1007/s10016-004-0059-9
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Article: Ruptured primary splenic angiosarcoma into the colon. Presentation as anal bleeding.

Jiménez-Heffernan, J A / Hardisson, D / Prieto-Nieto, M I / Burgos, E

Acta gastro-enterologica Belgica

1999 Volume 62, Issue 2, Page(s) 248–251

Abstract: A 71-year-old woman presented with a six month history of constipation and abdominal discomfort, with anal bleeding during the last days. Ultrasonography and CT-scan of the abdomen showed a large heterogeneous mass that was located in the splenic region, ...

Abstract	A 71-year-old woman presented with a six month history of constipation and abdominal discomfort, with anal bleeding during the last days. Ultrasonography and CT-scan of the abdomen showed a large heterogeneous mass that was located in the splenic region, but the nature and origin of the tumour could not be clearly established preoperatively. The clinical diagnosis was of abdominal tumour with colonic and splenic involvement, and a left hemicolectomy and splenectomy were performed. Pathologic examination revealed a primary angiosarcoma of the spleen with penetration and fistulization of the tumour into the large bowel. The patient received adjuvant radiation therapy, but she died of extensive metastastic disease from her primary angiosarcoma of the spleen nine months after surgery. In summary, splenic angiosarcoma is very difficult to diagnose preoperatively. This highly aggressive neoplasm has an overall poor prognosis, specially if it is associated with rupture and haemoperitoneum. As this case highlights, unusual forms of rupture may lead to atypical clinical presentations, increasing even more the difficulty in the diagnosis.
MeSH term(s)	Aged ; Anal Canal ; Colon ; Female ; Gastrointestinal Hemorrhage/etiology ; Hemangiosarcoma/complications ; Hemangiosarcoma/pathology ; Humans ; Rupture, Spontaneous ; Splenic Neoplasms/complications ; Splenic Neoplasms/pathology ; Splenic Rupture/complications ; Splenic Rupture/etiology
Language	English
Publishing date	1999-04
Publishing country	Belgium
Document type	Case Reports ; Journal Article
ZDB-ID	127060-6
ISSN	1784-3227 ; 0001-5644
ISSN	1784-3227 ; 0001-5644
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Article: Radiofrecuencia laparoscópica de lesión focal hepática de origen colorrectal.

Pérez-Robledo, J P / Prieto-Nieto, M I / Olveira, A / de Gracia, M Martí / Erdozain, J C / Carrión, G / Segura, J M / Rodríguez-Montes, J A / Martín, L García-Sancho

Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva

2008 Volume 100, Issue 4, Page(s) 250–252

Title translation	Laparoscopic radiofrequency of a liver focal lesion of colorrectal origin.
MeSH term(s)	Aged ; Catheter Ablation/methods ; Cecal Neoplasms ; Colorectal Neoplasms ; Humans ; Laparoscopy ; Liver Neoplasms/secondary ; Liver Neoplasms/surgery ; Male
Language	Spanish
Publishing date	2008-06-11
Publishing country	Spain
Document type	Case Reports ; Letter
ZDB-ID	1070381-0
ISSN	1130-0108 ; 0212-7512
ISSN	1130-0108 ; 0212-7512
DOI	10.4321/s1130-01082008000400017
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Article: Hepatectomía laparoscópica de lesión hiperplásica hepática.

Prieto Nieto, M I / Pérez Robledo, J P / Erdozain, J C / Caminoa Lizarralde, A / de la Torre, C / Carrión, G / Pascual, I / Burgos Lizaldez, E / Larrauri Martínez, J / Rodríguez-Montes, J A / García-Sancho Martín, L

Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva

2008 Volume 99, Issue 12, Page(s) 730–732

Title translation	Laparoscopic hepatectomy of a focal nodular hyperplasia of the liver.
MeSH term(s)	Adult ; Focal Nodular Hyperplasia/diagnosis ; Focal Nodular Hyperplasia/surgery ; Hepatectomy/methods ; Humans ; Laparoscopy ; Liver Diseases/diagnosis ; Liver Diseases/surgery ; Male
Language	Spanish
Publishing date	2008-02-16
Publishing country	Spain
Document type	Case Reports ; Letter
ZDB-ID	1070381-0
ISSN	1130-0108 ; 0212-7512
ISSN	1130-0108 ; 0212-7512
DOI	10.4321/s1130-01082007001200012
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Article: Paraganglioma retroperitoneal extraadrenal.

Prieto Nieto, M I / Pérez Robledo, J P / Hardisson, D / Palenzuela Fernández, J L / Nistal Martín, M

Archivos espanoles de urologia

1998 Volume 51, Issue 4, Page(s) 385–388

Abstract: Objective: To report a case of paraganglioma localized in the organ of Zuckerkandl and to discuss its diagnosis, treatment and outcome.: Methods/results: A 37-year-old female presented with a periumbilical mass and pain that radiated to the lumbar ... ...

Title translation	Extra-adrenal retroperitoneal paraganglioma.
Abstract	Objective: To report a case of paraganglioma localized in the organ of Zuckerkandl and to discuss its diagnosis, treatment and outcome. Methods/results: A 37-year-old female presented with a periumbilical mass and pain that radiated to the lumbar region for the past three months. Abdominal US and CT disclosed a well vascularized mass lying adjacent to the aorta, 1 cm from its bifurcation. At laparotomy, an 8 x 10 cm tumor was discovered at the aortic bifurcation that displaced the left ureter and included the inferior mesenteric artery. Pathological analysis of the surgical specimen revealed a paraganglioma. Conclusion: Extra-adrenal paraganglioma should be taken into account in the differential diagnosis of retroperitoneal masses, particularly those adjoining the abdominal aorta.
MeSH term(s)	Adult ; Female ; Humans ; Paraganglioma/pathology ; Paraganglioma/surgery ; Retroperitoneal Neoplasms/pathology ; Retroperitoneal Neoplasms/surgery
Language	Spanish
Publishing date	1998-05
Publishing country	Spain
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	211673-x
ISSN	0004-0614
ISSN	0004-0614
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