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Article ; Online: Selective Targeting of Regulated Rhabdomyosarcoma Cells by Trinuclear Ruthenium(II)-Arene Complexes.

Welsh, Athi / Serala, Karabo / Prince, Sharon / Smith, Gregory S

2024 Volume 67, Issue 8, Page(s) 6673–6686

Abstract: The use of benzimidazole-based trinuclear ruthenium(II)-arene complexes ( ...

Abstract	The use of benzimidazole-based trinuclear ruthenium(II)-arene complexes (
MeSH term(s)	Humans ; Rhabdomyosarcoma/drug therapy ; Rhabdomyosarcoma/pathology ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/chemical synthesis ; Cell Line, Tumor ; Ruthenium/chemistry ; Ruthenium/pharmacology ; Coordination Complexes/pharmacology ; Coordination Complexes/chemistry ; Coordination Complexes/chemical synthesis ; Apoptosis/drug effects ; Drug Screening Assays, Antitumor ; Structure-Activity Relationship ; DNA Damage/drug effects ; Benzimidazoles/pharmacology ; Benzimidazoles/chemistry ; Benzimidazoles/chemical synthesis ; Autophagy/drug effects ; Cell Movement/drug effects ; Cell Proliferation/drug effects
Chemical Substances	Antineoplastic Agents ; Ruthenium (7UI0TKC3U5) ; Coordination Complexes ; Benzimidazoles
Language	English
Publishing date	2024-04-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.4c00256
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Article ; Online: Delayed diagnosis of oral lymphoma: a case series.

Mills, Sophie / Lukosevicius, Evaldas / Sisson, Richard / Prince, Sharon

British dental journal

2023 Volume 234, Issue 3, Page(s) 151–154

Abstract: Lymphomas are the second most common neoplasm in the head and neck. The clinical and radiographic presentation of non-Hodgkin lymphoma in the oral cavity is non-specific and can be hard to differentiate from other common infectious or inflammatory ... ...

Abstract	Lymphomas are the second most common neoplasm in the head and neck. The clinical and radiographic presentation of non-Hodgkin lymphoma in the oral cavity is non-specific and can be hard to differentiate from other common infectious or inflammatory conditions. We report four cases of lymphoma of the head and neck, which presented as odontogenic infection, osteomyelitis, or cutaneous infection, and subsequently led to a delay in provision of appropriate treatment. Correlation between clinical, radiographic and histological findings is essential in reaching an accurate diagnosis. It is important for clinicians to consider malignant lesions, such as lymphoma, in the differential diagnosis of pain, swelling, tooth mobility or radiographic radiolucencies. Clinicians should maintain a high level of suspicion for malignancy when inflammatory lesions fail to respond to normal modes of treatment.
MeSH term(s)	Humans ; Delayed Diagnosis ; Lymphoma ; Diagnosis, Differential
Language	English
Publishing date	2023-02-10
Publishing country	England
Document type	Journal Article
ZDB-ID	218090-x
ISSN	1476-5373 ; 0007-0610
ISSN (online)	1476-5373
ISSN	0007-0610
DOI	10.1038/s41415-023-5462-0
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Article ; Online: Trinuclear ruthenium(II) polypyridyl complexes: Evaluation as photosensitizers for enhanced cervical cancer treatment.

Welsh, Athi / Matshitse, Refilwe / Khan, Saif F / Nyokong, Tebello / Prince, Sharon / Smith, Gregory S

Journal of inorganic biochemistry

2024 Volume 256, Page(s) 112545

Abstract: Trinuclear ruthenium(II) polypyridyl complexes anchored to benzimidazole-triazine / trisamine scaffolds were investigated as photosensitizers for photodynamic therapy. The trinuclear complexes were noted to produce a significant amount of singlet oxygen ... ...

Abstract	Trinuclear ruthenium(II) polypyridyl complexes anchored to benzimidazole-triazine / trisamine scaffolds were investigated as photosensitizers for photodynamic therapy. The trinuclear complexes were noted to produce a significant amount of singlet oxygen in both DMF and aqueous media, are photostable and show appreciable emission quantum yields (ɸ
Language	English
Publishing date	2024-03-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	162843-4
ISSN	1873-3344 ; 0162-0134
ISSN (online)	1873-3344
ISSN	0162-0134
DOI	10.1016/j.jinorgbio.2024.112545
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Article ; Online: Molecular mechanisms underpinning sarcomas and implications for current and future therapy.

Damerell, Victoria / Pepper, Michael S / Prince, Sharon

Signal transduction and targeted therapy

2021 Volume 6, Issue 1, Page(s) 246

Abstract: Sarcomas are complex mesenchymal neoplasms with a poor prognosis. Their clinical management is highly challenging due to their heterogeneity and insensitivity to current treatments. Although there have been advances in understanding specific genomic ... ...

Abstract	Sarcomas are complex mesenchymal neoplasms with a poor prognosis. Their clinical management is highly challenging due to their heterogeneity and insensitivity to current treatments. Although there have been advances in understanding specific genomic alterations and genetic mutations driving sarcomagenesis, the underlying molecular mechanisms, which are likely to be unique for each sarcoma subtype, are not fully understood. This is in part due to a lack of consensus on the cells of origin, but there is now mounting evidence that they originate from mesenchymal stromal/stem cells (MSCs). To identify novel treatment strategies for sarcomas, research in recent years has adopted a mechanism-based search for molecular markers for targeted therapy which has included recapitulating sarcomagenesis using in vitro and in vivo MSC models. This review provides a comprehensive up to date overview of the molecular mechanisms that underpin sarcomagenesis, the contribution of MSCs to modelling sarcomagenesis in vivo, as well as novel topics such as the role of epithelial-to-mesenchymal-transition (EMT)/mesenchymal-to-epithelial-transition (MET) plasticity, exosomes, and microRNAs in sarcomagenesis. It also reviews current therapeutic options including ongoing pre-clinical and clinical studies for targeted sarcoma therapy and discusses new therapeutic avenues such as targeting recently identified molecular pathways and key transcription factors.
MeSH term(s)	Animals ; Carcinogenesis/genetics ; Carcinogenesis/metabolism ; Carcinogenesis/pathology ; Epithelial-Mesenchymal Transition/genetics ; Humans ; Mesenchymal Stem Cells/metabolism ; Mesenchymal Stem Cells/pathology ; Neoplasms, Experimental/genetics ; Neoplasms, Experimental/metabolism ; Neoplasms, Experimental/pathology ; Neoplasms, Experimental/therapy ; Sarcoma/genetics ; Sarcoma/metabolism ; Sarcoma/pathology ; Sarcoma/therapy
Language	English
Publishing date	2021-06-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2886872-9
ISSN	2059-3635 ; 2095-9907
ISSN (online)	2059-3635
ISSN	2095-9907
DOI	10.1038/s41392-021-00647-8
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Article ; Online: Mononuclear η

Kanyora, Amos K / Omondi, Reinner O / Ongoma, Peter / Omolo, Josiah O / Welsh, Athi / Prince, Sharon / Gichumbi, Joel / Mambanda, Allen / Smith, Gregory S

Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry

2024

Abstract: Organometallic ... ...

Abstract	Organometallic η
Language	English
Publishing date	2024-03-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1464026-0
ISSN	1432-1327 ; 0949-8257
ISSN (online)	1432-1327
ISSN	0949-8257
DOI	10.1007/s00775-024-02043-3
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Article ; Online: Quinolyl-Based PGM Metallarectangles: Antiproliferative Activity, DNA and BSA Protein Interactions, and a Molecular Docking Perspective.

Golding, Taryn M / Omondi, Reinner O / Biswas, Supratim / Chakraborty, Suparna / Prince, Sharon / Smith, Gregory S

Chembiochem : a European journal of chemical biology

2023 Volume 24, Issue 13, Page(s) e202300271

Abstract: The increased success of small metal-containing molecules as pharmaceutical agents has prompted investigations into the pharmacological activity of a different class of metal-based compounds; supramolecular coordination complexes (SCCs). Such complexes ... ...

Abstract	The increased success of small metal-containing molecules as pharmaceutical agents has prompted investigations into the pharmacological activity of a different class of metal-based compounds; supramolecular coordination complexes (SCCs). Such complexes have been extensively investigated for their anticancer activity, with many displaying activities comparable or superior to available clinical chemotherapeutic drugs. Here, we evaluated a series of quinoline-containing binuclear complexes and metallarectangles for their in vitro anticancer activity in the hormone receptor positive MCF-7 and triple negative MDA-MB-231 breast cancer cell lines. The preliminary cytotoxic screen, in the MCF-7 cell line, revealed that the ligand (7-chloro-4-(pyridin-4-yl)quinoline, L) and metallarectangle [{Ir(μ-Cl)(Cp*)}
MeSH term(s)	Humans ; Female ; Cisplatin ; Molecular Docking Simulation ; Serum Albumin, Bovine/chemistry ; Ligands ; Coordination Complexes/chemistry ; Antineoplastic Agents/chemistry ; MCF-7 Cells ; Breast Neoplasms ; Quinolines ; DNA/chemistry ; Cell Line, Tumor ; Ruthenium/pharmacology ; Ruthenium/chemistry
Chemical Substances	4-cymene (1G1C8T1N7Q) ; Cisplatin (Q20Q21Q62J) ; Serum Albumin, Bovine (27432CM55Q) ; Ligands ; Coordination Complexes ; Antineoplastic Agents ; Quinolines ; DNA (9007-49-2) ; Ruthenium (7UI0TKC3U5)
Language	English
Publishing date	2023-06-02
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2020469-3
ISSN	1439-7633 ; 1439-4227
ISSN (online)	1439-7633
ISSN	1439-4227
DOI	10.1002/cbic.202300271
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Article ; Online: Gastrointestinal Nematode-Derived Antigens Alter Colorectal Cancer Cell Proliferation and Migration through Regulation of Cell Cycle and Epithelial-Mesenchymal Transition Proteins.

Jacobs, Brittany-Amber / Prince, Sharon / Smith, Katherine Ann

International journal of molecular sciences

2020 Volume 21, Issue 21

Abstract: As the global incidences of colorectal cancer rises, there is a growing importance in understanding the interaction between external factors, such as common infections, on the initiation and progression of this disease. While certain helminth infections ... ...

Abstract	As the global incidences of colorectal cancer rises, there is a growing importance in understanding the interaction between external factors, such as common infections, on the initiation and progression of this disease. While certain helminth infections have been shown to alter the severity and risk of developing colitis-associated colorectal cancer, whether these parasites can directly affect colorectal cancer progression is unknown. Here, we made use of murine and human colorectal cancer cell lines to demonstrate that exposure to antigens derived from the gastrointestinal nematode
MeSH term(s)	Animals ; Antigens, Helminth/immunology ; Antigens, Helminth/pharmacology ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Epithelial-Mesenchymal Transition/drug effects ; Epithelial-Mesenchymal Transition/physiology ; HCT116 Cells ; Humans ; Male ; Mice, Inbred C57BL ; Nematospiroides dubius/immunology ; Nematospiroides dubius/metabolism ; Schistosoma mansoni/immunology ; Schistosomiasis mansoni/immunology ; Species Specificity ; Tumor Suppressor Protein p53/metabolism ; beta Catenin/metabolism
Chemical Substances	Antigens, Helminth ; CTNNB1 protein, mouse ; Cyclin-Dependent Kinase Inhibitor p21 ; TP53 protein, human ; Tumor Suppressor Protein p53 ; beta Catenin
Language	English
Publishing date	2020-10-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms21217845
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Article: The "numb chin syndrome": A case report.

Hussain, Issar / Maharaj, Khemanand / Prince, Sharon

International journal of surgery case reports

2020 Volume 67, Page(s) 157–160

Abstract: Introduction: Neuroendocrine tumours comprise 0.5-2% of all malignancies in adulthood, and very rarely metastasize to the oral cavity. When they do metastasize to the oral cavity, the mandible is the most common site. This can lead to symptoms such as a ...

Abstract	Introduction: Neuroendocrine tumours comprise 0.5-2% of all malignancies in adulthood, and very rarely metastasize to the oral cavity. When they do metastasize to the oral cavity, the mandible is the most common site. This can lead to symptoms such as a numb chin and lip, which in the absence of any odontogenic cause may be an important sign indicating malignant disease. We present a rare case of metastatic neuroendocrine carcinoma to the mandible, resulting in the so-called "numb chin syndrome". Presentation of case: An elderly lady presented with numbness to the right chin and lip, as well as hypoglossal nerve palsy. She had significant back pain and gave a history of repeat chest infections. Intra-oral clinical examination was normal, but upon further special investigations, the right mental region was suspicious of multiple lytic lesion. Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) demonstrated marrow changes in the mandible suspicious of malignant disease. Further findings included multiple pathological fractures of the spine and a mass in the left lung base. A trephine biopsy gave a diagnosis of metastatic neuroendocrine carcinoma, with the left lung mass considered to be the primary site. Discussion: We discuss the rarity of metastatic disease to the oral cavity, and the importance of "numb chin syndrome" in indicating malignancy. Conclusions: This case promotes the importance of considering sinister pathology when presented with sudden, altered sensation to the chin and lips. The "numb chin syndrome" should always raise the suspicion of primary or metastatic disease to the mandible.
Language	English
Publishing date	2020-02-07
Publishing country	Netherlands
Document type	Case Reports
ISSN	2210-2612
ISSN	2210-2612
DOI	10.1016/j.ijscr.2020.02.013
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Article: The diaryl-imidazopyridazine anti-plasmodial compound, MMV652103, exhibits anti-breast cancer activity.

Neumann-Mufweba, Alexis / Kimani, Serah / Khan, Saif Feroz / Chibale, Kelly / Prince, Sharon

EXCLI journal

2022 Volume 21, Page(s) 656–679

Abstract: Breast cancer is the most common malignancy in women worldwide and it remains a global health burden, in part, due to poor response and tolerance to current therapeutics. Drug repurposing, which seeks to identify new indications for existing and ... ...

Abstract	Breast cancer is the most common malignancy in women worldwide and it remains a global health burden, in part, due to poor response and tolerance to current therapeutics. Drug repurposing, which seeks to identify new indications for existing and investigational drugs, has become an exciting strategy to address these challenges. Here we describe the anti-breast cancer activity of a diaryl-imidazopyridazine compound, MMV652103, which was previously identified for its anti-plasmodial activity. We demonstrate that MMV652103 potently inhibits the oncogenic PI4KB and PIK3C2G lipid kinases, is selectively cytotoxic to MCF7 and T47D estrogen receptor positive breast cancer cells and inhibits their ability to survive and migrate. The underlying mechanisms involved included the induction of reactive oxygen species and activation of the DNA damage and p38 MAPK stress signaling pathways. This was associated with a G1 cell cycle arrest and an increase in levels of the cyclin-dependent kinase inhibitor p21 and activation of apoptotic and autophagic cell death pathways. Lastly, MMV652103 significantly reduced the weight and metastases of MCF7 induced tumors in an
Language	English
Publishing date	2022-04-04
Publishing country	Germany
Document type	Journal Article
ISSN	1611-2156
ISSN	1611-2156
DOI	10.17179/excli2021-4323
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Article ; Online: Aminoquinoline-based Re(I) tricarbonyl complexes: Insights into their antiproliferative activity and mechanisms of action.

Zinman, Paige S / Welsh, Athi / Omondi, Reinner O / Khan, Saif / Prince, Sharon / Nordlander, Ebbe / Smith, Gregory S

European journal of medicinal chemistry

2023 Volume 266, Page(s) 116094

Abstract: In an effort to develop new potent anticancer agents, two Schiff base rhenium(I) tricarbonyl complexes, containing the ubiquitous aminoquinoline scaffold, were synthesized. Both aminoquinoline ligands and Re(I) complexes showed adequate stability over a ... ...

Abstract	In an effort to develop new potent anticancer agents, two Schiff base rhenium(I) tricarbonyl complexes, containing the ubiquitous aminoquinoline scaffold, were synthesized. Both aminoquinoline ligands and Re(I) complexes showed adequate stability over a 48-h incubation period. Furthermore, the cytotoxic activity of the precursor ligands and rhenium(I) complexes were evaluated against the hormone-dependent MCF-7 and hormone-independent triple negative MDA-MB-231 breast cancer cell lines. Inclusion of the [Re(CO)
MeSH term(s)	Humans ; Female ; Schiff Bases/pharmacology ; Schiff Bases/chemistry ; Rhenium/chemistry ; DNA/metabolism ; MCF-7 Cells ; Serum Albumin, Bovine/chemistry ; Breast Neoplasms ; Hormones ; Aminoquinolines/pharmacology ; Coordination Complexes/pharmacology ; Coordination Complexes/chemistry ; Antineoplastic Agents/chemistry ; Ligands
Chemical Substances	Schiff Bases ; Rhenium (7440-15-5) ; DNA (9007-49-2) ; Serum Albumin, Bovine (27432CM55Q) ; Hormones ; Aminoquinolines ; Coordination Complexes ; Antineoplastic Agents ; Ligands
Language	English
Publishing date	2023-12-27
Publishing country	France
Document type	Journal Article
ZDB-ID	188597-2
ISSN	1768-3254 ; 0009-4374 ; 0223-5234
ISSN (online)	1768-3254
ISSN	0009-4374 ; 0223-5234
DOI	10.1016/j.ejmech.2023.116094
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