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Book ; Online: Plasma in Cancer Treatment

Bogaerts, Annemie / Privat-Maldonado, Angela

2021

Keywords	Medicine ; cell adhesion ; plasma medicine ; oncology ; cold atmospheric plasma ; selectivity ; plasma-treated liquid ; dielectric barrier discharge ; pancreatic cancer ; pancreatic stellate cells ; immunogenic cell death ; dendritic cells ; cell communication ; extracellular matrix (ECM) ; reactive oxygen and nitrogen species (ROS) ; tumour microenvironment (TME) ; extracellular vesicles ; communication junctions ; three-dimensional in vitro culture models ; apoptosis ; breast cancer ; genome-wide expression ; reactive oxygen species ; anticancer drugs ; screening ; tumor spheroids ; combination therapy ; kINPen ; reactive oxygen and nitrogen species ; ROS ; cancer ; non-thermal atmospheric pressure plasma (NTP) ; indirect treatment ; plasma-treated phosphate-buffered saline ; electroporation ; electric pulses ; pulsed electric field amplitude ; melanoma ; long-lived reactive species ; bone cancer ; osteosarcoma ; reactive species ; plasma-activated liquid ; Ringer's saline ; organotypic model ; nonthermal biocompatible plasma ; soft jet plasma ; human glioblastoma ; p38/MAPK pathway ; tissue penetration ; non-thermal plasma ; non-invasive plasma treatment (NIPP) ; cervical intraepithelial neoplasia (CIN) ; Raman imaging ; Raman microspectroscopy ; Plasma lipid interactions ; cold physical plasma ; radiation therapy ; radio-frequency discharge ; PARP-inhibitor ; olaparib ; DNA-damage ; gold quantum dots ; plasma ; nanomaterials ; cellular uptake ; invasiveness ; cold atmospheric pressure plasma ; plasma-activated Ringer's lactate solution ; ovarian cancer ; cytotoxicity ; plasma-activated liquids ; multicellular tumor spheroids ; long-lived reactive oxygen and nitrogen species ; high frequency electrosurgery ; plasma treatment ; cold atmospheric plasma (CAP) ; free radicals ; cancer selectivity ; cervical cancer treatment ; cervical intraepithelial neoplasia ; cholangiocarcinoma ; cold plasma ; innovative therapy ; tumor cells ; macrophages ; plasma selectivity ; plasma jet ; n/a
Size	1 electronic resource (358 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel, Switzerland
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021291230
ISBN	9783036512082 ; 303651208X
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Plasma in Cancer Treatment.

Privat-Maldonado, Angela / Bogaerts, Annemie

Cancers

2020 Volume 12, Issue 9

Abstract: Cancer is the second leading cause of death worldwide, and while science has advanced significantly to improve the treatment outcome and quality of life in cancer patients, there are still many issues with the current therapies, such as toxicity and the ... ...

Abstract	Cancer is the second leading cause of death worldwide, and while science has advanced significantly to improve the treatment outcome and quality of life in cancer patients, there are still many issues with the current therapies, such as toxicity and the development of resistance to treatment [...].
Language	English
Publishing date	2020-09-14
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers12092617
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Modulating the Antioxidant Response for Better Oxidative Stress-Inducing Therapies: How to Take Advantage of Two Sides of the Same Medal?

Shaw, Priyanka / Kumar, Naresh / Sahun, Maxime / Smits, Evelien / Bogaerts, Annemie / Privat-Maldonado, Angela

Biomedicines

2022 Volume 10, Issue 4

Abstract: Oxidative stress-inducing therapies are characterized as a specific treatment that involves the production of reactive oxygen and nitrogen species (RONS) by external or internal sources. To protect cells against oxidative stress, cells have evolved a ... ...

Abstract	Oxidative stress-inducing therapies are characterized as a specific treatment that involves the production of reactive oxygen and nitrogen species (RONS) by external or internal sources. To protect cells against oxidative stress, cells have evolved a strong antioxidant defense system to either prevent RONS formation or scavenge them. The maintenance of the redox balance ensures signal transduction, development, cell proliferation, regulation of the mechanisms of cell death, among others. Oxidative stress can beneficially be used to treat several diseases such as neurodegenerative disorders, heart disease, cancer, and other diseases by regulating the antioxidant system. Understanding the mechanisms of various endogenous antioxidant systems can increase the therapeutic efficacy of oxidative stress-based therapies, leading to clinical success in medical treatment. This review deals with the recent novel findings of various cellular endogenous antioxidant responses behind oxidative stress, highlighting their implication in various human diseases, such as ulcers, skin pathologies, oncology, and viral infections such as SARS-CoV-2.
Language	English
Publishing date	2022-03-31
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines10040823
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Cold Atmospheric Plasma Treatment for Pancreatic Cancer-The Importance of Pancreatic Stellate Cells.

Verloy, Ruben / Privat-Maldonado, Angela / Smits, Evelien / Bogaerts, Annemie

Cancers

2020 Volume 12, Issue 10

Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with low five-year survival rates of 8% by conventional treatment methods, e.g., chemotherapy, radiotherapy, and surgery. PDAC shows high resistance towards chemo- and radiotherapy and only 15- ... ...

Abstract	Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with low five-year survival rates of 8% by conventional treatment methods, e.g., chemotherapy, radiotherapy, and surgery. PDAC shows high resistance towards chemo- and radiotherapy and only 15-20% of all patients can have surgery. This disease is predicted to become the third global leading cause of cancer death due to its significant rise in incidence. Therefore, the development of an alternative or combinational method is necessary to improve current approaches. Cold atmospheric plasma (CAP) treatments could offer multiple advantages to this emerging situation. The plasma-derived reactive species can induce oxidative damage and a cascade of intracellular signaling pathways, which could lead to cell death. Previous reports have shown that CAP treatment also influences cells in the tumor microenvironment, such as the pancreatic stellate cells (PSCs). These PSCs, when activated, play a crucial role in the propagation, growth and survival of PDAC tumors. However, the effect of CAP on PSCs is not yet fully understood. This review focuses on the application of CAP for PDAC treatment and the importance of PSCs in the response to treatment.
Language	English
Publishing date	2020-09-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers12102782
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Cold Atmospheric Plasma Increases Temozolomide Sensitivity of Three-Dimensional Glioblastoma Spheroids via Oxidative Stress-Mediated DNA Damage.

Shaw, Priyanka / Kumar, Naresh / Privat-Maldonado, Angela / Smits, Evelien / Bogaerts, Annemie

Cancers

2021 Volume 13, Issue 8

Abstract: Glioblastoma multiforme (GBM) is the most frequent and aggressive primary malignant brain tumor in adults. Current standard radiotherapy and adjuvant chemotherapy with the alkylating agent temozolomide (TMZ) yield poor clinical outcome. This is due to ... ...

Abstract	Glioblastoma multiforme (GBM) is the most frequent and aggressive primary malignant brain tumor in adults. Current standard radiotherapy and adjuvant chemotherapy with the alkylating agent temozolomide (TMZ) yield poor clinical outcome. This is due to the stem-like properties of tumor cells and genetic abnormalities in GBM, which contribute to resistance to TMZ and progression. In this study, we used cold atmospheric plasma (CAP) to enhance the sensitivity to TMZ through inhibition of antioxidant signaling (linked to TMZ resistance). We demonstrate that CAP indeed enhances the cytotoxicity of TMZ by targeting the antioxidant specific glutathione (GSH)/glutathione peroxidase 4 (GPX4) signaling. We optimized the threshold concentration of TMZ on five different GBM cell lines (U251, LN18, LN229, U87-MG and T98G). We combined TMZ with CAP and tested it on both TMZ-sensitive (U251, LN18 and LN229) and TMZ-resistant (U87-MG and T98G) cell lines using two-dimensional cell cultures. Subsequently, we used a three-dimensional spheroid model for the U251 (TMZ-sensitive) and U87-MG and T98G (TMZ-resistant) cells. The sensitivity of TMZ was enhanced, i.e., higher cytotoxicity and spheroid shrinkage was obtained when TMZ and CAP were administered together. We attribute the anticancer properties to the release of intracellular reactive oxygen species, through inhibiting the GSH/GPX4 antioxidant machinery, which can lead to DNA damage. Overall, our findings suggest that the combination of CAP with TMZ is a promising combination therapy to enhance the efficacy of TMZ towards the treatment of GBM spheroids.
Language	English
Publishing date	2021-04-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers13081780
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effect of Cysteine Oxidation in SARS-CoV-2 Receptor-Binding Domain on Its Interaction with Two Cell Receptors: Insights from Atomistic Simulations.

Ghasemitarei, Maryam / Privat-Maldonado, Angela / Yusupov, Maksudbek / Rahnama, Shadi / Bogaerts, Annemie / Ejtehadi, Mohammad Reza

Journal of chemical information and modeling

2021 Volume 62, Issue 1, Page(s) 129–141

Abstract: Binding of the SARS-CoV-2 S-glycoprotein to cell receptors is vital for the entry of the virus into cells and subsequent infection. ACE2 is the main cell receptor for SARS-CoV-2, which can attach to the C-terminal receptor-binding domain (RBD) of the ... ...

Abstract	Binding of the SARS-CoV-2 S-glycoprotein to cell receptors is vital for the entry of the virus into cells and subsequent infection. ACE2 is the main cell receptor for SARS-CoV-2, which can attach to the C-terminal receptor-binding domain (RBD) of the SARS-CoV-2 S-glycoprotein. The GRP78 receptor plays an anchoring role, which attaches to the RBD and increases the chance of other RBDs binding to ACE2. Although high levels of reactive oxygen and nitrogen species (RONS) are produced during viral infections, it is not clear how they affect the RBD structure and its binding to ACE2 and GRP78. In this research, we apply molecular dynamics simulations to study the effect of oxidation of the highly reactive cysteine (Cys) amino acids of the RBD on its binding to ACE2 and GRP78. The interaction energy of both ACE2 and GRP78 with the whole RBD, as well as with the RBD main regions, is compared in both the native and oxidized RBDs. Our results show that the interaction energy between the oxidized RBD and ACE2 is strengthened by 155 kJ/mol, increasing the binding of the RBD to ACE2 after oxidation. In addition, the interaction energy between the RBD and GRP78 is slightly increased by 8 kJ/mol after oxidation, but this difference is not significant. Overall, these findings highlight the role of RONS in the binding of the SARS-CoV-2 S-glycoprotein to host cell receptors and suggest an alternative mechanism by which RONS could modulate the entrance of viral particles into the cells.
MeSH term(s)	Angiotensin-Converting Enzyme 2/metabolism ; COVID-19 ; Cysteine/chemistry ; Endoplasmic Reticulum Chaperone BiP/metabolism ; Humans ; Reactive Nitrogen Species ; Reactive Oxygen Species ; Receptors, Virus/metabolism ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/chemistry
Chemical Substances	Endoplasmic Reticulum Chaperone BiP ; HSPA5 protein, human ; Reactive Nitrogen Species ; Reactive Oxygen Species ; Receptors, Virus ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; Cysteine (K848JZ4886)
Language	English
Publishing date	2021-12-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	190019-5
ISSN	1549-960X ; 0095-2338
ISSN (online)	1549-960X
ISSN	0095-2338
DOI	10.1021/acs.jcim.1c00853
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Analysis of Short-Lived Reactive Species in Plasma-Air-Water Systems: The Dos and the Do Nots.

Gorbanev, Yury / Privat-Maldonado, Angela / Bogaerts, Annemie

Analytical chemistry

2018 Volume 90, Issue 22, Page(s) 13151–13158

Abstract: This Feature addresses the analysis of the reactive species generated by nonthermal atmospheric pressure plasmas, which are widely employed in industrial and biomedical research, as well as first clinical applications. We summarize the progress in ... ...

Abstract	This Feature addresses the analysis of the reactive species generated by nonthermal atmospheric pressure plasmas, which are widely employed in industrial and biomedical research, as well as first clinical applications. We summarize the progress in detection of plasma-generated short-lived reactive oxygen and nitrogen species in aqueous solutions, discuss the potential and limitations of various analytical methods in plasma-liquid systems, and provide an outlook on the possible future research goals in development of short-lived reactive species analysis methods for a general nonspecialist audience.
Language	English
Publishing date	2018-10-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.8b03336
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 4033: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Cold Atmospheric Plasma Does Not Affect Stellate Cells Phenotype in Pancreatic Cancer Tissue in Ovo.

Privat-Maldonado, Angela / Verloy, Ruben / Cardenas Delahoz, Edgar / Lin, Abraham / Vanlanduit, Steve / Smits, Evelien / Bogaerts, Annemie

International journal of molecular sciences

2022 Volume 23, Issue 4

Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a challenging neoplastic disease, mainly due to the development of resistance to radio- and chemotherapy. Cold atmospheric plasma (CAP) is an alternative technology that can eliminate cancer cells through ... ...

Abstract	Pancreatic ductal adenocarcinoma (PDAC) is a challenging neoplastic disease, mainly due to the development of resistance to radio- and chemotherapy. Cold atmospheric plasma (CAP) is an alternative technology that can eliminate cancer cells through oxidative damage, as shown in vitro, in ovo, and in vivo. However, how CAP affects the pancreatic stellate cells (PSCs), key players in the invasion and metastasis of PDAC, is poorly understood. This study aims to determine the effect of an anti-PDAC CAP treatment on PSCs tissue developed in ovo using mono- and co-cultures of RLT-PSC (PSCs) and Mia PaCa-2 cells (PDAC). We measured tissue reduction upon CAP treatment and mRNA expression of PSC activation markers and extracellular matrix (ECM) remodelling factors via qRT-PCR. Protein expression of selected markers was confirmed via immunohistochemistry. CAP inhibited growth in Mia PaCa-2 and co-cultured tissue, but its effectiveness was reduced in the latter, which correlates with reduced ki67 levels. CAP did not alter the mRNA expression of PSC activation and ECM remodelling markers. No changes in MMP2 and MMP9 expression were observed in RLT-PSCs, but small changes were observed in Mia PaCa-2 cells. Our findings support the ability of CAP to eliminate PDAC cells, without altering the PSCs.
MeSH term(s)	Adenocarcinoma/metabolism ; Adenocarcinoma/therapy ; Animals ; Carcinoma, Pancreatic Ductal/metabolism ; Carcinoma, Pancreatic Ductal/therapy ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Chickens ; Extracellular Matrix/metabolism ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Matrix Metalloproteinase 2/metabolism ; Matrix Metalloproteinase 9/metabolism ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/therapy ; Pancreatic Stellate Cells/drug effects ; Pancreatic Stellate Cells/metabolism ; Phenotype ; Plasma Gases/pharmacology ; Tumor Microenvironment/drug effects
Chemical Substances	Plasma Gases ; Matrix Metalloproteinase 2 (EC 3.4.24.24) ; Matrix Metalloproteinase 9 (EC 3.4.24.35)
Language	English
Publishing date	2022-02-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23041954
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Inactivation of SARS-CoV-2 and Other Enveloped and Non-Enveloped Viruses with Non-Thermal Plasma for Hospital Disinfection.

Sahun, Maxime / Privat-Maldonado, Angela / Lin, Abraham / De Roeck, Naomi / Van der Heyden, Lisa / Hillen, Michaël / Michiels, Johan / Steenackers, Gunther / Smits, Evelien / Ariën, Kevin K / Jorens, Philippe G / Delputte, Peter / Bogaerts, Annemie

ACS sustainable chemistry & engineering

2023 Volume 11, Issue 13, Page(s) 5206–5215

Abstract: As recently highlighted by the SARS-CoV-2 pandemic, viruses have become an increasing burden for health, global economy, and environment. The control of transmission by contact with contaminated materials represents a major challenge, particularly in ... ...

Abstract	As recently highlighted by the SARS-CoV-2 pandemic, viruses have become an increasing burden for health, global economy, and environment. The control of transmission by contact with contaminated materials represents a major challenge, particularly in hospital environments. However, the current disinfection methods in hospital settings suffer from numerous drawbacks. As a result, several medical supplies that cannot be properly disinfected are not reused, leading to severe shortages and increasing amounts of waste, thus prompting the search for alternative solutions. In this work, we report that non-thermal plasma (NTP) can effectively inactivate SARS-CoV-2 from non-porous and porous materials commonly found in healthcare facilities. We demonstrated that 5 min treatment with a dielectric barrier discharge NTP can inactivate 100% of SARS-CoV-2 (Wuhan and Omicron strains) from plastic material. Using porcine respiratory coronavirus (surrogate for SARS-CoV-2) and coxsackievirus B3 (highly resistant non-enveloped virus), we tested the NTP virucidal activity on hospital materials and obtained complete inactivation after 5 and 10 min, respectively. We hypothesize that the produced reactive species and local acidification contribute to the overall virucidal effect of NTP. Our results demonstrate the potential of dielectric barrier discharge NTPs for the rapid, efficient, and low-cost disinfection of healthcare materials.
Language	English
Publishing date	2023-03-23
Publishing country	United States
Document type	Journal Article
ISSN	2168-0485
ISSN	2168-0485
DOI	10.1021/acssuschemeng.2c07622
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Oxidative damage to hyaluronan-CD44 interactions as an underlying mechanism of action of oxidative stress-inducing cancer therapy.

Yusupov, Maksudbek / Privat-Maldonado, Angela / Cordeiro, Rodrigo M / Verswyvel, Hanne / Shaw, Priyanka / Razzokov, Jamoliddin / Smits, Evelien / Bogaerts, Annemie

Redox biology

2021 Volume 43, Page(s) 101968

Abstract: Multiple cancer therapies nowadays rely on oxidative stress to damage cancer cells. Here we investigated the biological and molecular effect of oxidative stress on the interaction between CD44 and hyaluronan (HA), as interrupting their binding can hinder ...

Abstract	Multiple cancer therapies nowadays rely on oxidative stress to damage cancer cells. Here we investigated the biological and molecular effect of oxidative stress on the interaction between CD44 and hyaluronan (HA), as interrupting their binding can hinder cancer progression. Our experiments demonstrated that the oxidation of HA decreased its recognition by CD44, which was further enhanced when both CD44 and HA were oxidized. The reduction of CD44-HA binding negatively affected the proliferative state of cancer cells. Our multi-level atomistic simulations revealed that the binding free energy of HA to CD44 decreased upon oxidation. The effect of HA and CD44 oxidation on CD44-HA binding was similar, but when both HA and CD44 were oxidized, the effect was much larger, in agreement with our experiments. Hence, our experiments and computations support our hypothesis on the role of oxidation in the disturbance of CD44-HA interaction, which can lead to the inhibition of proliferative signaling pathways inside the tumor cell to induce cell death.
MeSH term(s)	Hyaluronan Receptors ; Hyaluronic Acid ; Neoplasms ; Oxidative Stress ; Signal Transduction
Chemical Substances	Hyaluronan Receptors ; Hyaluronic Acid (9004-61-9)
Language	English
Publishing date	2021-04-11
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2701011-9
ISSN	2213-2317 ; 2213-2317
ISSN (online)	2213-2317
ISSN	2213-2317
DOI	10.1016/j.redox.2021.101968
Database	MEDical Literature Analysis and Retrieval System OnLINE

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