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Article ; Online: Reproductive Justice Discourse vis-à-vis Abortion Law in India

Priyanka Tripathi

Space and Culture, India, Vol 10, Iss

A Critical Review

2023 Volume 4

Abstract: The narrative concerning third-world women has long been considered regressive, discriminatory, and monistic. The legal narratives, too, could not escape the traditional trope of identity ascribed to women. Though essentially empowering, the practical ... ...

Abstract	The narrative concerning third-world women has long been considered regressive, discriminatory, and monistic. The legal narratives, too, could not escape the traditional trope of identity ascribed to women. Though essentially empowering, the practical realisation of the Medical Termination of Pregnancy (MTP) Act of 1971 could never harness a sense of inclusivity until the amendment of 2021. But the seven categories of women included in the amended Act did not consider the issues of pregnancy arising out of a consensual sexual encounter (contraceptive failure) for an unmarried woman. For the first time, the Supreme Court of India has recognised the concept of agency for all women without any external factor functioning as an influence. The idea of choice has never been celebrated. Thus, in the context of contemporary India, where the idea of the metanarrative of identity appears imminent and the third-world postmodern feminism celebrates the ideals of intersectionality, the legal discourse of deconstructing the difference among women in the name of marital status to strip them of their fundamental rights to bodily autonomy and reproductive justice needs intervention. This review paper intends to diachronically approach the existing data of empirical and critical research on abortion vis-à-vis the human rights discourse in the context of Indian women.
Keywords	Abortion ; Reproductive Justice ; Women ; Ethnology. Social and cultural anthropology ; GN301-674
Subject code	170
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	ACCB Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Conceptualizing In-Text “Kshetra”

Chhandita Das / Priyanka Tripathi

Text Matters, Iss 11, Pp 389-

Postcolonial Allahabad’s Cultural Geography in Neelum Saran Gour’s Allahabad Aria and Invisible Ink

2021 Volume 403

Abstract: Literary renditions of cities have always gravitated towards the spatial imagination and its ethical counterpart outside the textual space. This paper explores the multicultural geography of the North Indian city Allahabad (recently renamed Prayagraj) ... ...

Abstract	Literary renditions of cities have always gravitated towards the spatial imagination and its ethical counterpart outside the textual space. This paper explores the multicultural geography of the North Indian city Allahabad (recently renamed Prayagraj) observed through Neelum Saran Gour’s postcolonial narratives Allahabad Aria and Invisible Ink, projecting the narrative alignment of spatial aesthetics and cultural ethics. Interrogating the spatial dimensions of a “narrative world” within narrative theory (Ryan) and its interdisciplinary crossover with cultural geography (Sauer; Mitchell; Anderson et al.), the article seeks to examine Gour’s literary city not simply as an objective homogeneous representation, but as a “kshetra” of spatio-cultural cosmos of lived traditions, memories, experiences and collective attitudes of its people, in the context of E. V. Ramakrishnan’s theoretical reflections. The article proposes new possibilities of adapting the Indian concept “kshetra” to spatial literary studies; its aim is also to suggest a new source of knowledge about the city of Allahabad through a community introspection of “doing culture” in the texts, bringing into view people’s shared experiences, beliefs, religious practices and traditions as offshoots of the postcolonial ethos. The article aims to re-contextualize the city’s longstanding multicultural ethics in the contemporary times of crisis, which may affect a shift in the city’s relevance: from regional concern to large-scale significance within ethnically diverse South Asian countries and beyond.
Keywords	“kshetra” ; cultural geography ; allahabad ; multiculturalism ; postcolonial ; Literature (General) ; PN1-6790
Subject code	820
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	Lodz University Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Early Alterations of RNA Binding Protein (RBP) Homeostasis and ER Stress-Mediated Autophagy Contributes to Progressive Retinal Degeneration in the rd10 Mouse Model of Retinitis Pigmentosa (RP)

Alfred Yamoah / Priyanka Tripathi / Haihong Guo / Leonie Scheve / Peter Walter / Sandra Johnen / Frank Müller / Joachim Weis / Anand Goswami

Cells, Vol 12, Iss 1094, p

2023 Volume 1094

Abstract: The retinal degeneration 10 ( rd10 ) mouse model is widely used to study retinitis pigmentosa (RP) pathomechanisms. It offers a rather unique opportunity to study trans-neuronal degeneration because the cell populations in question are separated ... ...

Abstract	The retinal degeneration 10 ( rd10 ) mouse model is widely used to study retinitis pigmentosa (RP) pathomechanisms. It offers a rather unique opportunity to study trans-neuronal degeneration because the cell populations in question are separated anatomically and the mutated Pde6b gene is selectively expressed in rod photoreceptors. We hypothesized that RNA binding protein (RBP) aggregation and abnormal autophagy might serve as early pathogenic events, damaging non-photoreceptor retinal cell types that are not primarily targeted by the Pde6b gene defect. We used a combination of immunohistochemistry (DAB, immunofluorescence), electron microscopy (EM), subcellular fractionation, and Western blot analysis on the retinal preparations obtained from both rd10 and wild-type mice. We found early, robust increases in levels of the protective endoplasmic reticulum (ER) calcium (Ca 2+ ) buffering chaperone Sigma receptor 1 (SigR1) together with other ER-Ca 2+ buffering proteins in both photoreceptors and non-photoreceptor neuronal cells before any noticeable photoreceptor degeneration. In line with this, we found markedly altered expression of the autophagy proteins p62 and LC3, together with abnormal ER widening and large autophagic vacuoles as detected by EM. Interestingly, these changes were accompanied by early, prominent cytoplasmic and nuclear aggregation of the key RBPs including pTDP-43 and FET family RBPs and stress granule formation. We conclude that progressive neurodegeneration in the rd10 mouse retina is associated with early disturbances of proteostasis and autophagy, along with abnormal cytoplasmic RBP aggregation.
Keywords	rd10 retina ; ER-Ca 2+ homeostasis ; ER chaperones ; autophagy ; RBP aggregation ; neurodegeneration ; Biology (General) ; QH301-705.5
Subject code	333
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The S1P receptor 1 antagonist Ponesimod reduces TLR4-induced neuroinflammation and increases Aβ clearance in 5XFAD miceResearch in context

Zhihui Zhu / Liping Zhang / Ahmed Elsherbini / Simone M. Crivelli / Priyanka Tripathi / Carmen Harper / Zainuddin Quadri / Stefka D. Spassieva / Erhard Bieberich

EBioMedicine, Vol 94, Iss , Pp 104713- (2023)

2023

Abstract: Summary: Background: Previously, we showed that the sphingosine-1-phosphate (S1P) transporter spinster 2 (Spns2) mediates activation of microglia in response to amyloid β peptide (Aβ). Here, we investigated if Ponesimod, a functional S1P receptor 1 ( ... ...

Abstract	Summary: Background: Previously, we showed that the sphingosine-1-phosphate (S1P) transporter spinster 2 (Spns2) mediates activation of microglia in response to amyloid β peptide (Aβ). Here, we investigated if Ponesimod, a functional S1P receptor 1 (S1PR1) antagonist, prevents Aβ-induced activation of glial cells and Alzheimer's disease (AD) pathology. Methods: We used primary cultures of glial cells and the 5XFAD mouse model to determine the effect of Aβ and Ponesimod on glial activation, Aβ phagocytosis, cytokine levels and pro-inflammatory signaling pathways, AD pathology, and cognitive performance. Findings: Aβ42 increased the levels of TLR4 and S1PR1, leading to their complex formation. Ponesimod prevented the increase in TLR4 and S1PR1 levels, as well as the formation of their complex. It also reduced the activation of the pro-inflammatory Stat1 and p38 MAPK signaling pathways, while activating the anti-inflammatory Stat6 pathway. This was consistent with increased phagocytosis of Aβ42 in primary cultured microglia. In 5XFAD mice, Ponesimod decreased the levels of TNF-α and CXCL10, which activate TLR4 and Stat1. It also increased the level of IL-33, an anti-inflammatory cytokine that promotes Aβ42 phagocytosis by microglia. As a result of these changes, Ponesimod decreased the number of Iba-1+ microglia and GFAP+ astrocytes, and the size and number of amyloid plaques, while improving spatial memory as measured in a Y-maze test. Interpretation: Ponesimod targeting S1PR1 is a promising therapeutic approach to reprogram microglia, reduce neuroinflammation, and increase Aβ clearance in AD. Funding: NIH R01AG064234, RF1AG078338, R21AG078601, VA I01BX003643.
Keywords	Alzheimer's disease ; Sphingosine-1-phosphate ; Neuroinflammation ; Ponesimod ; Toll-like receptor 4 ; Phagocytosis ; Medicine ; R ; Medicine (General) ; R5-920
Language	English
Publishing date	2023-08-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Menopausal Symptoms in Premenopausal Women Among the Cohort of Gynecological Patients Attending Outpatient Department of Dhulikhel Hospital.

Anjana Dongol / Shreya Deoju / Shreeja Shikharakar / Sushil Jung Rayamajhi / Noora Pradhan / Priyanka Tripathi

Journal of Lumbini Medical College, Vol 9, Iss

2021 Volume 2

Abstract: Introduction: Perimenopause is the time when ovaries gradually produce less estrogen. The menopausal symptoms in perimenopausal women cause severe disturbance in the women’s life. This study aimed to identify menopausal symptoms in perimenopausal women. ... ...

Abstract	Introduction: Perimenopause is the time when ovaries gradually produce less estrogen. The menopausal symptoms in perimenopausal women cause severe disturbance in the women’s life. This study aimed to identify menopausal symptoms in perimenopausal women. Methods: This was a hospital-based descriptive, cross-sectional study conducted among 243 women aged between 45 to 55 years. The categorical variables were presented as frequency and percentage. The associations between categorical variables were tested using Chi-square or Fisher exact test. Result: The total prevalence of menopausal symptoms was 91.8%. Physical symptoms were identified to be prevailing symptom(n=184, 75.7%) followed by psychological (n=167, 69.5%). There were 136 (55.5%) women experiencing poor memory and 148 (60.9%) women having genitourinary symptoms. Stress urinary incontinence (n=73, 30.04%) was predominant over urge (n=58, 23.8%), mixed (n=43, 17.6%) and prolapse (n=49, 20.1%) symptoms. Vasomotor symptoms were experienced by123 (50.6%). Excessive sweating (n=114, 46.9%) was leading over hot flush(n=113, 46.5%), night sweat (n=107, 44.03%) and palpitation (n=96, 39.5%). A total of 114 (46.9%) women were facing sexual symptoms. The common sexual symptom was dyspareunia 68 (27.9%). The Menopausal Rating Scale (MRS) rating of overall symptoms showed women mostly suffer from mild symptoms during the perimenopausal period. Conclusion: Physical symptoms were identified to be predominating followed by psychological, genitourinary, vasomotor, and sexual. However rating of symptoms using MRS showed the majority of symptoms were mild. This study signifies the need to use the tool for the assessment of the severity of menopausal symptoms from the perimenopausal group.
Keywords	Menopause ; Menopause rating scale ; Perimenopause ; Symptoms ; Medicine (General) ; R5-920
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	Lumbini Medical College
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Novel Isolation Method Reveals Sex-Specific Composition and Neurotoxicity of Small Extracellular Vesicles in a Mouse Model of Alzheimer’s Disease

Ahmed Elsherbini / Zhihui Zhu / Zainuddin Quadri / Simone M. Crivelli / Xiaojia Ren / Hemendra J. Vekaria / Priyanka Tripathi / Liping Zhang / Wenbo Zhi / Erhard Bieberich

Cells, Vol 12, Iss 1623, p

2023 Volume 1623

Abstract: We developed a new method to isolate small extracellular vesicles (sEVs) from male and female wild-type and 5xFAD mouse brains to investigate the sex-specific functions of sEVs in Alzheimer’s disease (AD). A mass spectrometric analysis revealed that sEVs ...

Abstract	We developed a new method to isolate small extracellular vesicles (sEVs) from male and female wild-type and 5xFAD mouse brains to investigate the sex-specific functions of sEVs in Alzheimer’s disease (AD). A mass spectrometric analysis revealed that sEVs contained proteins critical for EV formation and Aβ. ExoView analysis showed that female mice contained more GFAP and Aβ-labeled sEVs, suggesting that a larger proportion of sEVs from the female brain is derived from astrocytes and/or more likely to bind to Aβ. Moreover, sEVs from female brains had more acid sphingomyelinase (ASM) and ceramide, an enzyme and its sphingolipid product important for EV formation and Aβ binding to EVs, respectively. We confirmed the function of ASM in EV formation and Aβ binding using co-labeling and proximity ligation assays, showing that ASM inhibitors prevented complex formation between Aβ and ceramide in primary cultured astrocytes. Finally, our study demonstrated that sEVs from female 5xFAD mice were more neurotoxic than those from males, as determined by impaired mitochondrial function (Seahorse assays) and LDH cytotoxicity assays. Our study suggests that sex-specific sEVs are functionally distinct markers for AD and that ASM is a potential target for AD therapy.
Keywords	extracellular vesicles ; Alzheimer’s ; acid sphingomyelinase ; ceramide ; neurotoxicity ; Biology (General) ; QH301-705.5
Subject code	570
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: R OLE OF OBE SITY IN L O W B A CK P AIN RELA TED DIS ABILITY IN FEMALE ADUL T S

Priyanka Tripathi / Jaspreet Kaur Malik / Shabnam Joshi

International Journal of Physiotherapy and Research, Vol 01, Iss 03, Pp 93-

2013 Volume 98

Abstract: Objective:JThe aim of the study was to determine the association between obesity and low back pain.Materialsand Methods:Total 42 patients were taken and then the patients were divided into 2 groups. In group A (n=22)the female obese patients with low ... ...

Abstract	Objective:JThe aim of the study was to determine the association between obesity and low back pain.Materialsand Methods:Total 42 patients were taken and then the patients were divided into 2 groups. In group A (n=22)the female obese patients with low back pain and in group B (n=20) the female non-obese patients with lowback pain were included. Then the subjects were made to fill the Oswestry disability index for low back painand pain was assessed by using VAS (visual analogue scale).Results:Data analysis was done on 42 patientsusing unrelated t-test at (p=0.05) level for oswesrty reading and (p=0.10) level for VAS reading. Result showeda significant difference in pain and disability in non-obese low back pain patients than obese low back painpatients.Discussion:Women have a higher prevalence of low back pain as compared with men, possible reasonfor this could be hormonal changes, irregular or prolonged menstrual cycle and different pain perception.32Also abdominal obesity is the primary weight related risk factor for low back pain which is more common inwomen.33Conclusion:The present study concludes that obese with low back pain experience more disabled lifethan non-obese.
Keywords	LOW BACK PAIN ; OBESITY ; OSWESTRY DISABILITY INDEX ; VISUAL ANALOGUE SCALE ; Medicine (General) ; R5-920 ; Medicine ; R ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	616
Language	English
Publishing date	2013-08-01T00:00:00Z
Publisher	International Journal of Physiotherapy and Research
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: VAPB ER-Aggregates, A Possible New Biomarker in ALS Pathology

Maria Piera L Cadoni / Maria Luigia Biggio / Giannina Arru / Giannina Secchi / Nicola Orrù / Maria Grazia Clemente / GianPietro Sechi / Alfred Yamoah / Priyanka Tripathi / Sandro Orrù / Roberto Manetti / Grazia Galleri

Cells, Vol 9, Iss 1, p

2020 Volume 164

Abstract: A point mutation (P56S) in the gene-encoding vesicle-associated membrane-protein-associated protein B (VAPB) leads to an autosomal-dominant form of amyotrophic lateral sclerosis (ALS), classified as ALS-8. The mutant VAPB is characterized by ER- ... ...

Abstract	A point mutation (P56S) in the gene-encoding vesicle-associated membrane-protein-associated protein B (VAPB) leads to an autosomal-dominant form of amyotrophic lateral sclerosis (ALS), classified as ALS-8. The mutant VAPB is characterized by ER-associated aggregates that lead to a complete reorganization of ER structures. Growing evidences suggest VAPB involvement in ALS pathomechanisms. In fact, numerous studies demonstrated VAPB alteration also in sporadic ALS (sALS) and showed the presence of its aggregates when others ALS-related gene are mutant. Recently, the identification of new biomarkers in peripheral blood mononuclear cells (PBMCs) has been proposed as a good noninvasive option for studying ALS. Here, we evaluated VAPB as a possible ALS pathologic marker analyzing PBMCs of sALS patients. Immunofluorescence analysis (IFA) showed a peculiar pattern of VAPB aggregates in sALS, not evident in healthy control (HC) subjects and in Parkinson’s disease (PD) PBMCs. This specific pattern led us to suppose that VAPB could be misfolded in sALS. The data indirectly confirmed by flow cytometry assay (FCA) showed a reduction of VAPB fluorescent signals in sALS. However, our observations were not associated with the presence of a genetic mutation or altered gene expression of VAPB. Our study brings further evidences of the VAPB role in ALS as a diagnostic biomarker.
Keywords	als ; biomarker ; vapb er-aggregates ; endoplasmic reticulum ; flow cytometry ; pbmc ; immunofluorescence ; Biology (General) ; QH301-705.5
Subject code	612
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The mono-ADP-ribosyltransferase ARTD10 regulates the voltage-gated K+ channel Kv1.1 through protein kinase C delta

Yuemin Tian / Patricia Korn / Priyanka Tripathi / Daniel Komnig / Dominik Wiemuth / Azadeh Nikouee / Arno Classen / Carsten Bolm / Björn H. Falkenburger / Bernhard Lüscher / Stefan Gründer

BMC Biology, Vol 18, Iss 1, Pp 1-

2020 Volume 14

Abstract: Abstract Background ADP-ribosylation is a ubiquitous post-translational modification that involves both mono- and poly-ADP-ribosylation. ARTD10, also known as PARP10, mediates mono-ADP-ribosylation (MARylation) of substrate proteins. A previous screen ... ...

Abstract	Abstract Background ADP-ribosylation is a ubiquitous post-translational modification that involves both mono- and poly-ADP-ribosylation. ARTD10, also known as PARP10, mediates mono-ADP-ribosylation (MARylation) of substrate proteins. A previous screen identified protein kinase C delta (PKCδ) as a potential ARTD10 substrate, among several other kinases. The voltage-gated K+ channel Kv1.1 constitutes one of the dominant Kv channels in neurons of the central nervous system and the inactivation properties of Kv1.1 are modulated by PKC. In this study, we addressed the role of ARTD10-PKCδ as a regulator of Kv1.1. Results We found that ARTD10 inhibited PKCδ, which increased Kv1.1 current amplitude and the proportion of the inactivating current component in HeLa cells, indicating that ARTD10 regulates Kv1.1 in living cells. An inhibitor of ARTD10, OUL35, significantly decreased peak amplitude together with the proportion of the inactivating current component of Kv1.1-containing channels in primary hippocampal neurons, demonstrating that the ARTD10-PKCδ signaling cascade regulates native Kv1.1. Moreover, we show that the pharmacological blockade of ARTD10 increases excitability of hippocampal neurons. Conclusions Our results, for the first time, suggest that MARylation by ARTD10 controls neuronal excitability.
Keywords	Ion channel ; Potassium channel ; ADP ribosylation ; Posttranslational modification ; ADP ribosyltransferase ; Protein kinase C delta ; Biology (General) ; QH301-705.5
Subject code	572
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Isolation, Purification and Evaluation of Antibacterial Agents from Aloe vera

Rubina Lawrence / Priyanka Tripathi / Ebenezer Jeyakumar

Brazilian Journal of Microbiology, Vol 40, Iss 4, Pp 906-

2009 Volume 915

Abstract: The ethanol, methanol and acetone extracts of Aloe vera gel were studied for their antimicrobial activity against four Gram-positive and Gram-negative bacteria using agar well diffusion method. The extracts showed varied levels of antimicrobial activity ... ...

Abstract	The ethanol, methanol and acetone extracts of Aloe vera gel were studied for their antimicrobial activity against four Gram-positive and Gram-negative bacteria using agar well diffusion method. The extracts showed varied levels of antimicrobial activity against the tested pathogens. The ethanol and methanol extracts showed higher activity while acetone extract, showed least or no activity against most of the tested pathogens. Fractions obtained from the extracts by Thin Layer and Column Chromatography were studied for their antagonistic properties using Spot Assay Technique. Compounds with maximum antibacterial activity isolated from the ethanol and methanol extracts were identified as p - coumaric acid (Mol. wt.165), ascorbic acid (Mol. wt.177 ), pyrocatechol (Mol. wt.110 ) and cinnamic acid (Mol. wt.148), on the basis of Gas Chromatography Mass Spectrometry. The study suggests the antimicrobial activity of the A. vera gel extract to be dependant on the synergistic effect of different compounds. With the broad spectral antimicrobial effect of A. vera gel, it could be further recommended in the treatment of various bacterial diseases.
Keywords	Aloe vera ; gel ; antimicrobial ; compounds ; Microbiology ; QR1-502 ; Science ; Q ; DOAJ:Microbiology ; DOAJ:Biology ; DOAJ:Biology and Life Sciences
Subject code	540
Language	English
Publishing date	2009-12-01T00:00:00Z
Publisher	Sociedade Brasileira de Microbiologia
Document type	Article ; Online
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