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Article ; Online: Influence of Clinical Parameters on the Primary Stability of a Tapered Dental Implant: A Retrospective Analysis.

Blume, Oliver / Wildenhof, Jan / Otto, Sven / Probst, Florian A

The International journal of oral & maxillofacial implants

2021 Volume 36, Issue 4, Page(s) 762–770

Abstract: Purpose: The aim of this study was to investigate the influence of different clinical parameters on the primary stability of a variable thread tapered implant system with a focus on surgical undersizing protocols.: Materials and methods: This ... ...

Abstract	Purpose: The aim of this study was to investigate the influence of different clinical parameters on the primary stability of a variable thread tapered implant system with a focus on surgical undersizing protocols. Materials and methods: This retrospective study evaluated patients who received NobelActive implants in a single institution. The relationship between the independent variables, bone quality, implant diameter, implant length, implantation time, region of the jaw, and surgical undersizing protocol, and the dependent variable, maximum insertion torque, was investigated. Statistical analysis was conducted using analysis of variance (ANOVA) and multiple linear regression. Results: A total of 1,292 implants placed in 574 fully or partially edentulous patients were evaluated. For the total sample size, without further differentiation between bone qualities, statistically significantly higher primary stability values were shown for an 8% to 9% undersized group (50.33 ± 17.16 Ncm), compared with a 16% undersized group (41.88 ± 17.63 Ncm), a 20% undersized group (33.65 ± 15.78 Ncm), a 26% to 28% undersized group (34.53 ± 15.49 Ncm), and a 35% to 44% undersized group (32.78 ± 18.80 Ncm). No statistical differences were found for undersizing protocols in bone quality 4. Bone quality had the highest influence on primary stability (Welch-Test F(3, 65.57) = 119.48, P < .001, η Conclusion: Undersizing protocols exceeding 8% to 9% do not seem to enhance primary stability values. Further studies are needed to investigate the biologic consequences of undersizing, including the impact of implant design characteristics.
MeSH term(s)	Dental Implantation, Endosseous ; Dental Implants ; Dental Prosthesis Design ; Humans ; Retrospective Studies ; Torque
Chemical Substances	Dental Implants
Language	English
Publishing date	2021-08-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	632880-5
ISSN	1942-4434 ; 0882-2786
ISSN (online)	1942-4434
ISSN	0882-2786
DOI	10.11607/jomi.8682
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Chronic Periodontal Infection and Not Iatrogenic Interference Is the Trigger of Medication-Related Osteonecrosis of the Jaw: Insights from a Large Animal Study (PerioBRONJ Pig Model).

Troeltzsch, Matthias / Zeiter, Stephan / Arens, Daniel / Nehrbass, Dirk / Probst, Florian A / Liokatis, Paris / Ehrenfeld, Michael / Otto, Sven

Medicina (Kaunas, Lithuania)

2023 Volume 59, Issue 5

Abstract: Background and ... ...

Abstract	Background and Objectives
MeSH term(s)	Animals ; Swine ; Bisphosphonate-Associated Osteonecrosis of the Jaw/diagnostic imaging ; Bisphosphonate-Associated Osteonecrosis of the Jaw/etiology ; Bisphosphonate-Associated Osteonecrosis of the Jaw/drug therapy ; Swine, Miniature ; Diphosphonates/adverse effects ; Zoledronic Acid/adverse effects ; Bone Density Conservation Agents/adverse effects ; Disease Models, Animal ; Periodontitis/etiology ; Silk
Chemical Substances	Diphosphonates ; Zoledronic Acid (6XC1PAD3KF) ; Bone Density Conservation Agents ; Silk
Language	English
Publishing date	2023-05-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina59051000
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Article ; Online: Long-Term Efficacy of Variable-Thread Tapered Implants-A Retrospective, Clinical and Radiological Evaluation.

Blume, Oliver / Schnödt, Eva Maria / Back, Michael / Wildenhof, Jan Ir / Probst, Florian A / Otto, Sven

Medicina (Kaunas, Lithuania)

2020 Volume 56, Issue 11

Abstract: Background and Objective: ...

Abstract	Background and Objective:
MeSH term(s)	Aged ; Cohort Studies ; Female ; Humans ; Male ; Peri-Implantitis/diagnostic imaging ; Peri-Implantitis/epidemiology ; Retrospective Studies ; Risk Factors
Language	English
Publishing date	2020-10-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina56110564
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Article ; Online: Correction: Primary cold atmospheric plasma combined with low dose cisplatin as a possible adjuvant combination therapy for HNSCC cells-an in‑vitro study.

Brunner, Teresa F / Probst, Florian A / Troeltzsch, Matthias / Schwenk-Zieger, Sabina / Zimmermann, Julia L / Morfill, Gregor / Becker, Sven / Harréus, Ulrich / Welz, Christian

Head & face medicine

2023 Volume 19, Issue 1, Page(s) 35

Language	English
Publishing date	2023-08-18
Publishing country	England
Document type	Published Erratum
ZDB-ID	2202219-3
ISSN	1746-160X ; 1746-160X
ISSN (online)	1746-160X
ISSN	1746-160X
DOI	10.1186/s13005-023-00386-x
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Article ; Online: Accuracy of maxillary positioning using computer-designed and manufactured occlusal splints or patient-specific implants in orthognathic surgery.

Malenova, Yoana / Ortner, Florian / Liokatis, Paris / Haidari, Selgai / Tröltzsch, Matthias / Fegg, Florian / Obermeier, Katharina T / Hartung, Jens T / Kakoschke, Tamara K / Burian, Egon / Otto, Sven / Sabbagh, Hisham / Probst, Florian A

Clinical oral investigations

2023 Volume 27, Issue 9, Page(s) 5063–5072

Abstract: Objective: To determine the accuracy of maxillary positioning using computer-designed and manufactured occlusal splints or patient-specific implants in orthognathic surgery.: Material and methods: A retrospective analysis of 28 patients that ... ...

Abstract	Objective: To determine the accuracy of maxillary positioning using computer-designed and manufactured occlusal splints or patient-specific implants in orthognathic surgery. Material and methods: A retrospective analysis of 28 patients that underwent virtually planned orthognathic surgery with maxillary Le Fort I osteotomy either using VSP-generated splints (n = 13) or patient-specific implants (PSI) (n = 15) was conducted. The accuracy and surgical outcome of both techniques were compared by superimposing preoperative surgical planning with postoperative CT scans and measurement of translational and rotational deviation for each patient. Results: The 3D global geometric deviation between the planned position and the postoperative outcome was 0.60 mm (95%-CI 0.46-0.74, range 0.32-1.11 mm) for patients with PSI and 0.86 mm (95%-CI 0.44-1.28, range 0.09-2.60 mm) for patients with surgical splints. Postoperative differences for absolute and signed single linear deviations between planned and postoperative position were a little higher regarding the x-axis and pitch but lower regarding the y- and z-axis as well as yaw and roll for PSI compared to surgical splints. There were no significant differences regarding global geometric deviation, absolute and signed linear deviations in the x-, y-, and z-axis, and rotations (yaw, pitch, and roll) between both groups. Conclusions: Regarding accuracy for positioning of maxillary segments after Le Fort I osteotomy in orthognathic surgery patient-specific implants and surgical splints provide equivalent high accuracy. Clinical relevance: Patient-specific implants for maxillary positioning and fixation facilitate the concept of splintless orthognathic surgery and can be reliably used in clinical routines.
MeSH term(s)	Humans ; Orthognathic Surgery ; Occlusal Splints ; Orthognathic Surgical Procedures/methods ; Retrospective Studies ; Surgery, Computer-Assisted/methods ; Dental Implants ; Maxilla/surgery ; Computers ; Imaging, Three-Dimensional/methods ; Osteotomy, Le Fort/methods
Chemical Substances	Dental Implants
Language	English
Publishing date	2023-06-29
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1364490-7
ISSN	1436-3771 ; 1432-6981
ISSN (online)	1436-3771
ISSN	1432-6981
DOI	10.1007/s00784-023-05125-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Evaluation of 3D MRI for early detection of bone edema associated with apical periodontitis.

Feuerriegel, Georg C / Burian, Egon / Sollmann, Nico / Leonhardt, Yannik / Burian, Gintare / Griesbauer, Magdalena / Bumm, Caspar / Makowski, Marcus R / Probst, Monika / Probst, Florian A / Karampinos, Dimitrios C / Folwaczny, Matthias

Clinical oral investigations

2023 Volume 27, Issue 9, Page(s) 5403–5412

Abstract: Objectives: To detect and evaluate early signs of apical periodontitis using MRI based on a 3D short-tau-inversion-recovery (STIR) sequence compared to conventional panoramic radiography (OPT) and periapical radiographs in patients with apical ... ...

Abstract	Objectives: To detect and evaluate early signs of apical periodontitis using MRI based on a 3D short-tau-inversion-recovery (STIR) sequence compared to conventional panoramic radiography (OPT) and periapical radiographs in patients with apical periodontitis. Materials and methods: Patients with clinical evidence of periodontal disease were enrolled prospectively and received OPT as well as MRI of the viscerocranium including a 3D-STIR sequence. The MRI sequences were assessed for the occurrence and extent of bone changes associated with apical periodontitis including bone edema, periradicular cysts, and dental granulomas. OPTs and intraoral periapical radiographs, if available, were assessed for corresponding periapical radiolucencies using the periapical index (PAI). Results: In total, 232 teeth of 37 patients (mean age 62±13.9 years, 18 women) were assessed. In 69 cases reactive bone edema was detected on MRI with corresponding radiolucency according to OPT. In 105 cases edema was detected without corresponding radiolucency on OPT. The overall extent of edema measured on MRI was significantly larger compared to the radiolucency on OPT (mean: STIR 2.4±1.4 mm, dental radiograph 1.3±1.2 mm, OPT 0.8±1.1 mm, P=0.01). The overall PAI score was significantly higher on MRI compared to OPT (mean PAI: STIR 1.9±0.7, dental radiograph 1.3±0.5, OPT 1.2±0.7, P=0.02). Conclusion: Early detection and assessment of bone changes of apical periodontitis using MRI was feasible while the extent of bone edema measured on MRI exceeded the radiolucencies measured on OPT. Clinical relevance: In clinical routine, dental MRI might be useful for early detection and assessment of apical periodontitis before irreversible bone loss is detected on conventional panoramic and intraoral periapical radiographs.
MeSH term(s)	Humans ; Female ; Middle Aged ; Aged ; Root Canal Therapy ; Periapical Periodontitis/complications ; Radiography ; Magnetic Resonance Imaging ; Tooth, Nonvital/diagnostic imaging
Language	English
Publishing date	2023-07-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1364490-7
ISSN	1436-3771 ; 1432-6981
ISSN (online)	1436-3771
ISSN	1432-6981
DOI	10.1007/s00784-023-05159-z
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Article ; Online: Primary cold atmospheric plasma combined with low dose cisplatin as a possible adjuvant combination therapy for HNSCC cells-an in-vitro study.

Brunner, Teresa F / Probst, Florian A / Troeltzsch, Matthias / Schwenk-Zieger, Sabina / Zimmermann, Julia L / Morfill, Gregor / Becker, Sven / Harréus, Ulrich / Welz, Christian

Head & face medicine

2022 Volume 18, Issue 1, Page(s) 21

Abstract: Background: The aim of the present study was to examine the cytostatic effects of cold atmospheric plasma (CAP) on different head and neck squamous carcinoma (HNSCC) cell lines either in isolation or in combination with low dose cisplatin. The effect of ...

Abstract	Background: The aim of the present study was to examine the cytostatic effects of cold atmospheric plasma (CAP) on different head and neck squamous carcinoma (HNSCC) cell lines either in isolation or in combination with low dose cisplatin. The effect of CAP treatment was investigated by using three different HNSCC cell lines (chemo-resistant Cal 27, chemo-sensitive FaDu and OSC 19). Materials and method: Cell lines were exposed to CAP treatment for 30, 60, 90, 120 and 180 s (s). Cisplatin was added concurrently (cc) or 24 h after CAP application (cs). Cell viability, DNA damage and apoptosis was evaluated by dye exclusion, MTT, alkaline microgel electrophoresis assay and Annexin V-Fit-C/PI respectively. Results: In all cell lines, 120 s of CAP exposure resulted in a significant reduction of cell viability. DNA damage significantly increased after 60 s. Combined treatment of cells with CAP and low dose cisplatin showed additive effects. A possible sensitivity to cisplatin could be restored in Cal 27 cells by CAP application. Conclusion: CAP shows strong cytostatic effects in HNSCC cell lines that can be increased by concurrent cisplatin treatment, suggesting that CAP may enhance the therapeutic efficacy of low dose cisplatin.
MeSH term(s)	Carcinoma, Squamous Cell/drug therapy ; Carcinoma, Squamous Cell/genetics ; Cell Line, Tumor ; Cisplatin/pharmacology ; Cisplatin/therapeutic use ; Cytostatic Agents/therapeutic use ; Head and Neck Neoplasms/drug therapy ; Humans ; Plasma Gases/pharmacology ; Plasma Gases/therapeutic use ; Squamous Cell Carcinoma of Head and Neck/drug therapy
Chemical Substances	Cytostatic Agents ; Plasma Gases ; Cisplatin (Q20Q21Q62J)
Language	English
Publishing date	2022-06-29
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2202219-3
ISSN	1746-160X ; 1746-160X
ISSN (online)	1746-160X
ISSN	1746-160X
DOI	10.1186/s13005-022-00322-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Festsitzende prothetische Versorgung bei ausgeprägter Atrophie des zahnlosen Ober- und Unterkiefers

Schiel, Sebastian / Probst, Florian A. / Stachulla, Gerhard / Nold, Ephraim

Implantologie

2018 Volume 26, Issue 4, Page(s) 395

Language	German
Document type	Article
ZDB-ID	1151752-9
ISSN	0943-9692
Database	Current Contents Medicine

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Zs.A 3990: Show issues

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Article: Fatty Acid Receptor CD36 Functions as a Surrogate Parameter for Lymph Node Metastasis in Oral Squamous Cell Carcinoma.

Haidari, Selgai / Tröltzsch, Matthias / Knösel, Thomas / Liokatis, Paris / Kasintsova, Anastasia / Eberl, Marian / Ortner, Florian / Otto, Sven / Fegg, Florian / Boskov, Marko / Probst, Florian A

Cancers

2021 Volume 13, Issue 16

Abstract: Purpose: To investigate the expression pattern of CD36 in a patient population with oral squamous cell carcinoma (OSCC) and to correlate CD36 expression with clinical and histopathological parameters. The hypothesis was that CD36 expression correlates ... ...

Abstract	Purpose: To investigate the expression pattern of CD36 in a patient population with oral squamous cell carcinoma (OSCC) and to correlate CD36 expression with clinical and histopathological parameters. The hypothesis was that CD36 expression correlates with the occurrence of lymph node metastasis. Methods: To address the study objectives, a retrospective cohort study was conducted. Study variables included demographic, histopathological and survival data. CD36 expression patterns were assessed by immunohistochemistry on tissue microarrays (TMA). Logistic regression analysis, survival analysis and Cox proportional hazards model were performed. Results: High CD36 expression correlated significantly with a higher T-status, grading and occurrence of lymph node metastasis. The logistic regression with binary N status as a dependent variable showed that high CD36 expression increased the chance for lymph node metastasis 45-fold (OR = 44.7, 95% CI: 10.0-316). Patients with high CD36 expression had lower probabilities of progression-free survival. CD36 had a small and non-significant independent influence on progression-free survival. Conclusions: CD36 is expressed in OSCC and correlates with tumor grading, T-status, and especially the occurrence of lymph node metastasis. CD36 may be useful for risk stratification regarding lymph node metastasis in OSCC.
Language	English
Publishing date	2021-08-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers13164125
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: CAD reconstruction using contralateral mirrored anterior teeth: a 3-dimensional metric and visual evaluation.

Probst, Florian A / Mehl, Albert

The International journal of prosthodontics

2008 Volume 21, Issue 6, Page(s) 521–523

Abstract: This study evaluated the concept of computer-aided design of anterior teeth by integrating morphologic information about the mirrored contralateral teeth. With the aid of a digital 3-dimensional tooth library, ipsilateral teeth were automatically ... ...

Abstract	This study evaluated the concept of computer-aided design of anterior teeth by integrating morphologic information about the mirrored contralateral teeth. With the aid of a digital 3-dimensional tooth library, ipsilateral teeth were automatically mirrored, rotated, and translated to fit in the locations of the contralateral teeth. The reconstruction outcomes were evaluated via 3-dimensional similarity measures, measurements of approximal and antagonistic relationships, and visual ratings of experts. Metric and visual judgments indicate that integrating the shape of a symmetrically located contralateral anterior tooth seems to be a suitable base concept for computer-aided design of anterior restorations.
MeSH term(s)	Adolescent ; Adult ; Computer-Aided Design ; Cuspid/anatomy & histology ; Dental Models ; Dental Prosthesis Design ; Humans ; Imaging, Three-Dimensional ; Incisor/anatomy & histology ; Odontometry ; Tooth, Artificial ; Young Adult
Language	English
Publishing date	2008-11
Publishing country	United States
Document type	Evaluation Studies ; Journal Article
ZDB-ID	645046-5
ISSN	1942-4426 ; 0893-2174
ISSN (online)	1942-4426
ISSN	0893-2174
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