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Book ; Online ; Thesis: Konzept eines dynamischen Qualitätssicherungssystems für den Kontrollbereich Reproduktion in Milcherzeugerbetrieben

Probst, Monika

2008

Author's details	von Monika Anna Christina Probst
Subject code	637.1068
Language	German
Publishing country	Germany
Document type	Book ; Online ; Thesis
Thesis / German Habilitation thesis	München, Univ., Diss., 2008
Note	Open Access
HBZ-ID	HT015925127
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Bilateral juvenile osteochondrosis dissecans in monozygotic twins: a case report.

Bausch, Luca / Probst, Monika / Fritsch, Lorenz / Mehl, Julian / Siebenlist, Sebastian / Willinger, Lukas

Journal of orthopaedic surgery and research

2024 Volume 19, Issue 1, Page(s) 208

Abstract: Introduction: The etiology of osteochondrosis dissecans (OCD), a chondropathy associated with detachment of the subchondral bone and the overlaying cartilage, is not yet fully understood. While repetitive physical exercise-related stress is usually ... ...

Abstract	Introduction: The etiology of osteochondrosis dissecans (OCD), a chondropathy associated with detachment of the subchondral bone and the overlaying cartilage, is not yet fully understood. While repetitive physical exercise-related stress is usually assumed to be the main risk factor for the occurrence of OCD, genetic predisposition could have an underestimated influence on the development of the disease. Case report: We report a case of monozygotic twins with almost identical stages of bilateral osteochondrosis dissecans of the knee joint. In both patients, initially, a unilateral lesion occurred; despite restricted physical exercise, in the further course of the disease a lesion also developed on the contralateral side. While the lesion found most recently demonstrated an ongoing healing process at a 6-month follow-up, the other three lesions showed a natural course of healing under conservative treatment with significant clinical as well as radiological improvements after one year and complete consolidation in magnetic resonance imaging (MRI) after 2 years. Conclusion: There could be a genetic component to the development of OCD, although this has not yet been proven. Based on a two-year MRI follow-up, we were able to show the self-limiting characteristics of juvenile osteochondrosis dissecans.
MeSH term(s)	Humans ; Knee Joint/pathology ; Magnetic Resonance Imaging ; Osteochondritis Dissecans/diagnostic imaging ; Osteochondritis Dissecans/genetics ; Osteochondrosis/diagnostic imaging ; Osteochondrosis/genetics ; Radiography ; Twins, Monozygotic
Language	English
Publishing date	2024-04-01
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	2252548-8
ISSN	1749-799X ; 1749-799X
ISSN (online)	1749-799X
ISSN	1749-799X
DOI	10.1186/s13018-024-04683-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Visualization of clinically silent, odontogenic maxillary sinus mucositis originating from periapical inflammation using MRI: a feasibility study.

Burian, Egon / Feuerriegel, Georg / Sollmann, Nico / Burian, Gintare / Palla, Benjamin / Griesbauer, Magdalena / Bumm, Caspar / Probst, Monika / Beer, Meinrad / Folwaczny, Matthias

Clinical oral investigations

2023 Volume 27, Issue 7, Page(s) 3705–3712

Abstract: Objectives: Maxillary sinus mucositis is frequently associated with odontogenic foci. Periapical inflammation of maxillary molars and premolars cannot be visualized directly using radiation-based imaging. The purpose of this study was to answer the ... ...

Abstract	Objectives: Maxillary sinus mucositis is frequently associated with odontogenic foci. Periapical inflammation of maxillary molars and premolars cannot be visualized directly using radiation-based imaging. The purpose of this study was to answer the following clinical question: among patients with periapical inflammatory processes in the maxilla, does the use of magnetic resonance imaging (MRI), as compared to conventional periapical (AP) and panoramic radiography (OPT), improve diagnostic accuracy? Methods: Forty-two subjects with generalized periodontitis were scanned on a 3 T MRI. Sixteen asymptomatic subjects with mucosal swelling of the maxillary sinus were enrolled in the study. Periapical edema was assessed using short tau inversion recovery (STIR) sequence. Apical osteolysis and mucosal swelling were assessed by MRI, AP, and OPT imaging using the periapical index score (PAI). Comparisons between groups were performed with chi-squared tests with Yates' correction. Significance was set at p < 0.05. Results: Periapical lesions of maxillary premolars and molars were identified in 16 subjects, 21 sinuses, and 58 teeth. Bone edema and PAI scores were significantly higher using MRI as compared to OPT and AP (p < 0.05). Using the STIR sequence, a significant association of PAI score > 1 and the presence of mucosal swelling in the maxillary sinus was detected (p = 0.03). Conclusion: Periapical inflammation and maxillary mucositis could be visualized using STIR imaging. The use of MRI may help detect early, subtle inflammatory changes in the periapical tissues surrounding maxillary dentition. Early detection could guide diagnostic criteria, as well as treatment and prevention.
MeSH term(s)	Humans ; Maxillary Sinus/diagnostic imaging ; Maxillary Sinus/pathology ; Mucositis ; Feasibility Studies ; Inflammation/diagnostic imaging ; Inflammation/pathology ; Periapical Periodontitis/complications ; Magnetic Resonance Imaging ; Cone-Beam Computed Tomography/methods
Language	English
Publishing date	2023-04-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1364490-7
ISSN	1436-3771 ; 1432-6981
ISSN (online)	1436-3771
ISSN	1432-6981
DOI	10.1007/s00784-023-04986-4
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Article ; Online: Detection of caries lesions using a water-sensitive STIR sequence in dental MRI.

Burian, Egon / Lenhart, Nicolas / Greve, Tobias / Bodden, Jannis / Burian, Gintare / Palla, Benjamin / Probst, Florian / Probst, Monika / Beer, Meinrad / Folwaczny, Matthias / Schwarting, Julian

Scientific reports

2024 Volume 14, Issue 1, Page(s) 663

Abstract: In clinical practice, diagnosis of suspected carious lesions is verified by using conventional dental radiography (DR), including panoramic radiography (OPT), bitewing imaging, and dental X-ray. The aim of this study was to evaluate the use of magnetic ... ...

Abstract	In clinical practice, diagnosis of suspected carious lesions is verified by using conventional dental radiography (DR), including panoramic radiography (OPT), bitewing imaging, and dental X-ray. The aim of this study was to evaluate the use of magnetic resonance imaging (MRI) for caries visualization. Fourteen patients with clinically suspected carious lesions, verified by standardized dental examination including DR and OPT, were imaged with 3D isotropic T2-weighted STIR (short tau inversion recovery) and T1 FFE Black bone sequences. Intensities of dental caries, hard tissue and pulp were measured and calculated as aSNR (apparent signal to noise ratio) and aHTMCNR (apparent hard tissue to muscle contrast to noise ratio) in both sequences. Imaging findings were then correlated to clinical examination results. In STIR as well as in T1 FFE black bone images, aSNR and aHTMCNR was significantly higher in carious lesions than in healthy hard tissue (p < 0.001). Using water-sensitive STIR sequence allowed for detecting significantly lower aSNR and aHTMCNR in carious teeth compared to healthy teeth (p = 0.01). The use of MRI for the detection of caries is a promising imaging technique that may complement clinical exams and traditional imaging.
MeSH term(s)	Humans ; Dental Caries/diagnostic imaging ; Dental Caries Susceptibility ; Magnetic Resonance Imaging ; Chromosome Inversion ; Health Status
Language	English
Publishing date	2024-01-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-51151-2
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Article ; Online: Evaluating the effect of rapamycin treatment in Alzheimer's disease and aging using in vivo imaging: the ERAP phase IIa clinical study protocol.

Svensson, Jonas E / Bolin, Martin / Thor, Daniel / Williams, Pete A / Brautaset, Rune / Carlsson, Marcus / Sörensson, Peder / Marlevi, David / Spin-Neto, Rubens / Probst, Monika / Hagman, Göran / Morén, Anton Forsberg / Kivipelto, Miia / Plavén-Sigray, Pontus

BMC neurology

2024 Volume 24, Issue 1, Page(s) 111

Abstract: Background: Rapamycin is an inhibitor of the mechanistic target of rapamycin (mTOR) protein kinase, and preclinical data demonstrate that it is a promising candidate for a general gero- and neuroprotective treatment in humans. Results from mouse models ... ...

Abstract	Background: Rapamycin is an inhibitor of the mechanistic target of rapamycin (mTOR) protein kinase, and preclinical data demonstrate that it is a promising candidate for a general gero- and neuroprotective treatment in humans. Results from mouse models of Alzheimer's disease have shown beneficial effects of rapamycin, including preventing or reversing cognitive deficits, reducing amyloid oligomers and tauopathies and normalizing synaptic plasticity and cerebral glucose uptake. The "Evaluating Rapamycin Treatment in Alzheimer's Disease using Positron Emission Tomography" (ERAP) trial aims to test if these results translate to humans through evaluating the change in cerebral glucose uptake following six months of rapamycin treatment in participants with early-stage Alzheimer's disease. Methods: ERAP is a six-month-long, single-arm, open-label, phase IIa biomarker-driven study evaluating if the drug rapamycin can be repurposed to treat Alzheimer's disease. Fifteen patients will be included and treated with a weekly dose of 7 mg rapamycin for six months. The primary endpoint will be change in cerebral glucose uptake, measured using [ Discussion: The ERAP study is a clinical trial using in vivo imaging biomarkers to assess the repurposing of rapamycin for the treatment of Alzheimer's disease. If successful, the study would provide a strong rationale for large-scale evaluation of mTOR-inhibitors as a potential disease-modifying treatment in Alzheimer's disease. Trial registration: ClinicalTrials.gov ID NCT06022068, date of registration 2023-08-30.
MeSH term(s)	Animals ; Mice ; Humans ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/drug therapy ; Alzheimer Disease/complications ; Aging ; Cognition Disorders ; Positron-Emission Tomography/methods ; Glucose/metabolism ; TOR Serine-Threonine Kinases ; Amyloid beta-Peptides/cerebrospinal fluid ; Clinical Trials, Phase II as Topic
Chemical Substances	Glucose (IY9XDZ35W2) ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Amyloid beta-Peptides
Language	English
Publishing date	2024-04-04
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	2041347-6
ISSN	1471-2377 ; 1471-2377
ISSN (online)	1471-2377
ISSN	1471-2377
DOI	10.1186/s12883-024-03596-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Thesis: LEBENSRAUM UND LEBENSSTIL ANFALLSKRANKER

Probst, Monika

ERGEBNISSE EINER UNTERSUCHUNG, DURCHGEFUEHRT AN ELF KRANKEN UND DEREN FAMILIEN

1978

Size	159 S.
Document type	Book ; Thesis
Thesis / German Habilitation thesis	MAINZ, UNIV., FACHBEREICH 05 - 10 - MEDIZIN, DISS., 1978
HBZ-ID	HT002593593
Database	Catalogue ZB MED Medicine, Health

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79 D 1394	order for loan	Magazin

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Book ; Online ; Thesis: Konzept eines dynamischen Qualitätssicherungssystems für den Kontrollbereich Reproduktion in Milcherzeugerbetrieben

Probst, Monika

2008

Author's details	von Monika Anna Christina Probst
Language	German
Size	Online-Ressource
Document type	Book ; Online ; Thesis
Thesis / German Habilitation thesis	Univ., Diss--München, 2008
Database	Special collection on veterinary medicine and general parasitology

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Article: Digital planning and individual implants for secondary reconstruction of midfacial deformities: A pilot study.

Liokatis, Paris / Malenova, Yoana / Fegg, Florian-Nepomuk / Haidari, Selgai / Probst, Monika / Boskov, Marko / Cornelius, Carl-Peter / Troeltzsch, Matthias / Probst, Florian-Andreas

Laryngoscope investigative otolaryngology

2022 Volume 7, Issue 2, Page(s) 369–379

Abstract: Objective: To evaluate the feasibility and accuracy of implementing three-dimensional virtual surgical planning (VSP) and subsequent transfer by additive manufactured tools in the secondary reconstruction of residual post-traumatic deformities in the ... ...

Abstract	Objective: To evaluate the feasibility and accuracy of implementing three-dimensional virtual surgical planning (VSP) and subsequent transfer by additive manufactured tools in the secondary reconstruction of residual post-traumatic deformities in the midface. Methods: Patients after secondary reconstruction of post-traumatic midfacial deformities were included in this case series. The metrical deviation between the virtually planned and postoperative position of patient-specific implants (PSI) and bone segments was measured at corresponding reference points. Further information collected included demographic data, post-traumatic symptoms, and type of transfer tools. Results: Eight consecutive patients were enrolled in the study. In five patients, VSP with subsequent manufacturing of combined predrilling/osteotomy guides and PSI was performed. In three patients, osteotomy guides, repositioning guides, and individually prebent plates were used following VSP. The median distances between the virtually planned and the postoperative position of the PSI were 2.01 mm ( Conclusion: This study demonstrated the feasibility of VSP and transfer by additive manufactured tools for the secondary reconstruction of complex residual post-traumatic deformities in the midface. However, the median deviations observed in this case series were unexpectedly high. The use of navigational systems may further improve the level of accuracy.
Language	English
Publishing date	2022-02-04
Publishing country	United States
Document type	Journal Article
ISSN	2378-8038
ISSN	2378-8038
DOI	10.1002/lio2.753
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Magnetic resonance imaging based computer-guided dental implant surgery-A clinical pilot study.

Probst, Florian Andreas / Schweiger, Josef / Stumbaum, Maria Juliane / Karampinos, Dimitrios / Burian, Egon / Probst, Monika

Clinical implant dentistry and related research

2020 Volume 22, Issue 5, Page(s) 612–621

Abstract: Background: Computer-guided implant surgery is currently based on radiographic techniques exposing patients to ionizing radiation.: Purpose: To assess, whether computer-assisted 3D implant planning with template-guided placement of dental implants ... ...

Abstract	Background: Computer-guided implant surgery is currently based on radiographic techniques exposing patients to ionizing radiation. Purpose: To assess, whether computer-assisted 3D implant planning with template-guided placement of dental implants based on magnetic resonance imaging (MRI) is feasible. Materials and methods: 3-Tesla MRI was performed in 12 subjects as a basis for prosthetically driven virtual planning and subsequent guided implant surgery. To evaluate the transferability of the virtually planned implant position, deviations between virtually planned and resulting implant position were studied. Matching of occlusal surfaces was assessed by comparing surface scans with MRI-derived images. In addition, the overall image quality and the ability of depicting anatomically important structures were rated. Results: MRI-based guided implant surgery with subsequent prosthetic treatment was successfully performed in nine patients. Mean deviations between virtually planned and resulting implant position (error at entry point 0.8 ± 0.3 mm, error at apex 1.2 ± 0.6 mm, angular deviation 4.9 ± 3.6°), mean deviation of occlusal surfaces between surface scans and MRI-based tooth reconstructions (mean 0.254 ± 0.026 mm) as well as visualization of important anatomical structures were acceptable for clinical application. Conclusion: Magnetic resonance imaging (MRI) based computer-assisted implant surgery is a feasible and accurate procedure that avoids exposure to ionizing radiation.
MeSH term(s)	Computer-Aided Design ; Computers ; Cone-Beam Computed Tomography ; Dental Implantation, Endosseous ; Dental Implants ; Humans ; Imaging, Three-Dimensional ; Magnetic Resonance Imaging ; Patient Care Planning ; Pilot Projects ; Surgery, Computer-Assisted
Chemical Substances	Dental Implants
Language	English
Publishing date	2020-09-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2094300-3
ISSN	1708-8208 ; 1523-0899
ISSN (online)	1708-8208
ISSN	1523-0899
DOI	10.1111/cid.12939
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Article ; Online: MRI-detected intraosseous bone marrow edema recedes after effective therapy of periodontitis.

Schwarting, Julian / Probst, Florian Andreas / Griesbauer, Magdalena / Robl, Teresa / Burian, Egon / Wiestler, Benedikt / Brunner, Teresa / Malenova, Yoana / Bumm, Caspar / Folwaczny, Matthias / Probst, Monika

European radiology

2023

Abstract: Objectives: T2 STIR MRI sequences can detect preclinical changes associated with periodontal inflammation, i.e. intraosseous edema in the tooth-supporting bone. In this study, we assessed whether MRI can be used for monitoring periodontal disease.: ... ...

Abstract	Objectives: T2 STIR MRI sequences can detect preclinical changes associated with periodontal inflammation, i.e. intraosseous edema in the tooth-supporting bone. In this study, we assessed whether MRI can be used for monitoring periodontal disease. Material and methods: In a prospective cohort study, we examined 35 patients with periodontitis between 10/2018 and 04/2019 by using 3D isotropic T2-weighted short tau inversion recovery (STIR) and Fast Field Echo T1-weighted Black bone sequences. All patients received standardized clinical exams before and three months after non-surgical periodontal therapy. Bone marrow edema extent was quantified in the STIR sequence at 922 sites before and after treatment. Results were compared with standard clinical findings. Non-parametric statistical analysis was performed. Results: Non-surgical periodontal treatment caused significant improvement in mean probing depth (p < 0.001) and frequency of bleeding on probing (p < 0.001). The mean depth of osseous edema per site was reduced from a median [IQR] of 2 [1, 3] mm at baseline to 1 [0, 3] mm, (p < 0.001). Periodontal treatment reduced the frequency of sites with edema from 35 to 24% (p < 0.01). Conclusion: The decrease of periodontal bone marrow edema, as observed with T2 STIR MR imaging, is indicative of successful periodontal healing. Clinical relevance statement: T2 STIR hyperintense bone marrow edema in the periodontal bone decreases after treatment and can therefore be used to evaluate treatment success. Furthermore, MRI reveals new options to depict hidden aspects of periodontitis. Key points: • T2 STIR hyperintense periodontal intraosseous edema was prospectively investigated in 35 patients with periodontitis before and after treatment and compared to clinical outcomes. • The frequency of affected sites was reduced from 35 to 24% (p < 0.001), and mean edema depth was reduced from a median [IQR] of 2 [1, 3] mm at baseline to 1 [0, 3] mm 3 months after treatment. (p < 0.001). • T2 STIR sequences can be used to monitor the posttreatment course of periodontitis.
Language	English
Publishing date	2023-10-19
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1085366-2
ISSN	1432-1084 ; 0938-7994 ; 1613-3749
ISSN (online)	1432-1084
ISSN	0938-7994 ; 1613-3749
DOI	10.1007/s00330-023-10327-6
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