Article ; Online: The Effect of Fermentable, Oligosaccharides, Disaccharides, Monosaccharides, and Polyols (FODMAP) Meals on Transient Lower Esophageal Relaxations (TLESR) in Gastroesophageal Reflux Disease (GERD) Patients with Overlapping Irritable Bowel Syndrome (IBS).
2022 Volume 14, Issue 9
Abstract: A randomized crossover study in eight patients (6 F, age 57 ± 13) with overlapping GERD-IBS (non-constipation) was conducted to evaluate the effects of rice noodle vs. wheat noodle meals for breakfast and lunch on postprandial TLESR, intestinal gas ... ...
| Abstract | A randomized crossover study in eight patients (6 F, age 57 ± 13) with overlapping GERD-IBS (non-constipation) was conducted to evaluate the effects of rice noodle vs. wheat noodle meals for breakfast and lunch on postprandial TLESR, intestinal gas production, and GERD/GI symptoms. Results: Wheat ingestion was significantly associated with more frequent TLESR after lunch than rice (5.0 ± 0.7 vs. 1.9 ± 0.3 times/2 h, p = 0.01). After lunch, wheat ingestion was significantly associated with higher H2 and CH4 levels compared to rice ingestion (p < 0.05), while H2 and CH4 levels before lunch were similar (p > 0.05). The area under curve of H2 concentration until 2 h after lunch significantly correlated with the TLESR number (r = 0.69, p = 0.04). Postprandial regurgitation (2.9 ± 1.2 vs. 0.4 ± 0.2), bloating (7.0 ± 0.4 vs. 3.1 ± 0.9), satiety (7.7 ± 0.4 vs. 3.5 ± 0.9), and belching (3.8 ± 1.2 vs. 1.1 ± 0.6) symptom scores were significantly greater after wheat compared to rice noodle ingestion (p < 0.05). Conclusion: Wheat noodle meals, part of a high FODMAP diet, induced a higher frequency of TLESRs, a higher GERD, and higher upper-GI symptom scores than rice noodle meals, part of a low FODMAP diet, in patients with overlapping IBS-GERD. These effects were associated with more intestinal gas production. Thus, a low FODMAP diet may relieve GERD symptoms in GERD patients with overlapping IBS. |
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| MeSH term(s) | Adult ; Aged ; Cross-Over Studies ; Diet, Carbohydrate-Restricted ; Disaccharides ; Fermentation ; Gastroesophageal Reflux ; Humans ; Irritable Bowel Syndrome ; Meals ; Middle Aged ; Monosaccharides ; Oligosaccharides ; Oryza ; Polymers ; Triticum |
| Chemical Substances | Disaccharides ; Monosaccharides ; Oligosaccharides ; Polymers ; polyol |
| Language | English |
| Publishing date | 2022-04-22 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Randomized Controlled Trial |
| ZDB-ID | 2518386-2 |
| ISSN | 2072-6643 ; 2072-6643 |
| ISSN (online) | 2072-6643 |
| ISSN | 2072-6643 |
| DOI | 10.3390/nu14091755 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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