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Book ; Online ; E-Book: Brain metastases

Dolgushin, Mikhail / Kornienko, Valery N. / Pronin, Igor

advanced neuroimaging

2018

Author's details	by Mikhail Dolgushin, Valery Kornienko, Igor Pronin
Keywords	Medicine ; Neuroradiology ; Neurosurgery ; Medicine & Public Health
Language	English
Size	1 Online-Ressource (xiii, 469 Seiten), Illustrationen, Diagramme
Publisher	Springer
Publishing place	Cham
Publishing country	Switzerland
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT019516813
ISBN	978-3-319-57760-9 ; 9783319577586 ; 3-319-57760-3 ; 3319577581
DOI	10.1007/978-3-319-57760-9
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: The Bi-(AID-1-T) G-Quadruplex Has a Janus Effect on Primary and Recurrent Gliomas: Anti-Proliferation and Pro-Migration.

Pavlova, Svetlana / Fab, Lika / Savchenko, Ekaterina / Ryabova, Anastasia / Ryzhova, Marina / Revishchin, Alexander / Pronin, Igor / Usachev, Dmitry / Kopylov, Alexey / Pavlova, Galina

Pharmaceuticals (Basel, Switzerland)

2024 Volume 17, Issue 1

Abstract: High-grade gliomas are considered an incurable disease. Despite all the various therapy options available, patient survival remains low, and the tumor usually returns. Tumor resistance to conventional therapy and stimulation of the migratory activity of ... ...

Abstract	High-grade gliomas are considered an incurable disease. Despite all the various therapy options available, patient survival remains low, and the tumor usually returns. Tumor resistance to conventional therapy and stimulation of the migratory activity of surviving cells are the main factors that lead to recurrent tumors. When developing new treatment approaches, the effect is most often evaluated on standard and phenotypically depleted cancer cell lines. Moreover, there is much focus on the anti-proliferative effect of such therapies without considering the possible stimulation of migratory activity. In this paper, we studied how glioma cell migration changes after exposure to bi-(AID-1-T), an anti-proliferative aptamer. We investigated the effect of this aptamer on eight human glioma cell cultures (Grades III and IV) that were derived from patients' tumor tissue; the difference between primary and recurrent tumors was taken into account. Despite its strong anti-proliferative activity, bi-(AID-1-T) was shown to induce migration of recurrent tumor cells. This result shows the importance of studying the effect of therapeutic molecules on the invasive properties of glioma tumor cells in order to reduce the likelihood of inducing tumor recurrence.
Language	English
Publishing date	2024-01-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph17010074
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Article ; Online: Radiomics Enhances Diagnostic and Prognostic Value of Diffusion Kurtosis Imaging in Diffuse Axonal Injury.

Danilov, Gleb / Afandiev, Ramin / Pogosbekyan, Eduard / Goraynov, Sergey / Pronin, Igor / Zakharova, Natalia

Studies in health technology and informatics

2023 Volume 309, Page(s) 287–291

Abstract: The aim of our study was to investigate the potential of advanced radiomics in analyzing diffusion kurtosis MRI (DKI) to increase the informativeness of DKI in diffuse axonal injury (DAI). We hypothesized that DKI radiomic features could be used to ... ...

Abstract	The aim of our study was to investigate the potential of advanced radiomics in analyzing diffusion kurtosis MRI (DKI) to increase the informativeness of DKI in diffuse axonal injury (DAI). We hypothesized that DKI radiomic features could be used to detect microstructural brain injury and predict outcomes in DAI. The study enrolled 31 patients with DAI (mean age 31.48 ± 11.10 years, 8 (25.8%) female) and 12 healthy volunteers (mean age 33.67 ± 11.06 years, 4 (33.3%) female). A total of 342,300 radiomic features were calculated (2282 features per each combination of 10 parametric DKI maps with 15 ROIs). Our results showed that several radiomic features were capable of distinguishing between healthy and injured brain tissue and accurately predicting outcomes with an accuracy of over 0.9. Advanced DKI radiomic features show high diagnostic and prognostic potential in DAI and may outperform average ROI values in DKI maps.
MeSH term(s)	Humans ; Female ; Young Adult ; Adult ; Male ; Prognosis ; Diffuse Axonal Injury/diagnostic imaging ; Diffusion Tensor Imaging/methods ; Diffusion Magnetic Resonance Imaging/methods ; Brain
Language	English
Publishing date	2023-11-01
Publishing country	Netherlands
Document type	Journal Article
ISSN	1879-8365
ISSN (online)	1879-8365
DOI	10.3233/SHTI230798
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Article ; Online: Median trans-atlanto-occipital membrane microsurgical approach to the posterior cranial fossa without craniotomy.

Pitskhelauri, David / Sufianov, Rinat / Konovalov, Alexander / Pronin, Igor / Sanikidze, Alexander

Journal of neurosurgery

2022 Volume 138, Issue 2, Page(s) 374–381

Abstract: Minimally invasive approaches are becoming increasingly popular and contributing to improving the results of the surgical treatment of a wide variety of intracranial pathologies. Fifteen patients with posterior cranial fossa tumors underwent microsurgery ...

Abstract	Minimally invasive approaches are becoming increasingly popular and contributing to improving the results of the surgical treatment of a wide variety of intracranial pathologies. Fifteen patients with posterior cranial fossa tumors underwent microsurgery through the atlanto-occipital membrane without resection of any bone structures. Tumors were localized in the brainstem in 8 patients and in the fourth ventricle in 7 patients. According to preoperative MRI and CT scans, the distance between the posterior arch of the atlas and the opisthion ranged from 9.9 to 16.5 mm (median 13 mm). The surgery was performed with the patient in the prone position and the head flexed. The trajectory of the surgical approach was directed from the skin incision located above the C2 spinous process 3.5-4 cm rostral along the midline. Total tumor resection was performed in 10 patients, subtotal resection in 2 patients, partial resection in 1 patient, and open biopsy in 2 patients. Surgical complications occurred in only 1 patient (meningoencephalitis). This minimally invasive trans-atlanto-occipital membrane approach for posterior cranial fossa tumors provides adequate visualization of the caudal part of the fourth ventricle and brainstem when the anthropometric parameters of the patient are suitable.
MeSH term(s)	Humans ; Craniotomy/methods ; Neurosurgical Procedures/methods ; Brain Neoplasms/surgery ; Fourth Ventricle/diagnostic imaging ; Fourth Ventricle/surgery ; Cranial Fossa, Posterior/diagnostic imaging ; Cranial Fossa, Posterior/surgery
Language	English
Publishing date	2022-07-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	3089-2
ISSN	1933-0693 ; 0022-3085
ISSN (online)	1933-0693
ISSN	0022-3085
DOI	10.3171/2022.5.JNS22111
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Article ; Online: Magnetic resonance relaxometry in quantitative imaging of brain gliomas: A literature review.

Chekhonin, Ivan V / Cohen, Ouri / Otazo, Ricardo / Young, Robert J / Holodny, Andrei I / Pronin, Igor N

The neuroradiology journal

2023 , Page(s) 19714009231173100

Abstract: Magnetic resonance (MR) relaxometry is a quantitative imaging method that measures tissue relaxation properties. This review discusses the state of the art of clinical proton MR relaxometry for glial brain tumors. Current MR relaxometry technology also ... ...

Abstract	Magnetic resonance (MR) relaxometry is a quantitative imaging method that measures tissue relaxation properties. This review discusses the state of the art of clinical proton MR relaxometry for glial brain tumors. Current MR relaxometry technology also includes MR fingerprinting and synthetic MRI, which solve the inefficiencies and challenges of earlier techniques. Despite mixed results regarding its capability for brain tumor differential diagnosis, there is growing evidence that MR relaxometry can differentiate between gliomas and metastases and between glioma grades. Studies of the peritumoral zones have demonstrated their heterogeneity and possible directions of tumor infiltration. In addition, relaxometry offers T2* mapping that can define areas of tissue hypoxia not discriminated by perfusion assessment. Studies of tumor therapy response have demonstrated an association between survival and progression terms and dynamics of native and contrast-enhanced tumor relaxometric profiles. In conclusion, MR relaxometry is a promising technique for glial tumor diagnosis, particularly in association with neuropathological studies and other imaging techniques.
Language	English
Publishing date	2023-05-03
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2257770-1
ISSN	2385-1996 ; 1971-4009 ; 1120-9976
ISSN (online)	2385-1996
ISSN	1971-4009 ; 1120-9976
DOI	10.1177/19714009231173100
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Article: The Role of 3D-pCASL MRI in the Differential Diagnosis of Glioblastoma and Brain Metastases.

Solozhentseva, Kristina / Batalov, Artem / Zakharova, Natalia / Goryaynov, Sergey / Pogosbekyan, Eduard / Pronin, Igor

Frontiers in oncology

2022 Volume 12, Page(s) 874924

Abstract: Purpose: The first aim of this study was to compare the intratumoral and peritumoral blood flow parameters in glioblastomas and brain metastases measured by pseudocontinuous arterial spin labeling MRI (3D pCASL). The second aim of this study was to ... ...

Abstract	Purpose: The first aim of this study was to compare the intratumoral and peritumoral blood flow parameters in glioblastomas and brain metastases measured by pseudocontinuous arterial spin labeling MRI (3D pCASL). The second aim of this study was to determine whether pCASL could aid in identifying the source of brain metastases. Materials and methods: This study included 173 patients aged 12 to 83 years (median age-61 years), who were observed at the National Medical Research Center for Neurosurgery. All patients underwent preoperative MRI with pCASL perfusion. Thereafter patients were operated on and received histological diagnosis. No patients received preoperative chemo or radiotherapy. Results: The values of maximum and normalized intratumoral blood flow were significantly higher in the group with gliblastoma than in the group with brain metastases: 168.98 + -91.96 versus 152.1 + -173.32 and 7.6 + -8.4 versus 9.3 + -5.33 respectively (p <0.01). However, ROC analysis showed low AUC specificity and sensitivity (0.64, 70%, 60% for mTBF and 0.66, 77%, 62% for nTBF). Peritumoral blood flow parameters were also higher in the glioblastoma group (29.61 + -22.89 versus 16.58 + -6.46 for mTBF and 1.63 + -1.14 versus 0.88 + -0.38 for nTBF, respectively; p <0.01). ROC analysis showed the following measurements of AUC, specificity, and sensitivity (0.75, 68%, 73% for mTBF and 0.77, 58%, 91% for nTBF). Regarding pCASL and various histological subsets of brain metastases, the study found statistically significant differences between the lung and melanoma metastases and the lung and kidney metastases. ROC analysis gave the following values for lung and melanoma metastases: AUC-0.76, specificity-75%, and sensitivity-73% for mTBF; 0.83, 67%, and 93% respectively, for nTBF. For lung and kidney metastases: AUC-0.74, specificity-70%, and sensitivity-93% for mTBF; 0.75, 70%, and 93% respectively, for nTBF. Conclusions: pCASL could aid in differential diagnosis between glioblastoma and brain metastases. Measurement of peritumoral blood flow demonstrates higher specificity and sensitivity than with intratumoral blood flow. Moreover, pCASL provides the ability to distinguish lung metastases from kidney and melanoma metastases.
Language	English
Publishing date	2022-04-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2022.874924
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Article ; Online: The Assessment of Glioblastoma Metabolic Activity via 11C-Methionine PET and Radiomics.

Danilov, Gleb / Kalaeva, Diana / Vikhrova, Nina / Konakova, Tatiana / Zagorodnova, Anna / Popova, Angelina / Postnov, Andrey / Shugay, Svetlana / Shifrin, Michael / Pronin, Igor

Studies in health technology and informatics

2023 Volume 302, Page(s) 972–976

Abstract: Nowadays, the quantitative analysis of PET/CT data in patients with glioblastoma is not strictly standardized in the clinic and does not exclude the human factor. This study aimed to evaluate the relationship between the radiomic features of glioblastoma ...

Abstract	Nowadays, the quantitative analysis of PET/CT data in patients with glioblastoma is not strictly standardized in the clinic and does not exclude the human factor. This study aimed to evaluate the relationship between the radiomic features of glioblastoma 11C-methionine PET images and the tumor-to-normal brain (T/N) ratio determined by radiologists in clinical routine. PET/CT data were obtained for 40 patients (mean age 55 ± 12 years; 77.5% men) with a histologically confirmed diagnosis of glioblastoma. Radiomic features were calculated for the whole brain and tumor-containing regions of interest using the RIA package for R. We redesigned the original RIA functions for GLCM and GLRLM calculation to reduce computation time significantly. Machine learning over radiomic features was applied to predict T/N with the best median correlation between the true and predicted values of 0.73 (p = 0.01). The present study showed a reproducible linear relationship between 11C-methionine PET radiomic features and a T/N indicator routinely assessed in brain tumors. Radiomics enabled utilizing texture properties of PET/CT neuroimaging that may reflect the biological activity of glioblastoma and can potentially augment the radiological assessment.
MeSH term(s)	Male ; Humans ; Adult ; Middle Aged ; Aged ; Female ; Glioblastoma/diagnostic imaging ; Positron Emission Tomography Computed Tomography ; Carbon Radioisotopes ; Positron-Emission Tomography/methods ; Methionine ; Retrospective Studies
Chemical Substances	Carbon-11 ; Carbon Radioisotopes ; carbon-11 methionine (58576-49-1) ; Methionine (AE28F7PNPL)
Language	English
Publishing date	2023-05-19
Publishing country	Netherlands
Document type	Journal Article
ISSN	1879-8365
ISSN (online)	1879-8365
DOI	10.3233/SHTI230320
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Article ; Online: Optical Differentiation of Brain Tumors Based on Raman Spectroscopy and Cluster Analysis Methods.

Ospanov, Anuar / Romanishkin, Igor / Savelieva, Tatiana / Kosyrkova, Alexandra / Shugai, Svetlana / Goryaynov, Sergey / Pavlova, Galina / Pronin, Igor / Loschenov, Victor

International journal of molecular sciences

2023 Volume 24, Issue 19

Abstract: In the present study, various combinations of dimensionality reduction methods with data clustering methods for the analysis of biopsy samples of intracranial tumors were investigated. Fresh biopsies of intracranial tumors were studied in the Laboratory ... ...

Abstract	In the present study, various combinations of dimensionality reduction methods with data clustering methods for the analysis of biopsy samples of intracranial tumors were investigated. Fresh biopsies of intracranial tumors were studied in the Laboratory of Neurosurgical Anatomy and Preservation of Biological Materials of N.N. Burdenko Neurosurgery Medical Center no later than 4 h after surgery. The spectra of Protoporphyrin IX (Pp IX) fluorescence, diffuse reflectance (DR) and Raman scattering (RS) of biopsy samples were recorded. Diffuse reflectance studies were carried out using a white light source in the visible region. Raman scattering spectra were obtained using a 785 nm laser. Patients diagnosed with meningioma, glioblastoma, oligodendroglioma, and astrocytoma were studied. We used the cluster analysis method to detect natural clusters in the data sample presented in the feature space formed based on the spectrum analysis. For data analysis, four clustering algorithms with eight dimensionality reduction algorithms were considered.
MeSH term(s)	Humans ; Spectrum Analysis, Raman/methods ; Brain Neoplasms/pathology ; Astrocytoma ; Glioblastoma/pathology ; Meningeal Neoplasms
Language	English
Publishing date	2023-09-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241914432
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Article: Spinal dural cerebrospinal fluid fistula as a cause of spontaneous intracranial hypotension syndrome: Diagnosis and surgical treatment.

Konovalov, Anton / Grebenev, Fyodor / Asyutin, Dmitry / Zakirov, Bahromon / Konovalov, Nikolay / Pronin, Igor / Eliava, Shalva / Chaurasia, Bipin

Journal of craniovertebral junction & spine

2023 Volume 14, Issue 1, Page(s) 108–112

Abstract: Spontaneous intracranial hypotension (SIH) syndrome most often occurs following a cerebrospinal fluid (CSF) fistula that develops in the spinal space. Neurologists and neurosurgeons lack an understanding of the pathophysiology and diagnosis of this ... ...

Abstract	Spontaneous intracranial hypotension (SIH) syndrome most often occurs following a cerebrospinal fluid (CSF) fistula that develops in the spinal space. Neurologists and neurosurgeons lack an understanding of the pathophysiology and diagnosis of this disease, which can make timely surgical care difficult. With the correct diagnostic algorithm, it is possible to identify the exact location of the liquor fistula in 90% of cases; subsequent microsurgical treatment can save the patient from the symptoms of intracranial hypotension and restore the ability to work. Female patient, 57 years old, was admitted with SIH syndrome. Magnetic resonance imaging (MRI) of the brain with contrast confirmed signs of intracranial hypotension. Computed tomography (CT) myelography was performed to pinpoint the location of the CSF fistula. The diagnostic algorithm and successful microsurgical treatment of a patient with spinal dural CSF fistula at the Th3-4 level using a posterolateral transdural approach. The patient was discharged on day 3 after the surgery when these complaints regressed completely. At the control examination of the patient 4 months postoperatively, there were no complaints. Identification of the cause and location of spinal the CSF fistula is a complex process that requires several stages of diagnosis. Examination of the entire back with MRI, CT myelography, or subtraction dynamic myelography is recommended. Microsurgical repair of a spinal fistula is an effective method for the treatment of SIH. The posterolateral transdural approach is effective in the repair of a spinal CSF fistula located ventrally in the thoracic spine.
Language	English
Publishing date	2023-03-13
Publishing country	India
Document type	Case Reports
ZDB-ID	2573344-8
ISSN	0976-9285 ; 0974-8237
ISSN (online)	0976-9285
ISSN	0974-8237
DOI	10.4103/jcvjs.jcvjs_135_22
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Article ; Online: Cerebellar anaplastic astrocytoma in adult patients: 15 consecutive cases from a single institution and literature review.

Belyaev, Artem / Usachev, Dmitry / Ryzhova, Marina / Gulida, Gleb / Skvortsova, Vasilisa / Pronin, Igor / Kobiakov, Grigory

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

2021 Volume 91, Page(s) 249–254

Abstract: Adult cerebellar anaplastic astrocytomas (cAA) are rare entities and their clinical and genetic appearances are still ill defined. Previously, malignant gliomas of the cerebellum were combined and reviewed together (cAA and cerebellar glioblastomas (cGB), ...

Abstract	Adult cerebellar anaplastic astrocytomas (cAA) are rare entities and their clinical and genetic appearances are still ill defined. Previously, malignant gliomas of the cerebellum were combined and reviewed together (cAA and cerebellar glioblastomas (cGB), that could have possibly affected overall survival (OS) and progression-free survival (PFS). We present characteristics of 15 adult patients with cAA and compared them to a series of 45 patients with a supratentorial AA (sAA) in order to elicit the effect of tumor location on OS and PFS. The mean age at cAA diagnosis was 39.3 years (range 19-72). A history of neurofibromatosis type I was noted in 1 patient (6.7%). An IDH-1 mutation was identified in 6/15 cases and a methylated MGMT promoter in 5/15 cases. Patients in study and control groups were matched in age, sex and IDH-1 mutation status. Patients in a study group tended to present with longer overall survival (50 vs. 36.5 months), but the difference did not reach statistical significance. In both cAA and supratentorial AA groups presence of the IDH-1 mutation remains a positive predictor for the prolonged survival. The present study suggests that adult cAA constitute a group of gliomas with relatively higher rate of IDH-1 mutations and prognosis similar to supratentorial AA. The present study is the first to systematically compare cAA and supratentorial AA with respect to their genetic characteristics and suggests that both groups show a similar survival prognosis.
MeSH term(s)	Adult ; Aged ; Astrocytoma ; Brain Neoplasms/genetics ; Brain Neoplasms/therapy ; Humans ; Isocitrate Dehydrogenase/genetics ; Middle Aged ; Mutation ; Prognosis ; Young Adult
Chemical Substances	Isocitrate Dehydrogenase (EC 1.1.1.41)
Language	English
Publishing date	2021-07-22
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	1193674-5
ISSN	1532-2653 ; 0967-5868
ISSN (online)	1532-2653
ISSN	0967-5868
DOI	10.1016/j.jocn.2021.07.010
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