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Article: Questions around a case of

Gerard, Delphine / Callies, Arnaud / Simon, Laure / Ternisien, Catherine / Prot-Labarthe, Sonia

European journal of hospital pharmacy : science and practice

2023

Abstract: We report the case of a preterm infant presenting a thrombosis, discovered on ultrasound at 22 weeks of gestational age and confirmed at birth following additional examinations. We describe the anticoagulant treatment of this patient by intravenous ... ...

Abstract	We report the case of a preterm infant presenting a thrombosis, discovered on ultrasound at 22 weeks of gestational age and confirmed at birth following additional examinations. We describe the anticoagulant treatment of this patient by intravenous enoxaparin, tinzaparin and rivaroxaban, from questioning to practice.
Language	English
Publishing date	2023-09-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2650179-X
ISSN	2047-9964 ; 2047-9956
ISSN (online)	2047-9964
ISSN	2047-9956
DOI	10.1136/ejhpharm-2023-003826
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Article: Cas clinique illustré autour d’un patient atteint d’un syndrome inflammatoire multisystémique pédiatrique.

Le Guen, Camille / Leroy, Estelle / Pennetier, Martine / Launay, Élise / Bichali, Saïd / Prot-Labarthe, Sonia

Soins. Pediatrie, puericulture

2023 Volume 44, Issue 335, Page(s) 42–47

Abstract: Between November 2020 and June 2021, twelve children were treated at a university hospital in western France for pediatric multisystem inflammatory syndrome (PIMS). While the clinical presentation may have been reminiscent of Kawasaki disease, PIMS, a ... ...

Title translation	Illustrated case study of a patient with pediatric multisystem inflammatory syndrome.
Abstract	Between November 2020 and June 2021, twelve children were treated at a university hospital in western France for pediatric multisystem inflammatory syndrome (PIMS). While the clinical presentation may have been reminiscent of Kawasaki disease, PIMS, a new nosological entity, was mentioned in the media in the context of the Covid-19 pandemic. In 2023, research into this syndrome will continue in France and Europe.
MeSH term(s)	Child ; Humans ; SARS-CoV-2 ; Pandemics ; COVID-19 ; France
Language	French
Publishing date	2023-11-08
Publishing country	France
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	1234484-9
ISSN	2214-9325 ; 1259-4792
ISSN (online)	2214-9325
ISSN	1259-4792
DOI	10.1016/j.spp.2023.10.010
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Article ; Online: Exploration of the barriers and enablers of benzodiazepines deprescribing in prisons: A qualitative study among health and social care professionals.

Fay, Clothilde / Bonsergent, Marion / Saillard, Justine / Huon, Jean-François / Prot-Labarthe, Sonia

Basic & clinical pharmacology & toxicology

2023 Volume 134, Issue 1, Page(s) 28–38

Abstract: Background: The prison environment is a place of high consumption of benzodiazepines (BZDs) due to the anxiety and sleep disturbances, mental disorders, detoxification and trafficking.: Objective: The study aims to explore experiences of health and ... ...

Abstract	Background: The prison environment is a place of high consumption of benzodiazepines (BZDs) due to the anxiety and sleep disturbances, mental disorders, detoxification and trafficking. Objective: The study aims to explore experiences of health and social care professionals on the use of BZDs in prisons, as well as the barriers and enablers to their deprescribing. Method: Semistructured individual interviews with professionals working in a prison setting were performed between March and April 2022, based on an interview guide. They were recorded and transcribed using the NVivo software. A qualitative analysis using an inductive approach based on a thematic analysis was performed. Results: Sixteen health professionals were interviewed, including psychiatrists, general practitioners, nurses, pharmacists, psychologists, musicologists and pharmacy technicians. The identified barriers to deprescribing BZDs were problems of coordination between prescribers, lack of time and alternatives. Concerning the enablers, therapeutic education groups, staff's awareness of the irrelevance of some medication and multi-professional advice were identified. Discussion: This study highlights the similarities in deprescribing difficulties between prison and other settings. Some of the levers identified in our study have shown their effectiveness in different settings. Conclusion: Deprescribing is done most of the time in good conditions but requires an additional delay compared to the outside environment.
MeSH term(s)	Humans ; Prisons ; Deprescriptions ; Benzodiazepines/adverse effects ; Qualitative Research ; General Practitioners
Chemical Substances	Benzodiazepines (12794-10-4)
Language	English
Publishing date	2023-06-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2134679-3
ISSN	1742-7843 ; 1742-7835
ISSN (online)	1742-7843
ISSN	1742-7835
DOI	10.1111/bcpt.13910
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Article ; Online: The experience of being a caregiver of patients with digestive cancer, from patients and caregivers' perception: A mixed study.

Grivel, Charlotte / Nizet, Pierre / Martin, Manon / Pécout, Solange / Lepeintre, Aurélie / Touchefeu, Yann / Prot-Labarthe, Sonia / Evin, Adrien / Huon, Jean-François

PloS one

2023 Volume 18, Issue 7, Page(s) e0287335

Abstract: Backgrounds: Caregivers are essential in the care of a patient with digestive cancer. Considering their experience and needs is crucial.: Objectives: To explore the experience of caregivers of patients with digestive cancer and to compare the ... ...

Abstract	Backgrounds: Caregivers are essential in the care of a patient with digestive cancer. Considering their experience and needs is crucial. Objectives: To explore the experience of caregivers of patients with digestive cancer and to compare the perspectives of patients and caregivers. Methods: A mixed-methods study with a cross-sectional prospective and a comprehensive qualitative dimension was performed in a medical oncology unit in a French tertiary hospital. Dyads made of patients with digestive cancer and their caregiver were recruited. The Caregiver Reaction Assessment (CRA) and the Supportive Care Needs Survey for Partners and Caregivers (SCNS-PC) questionnaires were distributed to caregivers. The CRA was used to measure the caregiver burden and the SCNS-PC was used to identify the unmet supportive care needs of caregivers. Semi-structured interviews with the dyads were conducted. Qualitative interviews addressed various dimensions of the caregiver's experience from each dyad's member perspective. Results: Thirty-two caregivers completed the questionnaires. Responses showed high self-esteem, schedule burden, and a need for care and information services. Ten dyads participated in the interviews. Three themes emerged from the caregiver's interviews: illness is an upheaval; loneliness and helplessness are experienced; caring is a natural role with positive outcomes. Four themes emerged from patient's interviews: the caregiver naturally assumes the role and gets closer; he is the patient's anchor; his life is disrupted; anxiety and guilt accompany the desire to protect him. In comparing patient and caregiver data, the main theme of disagreement was their relationship. Conclusions: Caregiver care does not appear to be optimal, particularly in terms of their need for information. Patients have a fairly good representation of their experience, but the caregivers' opinion need to be considered.
MeSH term(s)	Humans ; Male ; Caregivers ; Cross-Sectional Studies ; Prospective Studies ; Gastrointestinal Neoplasms ; Perception ; Quality of Life
Language	English
Publishing date	2023-07-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0287335
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Article ; Online: Observational and prospective study: evaluation of beliefs and representations of chronic treatments of polymedicated patients hospitalised in a vascular medicine and surgery department.

Kotry, Dounia / Saillard, Justine / Bonsergent, Marion / Volteau, Christelle / Benichou, Antoine / Prot-Labarthe, Sonia / Huon, Jean-François

BMJ open

2023 Volume 13, Issue 12, Page(s) e073250

Abstract: Objectives: Today, the involvement of patients in their care is essential. As the population ages increases, the number of patients with chronic diseases is increasing. In the vascular medicine and surgery departments, patients are polymedicated and ... ...

Abstract	Objectives: Today, the involvement of patients in their care is essential. As the population ages increases, the number of patients with chronic diseases is increasing. In the vascular medicine and surgery departments, patients are polymedicated and mostly suffer from several chronic diseases. Approximately 50% of patients with a chronic disease are not adherent. Among the factors that can influence therapeutic adherence are the beliefs and representations of patients.To evaluate the beliefs and representations of chronic treatments in patients with multiple medications and hospitalised in a vascular medicine and surgery department, and to evaluate the medication adherence, the knowledge and the importance patients attach to their treatments. Design: Observational, prospective and a single-centre study. Setting: The study was conducted in a French tertiary hospital centre of around 3000 beds in 9 institutions. Participants: Adult polymedicated (ie, minimum of five chronic treatments) patients hospitalised in a vascular medicine and surgery department were included after application of the exclusion criteria. Methods: Patient interviews were carried out in the department and were based on three interviewer-administered questionnaires (a global questionnaire, the Belief Medical Questionnaire and the GIRERD questionnaire). Results: Our study showed that patients perceived their treatments as beneficial rather than worrying. A correlation between medication adherence and beliefs was observed. 'Non-adherent'patients had a more negative overall view of medication than 'adherent' patients. The level of compliance and knowledge of our patients was low. Only 11% of the patients were 'good adherent', 16% of the patients could perfectly name their treatment and 36% knew all the indications. Conclusion: Knowledge of treatment representation and beliefs are central to understanding patient behaviour. Considering patients' representations will allow the identification of levers, and the development of actions and educational tools adapted to improve their adherence, their knowledge and therefore their drug management.
MeSH term(s)	Adult ; Humans ; Prospective Studies ; Health Knowledge, Attitudes, Practice ; Surveys and Questionnaires ; Chronic Disease ; Medication Adherence ; Cardiology
Language	English
Publishing date	2023-12-13
Publishing country	England
Document type	Observational Study ; Journal Article
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-073250
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Article ; Online: Factors influencing French community pharmacists' willingness to participate in research projects: a mixed method study.

Piraux, Arthur / Angibaud, Morgane / Nizet, Pierre / Navas, Dominique / Sallenave-Namont, Claire / Prot-Labarthe, Sonia / Huon, Jean-François

BMC primary care

2023 Volume 24, Issue 1, Page(s) 229

Abstract: Background: French community pharmacists are facing an increasing demand to provide a wider range of services to meet the needs of the population. These new missions must be evaluated by primary care research studies. This study aims to explore the ... ...

Abstract	Background: French community pharmacists are facing an increasing demand to provide a wider range of services to meet the needs of the population. These new missions must be evaluated by primary care research studies. This study aims to explore the factors that influence French community pharmacists' willingness to participate in research projects. Methods: A mixed-method design was adopted for this study, comprising an initial quantitative online survey followed by semi-directed interviews. The investigation was conducted at two French faculties of pharmacy, Angers and Nantes, involving students in their 6th and final year of pharmacy education, and their community pharmacist tutors. The survey items were based on a study by Saini et al. and participants responded using five-point Likert scales. The semi-directed interviews were conducted after the quantitative analysis, only with volunteer and already graduated community pharmacists. Results: A total of 131 people participated in the quantitative analysis, comprising 75 students and 56 pharmacists. Pharmacists and students agreed on the significance of two key aspects: the research must possess a clear and meaningful purpose, and researchers must keep the pharmacists informed about the study's results. Among the 27 proposed items, only three showed significantly different results between students and pharmacists. Moreover, 11 semi-structured interviews were conducted. Research in the community pharmacy domain is relatively new for many pharmacists. Despite limited training, their willingness to participate is contingent on being actively involved from the outset, receiving appropriate support and training. However, the research should be seamlessly integrated into their daily practice, without being too time-consuming and administratively burdensome. Time constraints emerged as the main obstacle, along with concerns about the availability of human resources. Pharmacists expressed strong motivation driven by the research topic's relevance, and its potential impact on patients or the profession. While financial compensation is desirable, it did not appear to be the main criterion for participation in a study. Conclusions: French pharmacists are willing to participate in research projects to improve patient care and develop the profession. Research teams must guide and involve from the project's inception.
MeSH term(s)	Humans ; Pharmacists ; Community Pharmacy Services ; Surveys and Questionnaires ; Pharmacy ; Pharmacies
Language	English
Publishing date	2023-11-03
Publishing country	England
Document type	Journal Article
ISSN	2731-4553
ISSN (online)	2731-4553
DOI	10.1186/s12875-023-02163-w
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Article: Médicaments et enfants : approche des risques par des mises en situation pratiques.

Douangmala, Jade / Bourdon, Olivier / Gaschignard, Jean / Durey, Véronique / Prot-Labarthe, Sonia

Soins. Pediatrie, puericulture

2021 Volume 42, Issue 320, Page(s) 41–47

Abstract: Medications are an important source of intoxication or misuse in the pediatric population. It is therefore important to raise parents' awareness on this point. To do so, a team of professionals has set up an e-learning, presented in the form of a slide ... ...

Title translation	Medication and children: Practical situations to address the risks.
Abstract	Medications are an important source of intoxication or misuse in the pediatric population. It is therefore important to raise parents' awareness on this point. To do so, a team of professionals has set up an e-learning, presented in the form of a slide show. Nineteen cases were selected, then divided into three themes (administration error, danger and storage error) and in four rooms of the home (living room, bathroom, child's room and parent's room).
MeSH term(s)	Child ; Humans ; Parents
Language	French
Publishing date	2021-03-26
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	1234484-9
ISSN	2214-9325 ; 1259-4792
ISSN (online)	2214-9325
ISSN	1259-4792
DOI	10.1016/j.spp.2021.03.010
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Article ; Online: Safety and Efficacy of Ceftaroline in Neonates With Staphylococcal Late-onset Sepsis: A Case Series Analysis.

Callies, Arnaud / Martin-Perceval, Lise / Crémet, Lise / Gély, Lilas / Ruellan, Anne-Lise / Verdier, Marie-Clemence / Gregoire, Matthieu / Flamant, Cyril / Guillouzouic, Aurélie / Prot-Labarthe, Sonia / Butin, Marine / Launay, Elise

The Pediatric infectious disease journal

2023 Volume 42, Issue 10, Page(s) 888–892

Abstract: Treatment of late-onset neonatal staphylococcal sepsis is sometimes challenging with feared side effects of vancomycin, increasing minimal inhibitory concentrations and questions about catheter management. In case of failure, ceftaroline was administered ...

Abstract	Treatment of late-onset neonatal staphylococcal sepsis is sometimes challenging with feared side effects of vancomycin, increasing minimal inhibitory concentrations and questions about catheter management. In case of failure, ceftaroline was administered as a compassionate treatment in 16 infants (gestational age of less than 32 weeks and less than 28 postnatal days), whose first-line treatment failed. We report 11 successes and no severe adverse drug reactions. Larger data are required to confirm these encouraging results.
MeSH term(s)	Infant, Newborn ; Infant ; Humans ; Anti-Bacterial Agents/adverse effects ; Staphylococcal Infections/drug therapy ; Vancomycin/adverse effects ; Bacteremia/drug therapy ; Neonatal Sepsis/drug therapy ; Sepsis/drug therapy ; Ceftaroline
Chemical Substances	Anti-Bacterial Agents ; Vancomycin (6Q205EH1VU)
Language	English
Publishing date	2023-07-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	392481-6
ISSN	1532-0987 ; 0891-3668
ISSN (online)	1532-0987
ISSN	0891-3668
DOI	10.1097/INF.0000000000004023
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Article ; Online: International consensus validation of the POPI tool (Pediatrics: Omission of Prescriptions and Inappropriate prescriptions) to identify inappropriate prescribing in pediatrics.

Sadozai, Laily / Sable, Shaya / Le Roux, Enora / Coste, Pierre / Guillot, Clémence / Boizeau, Priscilla / Berthe-Aucejo, Aurore / Angoulvant, François / Lorrot, Mathie / Bourdon, Olivier / Prot-Labarthe, Sonia

PloS one

2020 Volume 15, Issue 10, Page(s) e0240105

Abstract: Introduction: While drug prescription should be based on established recommendations stemming from clinical trials but in pediatrics, many drugs are used without marketing authorization. Consequently recommendations are often based on clinical ... ...

Abstract	Introduction: While drug prescription should be based on established recommendations stemming from clinical trials but in pediatrics, many drugs are used without marketing authorization. Consequently recommendations are often based on clinical experience and the risk of inappropriate prescription (IP) is high. A tool for detecting IP in pediatrics-called POPI (Pediatrics: Omission of Prescriptions and Inappropriate prescriptions)-has been developed in France. However the relevance of its use at an international level is not known. Our aim has been to adapt POPI for a worldwide use. Material and method: A two-round Delphi online questionnaire was completed and validated by international experts to identify consensual items. They were asked to rate the validity of each items taking into account the recommendations and practices in their countries. Only propositions obtaining a median score in the upper tertile with an agreement of more than 75% of the panel-for the first round-and 85%-for the second round-were retained. Results: Our panel included 11 pharmacists (55%) and 9 physicians (45%). The panelists came from 12 different countries: England, Belgium, Brazil, Canada, China, Ivory Coast, Ireland, Malaysia, Portugal, Switzerland, Turkey and Vietnam. At the end of the first round, of the 105 items of the original POPI tool, 80 items were retained including 16 items reworded and 25 items were deleted. In the second round, 14 experts participated in the study. This final international POPI tool is composed of 73 IP and omissions of prescriptions in the fields of neuropsychiatry, dermatology, infectiology, pneumology, gastroenterology, pain and fever. Discussion and conclusion: This study highlights international consensus on prescription practice in pediatrics. The use of this tool in everyday practice could reduce the risk of inappropriate prescription. The impact of the diffusion of POPI tool will be assessed in a prospective multicentric study.
MeSH term(s)	Adult ; Child ; Delphi Technique ; Drug Prescriptions/statistics & numerical data ; France ; Humans ; Inappropriate Prescribing/statistics & numerical data ; Middle Aged ; Pediatrics/statistics & numerical data ; Pharmacists ; Physicians
Language	English
Publishing date	2020-10-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0240105
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Article ; Online: High-alert medications in a French paediatric university hospital.

Bataille, Julie / Prot-Labarthe, Sonia / Bourdon, Olivier / Joret, Perrine / Brion, Françoise / Hartmann, Jean-François

Journal of evaluation in clinical practice

2015 Volume 21, Issue 2, Page(s) 262–270

Abstract: Rationale, aims and objectives: High-alert medications (HAMs) are medications that are associated with a high risk of serious harm if used improperly. The objective of this study was to identify paediatric HAM used in our institution and to identify ... ...

Abstract	Rationale, aims and objectives: High-alert medications (HAMs) are medications that are associated with a high risk of serious harm if used improperly. The objective of this study was to identify paediatric HAM used in our institution and to identify safety measures for their use. Methods: The list of HAM and the list of safety measures that were introduced in our department were based on (1) a literature search; (2) a survey of health care professionals in our department including doctors, head nurses, nurses and pharmacists; and (3) the drug steering committee. Results: We found four lists of HAM based on a literature search, including 27 classes of pharmaceutical agents, and 63 common drug names. The response rate of the survey was 20.7% (230 of 1113). Some of the HAMs included in our list were not identified by the literature search. These included neuroleptic drugs, anti-malarial agents, antiviral agents, anti-retroviral agents and intravenous acetaminophen. The drug steering committee selected 17 HAM and highlighted 53 safety measures involving seven broad aspects of pharmacological management. Conclusions: This project was part of the new safety strategies developed in a paediatric hospital. We set out to make a list of HAM relevant to paediatrics with additional safety measures to prevent medication errors associated and a 'joker' system. The various safety measures, such as double-checking of HAM prescriptions, should be reviewed during the year following their implementation. This list, which was developed in our hospital specifically for use in paediatrics, can be adapted for use in other paediatric departments.
MeSH term(s)	France ; Hospitals, Pediatric/organization & administration ; Hospitals, University/organization & administration ; Humans ; Medication Errors/prevention & control ; Patient Safety ; Personnel, Hospital ; Prescription Drugs/classification ; Risk Assessment
Chemical Substances	Prescription Drugs
Language	English
Publishing date	2015-04
Publishing country	England
Document type	Journal Article
ZDB-ID	1327355-3
ISSN	1365-2753 ; 1356-1294
ISSN (online)	1365-2753
ISSN	1356-1294
DOI	10.1111/jep.12302
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