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  1. Article ; Online: Right-sided subcutaneous implantable cardioverter-defibrillator placement in a patient with "acquired mesocardia".

    Prousi, George S / Nichols, Judy / Jacob, Sony

    Heart rhythm O2

    2022  Volume 3, Issue 5, Page(s) 587–588

    Language English
    Publishing date 2022-10-21
    Publishing country United States
    Document type Editorial
    ISSN 2666-5018
    ISSN (online) 2666-5018
    DOI 10.1016/j.hroo.2022.08.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A 75-Year-Old Woman with COVID-19 Pneumonia and Wellens Syndrome Diagnosed by Electrocardiography.

    Prousi, George S / Giordano, Jacob / McCann, Patrick J

    The American journal of case reports

    2021  Volume 22, Page(s) e930125

    Abstract: BACKGROUND There are increasing reports of cardiovascular complications associated with coronavirus disease 2019 (COVID-19) due to infection with severe acute respiratory syndrome coronavirus 2. Wellens syndrome, or left anterior descending T-wave ... ...

    Abstract BACKGROUND There are increasing reports of cardiovascular complications associated with coronavirus disease 2019 (COVID-19) due to infection with severe acute respiratory syndrome coronavirus 2. Wellens syndrome, or left anterior descending T-wave syndrome, is diagnosed by a pattern of electrocardiographic (ECG) changes that include inverted or biphasic T waves in leads V2-V3. CASE REPORT A 75-year-old woman presented to the emergency department with a 1-week history of fatigue and progressive shortness of breath who acutely decompensated, necessitating mechanical ventilator support. Initial lab workup revealed COVID-19 positivity, which was confirmed by repeat testing. A routine ECG obtained during her hospitalization and compared with her baseline revealed diffuse T-wave inversions of her precordial leads, which was highly suggestive of Wellens syndrome. Cardiac enzymes obtained were slightly elevated and an echocardiogram did not demonstrate wall motion abnormalities. The patient was initiated on non-ST segment elevation myocardial infarction protocol with heparin infusion for 48 hours and dual antiplatelet therapy, in addition to beta blockade. Repeat ECGs showed complete resolution of Wellens syndrome shortly after therapy. CONCLUSIONS Although rare, Wellens syndrome is a significant indicator of left anterior descending artery stenosis and is commonly associated with acute medical illness. COVID-19 pneumonia has been associated with many adverse cardiovascular outcomes, with ischemia and arrhythmia becoming increasingly more common. Diagnosis of Wellens often includes coronary angiography; however, during the current pandemic, many authorities have recommended medical management alone during the acute phase of care, depending on the severity of concomitant illness.
    MeSH term(s) Aged ; Arrhythmias, Cardiac/complications ; Arrhythmias, Cardiac/diagnosis ; COVID-19/complications ; COVID-19/diagnosis ; Coronary Artery Disease/complications ; Coronary Artery Disease/diagnosis ; Electrocardiography ; Female ; Humans
    Language English
    Publishing date 2021-02-03
    Publishing country United States
    Document type Journal Article ; Case Reports
    ZDB-ID 2517183-5
    ISSN 1941-5923 ; 1941-5923
    ISSN (online) 1941-5923
    ISSN 1941-5923
    DOI 10.12659/AJCR.930125
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The Impact of Angiotensin Receptor-Neprilysin Inhibitors on Arrhythmias in Patients with Heart Failure: A Systematic Review and Meta-analysis.

    Mujadzic, Hata / Prousi, George S / Napier, Rebecca / Siddique, Sultan / Zaman, Ninad

    The Journal of innovations in cardiac rhythm management

    2022  Volume 13, Issue 9, Page(s) 5164–5175

    Abstract: Angiotensin receptor-neprilysin inhibitor (ARNI) use has become increasingly popular. Current guidelines recommend using ARNI therapy for heart failure with reduced (HFrEF) and preserved ejection fraction (HFpEF). As therapies become more widely ... ...

    Abstract Angiotensin receptor-neprilysin inhibitor (ARNI) use has become increasingly popular. Current guidelines recommend using ARNI therapy for heart failure with reduced (HFrEF) and preserved ejection fraction (HFpEF). As therapies become more widely available, heart failure-associated burdens such as ventricular arrhythmias and sudden cardiac death (SCD) will become increasingly prevalent. We conducted a systematic review and meta-analysis to assess the impact of ARNI therapy on HFrEF and HFpEF pertaining to arrhythmogenesis and SCD. We performed a search of MEDLINE (PubMed), the Cochrane Library, and ClinicalTrials.gov for relevant studies. The odds ratios (ORs) of SCD, ventricular tachycardia (VT), ventricular fibrillation (VF), atrial fibrillation/flutter (AF), supraventricular tachycardia (SVT), and implantable cardioverter-defibrillator (ICD) shocks were calculated. A total of 10 studies, including 6 randomized controlled trials and 4 observational studies, were included in the analysis. A total of 18,548 patients from all studies were included, with 9,328 patients in the ARNI arm and 9,220 patients in the angiotensin-converting enzyme inhibitor (ACEI)/angiotensin II receptor blocker (ARB) arm, with a median follow-up time of 15 months. There was a significant reduction in the composite outcomes of SCD and ventricular arrhythmias in patients treated with ARNIs compared to those treated with ACEIs/ARBs (OR, 0.71; 95% confidence interval, 0.54-0.93;
    Language English
    Publishing date 2022-09-15
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2156-3977
    ISSN 2156-3977
    DOI 10.19102/icrm.2022.130905
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Vascular Inflammation, Cancer, and Cardiovascular Diseases.

    Prousi, George S / Joshi, Amogh M / Atti, Varun / Addison, Daniel / Brown, Sherry-Ann / Guha, Avirup / Patel, Brijesh

    Current oncology reports

    2023  Volume 25, Issue 9, Page(s) 955–963

    Abstract: Purpose of review: Cancer and cardiovascular disease are among the leading causes of morbidity and mortality in the USA. Cancer and cardiovascular disease have inflammatory underpinnings that have been associated with both the development and ... ...

    Abstract Purpose of review: Cancer and cardiovascular disease are among the leading causes of morbidity and mortality in the USA. Cancer and cardiovascular disease have inflammatory underpinnings that have been associated with both the development and progression of these disease states.
    Recent findings: Inflammatory signaling has been found to be a critical event in both cardiovascular disease and cancer formation and progression. Further, many chemotherapeutic agents potentiate inflammation exacerbating existing cardiovascular disease or leading to its presence. The exact mechanisms of these interactions remain poorly understood. The proinflammatory milieu observed in both cancer and cardiovascular disease likely plays an important role in the development and potentiation of both conditions. Further evaluation of this relationship will be critical in the development of new diagnostic and therapeutic modalities.
    MeSH term(s) Humans ; Cardiovascular Diseases/therapy ; Cardiotoxicity/etiology ; Neoplasms/therapy ; Inflammation/complications ; Signal Transduction
    Language English
    Publishing date 2023-06-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057359-5
    ISSN 1534-6269 ; 1523-3790
    ISSN (online) 1534-6269
    ISSN 1523-3790
    DOI 10.1007/s11912-023-01426-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5521: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Atrial Myxoma Presenting with Palpitations: A Case Report.

    Prousi, George S / Moran, Joseph V / Biggs, Ross G

    Cureus

    2019  Volume 11, Issue 2, Page(s) e4093

    Abstract: Atrial myxomas are a rare phenomenon and although benign, primary neoplasms of the heart can be burdensome depending on their location. Clinical symptoms are caused through a variety of mechanisms including conduction disturbances, obstruction, and ... ...

    Abstract Atrial myxomas are a rare phenomenon and although benign, primary neoplasms of the heart can be burdensome depending on their location. Clinical symptoms are caused through a variety of mechanisms including conduction disturbances, obstruction, and valvular interference. Size and symptom development are strongly correlated and can almost always be detected by the use of echocardiography, magnetic resonance imaging or computed tomography. This is a case of a 62-year-old female with no significant past medical history presented to our facility with complaints of palpitations and associated dizziness for three months.
    Language English
    Publishing date 2019-02-19
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.4093
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Microtubule Inhibitors and Cardiotoxicity.

    Joshi, Amogh M / Prousi, George S / Bianco, Christopher / Malla, Midhun / Guha, Avirup / Shah, Mahek / Brown, Sherry-Ann / Patel, Brijesh

    Current oncology reports

    2021  Volume 23, Issue 3, Page(s) 30

    Abstract: Purpose of review: Cancer and heart disease are the leading causes of mortality in the USA. Advances in cancer therapies, namely, the development and use of chemotherapeutic agents alone or in combination, are becoming increasingly prevalent.: Recent ... ...

    Abstract Purpose of review: Cancer and heart disease are the leading causes of mortality in the USA. Advances in cancer therapies, namely, the development and use of chemotherapeutic agents alone or in combination, are becoming increasingly prevalent.
    Recent findings: Many chemotherapeutic agents have been associated with adverse cardiovascular manifestations. The mechanisms of these sequelae remain incompletely understood. In particular, microtubule inhibitor (MTI) agents have been related to the development of heart failure, myocardial ischemia, and conduction abnormalities. At present, there are no guidelines for patients undergoing MTI therapy as it pertains to both preventative and mitigatory strategies for cardiovascular complications. We conducted a literature review focusing on content related to the use of MTIs and their effect on the cardiovascular system. MTIs have been associated with various forms of cardiotoxicity, and fatal cardiotoxicities are rare. The most well-described cardiotoxicities are brady- and tachyarrhythmias. The co-administration of anthracycline-based agents with MTIs can increase the risk of cardiotoxicity.
    MeSH term(s) Cardiotoxicity/etiology ; Heart Diseases/chemically induced ; Humans ; Neoplasms/drug therapy ; Tubulin Modulators/adverse effects ; Tubulin Modulators/therapeutic use
    Chemical Substances Tubulin Modulators
    Language English
    Publishing date 2021-02-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057359-5
    ISSN 1534-6269 ; 1523-3790
    ISSN (online) 1534-6269
    ISSN 1523-3790
    DOI 10.1007/s11912-021-01014-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5521: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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