Artikel ; Online: Estimating the hydrophobicity extent of molecular fragments using reversed-phase liquid chromatography.
2023 Band 46, Heft 18, Seite(n) e2300346
Abstract: A fast HPLC method was developed to study the hydrophobicity extent of pharmaceutically relevant molecular fragments. By this strategy, the reduced amount of sample available for physico-chemical evaluations in early-phase drug discovery programs does ... ...
| Abstract | A fast HPLC method was developed to study the hydrophobicity extent of pharmaceutically relevant molecular fragments. By this strategy, the reduced amount of sample available for physico-chemical evaluations in early-phase drug discovery programs does not represent a limiting factor. The sixteen acid fragments investigated were previously synthesized also determining potentiometrically their experimental log D values. For four fragments it was not possible to determine such property since their values were outside of the instrumental working range (2 < pK |
|---|---|
| Sprache | Englisch |
| Erscheinungsdatum | 2023-07-12 |
| Erscheinungsland | Germany |
| Dokumenttyp | Journal Article |
| ZDB-ID | 2047990-6 |
| ISSN | 1615-9314 ; 1615-9306 |
| ISSN (online) | 1615-9314 |
| ISSN | 1615-9306 |
| DOI | 10.1002/jssc.202300346 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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