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  1. Article ; Online: Three different pathways of IgM-antibody-dependent hemolysis are mainly regulated by complement.

    Bartolmäs, Thilo / Pruß, Axel / Mayer, Beate

    Frontiers in immunology

    2023  Volume 14, Page(s) 1114509

    Abstract: Antibodies to red blood cells (RBCs) may hemolyze ... ...

    Abstract Antibodies to red blood cells (RBCs) may hemolyze erythrocytes
    MeSH term(s) Humans ; Hemolysis ; Immunoglobulin M ; Anemia, Hemolytic, Autoimmune ; Erythrocytes ; Complement System Proteins
    Chemical Substances Immunoglobulin M ; Complement System Proteins (9007-36-7)
    Language English
    Publishing date 2023-02-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1114509
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Coding of Tissue and Cell Products.

    Pruß, Axel

    Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie

    2017  Volume 44, Issue 6, Page(s) 382

    Language English
    Publishing date 2017-11-21
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2100848-6
    ISSN 1660-3818 ; 1660-3796
    ISSN (online) 1660-3818
    ISSN 1660-3796
    DOI 10.1159/000484998
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 959: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article: Safety Aspects in Tissue Banking - An Update.

    Pruß, Axel / Schroeter, Jan

    Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie

    2021  Volume 48, Issue 1, Page(s) 1–2

    Language English
    Publishing date 2021-01-14
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2100848-6
    ISSN 1660-3818 ; 1660-3796
    ISSN (online) 1660-3818
    ISSN 1660-3796
    DOI 10.1159/000514111
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    In stock of ZB MED Cologne/Königswinter

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  4. Article: Coding of Tissue and Cell Products

    Pruß, Axel

    Transfusion Medicine and Hemotherapy

    2017  Volume 44, Issue 6, Page(s) 382–382

    Institution University Tissue Bank, Institute of Transfusion Medicine; Charité - University Medicine Berlin, Berlin, Germany
    Language English
    Publishing date 2017-11-21
    Publisher S. Karger GmbH
    Publishing place Freiburg, Germany
    Document type Article
    Note Editorial
    ZDB-ID 2100848-6
    ISSN 1660-3818 ; 1660-3796
    ISSN (online) 1660-3818
    ISSN 1660-3796
    DOI 10.1159/000484998
    Database Karger publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 959: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  5. Article: Tissue Banking and Transfusion Medicine - a Suitable Cooperation Model.

    Pruß, Axel

    Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie

    2011  Volume 38, Issue 6, Page(s) 349–350

    Language English
    Publishing date 2011-12-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2100848-6
    ISSN 1660-3818 ; 1660-3796
    ISSN (online) 1660-3818
    ISSN 1660-3796
    DOI 10.1159/000335157
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 959: Show issues Location:
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  6. Article: Validation of Microbiological Testing of Tissue Preparations with Different Incubation Temperatures.

    Herrlinger, Frithjof / Schulz, Tino / Pruß, Axel / Schulz, Eva

    Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie

    2020  Volume 48, Issue 1, Page(s) 23–31

    Abstract: Introduction: The European Pharmacopoeia (Ph. Eur.) provides principles for microbiological testing of tissue preparations. According to the Ph. Eur., tests should be performed at different temperatures for detection of aerobic bacteria and fungi (20-25° ...

    Abstract Introduction: The European Pharmacopoeia (Ph. Eur.) provides principles for microbiological testing of tissue preparations. According to the Ph. Eur., tests should be performed at different temperatures for detection of aerobic bacteria and fungi (20-25°C) vs. anaerobic bacteria (30-35°C). Semiautomated systems using blood culture bottles are already widely used and they are adequate for growth detection. Resin-containing bottles and the addition of penicillinase permit testing of culture media containing antibiotics.
    Materials and methods: At 3 temperatures (21, 30, and 35°C) cornea culture media with and without dextran (CM II and CM I) and thermal disinfected femoral head medium (FH) were spiked with the 6 reference strains recommended by the Ph. Eur. (additionally:
    Results: Growth for all strains was detected with each medium at all 3 temperatures, except for
    Conclusion: The requirements according to the Ph. Eur. for a successful method suitability test could be fulfilled for the semiautomated blood culture bottle system with the BACTEC
    Language English
    Publishing date 2020-12-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2100848-6
    ISSN 1660-3818 ; 1660-3796
    ISSN (online) 1660-3818
    ISSN 1660-3796
    DOI 10.1159/000513646
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 959: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  7. Article ; Online: Allografts: expanding the surgeon's armamentarium.

    Ahmed, Norus / Eras, Volker / Pruß, Axel / Perka, Carsten / Brune, Jan / Vu-Han, Tu-Lan

    Cell and tissue banking

    2022  Volume 24, Issue 1, Page(s) 273–283

    Abstract: In Germany, bone allografts are widely used and their application in clinics has increased over the years. Successful use of allografts depends on many factors such as the procurement, processing, sterilization and the surgeon's surgical experience. ... ...

    Abstract In Germany, bone allografts are widely used and their application in clinics has increased over the years. Successful use of allografts depends on many factors such as the procurement, processing, sterilization and the surgeon's surgical experience. Tissue banks have provided safe and sterile allografts for decades ranging from hard to soft tissue. Allografts are obtained from various tissues such as bone, tendon, amniotic membrane, meniscus and skin. An advantage of allografts is their wide applicability that has never been limited by indication restrictions thus providing a huge benefit for surgeon's. The use of the correct allograft in different indications is extremely important. Thereby surgeons have access to various allograft forms such as mineralized, demineralized, freeze-dried, paste, powder, chips strips and putty. The vast options of allografts allow surgeon's to use allografts in indications they deem fit. Currently, the application of allografts is at the discretion of the expert surgeon. However, regulations are often changed locally or internationally and may impact/limit allograft use to certain indications. Here, we report the different indications where our peracetic acid (PAA) sterilised bone allografts were used as well as general literature on bone allograft use in other indications.
    MeSH term(s) Transplantation, Homologous ; Tissue Banks ; Tendons/transplantation ; Sterilization ; Bone Transplantation ; Allografts
    Language English
    Publishing date 2022-06-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2170897-6
    ISSN 1573-6814 ; 1389-9333
    ISSN (online) 1573-6814
    ISSN 1389-9333
    DOI 10.1007/s10561-022-10015-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5972: Show issues Location:
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  8. Article: Recognition mechanisms of hemoglobin particles by monocytes - CD163 may just be one.

    Nimz, Jonathan-Gabriel / Rerkshanandana, Pichayut / Kloypan, Chiraphat / Kalus, Ulrich / Chaiwaree, Saranya / Pruß, Axel / Georgieva, Radostina / Xiong, Yu / Bäumler, Hans

    Beilstein journal of nanotechnology

    2023  Volume 14, Page(s) 1028–1040

    Abstract: Hemoglobin-based oxygen carriers (HBOCs) as blood substitutes are one of the great hopes of modern transfusion and emergency medicine. After the major safety-relevant challenges of the last decades seem to be largely overcome, current developments have ... ...

    Abstract Hemoglobin-based oxygen carriers (HBOCs) as blood substitutes are one of the great hopes of modern transfusion and emergency medicine. After the major safety-relevant challenges of the last decades seem to be largely overcome, current developments have in common that they are affected by degradation and excretion at an early stage in test organisms. Several possible mechanisms that may be responsible for this are discussed in the literature. One of them is CD163, the receptor of the complex of haptoglobin (Hp) and hemoglobin (Hb). The receptor has been shown in various studies to have a direct affinity for Hb in the absence of Hp. Thus, it seems reasonable that CD163 could possibly also bind Hb within HBOCs and cause phagocytosis of the particles. In this work we investigated the role of CD163 in the uptake of our hemoglobin sub-micron particles (HbMPs) in monocytes and additionally screened for alternative ways of particle recognition by monocytes. In our experiments, blockade of CD163 by specific monoclonal antibodies proved to partly inhibit HbMP uptake by monocytes. It appears, however, that several other phagocytosis pathways for HbMPs might exist, independent of CD163 and also Hb.
    Language English
    Publishing date 2023-10-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2583584-1
    ISSN 2190-4286
    ISSN 2190-4286
    DOI 10.3762/bjnano.14.85
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  9. Article ; Online: Riboflavin: The Health Benefits of a Forgotten Natural Vitamin.

    Suwannasom, Nittiya / Kao, Ijad / Pruß, Axel / Georgieva, Radostina / Bäumler, Hans

    International journal of molecular sciences

    2020  Volume 21, Issue 3

    Abstract: Riboflavin (RF) is a water-soluble member of the B-vitamin family. Sufficient dietary and supplemental RF intake appears to have a protective effect on various medical conditions such as sepsis, ischemia etc., while it also contributes to the reduction ... ...

    Abstract Riboflavin (RF) is a water-soluble member of the B-vitamin family. Sufficient dietary and supplemental RF intake appears to have a protective effect on various medical conditions such as sepsis, ischemia etc., while it also contributes to the reduction in the risk of some forms of cancer in humans. These biological effects of RF have been widely studied for their anti-oxidant, anti-aging, anti-inflammatory, anti-nociceptive and anti-cancer properties. Moreover, the combination of RF and other compounds or drugs can have a wide variety of effects and protective properties, and diminish the toxic effect of drugs in several treatments. Research has been done in order to review the latest findings about the link between RF and different clinical aberrations. Since further studies have been published in this field, it is appropriate to consider a re-evaluation of the importance of RF in terms of its beneficial properties.
    MeSH term(s) Animals ; Dietary Supplements ; Drug Interactions ; Functional Food ; Humans ; Riboflavin/chemistry ; Riboflavin/pharmacology ; Vitamin B Complex/chemistry ; Vitamin B Complex/pharmacology
    Chemical Substances Vitamin B Complex (12001-76-2) ; Riboflavin (TLM2976OFR)
    Language English
    Publishing date 2020-01-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21030950
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  10. Article ; Online: Intraoperative blood loss as indicated by haemoglobin trend is a predictor for the development of postoperative spinal implant infection-a matched-pair analysis.

    Schömig, Friederike / Bürger, Justus / Hu, Zhouyang / Pruß, Axel / Klotz, Edda / Pumberger, Matthias / Hipfl, Christian

    Journal of orthopaedic surgery and research

    2021  Volume 16, Issue 1, Page(s) 393

    Abstract: Background: With a reported rate of 0.7-20%, postoperative spinal implant infection (PSII) is one of the most common complications after spine surgery. While in arthroplasty both haematoma formation and perioperative blood loss have been identified as ... ...

    Abstract Background: With a reported rate of 0.7-20%, postoperative spinal implant infection (PSII) is one of the most common complications after spine surgery. While in arthroplasty both haematoma formation and perioperative blood loss have been identified as risk factors for developing periprosthetic joint infections and preoperative anaemia has been associated with increased complication rates, literature on the aetiology of PSII remains limited.
    Methods: We performed a matched-pair analysis of perioperative haemoglobin (Hb) and haematocrit (Hct) levels in aseptic and septic spine revision surgeries. 317 patients were included, 94 of which were classified as septic according to previously defined criteria. Patients were matched according to age, body mass index, diabetes, American Society of Anesthesiologists score and smoking habits. Descriptive summaries for septic and aseptic groups were analysed using Pearson chi-squared for categorical or Student t test for continuous variables.
    Results: Fifty patients were matched and did not differ significantly in their reason for revision, mean length of hospital stay, blood transfusion, operating time, or number of levels operated on. While there was no significant difference in preoperative Hb or Hct levels, the mean difference between pre- and postoperative Hb was higher in the septic group (3.45 ± 1.25 vs. 2.82 ± 1.48 g/dL, p = 0.034).
    Conclusions: We therefore show that the intraoperative Hb-trend is a predictor for the development of PSII independent of the amount of blood transfusions, operation time, number of spinal levels operated on and hospital length of stay, which is why strategies to reduce intraoperative blood loss in spine surgery need to be further studied.
    MeSH term(s) Aged ; Blood Loss, Surgical/statistics & numerical data ; Blood Transfusion/statistics & numerical data ; Female ; Hematocrit/statistics & numerical data ; Hemoglobins/analysis ; Humans ; Intraoperative Period ; Length of Stay/statistics & numerical data ; Male ; Matched-Pair Analysis ; Middle Aged ; Operative Time ; Predictive Value of Tests ; Prosthesis-Related Infections/etiology ; Reoperation/statistics & numerical data ; Retrospective Studies ; Risk Factors ; Sepsis/etiology ; Spine/surgery
    Chemical Substances Hemoglobins
    Language English
    Publishing date 2021-06-18
    Publishing country England
    Document type Journal Article
    ISSN 1749-799X
    ISSN (online) 1749-799X
    DOI 10.1186/s13018-021-02537-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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