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  1. Article ; Online: The association of myocardial infarction with cancer incidence.

    Psaty, Bruce M / Vasan, Ramachandran S

    European journal of epidemiology

    2023  Volume 38, Issue 8, Page(s) 851–852

    Abstract: In this commentary, the authors discuss the potential mechanisms for the finding of an association between myocardial infarction and cancer incidence. ...

    Abstract In this commentary, the authors discuss the potential mechanisms for the finding of an association between myocardial infarction and cancer incidence.
    MeSH term(s) Humans ; Incidence ; Myocardial Infarction/epidemiology ; Myocardial Infarction/etiology ; Neoplasms/epidemiology ; Neoplasms/etiology
    Language English
    Publishing date 2023-06-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 632614-6
    ISSN 1573-7284 ; 0393-2990
    ISSN (online) 1573-7284
    ISSN 0393-2990
    DOI 10.1007/s10654-023-01019-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Obtaining Valid Estimates of the Effect of CPAP Therapy: Reducing Healthy Adherer and Other Biases in Observational Studies.

    Kapur, Vishesh K / Psaty, Bruce M

    Chest

    2022  Volume 161, Issue 6, Page(s) 1444–1445

    MeSH term(s) Bias ; Continuous Positive Airway Pressure ; Health Status ; Humans
    Language English
    Publishing date 2022-06-09
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2022.03.027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Cardiovascular Safety Trials of Antidiabetic Therapies to Treat Type 2 Diabetes: Perhaps Asking the Wrong Question?

    Psaty, Bruce M / Fleming, Thomas R

    American journal of hypertension

    2019  Volume 32, Issue 10, Page(s) 927–929

    MeSH term(s) Biomarkers/blood ; Blood Glucose/drug effects ; Blood Glucose/metabolism ; Cardiovascular Diseases/mortality ; Cardiovascular Diseases/physiopathology ; Cardiovascular Diseases/prevention & control ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/mortality ; Endpoint Determination ; Humans ; Hypoglycemic Agents/adverse effects ; Hypoglycemic Agents/therapeutic use ; Product Surveillance, Postmarketing ; Research Design ; Risk Assessment ; Risk Factors ; Treatment Outcome
    Chemical Substances Biomarkers ; Blood Glucose ; Hypoglycemic Agents
    Language English
    Publishing date 2019-04-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 639383-4
    ISSN 1941-7225 ; 1879-1905 ; 0895-7061
    ISSN (online) 1941-7225 ; 1879-1905
    ISSN 0895-7061
    DOI 10.1093/ajh/hpz093
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  4. Article ; Online: Addressing the Opioid Epidemic - Opportunities in the Postmarketing Setting.

    Psaty, Bruce M / Merrill, Joseph O

    The New England journal of medicine

    2017  Volume 376, Issue 16, Page(s) 1502–1504

    MeSH term(s) Analgesics, Opioid/therapeutic use ; Direct-to-Consumer Advertising/legislation & jurisprudence ; Epidemics ; Government Regulation ; Humans ; Opioid-Related Disorders/epidemiology ; Product Surveillance, Postmarketing ; United States/epidemiology ; United States Food and Drug Administration
    Chemical Substances Analgesics, Opioid
    Language English
    Publishing date 2017-04-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMp1614972
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  5. Article ; Online: Stuck in a Bind With Phosphate Binders.

    Kestenbaum, Bryan / Psaty, Bruce M

    American journal of kidney diseases : the official journal of the National Kidney Foundation

    2017  Volume 71, Issue 2, Page(s) 254–256

    MeSH term(s) Humans ; Hyperphosphatemia ; Phosphates ; Prevalence ; Renal Dialysis ; Sevelamer
    Chemical Substances Phosphates ; Sevelamer (9YCX42I8IU)
    Language English
    Publishing date 2017-12-07
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1053/j.ajkd.2017.08.029
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    Zs.MO 468: Show issues

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  6. Article ; Online: Proteomics for heart failure risk stratification: a systematic review.

    Kuku, Kayode O / Oyetoro, Rebecca / Hashemian, Maryam / Livinski, Alicia A / Shearer, Joseph J / Joo, Jungnam / Psaty, Bruce M / Levy, Daniel / Ganz, Peter / Roger, Véronique L

    BMC medicine

    2024  Volume 22, Issue 1, Page(s) 34

    Abstract: Background: Heart failure (HF) is a complex clinical syndrome with persistently high mortality. High-throughput proteomic technologies offer new opportunities to improve HF risk stratification, but their contribution remains to be clearly defined. We ... ...

    Abstract Background: Heart failure (HF) is a complex clinical syndrome with persistently high mortality. High-throughput proteomic technologies offer new opportunities to improve HF risk stratification, but their contribution remains to be clearly defined. We aimed to systematically review prognostic studies using high-throughput proteomics to identify protein signatures associated with HF mortality.
    Methods: We searched four databases and two clinical trial registries for articles published from 2012 to 2023. HF proteomics studies measuring high numbers of proteins using aptamer or antibody-based affinity platforms on human plasma or serum with outcomes of all-cause or cardiovascular death were included. Two reviewers independently screened articles, extracted data, and assessed the risk of bias. A third reviewer resolved conflicts. We assessed the risk of bias using the Risk Of Bias In Non-randomized Studies-of Exposure tool.
    Results: Out of 5131 unique articles identified, nine articles were included in the review. The nine studies were observational; three used the aptamer platform, and six used the antibody platform. We found considerable heterogeneity across studies in measurement panels, HF definitions, ejection fraction categorization, follow-up duration, and outcome definitions, and a lack of risk estimates for most protein associations. Hence, we proceeded with a systematic review rather than a meta-analysis. In two comparable aptamer studies in patients with HF with reduced ejection fraction, 21 proteins were identified in common for the association with all-cause death. Among these, one protein, WAP four-disulfide core domain protein 2 was also reported in an antibody study on HFrEF and for the association with CV death. We proposed standardized reporting criteria to facilitate the interpretation of future studies.
    Conclusions: In this systematic review of nine studies evaluating the association of proteomics with mortality in HF, we identified a limited number of proteins common across several studies. Heterogeneity across studies compromised drawing broad inferences, underscoring the importance of standardized approaches to reporting.
    MeSH term(s) Humans ; Heart Failure/diagnosis ; Proteomics ; Stroke Volume ; Ventricular Dysfunction, Left
    Language English
    Publishing date 2024-01-25
    Publishing country England
    Document type Systematic Review ; Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 2131669-7
    ISSN 1741-7015 ; 1741-7015
    ISSN (online) 1741-7015
    ISSN 1741-7015
    DOI 10.1186/s12916-024-03249-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Investigating peripheral blood monocyte and T-cell subsets as non-invasive biomarkers for asymptomatic hepatic steatosis: results from the Multi-Ethnic Study of Atherosclerosis.

    Niedecker, Rhys W / Delaney, Joseph A / Doyle, Margaret F / Sparks, Andrew D / Sitlani, Colleen M / Buzkova, Petra / Zeb, Irfan / Tracy, Russell P / Psaty, Bruce M / Budoff, Matthew J / Olson, Nels C

    Frontiers in immunology

    2024  Volume 15, Page(s) 1243526

    Abstract: Background: Circulating immune cells have gained interest as biomarkers of hepatic steatosis. Data on the relationships between immune cell subsets and early-stage steatosis in population-based cohorts are limited.: Methods: This study included 1,944 ...

    Abstract Background: Circulating immune cells have gained interest as biomarkers of hepatic steatosis. Data on the relationships between immune cell subsets and early-stage steatosis in population-based cohorts are limited.
    Methods: This study included 1,944 asymptomatic participants of the Multi-Ethnic Study of Atherosclerosis (MESA) with immune cell phenotyping and computed tomography measures of liver fat. Participants with heavy alcohol use were excluded. A liver-to-spleen ratio Hounsfield units (HU) <1.0 and liver attenuation <40 HU were used to diagnose liver fat presence and >30% liver fat content, respectively. Logistic regression estimated cross-sectional associations of immune cell subsets with liver fat parameters adjusted for risk factors. We hypothesized that higher proportions of non-classical monocytes, Th1, Th17, and memory CD4
    Results: None of the hypothesized cells were associated with presence of liver fat. Higher memory CD4
    Conclusions: Higher circulating memory CD4
    MeSH term(s) Humans ; Monocytes ; Cross-Sectional Studies ; Fatty Liver/diagnosis ; T-Lymphocyte Subsets ; Biomarkers ; Atherosclerosis
    Chemical Substances Biomarkers
    Language English
    Publishing date 2024-03-26
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1243526
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  8. Article ; Online: Precision Medicine vs Preventive Medicine-Reply.

    Psaty, Bruce M / Dekkers, Olaf M / Cooper, Richard S

    JAMA

    2019  Volume 321, Issue 4, Page(s) 406–407

    MeSH term(s) Precision Medicine
    Language English
    Publishing date 2019-01-29
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2018.18664
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  9. Article ; Online: Innovation in Genomic Data Sharing at the NIH.

    Psaty, Bruce M / Rich, Stephen S / Boerwinkle, Eric

    The New England journal of medicine

    2019  Volume 380, Issue 23, Page(s) 2192–2195

    MeSH term(s) Databases, Genetic ; Datasets as Topic ; Genomics ; Humans ; Information Dissemination ; National Institutes of Health (U.S.) ; Organizational Policy ; United States
    Language English
    Publishing date 2019-06-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMp1902363
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  10. Article ; Online: Development and Validation of a Protein Risk Score for Mortality in Heart Failure : A Community Cohort Study.

    Kuku, Kayode O / Shearer, Joseph J / Hashemian, Maryam / Oyetoro, Rebecca / Park, Hoyoung / Dulek, Brittany / Bielinski, Suzette J / Larson, Nicholas B / Ganz, Peter / Levy, Daniel / Psaty, Bruce M / Joo, Jungnam / Roger, Véronique L

    Annals of internal medicine

    2024  Volume 177, Issue 1, Page(s) 39–49

    Abstract: Background: Heart failure (HF) is a complex clinical syndrome with high mortality. Current risk stratification approaches lack precision. High-throughput proteomics could improve risk prediction. Its use in clinical practice to guide the management of ... ...

    Abstract Background: Heart failure (HF) is a complex clinical syndrome with high mortality. Current risk stratification approaches lack precision. High-throughput proteomics could improve risk prediction. Its use in clinical practice to guide the management of patients with HF depends on validation and evidence of clinical benefit.
    Objective: To develop and validate a protein risk score for mortality in patients with HF.
    Design: Community-based cohort.
    Setting: Southeast Minnesota.
    Participants: Patients with HF enrolled between 2003 and 2012 and followed through 2021.
    Measurements: A total of 7289 plasma proteins in 1351 patients with HF were measured using the SomaScan Assay (SomaLogic). A protein risk score was derived using least absolute shrinkage and selection operator regression and temporal validation in patients enrolled between 2003 and 2007 (development cohort) and 2008 and 2012 (validation cohort). Multivariable Cox regression was used to examine the association between the protein risk score and mortality. The performance of the protein risk score to predict 5-year mortality risk was assessed using calibration plots, decision curves, and relative utility analyses and compared with a clinical model, including the Meta-Analysis Global Group in Chronic Heart Failure mortality risk score and
    Results: The development (
    Limitation: Participants were predominantly of European ancestry, potentially limiting the generalizability of the findings to different patient populations.
    Conclusion: Validation of the protein risk score demonstrated good calibration and evidence of predicted benefits to stratify the risk for death in HF superior to that of clinical methods. Further studies are needed to prospectively evaluate the score's performance in diverse populations and determine risk thresholds for interventions.
    Primary funding source: Division of Intramural Research at the National Heart, Lung, and Blood Institute of the National Institutes of Health.
    MeSH term(s) Humans ; Female ; Aged ; Male ; Cohort Studies ; Risk Assessment/methods ; Heart Failure ; Risk Factors ; Chronic Disease ; Prognosis
    Language English
    Publishing date 2024-01-02
    Publishing country United States
    Document type Meta-Analysis ; Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/M23-2328
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