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Article ; Online: Brief Report: Impact of Anti-Cancer Treatments on Outcomes of COVID-19 in Patients With Thoracic Cancers: A CCC19 Registry Analysis.

Kulkarni, Amit A / Hennessy, Cassandra / Wilson, Grace / Ramesh, Vidhyalakshmi / Hwang, Clara / Awosika, Joy / Bakouny, Ziad / Khan, Hina / Vilar-Compte, Diana / McKay, Rana / Jani, Chinmay / Weissmann, Lisa / Griffiths, Elizabeth / Batist, Gerald / Bouganim, Nathaniel / Mavromatis, Blanche / Bashir, Babar / Nguyen, Ryan H / Riess, Jonathan W /

Puc, Matthew / Kasi, Anup / Berg, Stephanie / Castillo, Dan Ran / Hayes-Lattin, Brandon / Hosmer, Wylie / Flora, Daniel / Mishra, Sanjay / French, Benjamin / Warner, Jeremy L / Lopes, Gilberto / Peters, Solange / Florez, Narjust

Clinical lung cancer

2024

Language	English
Publishing date	2024-04-10
Publishing country	United States
Document type	Case Reports
ZDB-ID	2145146-1
ISSN	1938-0690 ; 1525-7304
ISSN (online)	1938-0690
ISSN	1525-7304
DOI	10.1016/j.cllc.2024.04.003
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Article ; Online: Intradiaphragmatic Bronchogenic Cysts: Case Report and Systematic Review.

Mubang, Ronnie / Brady, John Joseph / Mao, Melissa / Burfeind, William / Puc, Matthew

Journal of cardiothoracic surgery

2016 Volume 11, Issue 1, Page(s) 79

Abstract: Bronchogenic cysts (BC) are congenital abnormalities that occur most commonly within the mediastinum, and rarely occur within the diaphragm. We present the 21st case of an intradiaphragmatic bronchogenic cyst in the English literature, and review all ... ...

Abstract	Bronchogenic cysts (BC) are congenital abnormalities that occur most commonly within the mediastinum, and rarely occur within the diaphragm. We present the 21st case of an intradiaphragmatic bronchogenic cyst in the English literature, and review all previous published cases. Analysis includes presenting clinical symptoms, relevant radiologic studies, surgical approaches to resection, and management of the diaphragm, among other relevant data. These lesions should remain on the differential diagnosis in cases of unusual masses in the region of the diaphragm.
MeSH term(s)	Adult ; Bronchogenic Cyst/diagnosis ; Bronchogenic Cyst/diagnostic imaging ; Bronchogenic Cyst/surgery ; Diagnosis, Differential ; Diaphragm/surgery ; Humans ; Magnetic Resonance Imaging ; Male
Language	English
Publishing date	2016-05-05
Publishing country	England
Document type	Case Reports ; Journal Article ; Review
ISSN	1749-8090
ISSN (online)	1749-8090
DOI	10.1186/s13019-016-0444-9
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Article ; Online: Preoperative CHA2DS2-VASc Score Predicts Postoperative Atrial Fibrillation after Lobectomy.

Lee, Charles T / Strauss, David M / Stone, Lauren E / Stoltzfus, Jill C / Puc, Matthew M / Burfeind, William R

The Thoracic and cardiovascular surgeon

2018 Volume 67, Issue 2, Page(s) 125–130

Abstract: Background: Postoperative atrial fibrillation (POAF) affects 10 to 20% of noncardiac thoracic surgeries and increases patient morbidity and costs. The purpose of this study is to determine if preoperative CHA: Methods: Patients with complete CHA: ... ...

Abstract	Background: Postoperative atrial fibrillation (POAF) affects 10 to 20% of noncardiac thoracic surgeries and increases patient morbidity and costs. The purpose of this study is to determine if preoperative CHA Methods: Patients with complete CHA Results: Of 525 total patients, 82 (15.6%) developed POAF (mean CHA Conclusions: Preoperatively calculated CHA
MeSH term(s)	Age Factors ; Aged ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/etiology ; Atrial Fibrillation/physiopathology ; Carcinoma, Non-Small-Cell Lung/pathology ; Carcinoma, Non-Small-Cell Lung/surgery ; Clinical Decision-Making ; Comorbidity ; Databases, Factual ; Decision Support Techniques ; Female ; Health Status ; Humans ; Lung Neoplasms/pathology ; Lung Neoplasms/surgery ; Male ; Middle Aged ; Pennsylvania ; Pneumonectomy/adverse effects ; Pneumonectomy/methods ; Predictive Value of Tests ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Sex Factors ; Thoracic Surgery, Video-Assisted/adverse effects ; Treatment Outcome
Language	English
Publishing date	2018-11-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	800050-5
ISSN	1439-1902 ; 0171-6425 ; 0946-4778 ; 0172-6137
ISSN (online)	1439-1902
ISSN	0171-6425 ; 0946-4778 ; 0172-6137
DOI	10.1055/s-0038-1675638
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Article ; Online: Esophageal stenting in the setting of malignancy.

Martinez, Juan Carlos / Puc, Matthew M / Quiros, Roderick M

ISRN gastroenterology

2011 Volume 2011, Page(s) 719575

Abstract: Esophageal cancer is often diagnosed at an advanced stage, with many patients found to have locoregional or metastatic disease at time of diagnosis. Because of this, cure may be unlikely, leading treatment efforts to focus more on symptom palliation and ... ...

Abstract	Esophageal cancer is often diagnosed at an advanced stage, with many patients found to have locoregional or metastatic disease at time of diagnosis. Because of this, cure may be unlikely, leading treatment efforts to focus more on symptom palliation and improving patient quality of life. The majority of patients with advanced disease suffer from some degree of dysphagia. Palliative efforts are therefore directed at relieving dysphagia, allowing patients to manage their oropharyngeal secretions, reduce aspiration risk, and maintain caloric intake orally. A variety of endoscopic treatment modalities have been utilized with these objectives in mind, with options determined by the location and size of the tumor, as well as the patient's expected prognosis. In this article, we review the use of endoscopically-placed stents for palliation in patients with advanced esophageal cancer. We discuss the history of stent use in such cases, as well as more recent developments in stent technology. We give an overview of some of the more commonly used stents in practice, discuss the technique of insertion, and survey the short- and long-term outcomes of stent placement.
Language	English
Publishing date	2011-08-08
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2589532-1
ISSN	2090-4401 ; 2090-4398
ISSN (online)	2090-4401
ISSN	2090-4398
DOI	10.5402/2011/719575
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Article: Early outcomes after bilateral thoracoscopy versus median sternotomy for lung volume reduction.

Puc, Matthew M / Sonnad, Seema S / Shrager, Joseph B

Innovations (Philadelphia, Pa.)

2010 Volume 5, Issue 2, Page(s) 97–102

Abstract: Objective: : A National Emphysema Treatment Trial subanalysis, although finally describing outcomes as "comparable," suggested that bilateral lung volume reduction surgery (LVRS) by video-assisted thoracoscopic surgery (VATS) may be slightly less morbid ...

Abstract	Objective: : A National Emphysema Treatment Trial subanalysis, although finally describing outcomes as "comparable," suggested that bilateral lung volume reduction surgery (LVRS) by video-assisted thoracoscopic surgery (VATS) may be slightly less morbid than by median sternotomy (MS). We report a single surgeon experience using both the MS and VATS approaches to provide additional information on this issue in a setting of uniform patient selection and perioperative management. Our hypothesis was that a VATS approach would provide equivalent or less morbidity than MS despite being applied to a group of patients subjectively selected to be higher risk than those undergoing MS. Methods: : Consecutive patients over a 9-year period underwent LVRS by one surgeon by either MS or VATS in a nonrandomized fashion. Thoracoscopy was selected over MS primarily when the surgeon estimated a greater overall risk profile and thus a greater chance of morbidity/mortality in a particular patient. Results: : There were 15 patients in the VATS group and 35 in the MS group. In terms of measures of risk profile, there were no differences between the groups that met statistical significance, but several values trended toward higher risk within the VATS group (eg, age, 63 VATS vs. 59 MS, P = 0.08; moderate pulmonary hypertension, 38% VATS vs. 14% MS, P = 0.11; and residual volume, 241% VATS vs. 226% MS, P = 0.32). With regard to outcomes, operative time was significantly longer in the VATS group (VATS = 155 minutes vs. MS=129 minutes, P = 0.01). All other outcomes, including the incidence of major complications (13.3% VATS vs. 17.1% MS, P = 0.39), were similar between the groups. There was a single death within 90 days (1.9% of entire series; 2.9% of MS group). Conclusions: : In this series, although patients undergoing LVRS by VATS tended to have a higher risk profile, their outcomes were no worse than in those undergoing LVRS by MS. This suggests that the VATS approach to bilateral LVRS may incur slightly less morbidity and thus may be the best option in the most compromised patients who is nonetheless felt will benefit from LVRS.
Keywords	covid19
Language	English
Publishing date	2010-03
Publishing country	United States
Document type	Journal Article
ISSN	1556-9845
ISSN	1556-9845
DOI	10.1097/IMI.0b013e3181d9277d
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Article ; Online: Disparities in outcomes between Black and White patients in North America with thoracic malignancies and COVID-19 infection (TERAVOLT).

Burns, Laura / Hsu, Chih-Yuan / Whisenant, Jennifer G / Marmarelis, Melina E / Presley, Carolyn J / Reckamp, Karen L / Khan, Hina / Jo Fidler, Mary / Bestvina, Christine M / Brahmer, Julie / Puri, Sonam / Patel, Jyoti D / Halmos, Balazs / Hirsch, Fred R / Liu, Stephen V / Costa, Daniel B / Goldberg, Sarah B / Feldman, Lawrence E / Mamdani, Hirva /

Puc, Matthew / Mansfield, Aaron S / Islam, Nahida / Scilla, Katherine A / Garassino, Marina C / Horn, Leora / Peters, Solange / Wakelee, Heather A / Charlot, Marjory / Tapan, Umit

Lung cancer (Amsterdam, Netherlands)

2023 Volume 186, Page(s) 107423

Abstract: Background: Patients with thoracic malignancies who develop COVID-19 infection have a higher hospitalization rate compared to the general population and to those with other cancer types, but how this outcome differs by race and ethnicity is relatively ... ...

Abstract	Background: Patients with thoracic malignancies who develop COVID-19 infection have a higher hospitalization rate compared to the general population and to those with other cancer types, but how this outcome differs by race and ethnicity is relatively understudied. Methods: The TERAVOLT database is an international, multi-center repository of cross-sectional and longitudinal data studying the impact of COVID-19 on individuals with thoracic malignancies. Patients from North America with thoracic malignancies and confirmed COVID-19 infection were included for this analysis of racial and ethnic disparities. Patients with missing race data or races and ethnicities with fewer than 50 patients were excluded from analysis. Multivariable analyses for endpoints of hospitalization and death were performed on these 471 patients. Results: Of the 471 patients, 73% were White and 27% were Black. The majority (90%) were non-Hispanic ethnicity, 5% were Hispanic, and 4% were missing ethnicity data. Black patients were more likely to have an Eastern Cooperative Oncology Group (ECOG) Performance Status ≥ 2 (p-value = 0.04). On multivariable analysis, Black patients were more likely than White patients to require hospitalization (Odds Ratio (OR): 1.69, 95% CI: 1.01-2.83, p-value = 0.044). These differences remained across different waves of the pandemic. However, no statistically significant difference in mortality was found between Black and White patients (OR 1.29, 95% CI: 0.69-2.40, p-value = 0.408). Conclusions: Black patients with thoracic malignancies who acquire COVID-19 infection are at a significantly higher risk of hospitalization compared to White patients, but there is no significant difference in mortality. The underlying drivers of racial disparity among patients with thoracic malignancies and COVID-19 infection require ongoing investigation.
MeSH term(s)	Humans ; COVID-19/epidemiology ; COVID-19/ethnology ; Cross-Sectional Studies ; North America/epidemiology ; Thoracic Neoplasms/epidemiology ; Thoracic Neoplasms/ethnology ; White ; Black or African American ; Health Status Disparities
Language	English
Publishing date	2023-11-13
Publishing country	Ireland
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	632771-0
ISSN	1872-8332 ; 0169-5002
ISSN (online)	1872-8332
ISSN	0169-5002
DOI	10.1016/j.lungcan.2023.107423
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Article: Preoperative CHA2DS2-VASc Score Predicts Postoperative Atrial Fibrillation after Lobectomy

Lee, Charles T. / Strauss, David M. / Stone, Lauren E. / Stoltzfus, Jill C. / Puc, Matthew M. / Burfeind, William R.

The Thoracic and Cardiovascular Surgeon

2018 Volume 67, Issue 02, Page(s) 125–130

Abstract	Background: Postoperative atrial fibrillation (POAF) affects 10 to 20% of noncardiac thoracic surgeries and increases patient morbidity and costs. The purpose of this study is to determine if preoperative CHA 2 DS 2 -VASc score can predict POAF after pulmonary lobectomy for nonsmall cell lung cancer. Methods: Patients with complete CHA 2 DS 2 -VASc data who underwent lobectomies from January 2007 to January 2016 at a single institution were analyzed in a retrospective case–control study using a prospective database. An independent samples t -test was used to compare the mean CHA 2 DS 2 -VASc scores of POAF and non-POAF groups. A multivariable logistic regression analysis (MVA) evaluated the independent contribution of variables of the CHA 2 DS 2 -VASc score in predicting POAF. Chi-square test with univariate odds ratios (ORs) was used to determine a statistically significant cutoff score for predicting POAF. Results: Of 525 total patients, 82 (15.6%) developed POAF (mean CHA 2 DS 2 -VASc score: 2.7) and 443 (84.4%) did not develop POAF (mean score: 2.3). Mean difference between these groups was significant at 0.43 ( p = 0.01; 95% confidence interval [CI]: 0.09–0.76). In the MVA, significant predictors of POAF were age 65 to 74 years (adjusted OR [aOR] = 2.45; 95% CI: 1.31–4.70; p = 0.006) and age ≥75 years (aOR = 3.11; 95% CI: 1.62–5.95; p = 0.0006). Patients with CHA 2 DS 2 -VASc scores ≥5 had significantly increased OR for POAF (OR = 2.59; 95% CI: 1.22–5.50). Conclusions: Preoperatively calculated CHA 2 DS 2 -VASc score can predict POAF in patients undergoing pulmonary lobectomy. Age is the most statistically significant independent predictor, and patients with scores ≥5 have significantly increased risk. Trials for POAF prophylaxis should target this population.
Keywords	thoracoscopy/VATS ; lung cancer treatment ; arrhythmia therapy ; Maze ; surgical ablation
Language	English
Publishing date	2018-11-28
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	800050-5
ISSN	1439-1902 ; 0171-6425 ; 0946-4778 ; 0172-6137
ISSN (online)	1439-1902
ISSN	0171-6425 ; 0946-4778 ; 0172-6137
DOI	10.1055/s-0038-1675638
Database	Thieme publisher's database

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Article ; Online: The impact of cancer metastases on COVID-19 outcomes: A COVID-19 and Cancer Consortium registry-based retrospective cohort study.

Castellano, Cecilia A / Sun, Tianyi / Ravindranathan, Deepak / Hwang, Clara / Balanchivadze, Nino / Singh, Sunny R K / Griffiths, Elizabeth A / Puzanov, Igor / Ruiz-Garcia, Erika / Vilar-Compte, Diana / Cárdenas-Delgado, Ana I / McKay, Rana R / Nonato, Taylor K / Ajmera, Archana / Yu, Peter P / Nadkarni, Rajani / O'Connor, Timothy E / Berg, Stephanie / Ma, Kim /

Farmakiotis, Dimitrios / Vieira, Kendra / Arvanitis, Panos / Saliby, Renee M / Labaki, Chris / El Zarif, Talal / Wise-Draper, Trisha M / Zamulko, Olga / Li, Ningjing / Bodin, Brianne E / Accordino, Melissa K / Ingham, Matthew / Joshi, Monika / Polimera, Hyma V / Fecher, Leslie A / Friese, Christopher R / Yoon, James J / Mavromatis, Blanche H / Brown, Jacqueline T / Russell, Karen / Nanchal, Rahul / Singh, Harpreet / Tachiki, Lisa / Moria, Feras A / Nagaraj, Gayathri / Cortez, Kimberly / Abbasi, Saqib H / Wulff-Burchfield, Elizabeth M / Puc, Matthew / Weissmann, Lisa B / Bhatt, Padmanabh S / Mariano, Melissa G / Mishra, Sanjay / Halabi, Susan / Beeghly, Alicia / Warner, Jeremy L / French, Benjamin / Bilen, Mehmet A

Cancer

2024

Abstract: Background: COVID-19 can have a particularly detrimental effect on patients with cancer, but no studies to date have examined if the presence, or site, of metastatic cancer is related to COVID-19 outcomes.: Methods: Using the COVID-19 and Cancer ... ...

Abstract	Background: COVID-19 can have a particularly detrimental effect on patients with cancer, but no studies to date have examined if the presence, or site, of metastatic cancer is related to COVID-19 outcomes. Methods: Using the COVID-19 and Cancer Consortium (CCC19) registry, the authors identified 10,065 patients with COVID-19 and cancer (2325 with and 7740 without metastasis at the time of COVID-19 diagnosis). The primary ordinal outcome was COVID-19 severity: not hospitalized, hospitalized but did not receive supplemental O Results: Compared to patients without metastasis, patients with metastases have increased hospitalization rates (59% vs. 49%) and higher 30 day mortality (18% vs. 9%). Patients with metastasis to bone, lung, liver, lymph nodes, and brain have significantly higher COVID-19 severity (adjusted odds ratios [ORs], 1.38, 1.59, 1.38, 1.00, and 2.21) compared to patients without metastases at those sites. Patients with metastasis to the lung have significantly higher odds of 30-day mortality (adjusted OR, 1.53; 95% confidence interval, 1.17-2.00) when adjusting for COVID-19 severity. Conclusions: Patients with metastatic cancer, especially with metastasis to the brain, are more likely to have severe outcomes after COVID-19 whereas patients with metastasis to the lung, compared to patients with cancer metastasis to other sites, have the highest 30-day mortality after COVID-19.
Language	English
Publishing date	2024-02-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	1429-1
ISSN	1097-0142 ; 0008-543X ; 1934-662X
ISSN (online)	1097-0142
ISSN	0008-543X ; 1934-662X
DOI	10.1002/cncr.35247
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Article ; Online: Breakthrough SARS-CoV-2 infections among patients with cancer following two and three doses of COVID-19 mRNA vaccines: a retrospective observational study from the COVID-19 and Cancer Consortium.

Choueiri, Toni K / Labaki, Chris / Bakouny, Ziad / Hsu, Chih-Yuan / Schmidt, Andrew L / de Lima Lopes, Gilberto / Hwang, Clara / Singh, Sunny R K / Jani, Chinmay / Weissmann, Lisa B / Griffiths, Elizabeth A / Halabi, Susan / Wu, Ulysses / Berg, Stephanie / O'Connor, Timothy E / Wise-Draper, Trisha M / Panagiotou, Orestis A / Klein, Elizabeth J / Joshi, Monika /

Yared, Fares / Dutra, Miriam Santos / Gatson, Na Tosha N / Blau, Sibel / Singh, Harpreet / Nanchal, Rahul / McKay, Rana R / Nonato, Taylor K / Quinn, Ryann / Rubinstein, Samuel M / Puc, Matthew / Mavromatis, Blanche H / Vikas, Praveen / Faller, Bryan / Zaren, Howard A / Del Prete, Salvatore / Russell, Karen / Reuben, Daniel Y / Accordino, Melissa K / Friese, Christopher R / Mishra, Sanjay / Rivera, Donna R / Shyr, Yu / Farmakiotis, Dimitrios / Warner, Jeremy L

Lancet regional health. Americas

2023 Volume 19, Page(s) 100445

Abstract: Background: Breakthrough SARS-CoV-2 infections following vaccination against COVID-19 are of international concern. Patients with cancer have been observed to have worse outcomes associated with COVID-19 during the pandemic. We sought to evaluate the ... ...

Abstract	Background: Breakthrough SARS-CoV-2 infections following vaccination against COVID-19 are of international concern. Patients with cancer have been observed to have worse outcomes associated with COVID-19 during the pandemic. We sought to evaluate the clinical characteristics and outcomes of patients with cancer who developed breakthrough SARS-CoV-2 infections after 2 or 3 doses of mRNA vaccines. Methods: We evaluated the clinical characteristics of patients with cancer who developed breakthrough infections using data from the multi-institutional COVID-19 and Cancer Consortium (CCC19; NCT04354701). Analysis was restricted to patients with laboratory-confirmed SARS-CoV-2 diagnosed in 2021 or 2022, to allow for a contemporary unvaccinated control population; potential differences were evaluated using a multivariable logistic regression model after inverse probability of treatment weighting to adjust for potential baseline confounding variables. Adjusted odds ratios (aOR) and 95% confidence intervals (CI) are reported. The primary endpoint was 30-day mortality, with key secondary endpoints of hospitalization and ICU and/or mechanical ventilation (ICU/MV). Findings: The analysis included 2486 patients, of which 564 and 385 had received 2 or 3 doses of an mRNA vaccine prior to infection, respectively. Hematologic malignancies and recent receipt of systemic anti-neoplastic therapy were more frequent among vaccinated patients. Vaccination was associated with improved outcomes: in the primary analysis, 2 doses (aOR: 0.62, 95% CI: 0.44-0.88) and 3 doses (aOR: 0.20, 95% CI: 0.11-0.36) were associated with decreased 30-day mortality. There were similar findings for the key secondary endpoints of ICU/MV (aOR: 0.60, 95% CI: 0.45-0.82 and 0.37, 95% CI: 0.24-0.58) and hospitalization (aOR: 0.60, 95% CI: 0.48-0.75 and 0.35, 95% CI: 0.26-0.46) for 2 and 3 doses, respectively. Importantly, Black patients had higher rates of hospitalization (aOR: 1.47, 95% CI: 1.12-1.92), and Hispanic patients presented with higher rates of ICU/MV (aOR: 1.61, 95% CI: 1.06-2.44). Interpretation: Vaccination against COVID-19, especially with additional doses, is a fundamental strategy in the prevention of adverse outcomes including death, among patients with cancer. Funding: This study was partly supported by grants from the National Cancer Institute grant number P30 CA068485 to C-YH, YS, SM, JLW; T32-CA236621 and P30-CA046592 to C.R.F; CTSA 2UL1TR001425-05A1 to TMW-D; ACS/FHI Real-World Data Impact Award, P50 MD017341-01, R21 CA242044-01A1, Susan G. Komen Leadership Grant Hunt to MKA. REDCap is developed and supported by Vanderbilt Institute for Clinical and Translational Research grant support (UL1 TR000445 from NCATS/NIH).
Language	English
Publishing date	2023-02-13
Publishing country	England
Document type	Journal Article
ISSN	2667-193X
ISSN (online)	2667-193X
DOI	10.1016/j.lana.2023.100445
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Article ; Online: Impact of COVID-19 in patients on active melanoma therapy and with history of melanoma.

Johnson, Douglas B / Atkins, Michael B / Hennessy, Cassandra / Wise-Draper, Trisha / Heilman, Hannah / Awosika, Joy / Bakouny, Ziad / Labaki, Chris / Saliby, Renee Maria / Hwang, Clara / Singh, Sunny R K / Balanchivadze, Nino / Friese, Christopher R / Fecher, Leslie A / Yoon, James J / Hayes-Lattin, Brandon / Bilen, Mehmet A / Castellano, Cecilia A / Lyman, Gary H /

Tachiki, Lisa / Shah, Sumit A / Glover, Michael J / Flora, Daniel B / Wulff-Burchfield, Elizabeth / Kasi, Anup / Abbasi, Saqib H / Farmakiotis, Dimitrios / Viera, Kendra / Klein, Elizabeth J / Weissman, Lisa B / Jani, Chinmay / Puc, Matthew / Fahey, Catherine C / Reuben, Daniel Y / Mishra, Sanjay / Beeghly-Fadiel, Alicia / French, Benjamin / Warner, Jeremy L

BMC cancer

2023 Volume 23, Issue 1, Page(s) 265

Abstract: Introduction: COVID-19 particularly impacted patients with co-morbid conditions, including cancer. Patients with melanoma have not been specifically studied in large numbers. Here, we sought to identify factors that associated with COVID-19 severity ... ...

Abstract	Introduction: COVID-19 particularly impacted patients with co-morbid conditions, including cancer. Patients with melanoma have not been specifically studied in large numbers. Here, we sought to identify factors that associated with COVID-19 severity among patients with melanoma, particularly assessing outcomes of patients on active targeted or immune therapy. Methods: Using the COVID-19 and Cancer Consortium (CCC19) registry, we identified 307 patients with melanoma diagnosed with COVID-19. We used multivariable models to assess demographic, cancer-related, and treatment-related factors associated with COVID-19 severity on a 6-level ordinal severity scale. We assessed whether treatment was associated with increased cardiac or pulmonary dysfunction among hospitalized patients and assessed mortality among patients with a history of melanoma compared with other cancer survivors. Results: Of 307 patients, 52 received immunotherapy (17%), and 32 targeted therapy (10%) in the previous 3 months. Using multivariable analyses, these treatments were not associated with COVID-19 severity (immunotherapy OR 0.51, 95% CI 0.19 - 1.39; targeted therapy OR 1.89, 95% CI 0.64 - 5.55). Among hospitalized patients, no signals of increased cardiac or pulmonary organ dysfunction, as measured by troponin, brain natriuretic peptide, and oxygenation were noted. Patients with a history of melanoma had similar 90-day mortality compared with other cancer survivors (OR 1.21, 95% CI 0.62 - 2.35). Conclusions: Melanoma therapies did not appear to be associated with increased severity of COVID-19 or worsening organ dysfunction. Patients with history of melanoma had similar 90-day survival following COVID-19 compared with other cancer survivors.
MeSH term(s)	Humans ; COVID-19/therapy ; Multiple Organ Failure ; Melanoma/complications ; Melanoma/therapy ; Immunotherapy
Language	English
Publishing date	2023-03-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2041352-X
ISSN	1471-2407 ; 1471-2407
ISSN (online)	1471-2407
ISSN	1471-2407
DOI	10.1186/s12885-023-10708-6
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