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  1. Article ; Online: Reassortant Cache Valley Virus Associated With Acute Febrile, Nonneurologic Illness, Missouri.

    Baker, Molly / Hughes, Holly R / Naqvi, S Hasan / Yates, Karen / Velez, Jason O / McGuirk, Sophia / Schroder, Barb / Lambert, Amy J / Kosoy, Olga I / Pue, Howard / Turabelidze, George / Staples, J Erin

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2021  Volume 73, Issue 9, Page(s) 1700–1702

    Abstract: An adult male from Missouri sought care for fever, fatigue, and gastrointestinal symptoms. He had leukopenia and thrombocytopenia and was treated for a presumed tickborne illness. His condition deteriorated with respiratory and renal failure, lactic ... ...

    Abstract An adult male from Missouri sought care for fever, fatigue, and gastrointestinal symptoms. He had leukopenia and thrombocytopenia and was treated for a presumed tickborne illness. His condition deteriorated with respiratory and renal failure, lactic acidosis, and hypotension. Next-generation sequencing and phylogenetic analysis identified a reassortant Cache Valley virus.
    MeSH term(s) Adult ; Bunyamwera virus ; Bunyaviridae Infections/diagnosis ; Bunyaviridae Infections/epidemiology ; Fever ; Humans ; Male ; Missouri/epidemiology ; Phylogeny
    Language English
    Publishing date 2021-02-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciab175
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1505: Show issues Location:
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  2. Article: First human rabies case in Missouri in 50 years causes death in outdoorsman.

    Turabelidze, George / Pue, Howard / Grim, Autumn / Patrick, Sarah

    Missouri medicine

    2009  Volume 106, Issue 6, Page(s) 417–419

    Abstract: This report describes the first case of human rabies in Missouri in 50 years that resulted in a patient fatality. Current rabies epidemiology, treatment and management of exposures, and the signs and symptoms and treatment of human rabies is discussed. ...

    Abstract This report describes the first case of human rabies in Missouri in 50 years that resulted in a patient fatality. Current rabies epidemiology, treatment and management of exposures, and the signs and symptoms and treatment of human rabies is discussed.
    MeSH term(s) Animals ; Bites and Stings ; Chiroptera ; Contact Tracing ; Fatal Outcome ; Humans ; Male ; Middle Aged ; Missouri ; Rabies/diagnosis ; Rabies/physiopathology ; Rabies/transmission
    Language English
    Publishing date 2009-11
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 427362-x
    ISSN 0026-6620
    ISSN 0026-6620
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: An Investigation of a Cluster of Parapoxvirus Cases in Missouri, Feb–May 2006: Epidemiologic, Clinical and Molecular Aspects

    Lederman, Edith R / Tao, Min / Reynolds, Mary G / Li, Yu / Zhao, Hui / Smith, Scott K / Sitler, Lisa / Haberling, Dana L / Davidson, Whitni / Hutson, Christina / Emerson, Ginny / Schnurr, David / Regnery, Russell / Zhu, Bao-Ping / Pue, Howard / Damon, Inger K

    Animals. 2013 Feb. 28, v. 3, no. 1

    2013  

    Abstract: In the spring of 2006, four human cases of parapoxvirus infections in Missouri residents were reported to the Centers for Disease Control and Prevention (CDC), two of which were initially diagnosed as cutaneous anthrax. This investigation was conducted ... ...

    Abstract In the spring of 2006, four human cases of parapoxvirus infections in Missouri residents were reported to the Centers for Disease Control and Prevention (CDC), two of which were initially diagnosed as cutaneous anthrax. This investigation was conducted to determine the level of recognition of zoonotic parapoxvirus infections and prevention measures, the degree to which veterinarians may be consulted on human infections and what forces were behind this perceived increase in reported infections. Interviews were conducted and clinical and environmental sampling was performed. Swab and scab specimens were analyzed by real-time polymerase chain reaction (PCR), whereas serum specimens were evaluated for parapoxvirus antibodies. Three case patients were found to have fed ill juvenile animals without using gloves. Forty-six percent of veterinarians reported having been consulted regarding suspected human orf infections. Orf virus DNA was detected from five of 25 asymptomatic sheep. Analysis of extracellular envelope gene sequences indicated that sheep and goat isolates clustered in a species-preferential fashion. Parapoxvirus infections are common in Missouri ruminants and their handlers. Infected persons often do not seek medical care; some may seek advice from veterinarians rather than physicians. The initial perception of increased incidence in Missouri may have arisen from a reporting artifact stemming from heightened concern about anthrax. Asymptomatic parapoxvirus infections in livestock may be common and further investigation warranted.
    Keywords DNA ; Orf virus ; anthrax ; blood serum ; genes ; goats ; humans ; juveniles ; quantitative polymerase chain reaction ; sheep ; spring ; Missouri
    Language English
    Dates of publication 2013-0228
    Size p. 142-157.
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-light
    ISSN 2076-2615
    DOI 10.3390/ani3010142
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: Diagnosis of West Nile virus infection in horses.

    Kleiboeker, Steven B / Loiacono, Christina M / Rottinghaus, Audrey / Pue, Howard L / Johnson, Gayle C

    Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc

    2003  Volume 16, Issue 1, Page(s) 2–10

    Abstract: The North American West Nile virus (WNV) epizootic, which began in 1999, has caused significant morbidity and mortality in horses. Because experimental infection has failed to consistently produce encephalitis in inoculated horses, investigation of ... ...

    Abstract The North American West Nile virus (WNV) epizootic, which began in 1999, has caused significant morbidity and mortality in horses. Because experimental infection has failed to consistently produce encephalitis in inoculated horses, investigation of naturally occurring cases was used to optimize strategies for diagnosis of this disease. Although WNV RNA could be detected by reverse transcriptase-polymerase chain reaction (RT-PCR) performed on whole blood collected from both clinically affected horses and unaffected herdmates, the diagnostic sensitivity of this approach was low compared with IgM-capture enzyme-linked immunosorbent assay. In addition, it was observed that 18.5% of herdmates of clinically ill horses seroconverted to WNV yet exhibited no overt clinical signs of WNV encephalitis. West Nile viral RNA was detected in neural tissue of 46 of 64 dead horses that were suspected of having WNV encephalitis. Some of these animals were IgM negative or had not been tested serologically. A primary cause of death other than WNV encephalitis was identified in 15 of the 64 cases, whereas the final diagnosis for 3 of these cases remains unresolved. Quantitative RT-PCR analysis of neural tissue from WNV RNA-positive horses demonstrated that the medulla contained the highest mean concentration of viral RNA and that WNV RNA could be detected in samples extracted from formalin-fixed neural tissue. A comparison of WNV RT-PCR amplification strategies found that nested RT-PCR improved diagnostic sensitivity only slightly over a single round of amplification and that a quantitative (TaqMan) assay had sensitivity and specificity that were equivalent to those of nested amplification.
    MeSH term(s) Animals ; Antibodies, Viral/blood ; Brain Diseases/diagnosis ; Brain Diseases/epidemiology ; Brain Diseases/veterinary ; Brain Diseases/virology ; Disease Outbreaks ; Enzyme-Linked Immunosorbent Assay/methods ; Enzyme-Linked Immunosorbent Assay/veterinary ; Horse Diseases/diagnosis ; Horse Diseases/epidemiology ; Horse Diseases/virology ; Horses ; Immunoglobulin M/blood ; Missouri/epidemiology ; RNA, Viral/chemistry ; RNA, Viral/genetics ; Retrospective Studies ; Reverse Transcriptase Polymerase Chain Reaction/methods ; Reverse Transcriptase Polymerase Chain Reaction/veterinary ; Sensitivity and Specificity ; West Nile Fever/diagnosis ; West Nile Fever/epidemiology ; West Nile Fever/veterinary ; West Nile Fever/virology ; West Nile virus/genetics ; West Nile virus/isolation & purification
    Chemical Substances Antibodies, Viral ; Immunoglobulin M ; RNA, Viral
    Language English
    Publishing date 2003-02-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 287603-6
    ISSN 1943-4936 ; 1040-6387
    ISSN (online) 1943-4936
    ISSN 1040-6387
    DOI 10.1177/104063870401600102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3645: Show issues Location:
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  5. Article: An Investigation of a Cluster of Parapoxvirus Cases in Missouri, Feb-May 2006: Epidemiologic, Clinical and Molecular Aspects.

    Lederman, Edith R / Tao, Min / Reynolds, Mary G / Li, Yu / Zhao, Hui / Smith, Scott K / Sitler, Lisa / Haberling, Dana L / Davidson, Whitni / Hutson, Christina / Emerson, Ginny / Schnurr, David / Regnery, Russell / Zhu, Bao-Ping / Pue, Howard / Damon, Inger K

    Animals : an open access journal from MDPI

    2013  Volume 3, Issue 1, Page(s) 142–157

    Abstract: In the spring of 2006, four human cases of parapoxvirus infections in Missouri residents were reported to the Centers for Disease Control and Prevention (CDC), two of which were initially diagnosed as cutaneous anthrax. This investigation was conducted ... ...

    Abstract In the spring of 2006, four human cases of parapoxvirus infections in Missouri residents were reported to the Centers for Disease Control and Prevention (CDC), two of which were initially diagnosed as cutaneous anthrax. This investigation was conducted to determine the level of recognition of zoonotic parapoxvirus infections and prevention measures, the degree to which veterinarians may be consulted on human infections and what forces were behind this perceived increase in reported infections. Interviews were conducted and clinical and environmental sampling was performed. Swab and scab specimens were analyzed by real-time polymerase chain reaction (PCR), whereas serum specimens were evaluated for parapoxvirus antibodies. Three case patients were found to have fed ill juvenile animals without using gloves. Forty-six percent of veterinarians reported having been consulted regarding suspected human orf infections. Orf virus DNA was detected from five of 25 asymptomatic sheep. Analysis of extracellular envelope gene sequences indicated that sheep and goat isolates clustered in a species-preferential fashion. Parapoxvirus infections are common in Missouri ruminants and their handlers. Infected persons often do not seek medical care; some may seek advice from veterinarians rather than physicians. The initial perception of increased incidence in Missouri may have arisen from a reporting artifact stemming from heightened concern about anthrax. Asymptomatic parapoxvirus infections in livestock may be common and further investigation warranted.
    Language English
    Publishing date 2013-02-28
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani3010142
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: ORF virus infection in children: clinical characteristics, transmission, diagnostic methods, and future therapeutics.

    Lederman, Edith R / Austin, Connie / Trevino, Ingrid / Reynolds, Mary G / Swanson, Holly / Cherry, Bryan / Ragsdale, Jennifer / Dunn, John / Meidl, Susan / Zhao, Hui / Li, Yu / Pue, Howard / Damon, Inger K

    The Pediatric infectious disease journal

    2007  Volume 26, Issue 8, Page(s) 740–744

    Abstract: Orf virus leads to self-limited, subacute cutaneous infections in children who have occupational or recreational contact with infected small ruminants. Breaches in the integument and contact with animals recently vaccinated for orf may be important risk ... ...

    Abstract Orf virus leads to self-limited, subacute cutaneous infections in children who have occupational or recreational contact with infected small ruminants. Breaches in the integument and contact with animals recently vaccinated for orf may be important risk factors in transmission. Common childhood behaviors are likely important factors in the provocation of significant contact (ie, bites) or in unusual lesion location (eg, facial lesions). Clinician recognition is important in distinguishing orf infection from life-threatening cutaneous zoonoses. Recently developed molecular techniques provide diagnostic precision and newer topical therapeutics may hasten healing.
    MeSH term(s) Adolescent ; Animals ; Child ; Child, Preschool ; Ecthyma, Contagious/diagnosis ; Ecthyma, Contagious/pathology ; Ecthyma, Contagious/physiopathology ; Ecthyma, Contagious/virology ; Female ; Humans ; Male ; Orf virus/isolation & purification ; Zoonoses/virology
    Language English
    Publishing date 2007-08
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 392481-6
    ISSN 1532-0987 ; 0891-3668
    ISSN (online) 1532-0987
    ISSN 0891-3668
    DOI 10.1097/INF.0b013e31806211bf
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1852: Show issues Location:
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  7. Article: Diagnosis of West Nile Virus Infection in Horses

    Kleiboeker, Steven B. / Loiacono, Christina M. / Rottinghaus, Audrey / Pue, Howard L. / Johnson, Gayle C.

    Journal of veterinary diagnostic investigation

    Volume v. 16,, Issue no. 1

    Abstract: The North American West Nile virus (WNV) epizootic, which began in 1999, has caused significant morbidity and mortality in horses. Because experimental infection has failed to consistently produce encephalitis in inoculated horses, investigation of ... ...

    Abstract The North American West Nile virus (WNV) epizootic, which began in 1999, has caused significant morbidity and mortality in horses. Because experimental infection has failed to consistently produce encephalitis in inoculated horses, investigation of naturally occurring cases was used to optimize strategies for diagnosis of this disease. Although WNV RNA could be detected by reverse transcriptase-polymerase chain reaction (RT-PCR) performed on whole blood collected from both clinically affected horses and unaffected herdmates, the diagnostic sensitivity of this approach was low compared with IgM-capture enzyme-linked immunosorbent assay. In addition, it was observed that 18.5% of herdmates of clinically ill horses seroconverted to WNV yet exhibited no overt clinical signs of WNV encephalitis. West Nile viral RNA was detected in neural tissue of 46 of 64 dead horses that were suspected of having WNV encephalitis. Some of these animals were IgM negative or had not been tested serologically. A primary cause of death other than WNV encephalitis was identified in 15 of the 64 cases, whereas the final diagnosis for 3 of these cases remains unresolved. Quantitative RT-PCR analysis of neural tissue from WNV RNA-positive horses demonstrated that the medulla contained the highest mean concentration of viral RNA and that WNV RNA could be detected in samples extracted from formalin-fixed neural tissue. A comparison of WNV RT-PCR amplification strategies found that nested RT-PCR improved diagnostic sensitivity only slightly over a single round of amplification and that a quantitative (TaqMan) assay had sensitivity and specificity that were equivalent to those of nested amplification.
    Keywords immunoglobulin M ; diagnostic sensitivity ; horses ; RNA ; death ; mortality ; encephalitis ; blood ; morbidity ; West Nile virus ; reverse transcriptase polymerase chain reaction ; enzyme-linked immunosorbent assay
    Language English
    Document type Article
    ISSN 1040-6387
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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