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  1. Article ; Online: Is Chronic Pain Temporal Pattern Associated with Middle-Aged and Older Adults' Perceptions of their Futures?

    Fennell, Gillian / Yip, Abby Pui Wang / Reid, M Carrington / Enguídanos, Susan / Zelinski, Elizabeth / Löckenhoff, Corinna

    Health psychology bulletin

    2021  Volume 5, Issue 1, Page(s) 136–144

    Abstract: A psychological consequence of chronic pain may be an inappropriately limited future time perspective (FTP) for middle-aged and older adults. FTP is defined as one's perception of time as limited or expansive. Potentially meaningful measures, like pain ... ...

    Abstract A psychological consequence of chronic pain may be an inappropriately limited future time perspective (FTP) for middle-aged and older adults. FTP is defined as one's perception of time as limited or expansive. Potentially meaningful measures, like pain temporal pattern, are often ignored in the chronic pain literature. The present study uses secondary data to assess the association between pain temporal pattern and FTP, and the moderating effect of pain duration. Among 140 individuals with chronic pain, there was no significant association between pain pattern and FTP. However, both pain-related activity interference and pain duration were associated with FTP where greater interference predicted more limited FTP (
    Language English
    Publishing date 2021-12-30
    Publishing country England
    Document type Journal Article
    ISSN 2398-5941
    ISSN (online) 2398-5941
    DOI 10.5334/hpb.34
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Is Chronic Pain Temporal Pattern Associated with Middle-Aged and Older Adults’ Perceptions of their Futures?

    Gillian Fennell / Abby Pui Wang Yip / M. Carrington Reid / Susan Enguídanos / Elizabeth Zelinski / Corinna Löckenhoff

    Health Psychology Bulletin, Vol 5, Iss

    2021  Volume 1

    Abstract: A psychological consequence of chronic pain may be an inappropriately limited future time perspective (FTP) for middle-aged and older adults. FTP is defined as one’s perception of time as limited or expansive. Potentially meaningful measures, like pain ... ...

    Abstract A psychological consequence of chronic pain may be an inappropriately limited future time perspective (FTP) for middle-aged and older adults. FTP is defined as one’s perception of time as limited or expansive. Potentially meaningful measures, like pain temporal pattern, are often ignored in the chronic pain literature. The present study uses secondary data to assess the association between pain temporal pattern and FTP, and the moderating effect of pain duration. Among 140 individuals with chronic pain, there was no significant association between pain pattern and FTP. However, both pain-related activity interference and pain duration were associated with FTP where greater interference predicted more limited FTP ('b' = –0.16, 'p' = .03) and longer pain duration contributed to more expansive FTP ('b' = 0.001, 'p' = .03). The temporal pattern x pain duration interaction terms were non-significant. We discuss implications, limitations, and future directions of these findings.
    Keywords future time perspective ; chronic pain ; temporal pattern ; duration ; interference ; Public aspects of medicine ; RA1-1270 ; Psychology ; BF1-990
    Subject code 120
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher Ubiquity Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: An intranasal influenza virus-vectored vaccine prevents SARS-CoV-2 replication in respiratory tissues of mice and hamsters

    Shaofeng Deng / Ying Liu / Rachel Chun-Yee Tam / Pin Chen / Anna Jinxia Zhang / Bobo Wing-Yee Mok / Teng Long / Anja Kukic / Runhong Zhou / Haoran Xu / Wenjun Song / Jasper Fuk-Woo Chan / Kelvin Kai-Wang To / Zhiwei Chen / Kwok-Yung Yuen / Pui Wang / Honglin Chen

    Nature Communications, Vol 14, Iss 1, Pp 1-

    2023  Volume 12

    Abstract: Abstract Current available vaccines for COVID-19 are effective in reducing severe diseases and deaths caused by SARS-CoV-2 infection but less optimal in preventing infection. Next-generation vaccines which are able to induce mucosal immunity in the upper ...

    Abstract Abstract Current available vaccines for COVID-19 are effective in reducing severe diseases and deaths caused by SARS-CoV-2 infection but less optimal in preventing infection. Next-generation vaccines which are able to induce mucosal immunity in the upper respiratory to prevent or reduce infections caused by highly transmissible variants of SARS-CoV-2 are urgently needed. We have developed an intranasal vaccine candidate based on a live attenuated influenza virus (LAIV) with a deleted NS1 gene that encodes cell surface expression of the receptor-binding-domain (RBD) of the SARS-CoV-2 spike protein, designated DelNS1-RBD4N-DAF. Immune responses and protection against virus challenge following intranasal administration of DelNS1-RBD4N-DAF vaccines were analyzed in mice and compared with intramuscular injection of the BioNTech BNT162b2 mRNA vaccine in hamsters. DelNS1-RBD4N-DAF LAIVs induced high levels of neutralizing antibodies against various SARS-CoV-2 variants in mice and hamsters and stimulated robust T cell responses in mice. Notably, vaccination with DelNS1-RBD4N-DAF LAIVs, but not BNT162b2 mRNA, prevented replication of SARS-CoV-2 variants, including Delta and Omicron BA.2, in the respiratory tissues of animals. The DelNS1-RBD4N-DAF LAIV system warrants further evaluation in humans for the control of SARS-CoV-2 transmission and, more significantly, for creating dual function vaccines against both influenza and COVID-19 for use in annual vaccination strategies.
    Keywords Science ; Q
    Subject code 570
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Characterization of an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction of the spike protein

    Pui Wang / Siu-Ying Lau / Shaofeng Deng / Pin Chen / Bobo Wing-Yee Mok / Anna Jinxia Zhang / Andrew Chak-Yiu Lee / Kwok-Hung Chan / Rachel Chun-Yee Tam / Haoran Xu / Runhong Zhou / Wenjun Song / Li Liu / Kelvin Kai-Wang To / Jasper Fuk-Woo Chan / Zhiwei Chen / Kwok-Yung Yuen / Honglin Chen

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Volume 10

    Abstract: The S1/S2 junction of the SARS-CoV-2 Spike protein is emerging as a key factor in virulence and pathogenesis. Here, the authors characterise an attenuated strain of SARS-CoV-2 with deletions in the critical S1/S2 junction and observe enhanced replication, ...

    Abstract The S1/S2 junction of the SARS-CoV-2 Spike protein is emerging as a key factor in virulence and pathogenesis. Here, the authors characterise an attenuated strain of SARS-CoV-2 with deletions in the critical S1/S2 junction and observe enhanced replication, generation of potent adaptive immunity but reduced immunopathology in a hamster model of infection.
    Keywords Science ; Q
    Language English
    Publishing date 2021-05-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: A broadly neutralizing antibody protects Syrian hamsters against SARS-CoV-2 Omicron challenge

    Biao Zhou / Runhong Zhou / Bingjie Tang / Jasper Fuk-Woo Chan / Mengxiao Luo / Qiaoli Peng / Shuofeng Yuan / Hang Liu / Bobo Wing-Yee Mok / Bohao Chen / Pui Wang / Vincent Kwok-Man Poon / Hin Chu / Chris Chung-Sing Chan / Jessica Oi-Ling Tsang / Chris Chun-Yiu Chan / Ka-Kit Au / Hiu-On Man / Lu Lu /
    Kelvin Kai-Wang To / Honglin Chen / Kwok-Yung Yuen / Shangyu Dang / Zhiwei Chen

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 14

    Abstract: SARS-CoV-2 variants of concern such as the Omicron variant pose a challenge for vaccination and antibody immunotherapy. Here, Zhou et al. isolate a broadly neutralizing antibody (bNAb), named ZCB11, that protects Golden Syrian hamsters against Omicron. ... ...

    Abstract SARS-CoV-2 variants of concern such as the Omicron variant pose a challenge for vaccination and antibody immunotherapy. Here, Zhou et al. isolate a broadly neutralizing antibody (bNAb), named ZCB11, that protects Golden Syrian hamsters against Omicron. Applying CryoEM the authors show that ZCB11 heavy chain predominantly interacts with RBD in up confirmation, which interferes with ACE2 receptor binding.
    Keywords Science ; Q
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: An NS-segment exonic splicing enhancer regulates influenza A virus replication in mammalian cells

    Xiaofeng Huang / Min Zheng / Pui Wang / Bobo Wing-Yee Mok / Siwen Liu / Siu-Ying Lau / Pin Chen / Yen-Chin Liu / Honglian Liu / Yixin Chen / Wenjun Song / Kwok-Yung Yuen / Honglin Chen

    Nature Communications, Vol 8, Iss 1, Pp 1-

    2017  Volume 15

    Abstract: Some circulating avian influenza A viruses can infect humans, but the mechanism enabling species jump is poorly understood. Here, Huanget al. identify a nucleotide in NEP of avian H7N9 viruses that affects splicing efficiency of the NS segment and ... ...

    Abstract Some circulating avian influenza A viruses can infect humans, but the mechanism enabling species jump is poorly understood. Here, Huanget al. identify a nucleotide in NEP of avian H7N9 viruses that affects splicing efficiency of the NS segment and supports virus replication in avian and mammalian cells.
    Keywords Science ; Q
    Language English
    Publishing date 2017-03-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Low dose inocula of SARS-CoV-2 Alpha variant transmits more efficiently than earlier variants in hamsters

    Bobo Wing-Yee Mok / Honglian Liu / Shaofeng Deng / Jiayan Liu / Anna Jinxia Zhang / Siu-Ying Lau / Siwen Liu / Rachel Chun-Yee Tam / Conor J. Cremin / Timothy Ting-Leung Ng / Jake Siu-Lun Leung / Lam-Kwong Lee / Pui Wang / Kelvin Kai-Wang To / Jasper Fuk-Woo Chan / Kwok-Hung Chan / Kwok-Yung Yuen / Gilman Kit-Hang Siu / Honglin Chen

    Communications Biology, Vol 4, Iss 1, Pp 1-

    2021  Volume 8

    Abstract: Bobo Wing-Yee Mok et al. observe that the Alpha (B.1.1.7) variant of SARS-CoV-2 exhibits increased competitive fitness over earlier lineages at lower doses in a hamster model of viral transmission. Their results suggest that the Alpha variant’s ability ... ...

    Abstract Bobo Wing-Yee Mok et al. observe that the Alpha (B.1.1.7) variant of SARS-CoV-2 exhibits increased competitive fitness over earlier lineages at lower doses in a hamster model of viral transmission. Their results suggest that the Alpha variant’s ability to initiate effective infection with a low dose may underlie its ability to rapidly transmit throughout a population.
    Keywords Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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