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  1. Book: Adverse reactions to biologics

    Puig, Lluís / Gulliver, Wayne

    (Current problems in dermatology ; 53)

    2018  

    Author's details volume editors Lluís Puig ; Wayne Gulliver
    Series title Current problems in dermatology ; 53
    Collection
    Keywords Skin Diseases / drug therapy ; Biological Products / adverse effcts ; Biological Products / therapeutic use ; Hautkrankheit ; Pharmakotherapie ; Biologika
    Subject Biologicals ; Biopharmazeutika ; Biopharmaka ; Biologics ; Biopharmazeutikum ; Arzneimitteltherapie ; Arzneitherapie ; Medikamentöse Therapie ; Dermatose ; Haut ; Hauterkrankung ; Hautkrankheiten
    Language English
    Size X, 108 Seiten, Illustrationen, Diagramme
    Publisher Karger
    Publishing place Basel
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT019526161
    ISBN 978-3-318-06100-0 ; 9783318061017 ; 3-318-06100-X ; 3318061018
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2017 A 2014 available for loan (reading room) Lesesaal EG

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  2. Article ; Online: Psoriasis treatment does not impair the immunogenicity of ChAOx1-S[recombinant] COVID-19 vaccination.

    Puig, Lluís

    The British journal of dermatology

    2023  Volume 188, Issue 2, Page(s) 163–165

    MeSH term(s) Humans ; COVID-19 Vaccines ; Prospective Studies ; COVID-19/prevention & control ; Vaccination ; Psoriasis/drug therapy
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2023-02-09
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1093/bjd/ljac081
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Psoriasis treatment: no more room on the summit?

    Puig, Lluís

    The British journal of dermatology

    2022  Volume 187, Issue 6, Page(s) 837

    MeSH term(s) Humans ; Psoriasis/drug therapy
    Language English
    Publishing date 2022-09-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/bjd.21848
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Multi-Omics Approach to Improved Diagnosis and Treatment of Atopic Dermatitis and Psoriasis.

    Rusiñol, Lluís / Puig, Lluís

    International journal of molecular sciences

    2024  Volume 25, Issue 2

    Abstract: Psoriasis and atopic dermatitis fall within the category of cutaneous immune-mediated inflammatory diseases (IMIDs). The prevalence of IMIDs is increasing in industrialized societies, influenced by both environmental changes and a genetic predisposition. ...

    Abstract Psoriasis and atopic dermatitis fall within the category of cutaneous immune-mediated inflammatory diseases (IMIDs). The prevalence of IMIDs is increasing in industrialized societies, influenced by both environmental changes and a genetic predisposition. However, the exact immune factors driving these chronic, progressive diseases are not fully understood. By using multi-omics techniques in cutaneous IMIDs, it is expected to advance the understanding of skin biology, uncover the underlying mechanisms of skin conditions, and potentially devise precise and personalized approaches to diagnosis and treatment. We provide a narrative review of the current knowledge in genomics, epigenomics, and proteomics of atopic dermatitis and psoriasis. A literature search was performed for articles published until 30 November 2023. Although there is still much to uncover, recent evidence has already provided valuable insights, such as proteomic profiles that permit differentiating psoriasis from mycosis fungoides and β-defensin 2 correlation to PASI and its drop due to secukinumab first injection, among others.
    MeSH term(s) Humans ; Dermatitis, Atopic/diagnosis ; Dermatitis, Atopic/drug therapy ; Dermatitis, Atopic/genetics ; Multiomics ; Proteomics ; Psoriasis/diagnosis ; Psoriasis/drug therapy ; Psoriasis/genetics ; Skin Neoplasms ; Immunomodulating Agents
    Chemical Substances Immunomodulating Agents
    Language English
    Publishing date 2024-01-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25021042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Choosing the right biologic treatment for moderate-to-severe plaque psoriasis: the impact of comorbidities.

    Mateu-Arrom, Laura / Puig, Lluis

    Expert review of clinical pharmacology

    2024  Volume 17, Issue 4, Page(s) 363–379

    Abstract: Introduction: Psoriasis is a chronic inflammatory skin disease often associated with several comorbidities, such as psoriatic arthritis, inflammatory bowel disease, obesity, diabetes mellitus or cardiovascular diseases, infections, or cancer, among ... ...

    Abstract Introduction: Psoriasis is a chronic inflammatory skin disease often associated with several comorbidities, such as psoriatic arthritis, inflammatory bowel disease, obesity, diabetes mellitus or cardiovascular diseases, infections, or cancer, among others. With the progressive aging of the population, a growing number of patients with psoriasis can be expected to present multiple comorbidities. Currently, there is a wide range of biological treatments available for moderate to severe psoriasis, including tumor necrosis alpha (TNF) inhibitors, IL12/23 inhibitor, IL17 inhibitors, and IL23 inhibitors.
    Areas covered: This review aims to describe the specific characteristics of these drugs in relation to psoriasis comorbidities, in order to facilitate decision-making in clinical practice.
    Expert opinion: Some of the biological treatments can influence comorbidities, in some cases even improving them. Therefore, comorbidities are a key factor when deciding on one biological treatment over another. The development of new drugs is expanding the therapeutic arsenal for psoriasis. A high level of expertise in the field with a detailed knowledge of the characteristics of every drug is imperative to provide personalized medicine.
    MeSH term(s) Humans ; Psoriasis/drug therapy ; Arthritis, Psoriatic/drug therapy ; Comorbidity ; Inflammatory Bowel Diseases/drug therapy ; Biological Products/adverse effects
    Chemical Substances Biological Products
    Language English
    Publishing date 2024-04-11
    Publishing country England
    Document type Journal Article ; Review
    ISSN 1751-2441
    ISSN (online) 1751-2441
    DOI 10.1080/17512433.2024.2340552
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The safety of ixekizumab in psoriasis drug therapy.

    Puig, Lluís

    Expert opinion on drug safety

    2020  Volume 19, Issue 2, Page(s) 117–130

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Antibodies, Monoclonal, Humanized/administration & dosage ; Antibodies, Monoclonal, Humanized/adverse effects ; Arthritis, Psoriatic/drug therapy ; Dermatologic Agents/administration & dosage ; Dermatologic Agents/adverse effects ; Humans ; Interleukin-17/antagonists & inhibitors ; Psoriasis/drug therapy ; Severity of Illness Index ; Spondylitis, Ankylosing/drug therapy
    Chemical Substances Antibodies, Monoclonal, Humanized ; Dermatologic Agents ; IL17A protein, human ; Interleukin-17 ; ixekizumab (BTY153760O)
    Language English
    Publishing date 2020-02-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2088728-0
    ISSN 1744-764X ; 1474-0338
    ISSN (online) 1744-764X
    ISSN 1474-0338
    DOI 10.1080/14740338.2020.1709440
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  7. Article ; Online: Genetic and Epigenetic Mechanisms of Psoriasis.

    Mateu-Arrom, Laura / Puig, Lluis

    Genes

    2023  Volume 14, Issue 8

    Abstract: Psoriasis is a disease involving the innate and adaptative components of the immune system, and it is triggered by environmental factors in genetically susceptible individuals. However, its physiopathology is not fully understood yet. Recent ... ...

    Abstract Psoriasis is a disease involving the innate and adaptative components of the immune system, and it is triggered by environmental factors in genetically susceptible individuals. However, its physiopathology is not fully understood yet. Recent technological advances, especially in genome and epigenome-wide studies, have provided a better understanding of the genetic and epigenetic mechanisms to determine the physiopathology of psoriasis and facilitate the development of new drugs. This review intends to summarize the current evidence on genetic and epigenetic mechanisms of psoriasis.
    MeSH term(s) Humans ; Epigenesis, Genetic ; Psoriasis/genetics ; Epigenome ; Acclimatization ; Genetic Predisposition to Disease
    Language English
    Publishing date 2023-08-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes14081619
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Ixekizumab for the treatment of moderate-to-severe plaque psoriasis: the first septennium.

    Carmona-Rocha, Elena / Puig, Lluís

    Immunotherapy

    2023  Volume 15, Issue 15, Page(s) 1209–1225

    Abstract: Ixekizumab is a humanized monoclonal antibody that specifically inhibits IL-17A. It has been approved for the treatment of adult and pediatric psoriasis, psoriatic arthritis and axial spondyloarthropathies by the US FDA and the EMA. Phase III trials, ...

    Abstract Ixekizumab is a humanized monoclonal antibody that specifically inhibits IL-17A. It has been approved for the treatment of adult and pediatric psoriasis, psoriatic arthritis and axial spondyloarthropathies by the US FDA and the EMA. Phase III trials,
    MeSH term(s) Adult ; Humans ; Child ; Psoriasis/drug therapy ; Antibodies, Monoclonal, Humanized/therapeutic use ; Arthritis, Psoriatic ; Biological Products
    Chemical Substances ixekizumab (BTY153760O) ; Antibodies, Monoclonal, Humanized ; Biological Products
    Language English
    Publishing date 2023-08-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2495964-9
    ISSN 1750-7448 ; 1750-743X
    ISSN (online) 1750-7448
    ISSN 1750-743X
    DOI 10.2217/imt-2023-0013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Pathogenic Role of IL-17 and Therapeutic Targeting of IL-17F in Psoriatic Arthritis and Spondyloarthropathies.

    Sánchez-Rodríguez, Guillermo / Puig, Lluís

    International journal of molecular sciences

    2023  Volume 24, Issue 12

    Abstract: The interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in host defence against microbial organisms and the development of inflammatory diseases, including psoriasis (PsO), axial spondyloarthritis (axSpA), and ...

    Abstract The interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in host defence against microbial organisms and the development of inflammatory diseases, including psoriasis (PsO), axial spondyloarthritis (axSpA), and psoriatic arthritis (PsA). IL-17A is the signature cytokine produced by T helper 17 (Th17) cells and is considered the most biologically active form. The pathogenetic involvement of IL-17A in these conditions has been confirmed, and its blockade with biological agents has provided a highly effective therapeutical approach. IL-17F is also overexpressed in the skin and synovial tissues of patients with these diseases, and recent studies suggest its involvement in promoting inflammation and tissue damage in axSpA and PsA. The simultaneous targeting of IL-17A and IL-17F by dual inhibitors and bispecific antibodies may improve the management of Pso, PsA, and axSpA, as demonstrated in the pivotal studies of dual specific antibodies such as bimekizumab. The present review focuses on the role of IL-17F and its therapeutic blockade in axSpA and PsA.
    MeSH term(s) Humans ; Arthritis, Psoriatic/drug therapy ; Interleukin-17 ; Psoriasis/drug therapy ; Inflammation ; Skin ; Cytokines/therapeutic use
    Chemical Substances Interleukin-17 ; Cytokines
    Language English
    Publishing date 2023-06-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241210305
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The biological basis of disease recurrence in psoriasis.

    Carmona-Rocha, Elena / Puig, Lluís

    Italian journal of dermatology and venereology

    2023  Volume 158, Issue 4, Page(s) 279–291

    Abstract: Despite the amazing advances produced in our understanding of the pathogenesis of psoriasis, which have led to a therapeutic revolution, our knowledge of the mechanisms of relapse and elicitation of lesions is just starting to unravel. This narrative ... ...

    Abstract Despite the amazing advances produced in our understanding of the pathogenesis of psoriasis, which have led to a therapeutic revolution, our knowledge of the mechanisms of relapse and elicitation of lesions is just starting to unravel. This narrative review tours the different cell types and mechanisms involved in the priming, maintenance, and relapse of psoriasis vulgaris. Our discussion includes dendritic cells, T cells, tissue resident memory cells and mast cells, with a foray into the epigenetic mechanisms of inflammatory memory in keratinocytes. Increasing knowledge is providing a glimpse of a potential therapeutic window of opportunity in psoriasis, providing long term remission and eventual modification of the natural history of the disease.
    MeSH term(s) Humans ; Psoriasis/genetics ; Psoriasis/therapy ; Recurrence ; Keratinocytes ; T-Lymphocytes ; Dendritic Cells
    Language English
    Publishing date 2023-07-05
    Publishing country Italy
    Document type Review ; Journal Article
    ZDB-ID 3065415-4
    ISSN 2784-8450
    ISSN (online) 2784-8450
    DOI 10.23736/S2784-8671.23.07583-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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