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  1. Article ; Online: Antibiotic Therapy and Prophylaxis for Snake-Bitten Patients.

    Kallel, Hatem / Pujo, Jean Marc / Resiere, Dabor

    The American journal of tropical medicine and hygiene

    2024  Volume 110, Issue 5, Page(s) 845–846

    MeSH term(s) Humans ; Anti-Bacterial Agents/therapeutic use ; Anti-Bacterial Agents/administration & dosage ; Snake Bites/drug therapy ; Antibiotic Prophylaxis/methods ; Animals ; Antivenins/therapeutic use
    Chemical Substances Anti-Bacterial Agents ; Antivenins
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article ; Editorial
    ZDB-ID 2942-7
    ISSN 1476-1645 ; 0002-9637
    ISSN (online) 1476-1645
    ISSN 0002-9637
    DOI 10.4269/ajtmh.24-0033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.61: Show issues Location:
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  2. Article ; Online: Epidemiologic analysis and mortality outcome of firearm injuries in French Guiana (2016-2019).

    Fremery, Alexis / Beguinot, Elliott / Franchi, Angélique / Douchet, Mathilde / Tertre, Victor / Hamiche, Karim / Adenis, Antoine / Pujo, Jean Marc / Kallel, Hatem

    European journal of trauma and emergency surgery : official publication of the European Trauma Society

    2024  

    Abstract: Background: French Guiana (FG) is a French territory located in South America with the highest rate of armed assaults. FG presents a poorly developed road system and a young and precarious population that makes the geographical and socio-demographic ... ...

    Abstract Background: French Guiana (FG) is a French territory located in South America with the highest rate of armed assaults. FG presents a poorly developed road system and a young and precarious population that makes the geographical and socio-demographic characteristics specific. No data concerning the firearm injury management are available in this country. Studying thesis trauma could permit to improve the management of victims. The objective of this study is to investigate the epidemiology of firearm injuries in FG, to define characteristics of the victims, and to assess factors associated with death. These identified factors could enable target primary prevention and intensification of medical management.
    Methods: From January 2016 to December 2019, we conducted a retrospective study at the Cayenne General Hospital (CGH), including all patients admitted for firearm injuries in the emergency department, the medical emergency and resuscitation service, and the forensic service. A bivariate analysis was performed to assess relevant clinical data that were entered into a logistic regression model to assess factors associated with death.
    Results: A total of 871 files were analyzed concerning 340 patients included after cross-checking. Victims were mainly males (90%) and young (30 ± 11 years old). The injury occurred mainly at night (60%), in a context of assaults (83%) and with long-barreled guns (82%). Among the 290 patients managed at the CGH, 60% were hospitalized including 12% that were in the intensive care unit, 41% that required surgical treatment, and 7% that died in hospital. The overall average length of stay was 10 ± 18 days. Overall mortality (n = 71, 21%) is statistically associated with male gender (p = 0.007) and suicide context (p < 0.001). In multivariate analysis, the sites of wounds (head and neck, thorax; p < 0.001) as well as induced organ injuries (neurological, respiratory, and vascular; p < 0.005) were independent factors associated to mortality.
    Conclusions: This work underlines the high incidence of ballistic trauma in FG. This mainly involves a young and male population linked to the use of long arms and assaults. Despite the geographical difficulties of the territory and the technical platform deficits (no neurosurgery, no cardiothoracic surgery, no interventional radiology), the mortality is comparable to other studies, but remains more than twice as high as in mainland France. Finally, despite a change in legislation restricting access to firearms, our results show that gunshot firearm injuries remain a major public health concern requiring greater political actions.
    Language English
    Publishing date 2024-03-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2275480-5
    ISSN 1863-9941 ; 1863-9933
    ISSN (online) 1863-9941
    ISSN 1863-9933
    DOI 10.1007/s00068-024-02499-7
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1221: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 607: Show issues

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  3. Article: Mitigation of Hepatic Impairment with Polysaccharides from Red Alga

    Ben Saad, Hajer / Frikha, Donyez / Bouallegue, Amir / Badraoui, Riadh / Mellouli, Manel / Kallel, Hatem / Pujo, Jean Marc / Ben Amara, Ibtissem

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 9

    Abstract: Sulfated polysaccharides from seaweed are highly active natural substances with valuable applications. In the present paper, attempts have been made to discuss the physicochemical and structural features of polysaccharides isolated from red marine ... ...

    Abstract Sulfated polysaccharides from seaweed are highly active natural substances with valuable applications. In the present paper, attempts have been made to discuss the physicochemical and structural features of polysaccharides isolated from red marine alga
    Language English
    Publishing date 2023-09-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16091305
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  4. Article ; Online: Mortality Trend of Severe COVID-19 in Under-Vaccinated Population Admitted to ICU in French Amazonia.

    Matheus, Séverine / Houcke, Stéphanie / Lontsi Ngoulla, Guy Roger / Higel, Nicolas / Ba, Abesetou / Cook, Fabrice / Gourjault, Cyrille / Nkontcho, Flaubert / Demar, Magalie / Nacher, Mathieu / Djossou, Félix / Hommel, Didier / Résiere, Dabor / Pujo, Jean Marc / Kallel, Hatem

    Tropical medicine and infectious disease

    2024  Volume 9, Issue 1

    Abstract: 1) Background: Until December 2021, French Guiana (FG), located in South America, faced four consecutive COVID-19 epidemic waves. This study sought to analyze the mortality trend of severe COVID-19 patients admitted to the referral ICU of FG. (2) ... ...

    Abstract (1) Background: Until December 2021, French Guiana (FG), located in South America, faced four consecutive COVID-19 epidemic waves. This study sought to analyze the mortality trend of severe COVID-19 patients admitted to the referral ICU of FG. (2) Methods: We conducted a prospective, observational, and non-interventional study in ICU at Cayenne Hospital. We included 383 patients older than 18 admitted with SARS-CoV-2-related pneumonia hospitalized from May 2020 to December 2021. The study covers three periods. Period 1 (Waves 1 and 2, original variant), period 2 (Wave 3, Gamma variant), and period 3 (Wave 4, Delta variant). (3) Results: The median age was 63 years (52-70). Frailty was diagnosed in 36 patients over 70 (32.4%). Only 4.8% of patients were vaccinated. The median ICU LOS was 10 days (6-19). Hospital mortality was 37.3%. It was 30.9% in period 1, 36.6% in period 2 (
    Language English
    Publishing date 2024-01-05
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2414-6366
    ISSN (online) 2414-6366
    DOI 10.3390/tropicalmed9010015
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  5. Article ; Online: Anti-Inflammatory and Immunomodulatory Properties of a Crude Polysaccharide Derived from Green Seaweed

    Kraiem, Marwa / Ben Hamouda, Sonia / Eleroui, Malek / Ajala, Marwa / Feki, Amal / Dghim, Amel / Boujhoud, Zakaria / Bouhamed, Marwa / Badraoui, Riadh / Pujo, Jean Marc / Essafi-Benkhadir, Khadija / Kallel, Hatem / Ben Amara, Ibtissem

    Marine drugs

    2024  Volume 22, Issue 2

    Abstract: In this study, we investigated for the first time the anti-inflammatory and immunomodulatory properties of crude polysaccharide (PSHT) extracted from green marine ... ...

    Abstract In this study, we investigated for the first time the anti-inflammatory and immunomodulatory properties of crude polysaccharide (PSHT) extracted from green marine algae
    MeSH term(s) Rats ; Mice ; Animals ; Antioxidants/pharmacology ; Nitric Oxide/metabolism ; Seaweed/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Cell Line ; Anti-Inflammatory Agents/pharmacology ; Polysaccharides/pharmacology ; Lipopolysaccharides/pharmacology ; Chlorophyta/metabolism ; Cyclooxygenase 2/metabolism ; Nitric Oxide Synthase Type II/metabolism
    Chemical Substances Antioxidants ; Nitric Oxide (31C4KY9ESH) ; Tumor Necrosis Factor-alpha ; Anti-Inflammatory Agents ; Polysaccharides ; Lipopolysaccharides ; Cyclooxygenase 2 (EC 1.14.99.1) ; Nitric Oxide Synthase Type II (EC 1.14.13.39)
    Language English
    Publishing date 2024-02-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md22020085
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  6. Article ; Online: Clinical and Epidemiological Characteristics of Severe Acute Adult Poisonings in French Amazonia: Urgent Need for a Toxicovigilance Monitoring Framework.

    Pujo, Jean Marc / Simon, Yann / Lontsi Ngoulla, Guy Roger / Signaté, Boubacar / Mutricy, Rémi / Frémery, Alexis / Burin, Antoine / Toffol, Bertrand de / Ben Amara, Ibtissem / Houcke, Stephanie / Nasri, Amina / Resiere, Dabor / Kallel, Hatem

    Toxics

    2024  Volume 12, Issue 3

    Abstract: Background: Acute poisonings (AP) are a significant public health problem, accounting for a high number of emergency department visits and thousands of deaths worldwide. This study aimed to assess the epidemiology of AP in an adult population admitted ... ...

    Abstract Background: Acute poisonings (AP) are a significant public health problem, accounting for a high number of emergency department visits and thousands of deaths worldwide. This study aimed to assess the epidemiology of AP in an adult population admitted to Cayenne Hospital (French Guiana) and to investigate the clinical and sociodemographic characteristics.
    Methods: We conducted a monocentric retrospective study from January 2010 to December 2022, including patients over eighteen years of age who had been admitted to the emergency department of Cayenne Hospital for acute poisoning.
    Results: We included 425 patients. The median age was 34 years (IQR: 25-47). The sex ratio (M/F) was 0.52. A psychiatric disorder was found in 41.9% of patients. The Poisoning Severity Score (PSS) on admission was 1 or 2 for 84% of patients, and the mortality rate was 3.9%. The main involved toxicants were psychotropic drugs (43.1%), benzodiazepines (34.8%), and paracetamol (25.6%). The most lethal toxic was paraquat (5.2%). Intoxication was due to intentional self-poisoning in 84.2% of cases. Independent factors associated with severe poisoning (PSS 3 or 4) were chloroquine, neuroleptics, or paraquat poisoning; metabolic acidosis; and hyperglycemia (>5.5 mmol/L). The mortality rate was 3.9%, and the most involved toxic in death was paraquat.
    Conclusion: This study shows the frequent and deadly use of paraquat in APs in French Guiana. Urgent attention should be given to establishing a toxicovigilance monitoring framework and an antipoison center in the region.
    Language English
    Publishing date 2024-03-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2733883-6
    ISSN 2305-6304 ; 2305-6304
    ISSN (online) 2305-6304
    ISSN 2305-6304
    DOI 10.3390/toxics12030200
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  7. Article ; Online: COVID-19 Outbreak: Burnout and Posttraumatic Stress Disorder, a Harmful Chronology for Health Caregivers in Emergency Departments and Intensive Care Units.

    Pujo, Jean Marc / Fitriani, Dewi Yunia / Adi, Nuri Purwito / Portecop, Patrick / Resiere, Dabor / Mansyur, Muchtaruddin / Kallel, Hatem

    Disaster medicine and public health preparedness

    2022  , Page(s) 1–2

    Language English
    Publishing date 2022-01-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2375268-3
    ISSN 1938-744X ; 1935-7893
    ISSN (online) 1938-744X
    ISSN 1935-7893
    DOI 10.1017/dmp.2022.24
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  8. Article: Bioactivity of

    Feki, Amal / Kammoun, Intissar / Eleroui, Malek / Kallel, Rim / Megdiche, Fatma / Hariz, Liwa / Boudawara, Tahia / Kallel, Choumous / Kallel, Hatem / Pujo, Jean Marc / Ben Amara, Ibtissem

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 4

    Abstract: This study aimed to evaluate the potentiality of a mineral and antioxidant-rich methanolic extract of the red marine ... ...

    Abstract This study aimed to evaluate the potentiality of a mineral and antioxidant-rich methanolic extract of the red marine alga
    Language English
    Publishing date 2023-04-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16040529
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  9. Article: The Potential Effect of Polysaccharides Extracted from Red Alga

    Ajala, Marwa / Droguet, Mickael / Kraiem, Marwa / Ben Saad, Hajer / Boujhoud, Zakaria / Hilali, Abderraouf / Kallel, Hatem / Pujo, Jean Marc / Ben Amara, Ibtissem

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 3

    Abstract: Gut injury is a severe and unpredictable illness related to the increased cell death of intestinal epithelial cells (IECs). Excessive IEC apoptotic cell death during the pathophysiological state entails chronic inflammatory diseases. This investigation ... ...

    Abstract Gut injury is a severe and unpredictable illness related to the increased cell death of intestinal epithelial cells (IECs). Excessive IEC apoptotic cell death during the pathophysiological state entails chronic inflammatory diseases. This investigation was undertaken to assess the cytoprotective action and underlying mechanisms of polysaccharides from Tunisian red alga,
    Language English
    Publishing date 2023-03-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16030444
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  10. Article ; Online: Effect of the time to antivenom administration on recovery from snakebite envenoming-related coagulopathy in French Guiana.

    Houcke, Stéphanie / Pujo, Jean Marc / Vauquelin, Segolene / Lontsi Ngoula, Guy Roger / Matheus, Severine / NkontCho, Flaubert / Pierre-Demar, Magalie / Gutiérrez, José María / Resiere, Dabor / Hommel, Didier / Kallel, Hatem

    PLoS neglected tropical diseases

    2023  Volume 17, Issue 4, Page(s) e0011242

    Abstract: Background: Snakebite (SB) envenoming is an acute emergency requiring an early care delivery. We aimed to search for the time to reach healthcare facilities in various regions of French Guiana (FG) and to assess the impact of time to antivenom (AV) on ... ...

    Abstract Background: Snakebite (SB) envenoming is an acute emergency requiring an early care delivery. We aimed to search for the time to reach healthcare facilities in various regions of French Guiana (FG) and to assess the impact of time to antivenom (AV) on the correction of coagulation parameters in these patients.
    Methodology: This is a prospective observational study conducted in Cayenne General Hospital between January 1st, 2016, and July 31st, 2022. We included all patients hospitalized for SB envenoming less than 48h after the bite, and receiving antivenom (AV). We assessed the time lapse between SB and medical attention and the time needed to return of the coagulation parameters to normal.
    Principal findings: Overall, 119 patients were investigated, and 48.7% were from remote areas. The median time from SB to AV therapy was 09:15 h (05:32-17:47). The time was longer in patients from remote rural locations. AV was dispensed within the first six hours after the SB in 45 cases (37.8%). Time from SB to reaching normal plasma fibrinogen concentration was 23:27 h (20:00-27:10) in patients receiving AV≤6h vs. 31:23 h (24:00-45:05) in those receiving AV>6h (p<0.001). Whereas, the time from AV administration to reach normal fibrinogen dosage was similar in the two groups.
    Conclusions: Patients from rural settings in FG suffer from a delay in AV administration after SB envenoming leading to an extended time in which patients are coagulopathic. Once AV is administered, clotting parameters recover at a similar rate. Supplying remote healthcare facilities with AV and with medical teams trained on its use should be planned.
    MeSH term(s) Humans ; Antivenins/therapeutic use ; Snake Bites/complications ; Snake Bites/drug therapy ; French Guiana ; Treatment Outcome ; Blood Coagulation Disorders/drug therapy ; Blood Coagulation Disorders/etiology ; Fibrinogen
    Chemical Substances Antivenins ; Fibrinogen (9001-32-5)
    Language English
    Publishing date 2023-04-24
    Publishing country United States
    Document type Observational Study ; Journal Article
    ZDB-ID 2429704-5
    ISSN 1935-2735 ; 1935-2735
    ISSN (online) 1935-2735
    ISSN 1935-2735
    DOI 10.1371/journal.pntd.0011242
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