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  1. Article ; Online: A Case Series on Neurological Insights of Scrub Typhus

    PUNEET SAXENA / DEEPAK CHADHA / RISHIKA GOYAL

    Journal of Clinical and Diagnostic Research, Vol 14, Iss 11, Pp OR05-OR

    2020  Volume 11

    Abstract: Scrub typhus is a rickettsial disease caused by gram negative coccobacilli and transmitted through the bite of larval stage of mite. The disease is notable in the Asia-Pacific belt with few sporadic and epidemic cases reported from India as well. The ... ...

    Abstract Scrub typhus is a rickettsial disease caused by gram negative coccobacilli and transmitted through the bite of larval stage of mite. The disease is notable in the Asia-Pacific belt with few sporadic and epidemic cases reported from India as well. The disease is well identified from North Western part of Rajasthan that are the areas with dense vegetation. The clinical scenario ranges from acute febrile illness to multiple organ dysfunction by virtue of haematogenous seedling. This case series highlights the neurological manifestations of scrub typhus that are diverse and life threatening but holding dearth of literature to convoy appropriately timed diagnosis and treatment.
    Keywords cerebellitis ; febrile illness ; meningoencephalitis ; neurological manifestations ; orientia tsutsugamushi ; rickettsia ; rickettsial diseases ; Medicine ; R
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher JCDR Research and Publications Private Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: A rare case of CNS tuberculosis with pregnancy

    Sanjay Singh / Tony Jose / Puneet Saxena

    International Journal of Reproduction, Contraception, Obstetrics and Gynecology, Vol 4, Iss 3, Pp 911-

    2015  Volume 914

    Abstract: Whereas pelvic tuberculosis leading to infertility is quite common in female population of developing countries, Central Nervous System (CNS) tuberculosis (TB) with pregnancy is a rare entity. Most of the information on this subject is based on sporadic ... ...

    Abstract Whereas pelvic tuberculosis leading to infertility is quite common in female population of developing countries, Central Nervous System (CNS) tuberculosis (TB) with pregnancy is a rare entity. Most of the information on this subject is based on sporadic case reports only. Most of the earlier reports suggest very high adverse outcome of CNS Tuberculosis in pregnancy. We are presenting a case of CNS Tuberculosis which was diagnosed timely and managed appropriately in our institute with a favourable outcome, thus highlighting the importance of early diagnosis and treatment. [Int J Reprod Contracept Obstet Gynecol 2015; 4(3.000): 911-914]
    Keywords Tuberculosis ; Central nervous system ; Meningitis ; Pregnancy ; ATT ; Gynecology and obstetrics ; RG1-991 ; Medicine ; R
    Language English
    Publishing date 2015-06-01T00:00:00Z
    Publisher Medip Academy
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Bilateral chylothorax as a complication of internal jugular vein cannulation

    Puneet Saxena / Subramanian Shankar / Vivek Kumar / Nardeep Naithani

    Lung India, Vol 32, Iss 4, Pp 370-

    2015  Volume 374

    Abstract: Central venous catheterization is one of the most prevalent procedures in the Intensive Care Unit. Complications are reported in about 15% of the patients and usually comprise of infection, arterial puncture, malpositioning, pneumothorax, local hematoma, ...

    Abstract Central venous catheterization is one of the most prevalent procedures in the Intensive Care Unit. Complications are reported in about 15% of the patients and usually comprise of infection, arterial puncture, malpositioning, pneumothorax, local hematoma, hemothorax, and so on. Chylothorax is a rare complication of this procedure. We present a 42-year-old lady, who developed bilateral massive chylothorax after cannulation of her left internal jugular vein (IJV), due to direct injury to the thoracic duct during the procedure. The patient was successfully managed with bilateral chest tube drainage and omission of oral feeds for four days. Development of bilateral chylothorax as a complication of IJV cannulation is rare, but merits reporting, in view of a large number of central venous cannulations being undertaken. Critical care professionals should be aware of this rare complication of a common procedure to facilitate early identification and institute appropriate therapy.
    Keywords Bilateral ; central venous catheters ; chylothorax ; complication ; internal jugular vein cannulation ; thoracic duct ; Diseases of the respiratory system ; RC705-779 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Bilateral chylothorax as a complication of internal jugular vein cannulation

    Puneet Saxena / Subramanian Shankar / Vivek Kumar / Nardeep Naithani

    Lung India, Vol 32, Iss 6, Pp 675-

    2015  Volume 676

    Keywords Diseases of the respiratory system ; RC705-779 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Shrinking lung syndrome in systemic lupus erythematosus-scleroderma overlap

    Vivek S Guleria / Pradeep K Singh / Puneet Saxena / Shankar Subramanian

    Lung India, Vol 31, Iss 4, Pp 407-

    2014  Volume 409

    Abstract: Shrinking lung syndrome (SLS) is a infrequently reported manifestation of systemic lupus erythematosus (SLE). Reported prevalence of SLS is about 0.5% in SLE patients. Pathogenesis is not fully understood and different therapeutic modalities have been ... ...

    Abstract Shrinking lung syndrome (SLS) is a infrequently reported manifestation of systemic lupus erythematosus (SLE). Reported prevalence of SLS is about 0.5% in SLE patients. Pathogenesis is not fully understood and different therapeutic modalities have been employed with variable results, as only 77 cases of SLS have been documented in literature. SLS in SLE-Scleroderma overlap has not been reported yet. We report a patient of SLE - scleroderma overlap presenting with dyspnea, intermittent orthopnea and pleuritic chest pain. Evaluation revealed elevated hemidiaphragms and severe restrictive defect. She was eventually diagnosed as a case of SLS. This case report is a reminder to the medical fraternity that SLS although a rare complication must be thought of in the special subset of patients of SLE having respiratory symptoms.
    Keywords Scleroderma ; scleroderma shrinking lung syndrome ; systemic lupus erythematosus ; Diseases of the respiratory system ; RC705-779 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Cyclic Peptides Acting as Allosteric Inhibitors of Human Thymidylate Synthase and Cancer Cell Growth

    Salvatore Pacifico / Matteo Santucci / Rosaria Luciani / Puneet Saxena / Pasquale Linciano / Glauco Ponterini / Angela Lauriola / Domenico D’Arca / Gaetano Marverti / Remo Guerrini / Maria Paola Costi

    Molecules, Vol 24, Iss 19, p

    2019  Volume 3493

    Abstract: Thymidylate synthase (TS) is a prominent drug target for different cancer types. However, the prolonged use of its classical inhibitors, substrate analogs that bind at the active site, leads to TS overexpression and drug resistance in the clinic. In the ... ...

    Abstract Thymidylate synthase (TS) is a prominent drug target for different cancer types. However, the prolonged use of its classical inhibitors, substrate analogs that bind at the active site, leads to TS overexpression and drug resistance in the clinic. In the effort to identify anti-TS drugs with new modes of action and able to overcome platinum drug resistance in ovarian cancer, octapeptides with a new allosteric inhibition mechanism were identified as cancer cell growth inhibitors that do not cause TS overexpression. To improve the biological properties, 10 cyclic peptides (cPs) were designed from the lead peptides and synthesized. The cPs were screened for the ability to inhibit recombinant human thymidylate synthase ( h TS), and peptide 7 was found to act as an allosteric inhibitor more potent than its parent open-chain peptide [Pro 3 ]LR . In cytotoxicity studies on three human ovarian cancer cell lines, IGROV-1, A2780, and A2780/CP, peptide 5 and two other cPs, including 7 , showed IC 50 values comparable with those of the reference drug 5-fluorouracil, of the open-chain peptide [ d -Gln 4 ]LR , and of another seven prolyl derivatives of the lead peptide LR . These promising results indicate cP 7 as a possible lead compound to be chemically modified with the aim of improving both allosteric TS inhibitory activity and anticancer effectiveness.
    Keywords cyclic peptides ; enzyme inhibition ; thymidylate synthase inhibitors ; allosteric inhibitors ; anticancer agents ; ovarian cancer ; Organic chemistry ; QD241-441
    Subject code 540
    Language English
    Publishing date 2019-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Price and consumption of tobacco

    Virendra Singh / Bharat Bhushan Sharma / Puneet Saxena / Hardayal Meena / Daya Krishan Mangal

    Lung India, Vol 29, Iss 3, Pp 212-

    2012  Volume 216

    Abstract: Background: It is thought that price increase in tobacco products leads to reduced consumption. Though many studies have substantiated this concept, it has not been well studied in India. Recently, price of tobacco products was increased due to ban on ... ...

    Abstract Background: It is thought that price increase in tobacco products leads to reduced consumption. Though many studies have substantiated this concept, it has not been well studied in India. Recently, price of tobacco products was increased due to ban on plastic sachets of chewing tobacco and increased tax in Rajasthan. This study was designed to evaluate the effect of price rise on overall consumption of tobacco in Jaipur city, Rajasthan. Materials and Methods: This study was carried out in Jaipur city. Two-staged stratified sampling was used. In the first phase of study, cost and consumption of various tobacco products in the months of February and April were enquired from 25 retail tobacco shops. In the second phase, tobacco consumption was enquired from 20 consecutive consumers purchasing any tobacco product from all the above retail tobacco shops. The data were statistically analyzed using descriptive statistics and paired "t" test. Results: The comparison of prices of tobacco products between February and April revealed that the price of cigarette, bidi, and chewing tobacco has increased by 19%, 21%, and 68%, respectively. Average decrease in sales of cigarettes, bidi, and chewing tobacco at shops included in the study were 14%, 23%, and 38%, respectively. The consumers purchasing tobacco also reported decreased consumption. Chewing tobacco showed the maximum reduction (21%). Consumption of cigarette and bidi has also reduced by 15% and 13%, respectively. Conclusion: It may be concluded that reduction in consumption is associated with increased price of tobacco products. Reduced consumption is comparative to the magnitude of price increase.
    Keywords Consumption ; legislation ; plastic sachet ; price ; tobacco sale ; tobacco taxes ; Diseases of the respiratory system ; RC705-779 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Subject code 580
    Language English
    Publishing date 2012-01-01T00:00:00Z
    Publisher Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery

    Pasquale Linciano / Alice Dawson / Ina Pöhner / David M. Costa / Monica S. Sá / Anabela Cordeiro-da-Silva / Rosaria Luciani / Sheraz Gul / Gesa Witt / Bernhard Ellinger / Maria Kuzikov / Philip Gribbon / Jeanette Reinshagen / Markus Wolf / Birte Behrens / Véronique Hannaert / Paul A. M. Michels / Erika Nerini / Cecilia Pozzi /
    Flavio di Pisa / Giacomo Landi / Nuno Santarem / Stefania Ferrari / Puneet Saxena / Sandra Lazzari / Giuseppe Cannazza / Lucio H. Freitas-Junior / Carolina B. Moraes / Bruno S. Pascoalino / Laura M. Alcântara / Claudia P. Bertolacini / Vanessa Fontana / Ulrike Wittig / Wolfgang Müller / Rebecca C. Wade / William N. Hunter / Stefano Mangani / Luca Costantino / Maria P. Costi

    ACS Omega, Vol 2, Iss 9, Pp 5666-

    2017  Volume 5683

    Keywords Chemistry ; QD1-999
    Language English
    Publishing date 2017-09-01T00:00:00Z
    Publisher American Chemical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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