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  1. Article ; Online: Androgens and COVID-19: exploring the role of testosterone replacement therapy.

    Punjani, Nahid / Flannigan, Ryan

    International journal of impotence research

    2022  Volume 34, Issue 7, Page(s) 649–651

    MeSH term(s) Humans ; Androgens/therapeutic use ; COVID-19 ; Hormone Replacement Therapy ; Testosterone/therapeutic use
    Chemical Substances Androgens ; Testosterone (3XMK78S47O)
    Language English
    Publishing date 2022-01-30
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1034295-3
    ISSN 1476-5489 ; 0955-9930
    ISSN (online) 1476-5489
    ISSN 0955-9930
    DOI 10.1038/s41443-021-00524-6
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2910: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Sleep-related painful erections treated with sodium oxybate.

    Chaudhary, Hira S / Zeidman, Eric / Punjani, Nahid / Tashman, Yasemin

    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

    2024  

    Abstract: A 39-year-old male with a medical history significant for migraine, psoriatic arthritis, postural orthostatic tachycardia syndrome (POTS), vitamin D deficiency and hypoglycemia presented with a two-year history of sleep-related painful erections (SRPE). ... ...

    Abstract A 39-year-old male with a medical history significant for migraine, psoriatic arthritis, postural orthostatic tachycardia syndrome (POTS), vitamin D deficiency and hypoglycemia presented with a two-year history of sleep-related painful erections (SRPE). Since the reported prevalence is low, there is limited understanding of the possible etiologies of the disorder and little published clinical data on treatment algorithms. Thus, he had tried multiple therapies. Baclofen was effective but not tolerated. Pelvic physiotherapy and tadalafil were ineffective. Imipramine, clonazepam, vitamin B, iron, and selenium provided minimal benefit. Opiates were initially effective, but lost efficacy after 2-3 weeks. Finally, he was started on sodium oxybate after fully counseling the patient on the potential side effects of the treatment and consenting the patient for off-label use. This has effectively treated his SRPE. Sodium oxybate is a novel therapy for and a possible new treatment for this rare and challenging disorder that merits further study.
    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2397213-0
    ISSN 1550-9397 ; 1550-9389
    ISSN (online) 1550-9397
    ISSN 1550-9389
    DOI 10.5664/jcsm.11120
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    Zs.A 6590: Show issues Location:
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  3. Article ; Online: Vasectomy: is the apparent decline real or not?

    Punjani, Nahid / Goldstein, Marc

    Nature reviews. Urology

    2021  Volume 19, Issue 2, Page(s) 69–70

    MeSH term(s) Humans ; Male ; Vasectomy
    Language English
    Publishing date 2021-11-05
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2493737-X
    ISSN 1759-4820 ; 1759-4812
    ISSN (online) 1759-4820
    ISSN 1759-4812
    DOI 10.1038/s41585-021-00538-1
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    Zs.A 6030: Show issues Location:
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  4. Article: The Association among Hypothalamic Subnits, Gonadotropic and Sex Hormone Plasmas Levels in Alzheimer's Disease.

    Ofori, Edward / Solis, Anamaria / Punjani, Nahid / On Behalf Of The Alzheimer's Disease Neuroimaging Initiative

    Brain sciences

    2024  Volume 14, Issue 3

    Abstract: This study investigates the sex-specific role of the Hypothalamic-Pituitary-Gonadal axis in Alzheimer's disease progression, utilizing ADNI1 data for 493 individuals, analyzing plasma levels of gonadotropic and sex hormones, and examining ... ...

    Abstract This study investigates the sex-specific role of the Hypothalamic-Pituitary-Gonadal axis in Alzheimer's disease progression, utilizing ADNI1 data for 493 individuals, analyzing plasma levels of gonadotropic and sex hormones, and examining neurodegeneration-related brain structures. We assessed plasma levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), progesterone (P4), and testosterone (T), along with volumetric measures of the hippocampus, entorhinal cortex, and hypothalamic subunits, to explore their correlation with Alzheimer's disease markers across different cognitive statuses and sexes. Significant cognitive status effects were observed for all volumetric measures, with a distinct sex-by-cognitive status interaction for hypothalamic volume, indicating a decrease in males but not in females across cognitive impairment stages. Regression analyses showed specific hypothalamic subunit volume related to hormone levels, accounting for up to approximately 40% of the variance (
    Language English
    Publishing date 2024-03-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci14030276
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  5. Article ; Online: Age, Sperm Retrieval, and Testicular Histology in Klinefelter Syndrome.

    Kang, Caroline / Punjani, Nahid / Kashanian, James A / Schlegel, Peter N

    The Journal of urology

    2023  Volume 211, Issue 1, Page(s) 163–169

    Abstract: Purpose: We sought to examine sperm retrieval and testicular histology in males of different ages with Klinefelter syndrome.: Materials and methods: We identified all males with Klinefelter syndrome who underwent microdissection testicular sperm ... ...

    Abstract Purpose: We sought to examine sperm retrieval and testicular histology in males of different ages with Klinefelter syndrome.
    Materials and methods: We identified all males with Klinefelter syndrome who underwent microdissection testicular sperm extraction at our institution from 1995 to 2020. Patients were divided into adolescent (<20 years) and adult (≥20 years) cohorts. Histology and sperm retrieval were compared using chi-square statistics. Multivariable logistic regression models were used to examine factors associated with successful sperm retrieval.
    Results: We identified 217 males with Klinefelter syndrome, of whom 59 were adolescents and 158 were adults. Adults were stratified into 10-year groupings (20-29 years, n = 62; 30-39 years, n = 88; ≥40 years, n = 8). Approximately 17% of adolescents had testis histology containing germ cells compared with 15% of the 20 to 29-year cohort, 14% of the 30 to 39-year cohort, and 0% over 40 years. In comparison to adolescents (53%), the sperm retrieval rate was significantly higher in the 20 to 29-year cohort (71%,
    Conclusions: Younger males more frequently had germ cell-containing testis histology, however this finding was not associated with a higher odds of sperm retrieval. Reproductive urologists should counsel azoospermic males with Klinefelter syndrome that sperm retrieval during adolescence for fertility preservation is not required and can be performed in young adulthood.
    MeSH term(s) Adult ; Adolescent ; Humans ; Male ; Young Adult ; Testis/pathology ; Klinefelter Syndrome/complications ; Klinefelter Syndrome/pathology ; Sperm Retrieval ; Semen ; Azoospermia/pathology ; Spermatozoa ; Retrospective Studies
    Language English
    Publishing date 2023-10-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3176-8
    ISSN 1527-3792 ; 0022-5347
    ISSN (online) 1527-3792
    ISSN 0022-5347
    DOI 10.1097/JU.0000000000003737
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    Ui VI Zs.91: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 331: Show issues

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  6. Article: Genetic Implications of Male-Reproductive-Health-Associated Comorbidities.

    Punjani, Nahid / Kang, Caroline / Lamb, Dolores J

    Turkish journal of urology

    2022  Volume 48, Issue 5, Page(s) 363–374

    Abstract: Male infertility is a common problem. There is growing evidence that infertile men may harbor significant illness and disease. Many of the genetic causes of male fertility have implications on other systemic illnesses. This review aims to discuss various ...

    Abstract Male infertility is a common problem. There is growing evidence that infertile men may harbor significant illness and disease. Many of the genetic causes of male fertility have implications on other systemic illnesses. This review aims to discuss various genetic conditions and gene mutations and alterations associated with male infertility and evidence for associated systemic conditions. These findings highlight the importance of a thorough workup in men presenting for a fertility assessment.
    Language English
    Publishing date 2022-10-01
    Publishing country Turkey
    Document type Journal Article
    ISSN 2149-3235
    ISSN 2149-3235
    DOI 10.5152/tud.2022.20463
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  7. Article ; Online: Male infertility and genitourinary birth defects: there is more than meets the eye.

    Punjani, Nahid / Lamb, Dolores J

    Fertility and sterility

    2020  Volume 114, Issue 2, Page(s) 209–218

    Abstract: Male factor infertility is a significant problem present in up to 50% of infertile couples. The relationship between male infertility and systemic disease is of significant interest, and emerging evidence suggests a relationship between male infertility ... ...

    Abstract Male factor infertility is a significant problem present in up to 50% of infertile couples. The relationship between male infertility and systemic disease is of significant interest, and emerging evidence suggests a relationship between male infertility and male genitourinary (GU) birth defects (cryptorchidism, hypospadias, ambiguous genitalia, and congenital anomalies of the kidney and urinary tract). Many of these birth defects are treated in isolation by busy urologists without acknowledgment that these may be related to more global syndromic conditions. Conversely, geneticists and nonurologists who treat variable systemic phenotypes may overlook GU defects, which are indeed related conditions. Many of these defects are attributed to copy number variants dosage-sensitive genes due to chromosome microdeletions or microduplications. These variants are responsible for disease phenotypes seen in the general population. The copy number variants described in this review are syndromic in some cases and responsible for both GU birth defects as well as other systemic phenotypes. This review highlights the emerging evidence between these birth defects, male infertility, and other systemic conditions.
    MeSH term(s) Chromosome Deletion ; Chromosome Duplication ; DNA Copy Number Variations ; Fertility ; Gene Dosage ; Genetic Predisposition to Disease ; Humans ; Infertility, Male/diagnosis ; Infertility, Male/etiology ; Infertility, Male/physiopathology ; Male ; Mutation ; Phenotype ; Risk Assessment ; Risk Factors ; Urogenital Abnormalities/complications ; Urogenital Abnormalities/diagnosis ; Urogenital Abnormalities/genetics
    Language English
    Publishing date 2020-09-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80133-1
    ISSN 1556-5653 ; 0015-0282
    ISSN (online) 1556-5653
    ISSN 0015-0282
    DOI 10.1016/j.fertnstert.2020.06.042
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    Zs.A 73: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Canary in the Coal Mine? Male Infertility as a Marker of Overall Health.

    Punjani, Nahid / Lamb, Dolores J

    Annual review of genetics

    2020  Volume 54, Page(s) 465–486

    Abstract: Male factor infertility is a common problem. Evidence is emerging regarding the spectrum of systemic disease and illness harbored by infertile men who otherwise appear healthy. In this review, we present evidence that infertile men have poor overall ... ...

    Abstract Male factor infertility is a common problem. Evidence is emerging regarding the spectrum of systemic disease and illness harbored by infertile men who otherwise appear healthy. In this review, we present evidence that infertile men have poor overall health and increased morbidity and mortality, increased rates of both genitourinary and non-genitourinary malignancy, and greater risks of systemic disease. The review also highlights numerous genetic conditions associated with male infertility as well as emerging translational evidence of genitourinary birth defects and their impact on male infertility. Finally, parallels to the overall health of infertile women are presented. This review highlights the importance of a comprehensive health evaluation of men who present for an infertility assessment.
    MeSH term(s) Animals ; Female ; Humans ; Infertility, Female/mortality ; Infertility, Female/pathology ; Infertility, Male/mortality ; Infertility, Male/pathology ; Male
    Language English
    Publishing date 2020-11-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 207928-8
    ISSN 1545-2948 ; 0066-4170 ; 0066-4197
    ISSN (online) 1545-2948
    ISSN 0066-4170 ; 0066-4197
    DOI 10.1146/annurev-genet-022020-023434
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    Zs.A 1109: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Management of Patients With Normal Physical Exams and Ultrasound Evidence of Isolated Septal and Punctate Penile Scarring.

    Stern, Noah / Punjani, Nahid / Brock, Gerald

    Sexual medicine

    2021  Volume 9, Issue 3, Page(s) 100346

    Abstract: Introduction: Atypical penile tunical lesions including isolated septal (ISS) and punctate scarring (PS) are an under recognized and difficult to treat subset of Peyronie's disease (PD) that often present with normal physical exams. Current guidelines ... ...

    Abstract Introduction: Atypical penile tunical lesions including isolated septal (ISS) and punctate scarring (PS) are an under recognized and difficult to treat subset of Peyronie's disease (PD) that often present with normal physical exams. Current guidelines provide little direction in the treatment of these men.
    Aim: To review the results of our treatment approach in men with ISS and PS.
    Methods: Data from all men undergoing duplex ultrasonography for either Peyronie's disease and/or erectile dysfunction over a 3-year period were reviewed. All men with ISS or PS and normal physical exams were included. First- and second-line treatment preferences and satisfaction with treatment in men with ISS and PS were retrospectively reviewed. Logistic regression was used to investigate associations between scar features and treatment preference MAIN OUTCOME MEASURES: Treatment preference patterns, treatment satisfaction.
    Results: A total of 217 men with ISS and 197 men with PS were identified. Of these, 71 ISS and 86 PS patients had normal physical exams. Majority of men in both ISS (70.4%) and PS (81.4%) cohorts initially opted for non-invasive management through either observation, oral therapy, or traction therapy. After initial management 84.5% of ISS and 93% of PS patients were satisfied with their results. A significant trend toward inflatable prostheses as second line therapy was seen in men with PS.
    Conclusions: There is a mounting need for clinical guidance in order to best manage men with atypical PD in the absence of societal guidelines and high-quality studies. This series provides guidance to clinicians on the management of these men, suggesting that conservative therapy and education may be sufficient. A standardized approach of increasing invasiveness showed reasonable rates of satisfaction with minimally invasive therapies playing a prominent role. Stern N, Punjani N, Brock G, Management of Patients With Normal Physical Exams and Ultrasound Evidence of Isolated Septal and Punctate Penile Scarring. Sex Med 2021;9:100346.
    Language English
    Publishing date 2021-05-30
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2734882-9
    ISSN 2050-1161
    ISSN 2050-1161
    DOI 10.1016/j.esxm.2021.100346
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  10. Article: Reproductive Chances of Men with Azoospermia Due to Spermatogenic Dysfunction.

    Kang, Caroline / Punjani, Nahid / Schlegel, Peter N

    Journal of clinical medicine

    2021  Volume 10, Issue 7

    Abstract: Non-obstructive azoospermia (NOA), or lack of sperm in the ejaculate due to spermatogenic dysfunction, is the most severe form of infertility. Men with this form of infertility should be evaluated prior to treatment, as there are various underlying ... ...

    Abstract Non-obstructive azoospermia (NOA), or lack of sperm in the ejaculate due to spermatogenic dysfunction, is the most severe form of infertility. Men with this form of infertility should be evaluated prior to treatment, as there are various underlying etiologies for NOA. While a significant proportion of NOA men have idiopathic spermatogenic dysfunction, known etiologies including genetic disorders, hormonal anomalies, structural abnormalities, chemotherapy or radiation treatment, infection and inflammation may substantively affect the prognosis for successful treatment. Despite the underlying etiology for NOA, most of these infertile men are candidates for surgical sperm retrieval and subsequent use in intracytoplasmic sperm injection (ICSI). In this review, we describe common etiologies of NOA and clinical outcomes following surgical sperm retrieval and ICSI.
    Language English
    Publishing date 2021-03-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm10071400
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