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  1. AU="Purcell, Helen"
  2. AU="Lima, L M"
  3. AU=Bousselmi Radhouane
  4. AU="Kilpeläinen, Elina"
  5. AU="Kong, Huating"
  6. AU="Chand, Chandini P"
  7. AU="Chen, Chenghao"
  8. AU="Dai, Guoping"
  9. AU=Liang Yulan AU=Liang Yulan
  10. AU="Llorens, Vincent"
  11. AU="Ansbacher, Tamar"
  12. AU=Ward Richard
  13. AU="Arnott, Wendy"
  14. AU="Jess L. Delves"
  15. AU="Fraigne, Jimmy"
  16. AU="Banerjee, Promila"
  17. AU="Bekier, John"
  18. AU="Lopes, Rogerio B"
  19. AU="Petese, Alessandro"
  20. AU="Villa, Eduardo"
  21. AU="Vinjamuri, Sobhan"
  22. AU="Schulze-Makuch, Dirk"
  23. AU=Lam Jamie C M
  24. AU="See Ting Leong"
  25. AU="Sangeeta Mangubhai"

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  1. Artikel ; Online: Mechanisms underlying exercise intolerance in long COVID: An accumulation of multisystem dysfunction.

    Jamieson, Alexandra / Al Saikhan, Lamia / Alghamdi, Lamis / Hamill Howes, Lee / Purcell, Helen / Hillman, Toby / Heightman, Melissa / Treibel, Thomas / Orini, Michele / Bell, Robert / Scully, Marie / Hamer, Mark / Chaturvedi, Nishi / Montgomery, Hugh / Hughes, Alun D / Astin, Ronan / Jones, Siana

    Physiological reports

    2024  Band 12, Heft 3, Seite(n) e15940

    Abstract: The pathogenesis of exercise intolerance and persistent fatigue which can follow an infection with the SARS-CoV-2 virus ("long COVID") is not fully understood. Cases were recruited from a long COVID clinic (N = 32; 44 ± 12 years; 10 (31%) men), and age-/ ... ...

    Abstract The pathogenesis of exercise intolerance and persistent fatigue which can follow an infection with the SARS-CoV-2 virus ("long COVID") is not fully understood. Cases were recruited from a long COVID clinic (N = 32; 44 ± 12 years; 10 (31%) men), and age-/sex-matched healthy controls (HC) (N = 19; 40 ± 13 years; 6 (32%) men) from University College London staff and students. We assessed exercise performance, lung and cardiac function, vascular health, skeletal muscle oxidative capacity, and autonomic nervous system (ANS) function. Key outcome measures for each physiological system were compared between groups using potential outcome means (95% confidence intervals) adjusted for potential confounders. Long COVID participant outcomes were compared to normative values. When compared to HC, cases exhibited reduced oxygen uptake efficiency slope (1847 (1679, 2016) vs. 2176 (1978, 2373) mL/min, p = 0.002) and anaerobic threshold (13.2 (12.2, 14.3) vs. 15.6 (14.4, 17.2) mL/kg/min, p < 0.001), and lower oxidative capacity, measured using near infrared spectroscopy (τ: 38.7 (31.9, 45.6) vs. 24.6 (19.1, 30.1) s, p = 0.001). In cases, ANS measures fell below normal limits in 39%. Long COVID is associated with reduced measures of exercise performance and skeletal muscle oxidative capacity in the absence of evidence of microvascular dysfunction, suggesting mitochondrial pathology. There was evidence of attendant ANS dysregulation in a significant proportion. These multisystem factors might contribute to impaired exercise tolerance in long COVID sufferers.
    Mesh-Begriff(e) Male ; Humans ; Female ; Post-Acute COVID-19 Syndrome ; SARS-CoV-2 ; COVID-19/metabolism ; Muscle, Skeletal/metabolism ; Exercise/physiology ; Exercise Test/methods ; Exercise Tolerance/physiology ; Oxygen Consumption/physiology
    Sprache Englisch
    Erscheinungsdatum 2024-02-10
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2724325-4
    ISSN 2051-817X ; 2051-817X
    ISSN (online) 2051-817X
    ISSN 2051-817X
    DOI 10.14814/phy2.15940
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Mechanisms underlying exercise intolerance in Long COVID: an accumulation of multi-system dysfunction

    Jamieson, Alexandra / Saikhan, Lamia Al / Alghamdi, Lamis / Howes, Lee Hamill / Purcell, Helen / Hillman, Toby / Heightman, Melissa / Treibel, Thomas / Orini, Michele / Bell, Robert / Scully, Marie / Hamer, Mark / Chaturvedi, Nishi / Montgomery, Hugh / Hughes, Alun D. / Astin, Ronan / Jones, Siana

    medRxiv

    Abstract: The pathogenesis of exercise intolerance and persistent fatigue which can follow an infection with the SARS-CoV-2 virus (9Long COVID9) is not fully understood. Cases were recruited from a Long COVID clinic (N=32; 44± 12y; 10(31%)men), and age/sex-matched ...

    Abstract The pathogenesis of exercise intolerance and persistent fatigue which can follow an infection with the SARS-CoV-2 virus (9Long COVID9) is not fully understood. Cases were recruited from a Long COVID clinic (N=32; 44± 12y; 10(31%)men), and age/sex-matched healthy controls (HC) (N=19; 40± 13y; 6(32%)men) from University College London staff and students. We assessed exercise performance, lung and cardiac function, vascular health, skeletal muscle oxidative capacity and autonomic nervous system (ANS) function. Key outcome measures for each physiological system were compared between groups using potential outcome means(95% confidence intervals) adjusted for potential confounders. Long COVID participant outcomes were compared to normative values. When compared to HC, cases exhibited reduced Oxygen Uptake Efficiency Slope (1847(1679,2016) vs (2176(1978,2373) ml/min, p=0.002) and Anaerobic Threshold (13.2(12.2,14.3) vs 15.6(14.4,17.2) ml/Kg/min, p<0.001), and lower oxidative capacity on near infrared spectroscopy (τ: 38.7(31.9,45.6) vs 24.6(19.1,30.1) seconds, p=0.001). In cases, ANS measures fell below normal limits in 39%. Long COVID is associated with reduced measures of exercise performance and skeletal muscle oxidative capacity in the absence of evidence of microvascular dysfunction, suggesting mitochondrial pathology. There was evidence of attendant ANS dysregulation in a significant proportion. These multi-system factors might contribute to impaired exercise tolerance in Long COVID sufferers.
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2023-12-09
    Verlag Cold Spring Harbor Laboratory Press
    Dokumenttyp Artikel ; Online
    DOI 10.1101/2023.12.07.23299429
    Datenquelle COVID19

    Volltext online

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  3. Artikel ; Online: Mechanisms underlying exercise intolerance in Long COVID: an accumulation of multi-system dysfunction

    Jamieson, Alexandra / Al Saikhan, Lamia / Alghamdi, Lamis / Hamill Howes, Lee / Purcell, Helen / Hillman, Toby / Heightman, Melissa J / Treibel, Thomas A. / Orini, Michele / Bell, Robert Midgley / Scully, Marie / Hamer, Mark / Chaturvedi, Nishi / Hughes, Alun / Astin, Ronan / Jones, Siana

    medRxiv

    Abstract: The pathogenesis of exercise intolerance and persistent fatigue which can follow an infection with the SARS-CoV-2 virus (9Long COVID9) is not fully understood. Cases were recruited from a Long COVID clinic (N=32; 44± 12y; 10(31%)men), and age/sex-matched ...

    Abstract The pathogenesis of exercise intolerance and persistent fatigue which can follow an infection with the SARS-CoV-2 virus (9Long COVID9) is not fully understood. Cases were recruited from a Long COVID clinic (N=32; 44± 12y; 10(31%)men), and age/sex-matched healthy controls (HC) (N=19; 40± 13y; 6(32%)men) from University College London staff and students. We assessed exercise performance, lung and cardiac function, vascular health, skeletal muscle oxidative capacity and autonomic nervous system (ANS) function. Key outcome measures for each physiological system were compared between groups using potential outcome means(95% confidence intervals) adjusted for potential confounders. Long COVID participant outcomes were compared to normative values. When compared to HC, cases exhibited reduced Oxygen Uptake Efficiency Slope (1847(1679,2016) vs (2176(1978,2373) ml/min, p=0.002) and Anaerobic Threshold (13.2(12.2,14.3) vs 15.6(14.4,17.2) ml/Kg/min, p<0.001), and lower oxidative capacity on near infrared spectroscopy (τ: 38.7(31.9,45.6) vs 24.6(19.1,30.1) seconds, p=0.001). In cases, ANS measures fell below normal limits in 39%. Long COVID is associated with reduced measures of exercise performance and skeletal muscle oxidative capacity in the absence of evidence of microvascular dysfunction, suggesting mitochondrial pathology. There was evidence of attendant ANS dysregulation in a significant proportion. These multi-system factors might contribute to impaired exercise tolerance in Long COVID sufferers.
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2023-12-09
    Verlag Cold Spring Harbor Laboratory Press
    Dokumenttyp Artikel ; Online
    DOI 10.1101/2023.12.07.23299429
    Datenquelle COVID19

    Volltext online

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  4. Artikel ; Online: Post-COVID-19 assessment in a specialist clinical service: a 12-month, single-centre, prospective study in 1325 individuals.

    Heightman, Melissa / Prashar, Jai / Hillman, Toby E / Marks, Michael / Livingston, Rebecca / Ridsdale, Heidi A / Bell, Robert / Zandi, Michael / McNamara, Patricia / Chauhan, Alisha / Denneny, Emma / Astin, Ronan / Purcell, Helen / Attree, Emily / Hishmeh, Lyth / Prescott, Gordon / Evans, Rebecca / Mehta, Puja / Brennan, Ewen /
    Brown, Jeremy S / Porter, Joanna / Logan, Sarah / Wall, Emma / Dehbi, Hakim-Moulay / Cone, Stephen / Banerjee, Amitava

    BMJ open respiratory research

    2021  Band 8, Heft 1

    Abstract: Introduction: Post-COVID-19 complications require simultaneous characterisation and management to plan policy and health system responses. We describe the 12-month experience of the first UK dedicated post-COVID-19 clinical service to include ... ...

    Abstract Introduction: Post-COVID-19 complications require simultaneous characterisation and management to plan policy and health system responses. We describe the 12-month experience of the first UK dedicated post-COVID-19 clinical service to include hospitalised and non-hospitalised patients.
    Methods: In a single-centre, observational analysis, we report the demographics, symptoms, comorbidities, investigations, treatments, functional recovery, specialist referral and rehabilitation of 1325 individuals assessed at the University College London Hospitals post-COVID-19 service between April 2020 and April 2021, comparing by referral route: posthospitalised (PH), non-hospitalised (NH) and post emergency department (PED). Symptoms associated with poor recovery or inability to return to work full time were assessed using multivariable logistic regression.
    Results: 1325 individuals were assessed (PH: 547, 41.3%; PED: 212, 16%; NH: 566, 42.7%). Compared with the PH and PED groups, the NH group were younger (median 44.6 (35.6-52.8) years vs 58.3 (47.0-67.7) years and 48.5 (39.4-55.7) years), more likely to be female (68.2%, 43.0% and 59.9%), less likely to be of ethnic minority (30.9%, 52.7% and 41.0%) or seen later after symptom onset (median (IQR): 194 (118-298) days, 69 (51-111) days and 76 (55-128) days; all p<0.0001). All groups had similar rates of onward specialist referral (NH 18.7%, PH 16.1% and PED 18.9%, p=0.452) and were more likely to require support for breathlessness (23.7%, 5.5% and 15.1%, p<0.001) and fatigue (17.8%, 4.8% and 8.0%, p<0.001). Hospitalised patients had higher rates of pulmonary emboli, persistent lung interstitial abnormalities and other organ impairment. 716 (54.0%) individuals reported <75% optimal health (median 70%, IQR 55%-85%). Less than half of employed individuals could return to work full time at first assessment.
    Conclusion: Post-COVID-19 symptoms were significant in PH and NH patients, with significant ongoing healthcare needs and utilisation. Trials of interventions and patient-centred pathways for diagnostic and treatment approaches are urgently required.
    Mesh-Begriff(e) COVID-19 ; Delivery of Health Care ; Ethnicity ; Female ; Humans ; Male ; Minority Groups ; Prospective Studies ; SARS-CoV-2
    Sprache Englisch
    Erscheinungsdatum 2021-11-11
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2736454-9
    ISSN 2052-4439 ; 2052-4439
    ISSN (online) 2052-4439
    ISSN 2052-4439
    DOI 10.1136/bmjresp-2021-001041
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Significance of Patent Foramen Ovale in Patients with GOLD Stage II Chronic Obstructive Pulmonary Disease (COPD).

    Martolini, Dario / Tanner, Rebecca / Davey, Claire / Patel, Mehul S / Elia, Davide / Purcell, Helen / Palange, Paolo / Hopkinson, Nicholas S / Polkey, Michael I

    Chronic obstructive pulmonary diseases (Miami, Fla.)

    2014  Band 1, Heft 2, Seite(n) 185–192

    Abstract: Background: ...

    Abstract Background:
    Sprache Englisch
    Erscheinungsdatum 2014-09-25
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2771715-X
    ISSN 2372-952X
    ISSN 2372-952X
    DOI 10.15326/jcopdf.1.2.2013.0003
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Post-COVID assessment in a specialist clinical service: a 12-month, single-centre analysis of symptoms and healthcare needs in 1325 individuals.

    Heightman, Melissa / Prashar, Jai / Hillman, Toby / Marks, Michael / Livingston, Rebecca / Ridsdale, Heidi / Roy, Kay / Bell, Robert / Zandi, Michael / McNamara, Patricia / Chauhan, Alisha / Denneny, Emma / Astin, Ronan / Purcell, Helen / Attree, Emily / Hishmeh, Lyth / Prescott, Gordon / Evans, Rebecca / Mehta, Puja /
    Brennan, Ewen / Brown, Jeremy / Porter, Joanna / Logan, Sarah / Wall, Emma / Dehbi, Hakim-Moulay / Cone, Stephen / Banerjee, Amitava

    medRxiv

    Abstract: Background. Complications following SARS-CoV-2 infection require simultaneous characterisation and management to plan policy and health system responses. We describe the 12-month experience of the first UK dedicated Post-COVID clinical service to include ...

    Abstract Background. Complications following SARS-CoV-2 infection require simultaneous characterisation and management to plan policy and health system responses. We describe the 12-month experience of the first UK dedicated Post-COVID clinical service to include both hospitalised and non-hospitalised patients. Methods. In a single-centre, observational analysis, we report outcomes for 1325 individuals assessed in the University College London Hospitals NHS Foundation Trust Post-COVID service between April 2020 and April 2021. Demography, symptoms, comorbidities, investigations, treatments, functional recovery, specialist referral and rehabilitation were compared by referral route (9post hospitalisation9, PH; 9non-hospitalised9, NH; and 9post emergency department9, PED). Symptoms associated with poor recovery or inability to return to work full-time were assessed using multivariable logistic regression. Findings. 1325 individuals were assessed (PH 547 [41.3%], PED 212 [16%], NH 566 [42.7%]. Compared with PH and PED groups, NH were younger (median 44.6 [35.6-52.8] vs 58.3 [47.0-67.7] and 48.5 [39.4-55.7] years), more likely to be female (68.2%, 43.0% and 59.9%), less likely to be from an ethnic minority (30.9%, 52.7% and 41.0%) and seen later after symptom onset (median [IQR]:194 [118-298], 69 [51-111] and 76 [55-128] days) (all p<0.0001). NH patients had similar rates of onward specialist referral as PH and PED groups (18.7%, 16.1% and 18.9%, p=0.452), and were more likely to require support for breathlessness (23.7%, 5.5% and 15.1%, p<0.001) and fatigue (17.8%, 4.8%, 8.0%, p<0.001). Hospitalised patients had higher rates of pulmonary emboli, persistent lung interstitial abnormalities, and other organ impairment. 716 (54.0%) individuals reported <75% of optimal health (median [IQR] 70% [55%-85%]). Overall, less than half of employed individuals felt able to return to work full-time at first assessment. Interpretation. Symptoms following SARS-CoV-2 infection were significant in both post- and non-hospitalised patients, with significant ongoing healthcare needs and utilisation. Trials of interventions and patient-centred pathways for diagnostic and treatment approaches are urgently required.
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2021-06-01
    Verlag Cold Spring Harbor Laboratory Press
    Dokumenttyp Artikel ; Online
    DOI 10.1101/2021.05.25.21257730
    Datenquelle COVID19

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  7. Artikel ; Online: Children must be protected from the tobacco industry's marketing tactics.

    Hopkinson, Nicholas / Wallis, Colin / Higgins, Bernard / Gaduzo, Stephen / Sherrington, Rebecca / Keilty, Sarah / Stern, Myra / Britton, John / Bush, Andrew / Moxham, John / Sylvester, Karl / Griffiths, Valerie / Sutherland, Tim / Crossingham, Iain / Raju, Raghu / Spencer, Charlotte / Safavi, Shahideh / Deegan, Paul / Seymour, John /
    Hickman, Katherine / Hughes, John / Wieboldt, Jason / Shaheen, Fizah / Peedell, Clive / Mackenzie, Nesta / Nicholl, David / Jolley, Caroline / Crooks, Gillian / Dow, Claire / Deveson, Pete / Bintcliffe, Oliver / Gray, Barry / Kumar, Sanjay / Haney, Sarah / Docherty, Marianne / Thomas, Angela / Chua, Felix / Dwarakanath, Akshay / Summers, Geoffrey / Prowse, Keith / Lytton, Stephen / Ong, Yee Ean / Graves, Jennifer / Banerjee, Tushar / English, Peter / Leonard, Andrew / Brunet, Martin / Chaudhry, Nauman / Ketchell, Robert Ian / Cummings, Natalie / Lebus, Jenny / Sharp, Charles / Meadows, Chris / Harle, Amelie / Stewart, Tara / Parry, Diane / Templeton-Wright, Suzanne / Moore-Gillon, John / Stratford- Martin, James / Saini, Sarvesh / Matusiewicz, Simon / Merritt, Simon / Dowson, Lee / Satkunam, Karnan / Hodgson, Luke / Suh, Eui-Sik / Durrington, Hannah / Browne, Emma / Walters, Nicola / Steier, Joerg / Barry, Simon / Griffiths, Mark / Hart, Nicholas / Nikolic, Marko / Berry, Matthew / Thomas, Ajit / Miller, Joy / McNicholl, Diarmuid / Marsden, Paul / Warwick, Geoffrey / Barr, Laura / Adeboyeku, David / Mohd Noh, Mohd Shahrin / Griffiths, Paul / Davies, Lisa / Quint, Jennifer / Lyall, Rebecca / Shribman, Jonathan / Collins, Andrea / Goldman, Jon / Bloch, Susannah / Gill, Alison / Man, William / Christopher, Anne / Yasso, Razouqi / Rajhan, Ashwin / Shrikrishna, Dinesh / Moore, Caroline / Absalom, Gareth / Booton, Richard / Fowler, Robert William / Mackinlay, Carolyn / Sapey, Elizabeth / Lock, Sara / Walker, Paul / Jha, Akhilesh / Satia, Imran / Bradley, Bethia / Mustfa, Naveed / Haqqee, Raana / Thomas, Matt / Patel, Anant / Redington, Anthony / Pillai, Anilkumar / Keaney, Niall / Fowler, Stephen / Lowe, Lesley / Brennan, Amanda / Morrison, Douglas / Murray, Clare / Hankinson, Jenny / Dutta, P / Maddocks, Matthew / Pengo, Martino / Curtis, Katrina / Rafferty, Gerrard / Hutchinson, John / Whitfield, Ruth / Turner, Steve / Breen, Ronan / Naveed, Shams-un-nisa / Goode, 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Jonathan / Powell, Helen / Dayer, Mark / Woolhouse, Ian / Georgiadi, Adamantia / Leonard, Helen / Dodd, James / Campbell, Ian / Ruiz, Gary / Zurek, Andrew / Paton, James Y / Malin, Adam / Wood, Fraser / Hynes, Gareth / Connell, David / Spencer, David / Brown, Sarah / Smith, David / Cooper, David / O'Kane, Cecilia / Hicks, Alex / Creagh-Brown, Ben / Lordan, James / Nickol, Annabel / Primhak, Robert / Fleming, Louise / Powrie, Duncan / Brown, Joanna / Zoumot, Zaid / Elkin, Sarah / Szram, Joanna / Scaffardi, Anthony / Marshall, Robert / Macdonald, Ian / Lightbody, Darren / Farmer, Ray / Wheatley, Iain / Radnan, Paul / Lane, Ian / Booth, Andrew / Tilbrook, Sean / Capstick, Toby / Hewitt, Lee / McHugh, Martin / Nelson, Christopher / Wilson, Patrick / Padmanaban, Vijay / White, John / Davison, John / O'Callaghan, Una / Hodson, Matthew / Edwards, John / Campbell, Colin / Ward, Simon / Wooler, Edwina / Ringrose, Elizabeth / Bridges, Diana / Matthew Hodson / John Edwards / Colin Campbell / 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    BMJ (Clinical research ed.)

    2013  Band 347, Seite(n) f7358

    Mesh-Begriff(e) Adolescent ; Child ; Humans ; Marketing/legislation & jurisprudence ; Marketing/standards ; Product Packaging/legislation & jurisprudence ; Product Packaging/standards ; Tobacco Industry/legislation & jurisprudence ; Tobacco Industry/standards ; Tobacco Products ; United Kingdom
    Sprache Englisch
    Erscheinungsdatum 2013-12-09
    Erscheinungsland England
    Dokumenttyp Letter
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.f7358
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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