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Article ; Online: Invited Perspective: How Far Have We Come? Revisiting a 2009 Report on Occupational Cancer Research Recommendations.

Purdue, Mark P / Ward, Mary H

2023 Volume 131, Issue 10, Page(s) 101303

Language	English
Publishing date	2023-10-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	195189-0
ISSN	1552-9924 ; 0091-6765 ; 1078-0475
ISSN (online)	1552-9924
ISSN	0091-6765 ; 1078-0475
DOI	10.1289/EHP13883
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Article ; Online: Associations of per- and polyfluoroalkyl substances and nonalcoholic fatty liver disease in the United States adult population, 2003-2018.

Momo, Harry D / Alvarez, Christian S / Purdue, Mark P / Graubard, Barry I / McGlynn, Katherine A

Environmental epidemiology (Philadelphia, Pa.)

2024 Volume 8, Issue 1, Page(s) e284

Abstract: Background: Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder worldwide and a leading cause of liver-related mortality. Prior studies have linked per- and polyfluoroalkyl substances (PFAS) exposure to liver dysfunction and ... ...

Abstract	Background: Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder worldwide and a leading cause of liver-related mortality. Prior studies have linked per- and polyfluoroalkyl substances (PFAS) exposure to liver dysfunction and alterations in metabolic pathways, but the extent of a PFAS-NAFLD relationship is unclear. Thus, the aim of the current study was to examine whether there were associations between PFAS exposures and NAFLD in the US adult population over a 16-year period. Methods: Data from 10,234 persons who participated in the National Health and Nutrition Examination Survey between 2003 and 2018 were analyzed. Odds ratios and 95% confidence intervals were calculated using multivariable logistic regression for the associations between PFAS and NAFLD, defined by the Hepatic Steatosis Index (NAFLD-HSI), the Fatty Liver Index (NAFLD-FLI), and by Transient Elastography with Controlled Attenuation Parameter (NAFLD-TE-CAP). Results: Overall, there was a significant inverse association between total PFAS and NAFLD-HSI ( Conclusions: The current study found no evidence of a positive association between the most common PFAS and NAFLD in the US population.
Language	English
Publishing date	2024-01-10
Publishing country	United States
Document type	Journal Article
ISSN	2474-7882
ISSN (online)	2474-7882
DOI	10.1097/EE9.0000000000000284
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Article: Explicit Flue Gas Adsorption Isotherm Model for Zeolite 13X Incorporating Enhancement of Nitrogen Loading by Adsorbed Carbon Dioxide and Multi-Site Affinity Shielding of Coadsorbate Dependent upon Water Vapor Content

Purdue, Mark J

Journal of physical chemistry. 2018 May 08, v. 122, no. 22

2018

Abstract: Carbon capture from flue gas by adsorption processes requires a suitable isotherm model for use in process simulators. Comparative physical adsorption isotherm models are here tested on an adsorption equilibrium loading data set for Zeolite 13X (Z13X) ... ...

Abstract	Carbon capture from flue gas by adsorption processes requires a suitable isotherm model for use in process simulators. Comparative physical adsorption isotherm models are here tested on an adsorption equilibrium loading data set for Zeolite 13X (Z13X) between 298 and 348 K. Dry flue gas mixture adsorption was found to involve enhanced adsorption of N2 by up to 85% relative to levels of N2 mixture adsorption predicted with pure species parameters. This relative N2 deviation was found strongly dependent upon the amount of adsorbed CO2 and suggested to be caused by optimization of molecular quadrupole interactions in the adsorbate layer. A supplemental isotherm expression dependent upon mixture fitting parameters characterized the phenomenon. Prediction of wet flue gas mixture adsorption on Z13X was tested with different numbers of adsorption sites in the α-cavity and logistic formulations to exclude CO2 and N2 from hydrophilic adsorption sites but without success. Shielding the affinity of Z13X toward coadsorbates using the moisture content in the gas mixture improved regression residuals. This method of sticking parameter adjustment described the influence of adsorbed H2O hydrogen-bonded clusters on CO2 and N2 and may provide a path to humid mixture adsorption prediction through studies of pure H2O in porous materials.
Keywords	adsorption ; carbon ; carbon dioxide ; data collection ; flue gas ; hydrogen bonding ; hydrophilicity ; models ; nitrogen ; pollution load ; prediction ; sorption isotherms ; water content ; water vapor ; zeolites
Language	English
Dates of publication	2018-0508
Size	p. 11832-11847.
Publishing place	American Chemical Society
Document type	Article
ISSN	1932-7455
DOI	10.1021/acs.jpcc.8b02071
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Blood lead levels and lung cancer mortality: An updated analysis of NHANES II and III.

Rhee, Jongeun / Graubard, Barry I / Purdue, Mark P

Cancer medicine

2021 Volume 10, Issue 12, Page(s) 4066–4074

Abstract: Previous analyses within the National Health and Nutrition Examination Survey (NHANES) II and III cycles suggested an association between blood lead levels (BLLs) and lung cancer mortality, although the evidence was limited by small case numbers. To ... ...

Abstract	Previous analyses within the National Health and Nutrition Examination Survey (NHANES) II and III cycles suggested an association between blood lead levels (BLLs) and lung cancer mortality, although the evidence was limited by small case numbers. To clarify this relationship, we conducted updated analyses of 4,182 and 15,629 participants in NHANES II and III, respectively, (extending follow-up 20 and 8 years) aged ≥20 with BLL measurements and mortality follow-up through 2014. We fit multivariable Cox models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) relating BLLs and lung cancer with adjustment for smoking and other factors. We did not observe an overall association between BLLs and lung cancer after adjustment for smoking (both surveys) and serum cotinine and environmental tobacco smoke exposure (NHANES III), although suggestive associations were observed among women (NHANES II: HR 2.7, 95% CI 0.7, 10.0 for ≥20.0 µg/dl vs. <10.0 µg/dl, P
MeSH term(s)	Adult ; Confidence Intervals ; Cotinine/blood ; Ex-Smokers ; Female ; Humans ; Lead/blood ; Lung Neoplasms/blood ; Lung Neoplasms/mortality ; Male ; Middle Aged ; Nutrition Surveys/statistics & numerical data ; Proportional Hazards Models ; Sex Factors ; Smokers ; Smoking/blood ; Tobacco Smoke Pollution/adverse effects
Chemical Substances	Tobacco Smoke Pollution ; Lead (2P299V784P) ; Cotinine (K5161X06LL)
Language	English
Publishing date	2021-05-07
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	2659751-2
ISSN	2045-7634 ; 2045-7634
ISSN (online)	2045-7634
ISSN	2045-7634
DOI	10.1002/cam4.3943
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Article ; Online: Coffee consumption and risk of renal cancer: a meta-analysis of cohort evidence.

Rhee, Jongeun / Lim, Rachel K / Purdue, Mark P

Cancer causes & control : CCC

2021 Volume 33, Issue 1, Page(s) 101–108

Abstract: Purpose: There is increasing evidence that coffee consumption is related to reduced risks for some cancers, but the evidence for renal cancer is inconclusive. Therefore, we conducted a meta-analysis to summarize the cohort evidence of this relationship.! ...

Abstract	Purpose: There is increasing evidence that coffee consumption is related to reduced risks for some cancers, but the evidence for renal cancer is inconclusive. Therefore, we conducted a meta-analysis to summarize the cohort evidence of this relationship. Methods: A literature search was performed in PubMed and Embase through February 2021. Meta-analyses using a random effects model were conducted for reported relative risk estimates (RRs) relating coffee intake and renal cancer incidence or mortality. We also performed a two-stage random effects exposure-response meta-analysis. Between-study heterogeneity was assessed. Results: In a meta-analysis of the ten identified cohort studies, we found a summary RR of 0.88 [95% confidence interval (CI) 0.78-0.99] relating the highest vs. the lowest category of coffee intake and renal cancer, with no significant between-study heterogeneity observed (I Conclusions: Our findings from this meta-analysis of the published cohort evidence are suggestive of an inverse association between coffee consumption and renal cancer risk.
MeSH term(s)	Coffee/adverse effects ; Cohort Studies ; Humans ; Incidence ; Kidney Neoplasms/epidemiology ; Kidney Neoplasms/etiology ; Risk Factors
Chemical Substances	Coffee
Language	English
Publishing date	2021-10-22
Publishing country	Netherlands
Document type	Journal Article ; Meta-Analysis
ZDB-ID	1064022-8
ISSN	1573-7225 ; 0957-5243
ISSN (online)	1573-7225
ISSN	0957-5243
DOI	10.1007/s10552-021-01506-1
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Article ; Online: Trichloroethylene and cancer.

Purdue, Mark P

Journal of the National Cancer Institute

2013 Volume 105, Issue 12, Page(s) 844–846

MeSH term(s)	Female ; Humans ; Male ; Neoplasms/chemically induced ; Neoplasms/epidemiology ; Occupational Diseases/chemically induced ; Occupational Diseases/epidemiology ; Solvents/poisoning ; Trichloroethylene/poisoning
Chemical Substances	Solvents ; Trichloroethylene (290YE8AR51)
Language	English
Publishing date	2013-05-30
Publishing country	United States
Document type	Editorial ; Research Support, N.I.H., Intramural ; Comment
ZDB-ID	2992-0
ISSN	1460-2105 ; 0027-8874 ; 0198-0157
ISSN (online)	1460-2105
ISSN	0027-8874 ; 0198-0157
DOI	10.1093/jnci/djt131
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Article ; Online: Improve the model of disease subtype heterogeneity by leveraging external summary data.

Fu, Sheng / Purdue, Mark P / Zhang, Han / Qin, Jing / Song, Lei / Berndt, Sonja I / Yu, Kai

PLoS computational biology

2023 Volume 19, Issue 7, Page(s) e1011236

Abstract: Researchers are often interested in understanding the disease subtype heterogeneity by testing whether a risk exposure has the same level of effect on different disease subtypes. The polytomous logistic regression (PLR) model provides a flexible tool for ...

Abstract	Researchers are often interested in understanding the disease subtype heterogeneity by testing whether a risk exposure has the same level of effect on different disease subtypes. The polytomous logistic regression (PLR) model provides a flexible tool for such an evaluation. Disease subtype heterogeneity can also be investigated with a case-only study that uses a case-case comparison procedure to directly assess the difference between risk effects on two disease subtypes. Motivated by a large consortium project on the genetic basis of non-Hodgkin lymphoma (NHL) subtypes, we develop PolyGIM, a procedure to fit the PLR model by integrating individual-level data with summary data extracted from multiple studies under different designs. The summary data consist of coefficient estimates from working logistic regression models established by external studies. Examples of the working model include the case-case comparison model and the case-control comparison model, which compares the control group with a subtype group or a broad disease group formed by merging several subtypes. PolyGIM efficiently evaluates risk effects and provides a powerful test for disease subtype heterogeneity in situations when only summary data, instead of individual-level data, is available from external studies due to various informatics and privacy constraints. We investigate the theoretic properties of PolyGIM and use simulation studies to demonstrate its advantages. Using data from eight genome-wide association studies within the NHL consortium, we apply it to study the effect of the polygenic risk score defined by a lymphoid malignancy on the risks of four NHL subtypes. These results show that PolyGIM can be a valuable tool for pooling data from multiple sources for a more coherent evaluation of disease subtype heterogeneity.
MeSH term(s)	Humans ; Genome-Wide Association Study ; Computer Simulation ; Logistic Models ; Lymphoma, Non-Hodgkin/genetics ; Multifactorial Inheritance
Language	English
Publishing date	2023-07-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	2193340-6
ISSN	1553-7358 ; 1553-734X
ISSN (online)	1553-7358
ISSN	1553-734X
DOI	10.1371/journal.pcbi.1011236
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Article ; Online: Military occupation and testicular germ cell tumour risk among US Air Force servicemen.

Denic-Roberts, Hristina / McGlynn, Katherine / Rhee, Jongeun / Byrne, Celia / Lang, Michael / Vu, Paul / Purdue, Mark / Rusiecki, Jennifer

Occupational and environmental medicine

2023 Volume 80, Issue 6, Page(s) 312–318

Abstract: Objectives: Testicular germ cell tumours (TGCTs) are the most commonly diagnosed malignancy among active duty US military servicemen. Occupational risk factors may play a role in TGCT aetiology, although the evidence is inconclusive. The objective of ... ...

Abstract	Objectives: Testicular germ cell tumours (TGCTs) are the most commonly diagnosed malignancy among active duty US military servicemen. Occupational risk factors may play a role in TGCT aetiology, although the evidence is inconclusive. The objective of our study was to investigate associations between military occupations and TGCT risk among US Air Force (USAF) servicemen. Methods: This nested case-control study among active duty USAF servicemen obtained information on military occupations for 530 histologically confirmed TGCT cases diagnosed during 1990-2018 and 530 individually matched controls. We determined military occupations using Air Force Specialty Codes ascertained at two time points: at case diagnosis and at a time point on average 6 years earlier. We computed adjusted ORs and 95% CIs from conditional logistic regression models to evaluate associations between occupations and TGCT risk. Results: The mean age at TGCT diagnosis was 30 years. Increased TGCT risk was observed for pilots (OR=2.84, 95% CI: 1.20-6.74) and servicemen with aircraft maintenance jobs (OR=1.85, 95% CI: 1.03-3.31) who held those jobs at both time points. Fighter pilots (n=18) and servicemen with firefighting jobs (n=18) at the time of case diagnosis had suggestively elevated TGCT odds (OR=2.73, 95% CI: 0.96-7.72 and OR=1.94, 95% CI: 0.72-5.20, respectively). Conclusions: In this matched, nested case-control study of young active duty USAF servicemen, we found that pilots and men with aircraft maintenance jobs had elevated TGCT risk. Further research is needed to elucidate specific occupational exposures underlying these associations.
MeSH term(s)	Male ; Humans ; Adult ; Military Personnel ; Case-Control Studies ; Occupations ; Testicular Neoplasms/epidemiology ; Testicular Neoplasms/etiology ; Neoplasms, Germ Cell and Embryonal/etiology ; Neoplasms, Germ Cell and Embryonal/complications ; Risk Factors
Language	English
Publishing date	2023-03-27
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Intramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1180733-7
ISSN	1470-7926 ; 1351-0711
ISSN (online)	1470-7926
ISSN	1351-0711
DOI	10.1136/oemed-2022-108628
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Article ; Online: Nested Case-Control Studies Investigating Serum Perfluorooctanoate and Perfluorooctane Sulfonate Levels and Pancreatic Ductal Adenocarcinoma in Two Cohorts.

Zhang, Ting / Fu, Sheng / Yu, Kai / Albanes, Demetrius / Moore, Steven C / Purdue, Mark P / Stolzenberg-Solomon, Rachael Z

Environmental health perspectives

2023 Volume 131, Issue 10, Page(s) 107702

MeSH term(s)	Humans ; Fluorocarbons ; Caprylates ; Case-Control Studies ; Adenocarcinoma ; Alkanesulfonic Acids ; Pancreatic Neoplasms/epidemiology
Chemical Substances	perfluorooctane (6P60ZBK0QL) ; perfluorooctanoic acid (947VD76D3L) ; Fluorocarbons ; Caprylates ; Alkanesulfonic Acids
Language	English
Publishing date	2023-10-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	195189-0
ISSN	1552-9924 ; 0091-6765 ; 1078-0475
ISSN (online)	1552-9924
ISSN	0091-6765 ; 1078-0475
DOI	10.1289/EHP13208
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Article: Adsorption and Diffusion of N₂ and CO₂ and Their Mixture on Silica Gel

Goyal, Prerna / Purdue, Mark J / Farooq, Shamsuzzaman

Industrial & engineering chemistry process design and development. 2019 Oct. 09, v. 58, no. 42

2019

Abstract: The rising concentration of CO₂, emitted into the atmosphere from power plant flue gas, is a major contributor to global warming. Silica gel is an important adsorbent to dry wet flue gas prior to sending the dried gas (CO₂/N₂ mixture) for carbon capture. ...

Abstract	The rising concentration of CO₂, emitted into the atmosphere from power plant flue gas, is a major contributor to global warming. Silica gel is an important adsorbent to dry wet flue gas prior to sending the dried gas (CO₂/N₂ mixture) for carbon capture. In the present work, a comprehensive experimental and simulation study is undertaken to establish the adsorption and diffusion of N₂ and CO₂ and their mixture on silica gel at pressures and temperatures relevant to vacuum swing adsorption (VSA) processes. The adsorption equilibrium of pure N₂ and CO₂ is captured well by the single component Langmuir isotherm model. Carefully designed controlled experiments are conducted to show that the transport mechanism for the adsorption of pure N₂ in silica gel pores is governed by Knudsen flow, while for CO₂, it is a combination of Knudsen and surface flow. Binary mixture experiments are performed to confirm the mixture equilibrium and kinetic models necessary to simulate the dry product end of a column in a VSA process for drying wet flue gas. For binary mixture equilibrium of these gases, there is no effect of competition from the other gas present in the mixture, implying that they exhibit noncompetitive adsorption on silica gel. Transport of CO₂/N₂ mixture in silica gel pores is well captured by the mechanism established from the single component study.
Keywords	adsorbents ; adsorption ; carbon ; carbon dioxide ; drying ; flue gas ; global warming ; kinetics ; models ; nitrogen ; overland flow ; power plants ; process design ; silica gel ; sorption isotherms ; temperature
Language	English
Dates of publication	2019-1009
Size	p. 19611-19622.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	1484436-9
ISSN	1520-5045 ; 0888-5885
ISSN (online)	1520-5045
ISSN	0888-5885
DOI	10.1021/acs.iecr.9b02685
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