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Article ; Online: Influence of thromboembolic events in the prognosis of COVID-19 hospitalized patients. Results from a cross sectional study.

Purroy, Francisco / Arqué, Gloria

2021 Volume 16, Issue 6, Page(s) e0252351

Abstract: Background: COVID-19 may predispose to both venous and arterial thromboembolism event (TEE). Reports on the prevalence and prognosis of thrombotic complications are still emerging.: Objective: To describe the rate of TEE complications and its ... ...

Abstract	Background: COVID-19 may predispose to both venous and arterial thromboembolism event (TEE). Reports on the prevalence and prognosis of thrombotic complications are still emerging. Objective: To describe the rate of TEE complications and its influence in the prognosis of hospitalized patients with COVID-19 after a cross-sectional study. Methods: We evaluated the prevalence of TEE and its relationship with in-hospital death among hospitalized patients with COVID-19 who were admitted between 1st March to 20th April 2020 in a multicentric network of sixteen Hospitals in Spain. TEE was defined by the occurrence of venous thromboembolism (VTE), acute ischemic stroke (AIS), systemic arterial embolism or myocardial infarction (MI). Results: We studied 1737 patients with proven COVID-19 infection of whom 276 died (15.9%). TEE were presented in 64 (3.7%) patients: 49 (76.6%) patients had a VTE, 8 (12.5%) patients had MI, 6 (9.4%%) patients had AIS, and one (1.5%) patient a thrombosis of portal vein. TEE patients exhibited a diffuse profile: older, high levels of D-dimer protein and a tendency of lower levels of prothrombin. The multivariate regression models, confirmed the association between in-hospital death and age (odds ratio [OR] 1.12 [95% CI 1.10-1.14], p<0.001), diabetes (OR 1.49 [95% CI 1.04-2.13], p = 0.029), chronic obstructive pulmonary disease (OR 1.61 [95% CI 1.03-2.53], p = 0.039), ICU care (OR 9.39 [95% CI 5.69-15.51], p<0.001), and TTE (OR 2.24 [95% CI 1.17-4.29], p = 0.015). Conclusions: Special attention is needed among hospitalized COVID-19 patients with TTE and other comorbidities as they have an increased risk of in-hospital death.
MeSH term(s)	Aged ; COVID-19/epidemiology ; COVID-19/mortality ; COVID-19/pathology ; COVID-19/virology ; Cross-Sectional Studies ; Female ; Hospital Mortality ; Hospitalization/statistics & numerical data ; Humans ; Male ; Prognosis ; Risk Factors ; SARS-CoV-2/isolation & purification ; Spain/epidemiology ; Survival Rate ; Thromboembolism/epidemiology ; Thromboembolism/mortality ; Thromboembolism/virology
Language	English
Publishing date	2021-06-09
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0252351
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Article ; Online: A Less Frequent Etiology of Limb Shaking Syndrome: A Severe Middle Cerebral Artery Stenosis.

Vicente-Pascual, Mikel / Mauri-Capdevila, Gerard / Purroy, Francisco

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

2021 Volume 30, Issue 4, Page(s) 105629

Abstract: Background: Limb Shaking Syndrome (LSS) is usually associated with internal carotid occlusion. There are few reported-cases in context of middle cerebral artery stenosis.: Methods: We presented LSS in a patient with middle cerebral artery stenosis ... ...

Abstract	Background: Limb Shaking Syndrome (LSS) is usually associated with internal carotid occlusion. There are few reported-cases in context of middle cerebral artery stenosis. Methods: We presented LSS in a patient with middle cerebral artery stenosis disease. Results: The patient was a 62-year-old man, smoker, with high blood pressure who suffered left hemifacial and limbs myoclonus. He was initially diagnosed with focal seizures and he started antiepileptic treatment. However, he repeated the episodes. The electroencephalogram showed no abnormalities, and a vascular study with ultrasounds and angio-MRI evidenced severe middle cerebral stenosis. Finally, a diagnosis of Limb Shaking Syndrome was established and he started antiplatelet and high dose lipid-lowering treatment. Conclusion: Not all abnormal movements are due to epileptic seizures. When we evaluate a patient with vascular risk factors it is important to perform a complete vascular study to discard not only critical carotid stenosis but also intracranial disease.
MeSH term(s)	Diagnostic Errors ; Epilepsy/diagnosis ; Epilepsy/physiopathology ; Humans ; Hypolipidemic Agents/therapeutic use ; Infarction, Middle Cerebral Artery/complications ; Infarction, Middle Cerebral Artery/diagnostic imaging ; Infarction, Middle Cerebral Artery/drug therapy ; Infarction, Middle Cerebral Artery/physiopathology ; Ischemic Attack, Transient/complications ; Ischemic Attack, Transient/diagnostic imaging ; Ischemic Attack, Transient/drug therapy ; Ischemic Attack, Transient/physiopathology ; Male ; Middle Aged ; Platelet Aggregation Inhibitors/therapeutic use ; Recurrence ; Syndrome ; Treatment Outcome ; Tremor/diagnosis ; Tremor/etiology ; Tremor/physiopathology
Chemical Substances	Hypolipidemic Agents ; Platelet Aggregation Inhibitors
Language	English
Publishing date	2021-01-23
Publishing country	United States
Document type	Case Reports
ZDB-ID	1131675-5
ISSN	1532-8511 ; 1052-3057
ISSN (online)	1532-8511
ISSN	1052-3057
DOI	10.1016/j.jstrokecerebrovasdis.2021.105629
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Article ; Online: Platelet levels and age are determinants of survival after mild-moderate TBI: A prospective study in Spain.

Yuguero, Oriol / Vena, Ana / Bernal, Maria / Martínez-Alonso, Montserrat / Farre, Joan / Purroy, Francisco

Frontiers in public health

2023 Volume 11, Page(s) 1109426

Abstract: Introduction: Traumatic brain injury (TBI) is a very important reason for consultation in emergency departments.: Methods: A hospital cohort study with patients who attended a hospital emergency department between June 1, 2018 and December 31, 2020 ... ...

Abstract	Introduction: Traumatic brain injury (TBI) is a very important reason for consultation in emergency departments. Methods: A hospital cohort study with patients who attended a hospital emergency department between June 1, 2018 and December 31, 2020 due to TBI was studied. Clinical and sociodemographic variables were recorded. The levels of biomarkers and management variables were used. Qualitative variables were analyzed using Pearson's chi-square test, and quantitative variables using the Mann-Whitney Results: A total of 540 patients were included. The mean age was 83 years, and 53.9% of the patients were men. Overall, 112 patients (20.7%) died during the study follow-up. The mortality rate per 100 person-years was 14.33 (11.8-17.24), the most frequent mechanism being falls in the home, with none caused on public roads. The multivariable Cox proportional hazards model showed that survival after TBI was significantly associated with age, S100 levels, Charlson index, patient's institutionalized status, the place where the TBI occurred, and hemoglobin and platelet levels. Discussion: The most common profile for a patient with a TBI was male and aged between 80 and 90 years. The combination of the variables age, Charlson index, place of TBI occurrence, and hemoglobin and platelet levels could offer early prediction of survival in our population independently of TBI severity. With the data obtained, a therapeutic algorithm could be established for patients suffering from mild TBI, allowing the patient to be supervised at home, avoiding futile referrals to emergency services.
MeSH term(s)	Aged, 80 and over ; Female ; Humans ; Male ; Brain Injuries, Traumatic/epidemiology ; Brain Injuries, Traumatic/therapy ; Prospective Studies ; Spain/epidemiology ; Platelet Count ; Age Factors ; Survival Analysis ; Injury Severity Score ; Aged
Language	English
Publishing date	2023-03-20
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2023.1109426
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Article ; Online: Clinical complications after a traumatic brain injury and its relation with brain biomarkers.

Yuguero, Oriol / Bernal, Maria / Farré, Joan / Martinez-Alonso, Montserrat / Vena, Ana / Purroy, Francisco

Scientific reports

2023 Volume 13, Issue 1, Page(s) 20057

Abstract: We aimed to find out which are the most frequent complications for patients who suffer a traumatic brain injury (TBI) and its relation with brain biomarker levels. We conducted a hospital cohort study with patients who attended the Hospital Emergency ... ...

Abstract	We aimed to find out which are the most frequent complications for patients who suffer a traumatic brain injury (TBI) and its relation with brain biomarker levels. We conducted a hospital cohort study with patients who attended the Hospital Emergency Department between 1 June 2018 and 31 December 2020. Different variables were collected such as biomarkers levels after 6 h and 12 h of TBI (S100, NSE, UCHL1 and GFAP), clinical and sociodemographic variables, complementary tests, and complications 48 h and 7 days after TBI. Qualitative variables were analysed with Pearson's chi-square test, and quantitative variables with the Mann-Whitney U test. A multivariate logistic regression model for the existence of complications one week after discharge was performed to assess the discriminatory capacity of the clinical variables. A total of 51 controls and 540 patients were included in this study. In the TBI group, the mean age was 83 years, and 53.9% of the patients were male. Complications at seven days were associated with the severity of TBI (p < 0.05) and the number of platelets (p = 0.016). All biomarkers except GFAP showed significant differences in their distribution of values according to gender, with significantly higher values of the three biomarkers for women with respect to men. Patients with complications presented significantly higher S100 values (p < 0.05). The patient's baseline status, the severity of the TBI and the S100 levels can be very important elements in determining whether a patient may develop complications in the few hours after TBI.
MeSH term(s)	Humans ; Male ; Female ; Aged, 80 and over ; Cohort Studies ; Brain Injuries, Traumatic/complications ; Biomarkers ; Logistic Models ; Brain
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-11-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-47267-6
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Article ; Online: Preclinical evidence of remote ischemic conditioning in ischemic stroke, a metanalysis update.

Torres-Querol, Coral / Quintana-Luque, Manuel / Arque, Gloria / Purroy, Francisco

Scientific reports

2021 Volume 11, Issue 1, Page(s) 23706

Abstract: Remote ischemic conditioning (RIC) is a promising therapeutic approach for ischemic stroke patients. It has been proven that RIC reduces infarct size and improves functional outcomes. RIC can be applied either before ischemia (pre-conditioning; RIPreC), ... ...

Abstract	Remote ischemic conditioning (RIC) is a promising therapeutic approach for ischemic stroke patients. It has been proven that RIC reduces infarct size and improves functional outcomes. RIC can be applied either before ischemia (pre-conditioning; RIPreC), during ischemia (per-conditioning; RIPerC) or after ischemia (post-conditioning; RIPostC). Our aim was to systematically determine the efficacy of RIC in reducing infarct volumes and define the cellular pathways involved in preclinical animal models of ischemic stroke. A systematic search in three databases yielded 50 peer-review articles. Data were analyzed using random effects models and results expressed as percentage of reduction in infarct size (95% CI). A meta-regression was also performed to evaluate the effects of covariates on the pooled effect-size. 95.3% of analyzed experiments were carried out in rodents. Thirty-nine out of the 64 experiments studied RIPostC (61%), sixteen examined RIPreC (25%) and nine tested RIPerC (14%). In all studies, RIC was shown to reduce infarct volume (- 38.36%; CI - 42.09 to - 34.62%) when compared to controls. There was a significant interaction caused by species. Short cycles in mice significantly reduces infarct volume while in rats the opposite occurs. RIPreC was shown to be the most effective strategy in mice. The present meta-analysis suggests that RIC is more efficient in transient ischemia, using a smaller number of RIC cycles, applying larger length of limb occlusion, and employing barbiturates anesthetics. There is a preclinical evidence for RIC, it is safe and effective. However, the exact cellular pathways and underlying mechanisms are still not fully determined, and its definition will be crucial for the understanding of RIC mechanism of action.
MeSH term(s)	Anesthetics/pharmacology ; Animals ; Disease Management ; Disease Models, Animal ; Disease Susceptibility ; Ischemic Postconditioning/methods ; Ischemic Preconditioning/methods ; Ischemic Stroke/diagnosis ; Ischemic Stroke/etiology ; Ischemic Stroke/therapy ; Mice ; Models, Animal ; Myocardial Infarction/diagnosis ; Myocardial Infarction/etiology ; Myocardial Infarction/therapy ; Rats ; Treatment Outcome
Chemical Substances	Anesthetics
Language	English
Publishing date	2021-12-09
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-03003-6
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Article: Editorial: Remote Ischemic Conditioning (Pre, Per, and Post) as an Emerging Strategy of Neuroprotection in Ischemic Stroke.

Purroy, Francisco / Beretta, Simone / England, Timothy J / Hess, David Charles / Pico, Fernando / Shuaib, Ashfaq

Frontiers in neurology

2022 Volume 13, Page(s) 932891

Language	English
Publishing date	2022-06-23
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2022.932891
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Article ; Online: Human Atheromatous Plaques Expressed Sensing Adaptor STING, a Potential Role in Vascular Inflammation Pathogenesis.

Pallarés, Judith / Torreguitart, Núria / Arqué, Gloria / Portero-Otin, Manuel / Purroy, Francisco

Thrombosis and haemostasis

2022 Volume 122, Issue 9, Page(s) 1621–1624

MeSH term(s)	Humans ; Inflammation ; Membrane Proteins ; Plaque, Atherosclerotic
Chemical Substances	Membrane Proteins
Language	English
Publishing date	2022-02-15
Publishing country	Germany
Document type	Letter
ZDB-ID	518294-3
ISSN	2567-689X ; 0340-6245
ISSN (online)	2567-689X
ISSN	0340-6245
DOI	10.1055/a-1772-1192
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Article ; Online: Acute ischemic stroke triggers a cellular senescence-associated secretory phenotype.

Torres-Querol, Coral / Torres, Pascual / Vidal, Noemí / Portero-Otín, Manel / Arque, Gloria / Purroy, Francisco

Scientific reports

2021 Volume 11, Issue 1, Page(s) 15752

Abstract: Senescent cells are capable of expressing a myriad of inflammatory cytokines and this pro-inflammatory phenomenon is known as senescence-associated secretory phenotype (SASP). The contribution of this phenomenon in brain ischemia was scarce. A mouse ... ...

Abstract	Senescent cells are capable of expressing a myriad of inflammatory cytokines and this pro-inflammatory phenomenon is known as senescence-associated secretory phenotype (SASP). The contribution of this phenomenon in brain ischemia was scarce. A mouse model of transient focal cerebral ischemia by compressing the distal middle cerebral artery (tMCAo) for 60 min was used. SASP, pro-inflammatory cytokines and cell cycle mRNAs levels were quantified at 30-min and 72 h post-surgery. Immunohistochemistry in paraffin embedded human brain slides and mouse brain tissue was performed. Our results showed an increase of both p16 and p21 mRNA restricted to the infarct area in the tMCAo brain. Moreover, there was an induction of Il6, Tnfa, Cxc11, and its receptor Cxcr2 mRNA pro-inflammatory cytokines with a high positive correlation with p16/p21 mRNA levels. The p16 was mainly shown in cytoplasm of neurons and cytoplasm/membrane of microglial cells. The p21 was observed in membrane of neurons and also it showed a mixed cytoplasmic and membranous pattern in the microglial cells. In a human stroke patient, an increase of P16 in the perimeter of the MCA infarct area was observed. These suggest a role of SASP in tMCAo mouse model and in human brain tissue. SASP potentially has a physiological role in acute ischemic stroke and neurological function loss.
MeSH term(s)	Aged ; Animals ; Biomarkers/analysis ; Brain Ischemia/etiology ; Brain Ischemia/metabolism ; Brain Ischemia/pathology ; Cell Cycle ; Cellular Senescence ; Disease Models, Animal ; Gene Expression Regulation ; Humans ; Infarction, Middle Cerebral Artery/complications ; Ischemic Stroke/etiology ; Ischemic Stroke/metabolism ; Ischemic Stroke/pathology ; Male ; Mice ; Middle Aged ; Phenotype
Chemical Substances	Biomarkers
Language	English
Publishing date	2021-08-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-95344-5
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Article ; Online: Basal IL-6 and S100b levels are associated with infarct volume.

Purroy, Francisco / Farré-Rodriguez, Joan / Mauri-Capdevila, Gerard / Vicente-Pascual, Mikel / Farré, Joan

Acta neurologica Scandinavica

2021 Volume 144, Issue 5, Page(s) 517–523

Abstract: Objectives: The study of biomarkers related to the infarct volume of acute ischaemic stroke (AIS) is a valuable clinical strategy. We conducted a prospective study to evaluate the relationship between a wide panel of biomarkers involved in different ... ...

Abstract	Objectives: The study of biomarkers related to the infarct volume of acute ischaemic stroke (AIS) is a valuable clinical strategy. We conducted a prospective study to evaluate the relationship between a wide panel of biomarkers involved in different biochemical pathways and lesion volume. Materials & methods: We studied 332 patients with AIS. Infarct volume was calculated from diffusion weighted imaging (DWI). Blood samples were drawn within 24 h of symptom onset to test a panel of biomarkers that included high-sensitivity C-reactive protein (hs-CRP), IL-6, neuron-specific enolase (NSE), N-terminal pro-B-type natriuretic peptide (NT-ProBNP), S100b, troponin and IL-10. Results: The median lesion volume was 2.5 cc (IQR: 0.6-15.3). Patients with previous atrial fibrillation, cardioembolic aetiology and total anterior circulation infarct TACI classification had higher lesion volumes than those without them. Patients with previous recent TIA had smaller ischaemic lesions than those without it. Age and NIHSS were significantly correlated with lesion volume. In a linear regression analysis adjusted by aetiology, S100b and IL-6 emerged as the only biomarkers independently associated with infarct volume. In contrast, previous recent TIA and small-vessel disease were inversely related to infarct volume. Conclusions: The correlation between the two blood marker levels and ischaemic lesion volume would support the use of these biomarkers as a surrogate endpoint in AIS, especially in centres without DWI 24/7 but these could not substitute basic neuroimaging. Our findings should be further explored in larger, preferably multicentre studies.
MeSH term(s)	Biomarkers ; Brain Ischemia/complications ; Brain Ischemia/diagnostic imaging ; Humans ; Infarction ; Interleukin-6 ; Prospective Studies ; S100 Calcium Binding Protein beta Subunit ; Stroke/diagnostic imaging
Chemical Substances	Biomarkers ; IL6 protein, human ; Interleukin-6 ; S100 Calcium Binding Protein beta Subunit ; S100B protein, human
Language	English
Publishing date	2021-06-16
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	90-5
ISSN	1600-0404 ; 0001-6314
ISSN (online)	1600-0404
ISSN	0001-6314
DOI	10.1111/ane.13487
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Article: Human Atheromatous Plaques Expressed Sensing Adaptor STING, a Potential Role in Vascular Inflammation Pathogenesis

Pallarés, Judith / Torreguitart, Núria / Arqué, Gloria / Portero-Otin, Manuel / Purroy, Francisco

Thrombosis and Haemostasis

2022 Volume 122, Issue 09, Page(s) 1621–1624

Language	English
Publishing date	2022-02-15
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	518294-3
ISSN	2567-689X ; 0340-6245
ISSN (online)	2567-689X
ISSN	0340-6245
DOI	10.1055/a-1772-1192
Database	Thieme publisher's database

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