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  1. Article ; Online: Recent Trends in Bio-nanomaterials and Non-invasive Combinatorial Approaches of Photothermal Therapy against Cancer.

    Beniwal, Nitisha / Verma, Anamika / Putta, Chandra Lekha / Rengan, Aravind Kumar

    Nanotheranostics

    2024  Volume 8, Issue 2, Page(s) 219–238

    Abstract: In 2020, approximately 10 million deaths worldwide were attributed to cancer, making it the primary cause of death globally. Photothermal therapy (PTT) is one of the novel ways to treat and abolish cancer. PTT significantly impacts cancer theranostics ... ...

    Abstract In 2020, approximately 10 million deaths worldwide were attributed to cancer, making it the primary cause of death globally. Photothermal therapy (PTT) is one of the novel ways to treat and abolish cancer. PTT significantly impacts cancer theranostics compared to other therapies like surgery, chemotherapy, and radiotherapy due to its remarkable binding capability to tumor sites and lower invasiveness into normal healthy tissues. PTT relies on photothermal agents (PTAs), which generate heat by absorbing the near-infrared (NIR) light and destroying cancer cells. Several PTT agents remain longer in the reticuloendothelial system (RES) and induce toxicity, restricting their use in the biomedical field. To overcome this problem, the usage of biodegradable nano-photothermal agents is required. This review has discussed the PTT mechanism of action and different types of novel bio-nanomaterials used for PTT. We also focussed on the combinatorial effects of PTT with other cancer therapies and their effect on human health. The role of LED lights and mild hypothermia in PTT has been discussed briefly in this review.
    MeSH term(s) Humans ; Photothermal Therapy ; Hot Temperature ; Nanostructures/therapeutic use ; Neoplasms/therapy
    Language English
    Publishing date 2024-02-17
    Publishing country Australia
    Document type Journal Article ; Review
    ISSN 2206-7418
    ISSN (online) 2206-7418
    DOI 10.7150/ntno.91356
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Telomerase: a nexus between cancer nanotherapy and circadian rhythm.

    Ghosh, Pramit Kumar / Rao, Maddila Jagapathi / Putta, Chandra Lekha / Ray, Sandipan / Rengan, Aravind Kumar

    Biomaterials science

    2024  Volume 12, Issue 9, Page(s) 2259–2281

    Abstract: Cancer represents a complex disease category defined by the unregulated proliferation and dissemination of anomalous cells within the human body. According to the GLOBOCAN 2020 report, the year 2020 witnessed the diagnosis of approximately 19.3 million ... ...

    Abstract Cancer represents a complex disease category defined by the unregulated proliferation and dissemination of anomalous cells within the human body. According to the GLOBOCAN 2020 report, the year 2020 witnessed the diagnosis of approximately 19.3 million new cases of cancer and 10.0 million individuals succumbed to the disease. A typical cell eventually becomes cancerous because of a long-term buildup of genetic instability and replicative immortality. Telomerase is a crucial regulator of cancer progression as it induces replicative immortality. In cancer cells, telomerase inhibits apoptosis by elongating the length of the telomeric region, which usually protects the genome from shortening. Many nanoparticles are documented as being available for detecting the presence of telomerase, and many were used as delivery systems to transport drugs. Furthermore, telomere homeostasis is regulated by the circadian time-keeping machinery, leading to 24-hour rhythms in telomerase activity and TERT mRNA expression in mammals. This review provides a comprehensive discussion of various kinds of nanoparticles used in telomerase detection, inhibition, and multiple drug-related pathways, as well as enlightens an imperative association between circadian rhythm and telomerase activity from the perspective of nanoparticle-based anticancer therapeutics.
    MeSH term(s) Humans ; Telomerase/metabolism ; Circadian Rhythm/physiology ; Neoplasms/therapy ; Neoplasms/drug therapy ; Animals ; Nanoparticles/chemistry ; Antineoplastic Agents/pharmacology
    Chemical Substances Telomerase (EC 2.7.7.49) ; Antineoplastic Agents
    Language English
    Publishing date 2024-04-30
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2693928-9
    ISSN 2047-4849 ; 2047-4830
    ISSN (online) 2047-4849
    ISSN 2047-4830
    DOI 10.1039/d4bm00024b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Camptothecin loaded casein nanosystem for tuning the therapeutic efficacy against highly metastatic triple-negative breast cancer cells.

    Khatun, Sajmina / Pebam, Monika / Putta, Chandra Lekha / Rengan, Aravind Kumar

    Biomaterials science

    2023  Volume 11, Issue 7, Page(s) 2518–2530

    Abstract: The heterogenic of TNBC and the side effects of chemo drugs lead to the failure of therapy. Protein-based nanoplatforms have emerged as an important domain in protein-engineered biomedicine for delivering anticancer therapeutics. Protein-based ... ...

    Abstract The heterogenic of TNBC and the side effects of chemo drugs lead to the failure of therapy. Protein-based nanoplatforms have emerged as an important domain in protein-engineered biomedicine for delivering anticancer therapeutics. Protein-based nanosystems are biocompatible and biodegradable, with a long half-life and high purity. TNBC is sensitive to DNA-damaging chemo drugs. In this study, we used 10-hydroxy camptothecin, which causes DNA damage in cancer cells. However, the inappropriate solubility and toxic side effects limit its application in cancer therapy. We encapsulated 10-Hydroxycamptothecin in biocompatible casein by synthesizing nanoparticles from it. The synthesized CS and CCS NPs showed excellent biocompatibility in fibroblast cell lines L929, NIH-3T3, and zebrafish embryos. Enhanced uptake of CCS NPs in zebrafish embryos and 4T1 cells, cancer cell toxicity of nearly 80-85%, sub-cellular mitochondrial localization, alterations of mitochondrial membrane potential, lysosomal localization, and reactive oxygen species generation that causes cancer cell apoptosis have been observed. Growth inhibition of 4T1 cell colonies and antimetastatic activity were also noted. Further upregulation of γ-H2AX which causes DNA damage, downregulation of the PARP protein related to DNA repair, and increased level of the CHOP protein marker for endoplasmic reticulum stress-mediated cell death were observed. The 3-D model of 4T1 cells exhibited deep tumor penetration with significant therapeutic efficacy for CCS NPs. These results imply that casein-based nanoformulation could open a new scope for safe and affordable cancer therapy in TNBC.
    MeSH term(s) Humans ; Animals ; Triple Negative Breast Neoplasms/metabolism ; Caseins ; Zebrafish ; Antineoplastic Agents ; Camptothecin/pharmacology ; Camptothecin/therapeutic use ; Nanoparticles ; Cell Line, Tumor
    Chemical Substances Caseins ; Antineoplastic Agents ; Camptothecin (XT3Z54Z28A)
    Language English
    Publishing date 2023-03-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2693928-9
    ISSN 2047-4849 ; 2047-4830
    ISSN (online) 2047-4849
    ISSN 2047-4830
    DOI 10.1039/d2bm01814d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Immunomodulatory nanosystems: An emerging strategy to combat viral infections.

    Khatun, Sajmina / Putta, Chandra Lekha / Hak, Arshadul / Rengan, Aravind Kumar

    Biomaterials and biosystems

    2023  Volume 9, Page(s) 100073

    Abstract: The viral infection spreads with the assistance of a host. Traditional antiviral therapies cannot provide long-term immunity against emerging and drug-resistant viral infections. Immunotherapy has evolved as an efficient approach for disease prevention ... ...

    Abstract The viral infection spreads with the assistance of a host. Traditional antiviral therapies cannot provide long-term immunity against emerging and drug-resistant viral infections. Immunotherapy has evolved as an efficient approach for disease prevention and treatment, which include cancer, infections, inflammatory, and immune disorders. Immunomodulatory nanosystems can dramatically enhance therapeutic outcomes by combating many therapeutic challenges, such as poor immune stimulation and off-target adverse effects. Recently, immunomodulatory nanosystems have emerged as a potent antiviral strategy to intercept viral infections effectively. This review introduces major viral infections with their primary symptoms, route of transmission & targeted organ, and different stages of the viral life cycle with respective traditional blockers. The IMNs have an exceptional capacity for precisely modulating the immune system for therapeutic applications. The nano sized immunomodulatory systems permit the immune cells to interact with infectious agents enhancing lymphatic drainage and endocytosis by the over-reactive immune cells in the infected areas. Immune cells that can be modulated upon viral infection via various immunomodulatory nanosystems have been discussed. Advancement in theranostics can yield an accurate diagnosis, adequate treatment, and real-time screening of viral infections. Nanosystem-based drug delivery can continue to thrive in diagnosing, treating, and preventing viral infections. The curative medicine for remerging and drug-resistant viruses remains challenging, though certain systems have expanded our perception and initiated a new research domain in antiviral treatments.
    Language English
    Publishing date 2023-01-30
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2666-5344
    ISSN (online) 2666-5344
    DOI 10.1016/j.bbiosy.2023.100073
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Development, systematic optimisation and biofilm disruption activity of eugenol-based nanosized emulsions stabilised with Tween 80.

    Putta, Chandra Lekha / Rahman, Syed Nazrin Ruhina / Chakraborty, Payel / Shunmugaperumal, Tamilvanan

    Journal of microencapsulation

    2023  Volume 40, Issue 7, Page(s) 517–533

    Abstract: The aims of this study were to systematically optimise a formula for eugenol emulsions via face-centered central composite design and to assess the activity against two-different bacterial strains ( ...

    Abstract The aims of this study were to systematically optimise a formula for eugenol emulsions via face-centered central composite design and to assess the activity against two-different bacterial strains (
    Language English
    Publishing date 2023-08-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 843632-0
    ISSN 1464-5246 ; 0265-2048
    ISSN (online) 1464-5246
    ISSN 0265-2048
    DOI 10.1080/02652048.2023.2244094
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Green synthesis of multi-functional carbon dots from medicinal plant leaves for antimicrobial, antioxidant, and bioimaging applications.

    Gedda, Gangaraju / Sankaranarayanan, Sri Amruthaa / Putta, Chandra Lekha / Gudimella, Krishna Kanthi / Rengan, Aravind Kumar / Girma, Wubshet Mekonnen

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 6371

    Abstract: In this research work, carbon dots (CDs) were synthesized from the renewable leaves of an indigenous medicinal plant by the one-pot sand bath method, Azadirachta indica. The synthesized CDs were characterized for its optical properties using UV-Vis, ... ...

    Abstract In this research work, carbon dots (CDs) were synthesized from the renewable leaves of an indigenous medicinal plant by the one-pot sand bath method, Azadirachta indica. The synthesized CDs were characterized for its optical properties using UV-Vis, Fluorescence and Fourier transform infrared (FT-IR) spectrophotometry and for structural properties using dynamic light scattering (DLS), X-ray Diffraction (XRD) and high resolution Transmission electron microscopy (HR-TEM). The synthesized CDs exhibited concentration dependent biocompatibility when tested in mouse fibroblast L929 cell line. The EC
    MeSH term(s) Animals ; Mice ; Humans ; Antioxidants/pharmacology ; Antioxidants/analysis ; Plants, Medicinal ; Spectroscopy, Fourier Transform Infrared ; Carbon/chemistry ; Quantum Dots/chemistry ; Anti-Infective Agents/pharmacology ; Anti-Infective Agents/analysis ; Plant Leaves/chemistry
    Chemical Substances Antioxidants ; Carbon (7440-44-0) ; Anti-Infective Agents
    Language English
    Publishing date 2023-04-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-33652-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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