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Article ; Online: Protective role of N-acetylcysteine and Sulodexide on endothelial cells exposed on patients' serum after SARS-CoV-2 infection.

Rajewska-Tabor, Justyna / Sosińska-Zawierucha, Patrycja / Pyda, Malgorzata / Lesiak, Maciej / Bręborowicz, Andrzej

Frontiers in cellular and infection microbiology

2023 Volume 13, Page(s) 1268016

Abstract: Severe acute respiratory syndrome coronavirus-2 causes hyperinflammation and activation of coagulation cascade and, as a result, aggravates endothelial cell dysfunction. N-acetylcysteine and Sulodexide have been found to mitigate endothelial damage. The ... ...

Abstract	Severe acute respiratory syndrome coronavirus-2 causes hyperinflammation and activation of coagulation cascade and, as a result, aggravates endothelial cell dysfunction. N-acetylcysteine and Sulodexide have been found to mitigate endothelial damage. The influence on coronary artery endothelial cells of serum collected after 4 ± 1 months from coronavirus infection was studied. The concentrations of serum samples of interleukin 6, von Willebrand Factor, tissue Plasminogen Activator, and Plasminogen Activator Inhibitor-1 were studied. The cultures with serum of patients after coronavirus infection were incubated with N-acetylcysteine and Sulodexide to estimate their potential protective role. The blood inflammatory parameters were increased in the group of cultures incubated with serum from patients after coronavirus infection. Supplementation of the serum from patients after coronavirus infection with N-acetylcysteine or Sulodexide reduced the synthesis of interleukin 6 and von Willebrand Factor. No changes in the synthesis of tissue Plasminogen Activator were observed. N-acetylcysteine reduced the synthesis of Plasminogen Activator Inhibitor-1. N-acetylcysteine and Sulodexide increased the tPA/PAI-1 ratio. N-acetylcysteine may have a role in reducing the myocardial injury occurring in the post-COVID-19 syndrome. Sulodexide can also play a protective role in post-COVID-19 patients.
MeSH term(s)	Humans ; COVID-19 ; Endothelial Cells ; Tissue Plasminogen Activator ; Acetylcysteine/pharmacology ; Interleukin-6 ; Post-Acute COVID-19 Syndrome ; von Willebrand Factor ; SARS-CoV-2
Chemical Substances	Tissue Plasminogen Activator (EC 3.4.21.68) ; glucuronyl glucosamine glycan sulfate (75HGV0062C) ; Acetylcysteine (WYQ7N0BPYC) ; Interleukin-6 ; von Willebrand Factor
Language	English
Publishing date	2023-12-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2023.1268016
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Article ; Online: Ebstein anomaly with severe tricuspid valve regurgitation: An unusual case of an 84-year natural course.

Nartowicz, Sonia Alicja / Janus, Magdalena / Ciepłucha, Aleksandra / Pyda, Małgorzata / Lesiak, Maciej / Trojnarska, Olga

Kardiologia polska

2023 Volume 82, Issue 3, Page(s) 343–344

MeSH term(s)	Humans ; Ebstein Anomaly/complications ; Ebstein Anomaly/diagnostic imaging ; Ebstein Anomaly/surgery ; Tricuspid Valve Insufficiency/complications ; Tricuspid Valve Insufficiency/diagnostic imaging ; Tricuspid Valve/diagnostic imaging ; Tricuspid Valve/surgery ; Cardiac Surgical Procedures
Language	English
Publishing date	2023-11-24
Publishing country	Poland
Document type	Case Reports ; Journal Article
ZDB-ID	411492-9
ISSN	1897-4279 ; 0022-9032
ISSN (online)	1897-4279
ISSN	0022-9032
DOI	10.33963/v.kp.97481
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Article ; Online: Protective role of N-acetylcysteine and Sulodexide on endothelial cells after SARS-CoV-2 infection

Rajewska-Tabor, Justyna / Sosinska, Patrycja / Pyda, Malgorzata / Breborowicz, Andrzej

bioRxiv

Abstract: Objective: Severe acute respiratory syndrome coronavirus-2 causes hyperinflammation and activation of coagulation cascade and in the result aggravates endothelial cell dysfunction. N-acetylcysteine and Sulodexide have been found to mitigate endothelial ... ...

Abstract	Objective: Severe acute respiratory syndrome coronavirus-2 causes hyperinflammation and activation of coagulation cascade and in the result aggravates endothelial cell dysfunction. N-acetylcysteine and Sulodexide have been found to mitigate endothelial damage. Approach and Results: The influence on coronary artery endothelial cells of serum collected after 4+/-1 months from coronavirus infection was studied. The concentrations of serum samples of interleukin 6, von Willebrand Factor, tissue Plasminogen Activator and Plasminogen Activator Inhibitor-1 were studied. The cultures with serum of patients after coronavirus infection were incubated with N-acetylocysteine and Sulodexide to estimate their potential protective role. The blood inflammato-ry parameters were increased in the group of cultures incubated with serum from patients after coronavirus infection. Supplementation of the serum from patients after coronavirus infection with N-acetylcysteine or Sulodexide reduced the synthesis of interleukin 6, von Willebrand Fac-tor. No changes in the synthesis of tissue Plasminogen Activator were observed. N-acetylcysteine reduced the synthesis of Plasminogen Activator Inhibitor-1. N-acetylcysteine and Sulodexide increased the tPA/PAI-1 ratio. Conclusion: N-acetylcysteine may have a role in reducing the myocardial injury occurring in the post-COVID-19 syndrome. Sulodexide can also play a protective role in post-COVID-19 patients.
Keywords	covid19
Language	English
Publishing date	2023-07-24
Publisher	Cold Spring Harbor Laboratory
Document type	Article ; Online
DOI	10.1101/2023.07.19.549800
Database	COVID19

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Article ; Online: The Effect of a Mixed Circuit of Aerobic and Resistance Training on Body Composition in Older Adults-Retrospective Study.

Pieczyńska, Anna / Zasadzka, Ewa / Trzmiel, Tomasz / Pyda, Małgorzata / Pawlaczyk, Mariola

International journal of environmental research and public health

2021 Volume 18, Issue 11

Abstract: Ageing is inevitably associated with body composition changes, such as loss of muscle mass, increase in the total fat mass, and unfavorable reduction of subcutaneous fat. Physical activity exerts significant effects on the body composition. The aim of ... ...

Abstract	Ageing is inevitably associated with body composition changes, such as loss of muscle mass, increase in the total fat mass, and unfavorable reduction of subcutaneous fat. Physical activity exerts significant effects on the body composition. The aim of the study was to investigate the effects of two different weekly doses of resistance-aerobic training on the body composition in older people. The study consisted in a retrospective data analysis of fitness club members aged ≥60. The trainees participated in resistance-aerobic training sessions two or three times/week for a minimum of two months. A body composition analysis was performed before and after the training sessions. Group 1 (36 subjects) and Group 2 (28 subjects) had two and three training sessions/week, respectively. A higher skeletal muscle mass was found in Group 1 and lower waist-hip-ratio indices were observed in Group 2. No statistically significant differences were found in the body mass, skeletal muscle mass, fat mass, total body water, lean mass, body mass index, visceral fat area between both groups. The number of training session/week proved to be statistically insignificant for all investigated variables. Resistance-aerobic training with two sessions/week may be as effective in maintaining proper body composition in older people as the same training at the dose of three sessions/week.
MeSH term(s)	Aged ; Body Composition ; Body Mass Index ; Exercise ; Humans ; Resistance Training ; Retrospective Studies
Language	English
Publishing date	2021-05-24
Publishing country	Switzerland
Document type	Journal Article
ISSN	1660-4601
ISSN (online)	1660-4601
DOI	10.3390/ijerph18115608
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Article ; Online: Massive atrial thrombus in sinus rhythm cardiac amyloidosis is not a wild goose chase?

Gościniak, Piotr / Baumert, Bartłomiej / Rajewska-Tabor, Justyna / Jędrzychowska-Baraniak, Joanna / Pyda, Małgorzata / Machaliński, Bogusław

Kardiologia polska

2022 Volume 80, Issue 4, Page(s) 507–508

MeSH term(s)	Amyloidosis/complications ; Arrhythmias, Cardiac ; Atrial Fibrillation ; Heart Diseases/diagnostic imaging ; Heart Diseases/etiology ; Heart Diseases/surgery ; Humans ; Thrombosis/diagnostic imaging ; Thrombosis/etiology ; Thrombosis/surgery
Language	English
Publishing date	2022-05-10
Publishing country	Poland
Document type	Journal Article
ZDB-ID	411492-9
ISSN	1897-4279 ; 0022-9032
ISSN (online)	1897-4279
ISSN	0022-9032
DOI	10.33963/KP.a2022.0073
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Article ; Online: Left, but not right, ventricular status determines heart failure in adults with Ebstein anomaly - A case-control study based on magnetic resonance.

Ciepłucha, Aleksandra / Trojnarska, Olga / Rajewska-Tabor, Justyna / Bartczak-Rutkowska, Agnieszka / Kramer, Lucyna / Pyda, Malgorzata

International journal of cardiology

2022 Volume 358, Page(s) 39–44

Abstract: Background: Ebstein anomaly (EA) is a congenital heart defect affecting the right heart. Heart failure (HF) is a significant complication in adults with EA. It may result not only from the right ventricle (RV), but also from the left ventricle (LV) ... ...

Abstract	Background: Ebstein anomaly (EA) is a congenital heart defect affecting the right heart. Heart failure (HF) is a significant complication in adults with EA. It may result not only from the right ventricle (RV), but also from the left ventricle (LV) abnormalities. We evaluate the size and function of both ventricles in patients with EA in cardiac magnetic resonance (CMR); to assess their association with the clinical markers of HF. Methods: Study group: 37 unoperated adults with EA (mean age 43.0 ± 14.4y, 21[56.8%] males). Controls: 25 volunteers (mean age 39.9 ± 10.9y, 15[60%] males). Study protocol included: CMR [ejection fraction (EF), end-diastolic (EDVind) and stroke volumes (SVind) indexed by body surface area]; cardiopulmonary test (peak VO2, %peak VO2, VE/VCO2 slope). Results: Size and systolic function of LV were reduced comparing to the controls [LVEDVind (ml/m2): 63.7(range 38.7-94.2) vs. 79.3(48.7-105.1), p < 0.001; LV SVind (ml/m2): 35.8(22.9-55.1) vs. 49.2(37.8-71.7), p < 0.0001; LVEF(%): 58.3(34-70.5) vs. 62.0(52.0-77.0), p = 0.009]. RV was enlarged comparing to the controls [RVEDVind (ml/m2): 124.3(52.8-378.9) vs. 83.0(64.0-102.0), p < 0.0001) with impaired systolic function (RV SVind (ml/m2): 22.7(11.1-74.1) vs. 48.0(37.8-71.7), p < 0.0001; RVEF(%): 38.0(21.0-66.1) vs. 59.0(49.0-69.0), p < 0.0001). A significant correlation was found between LVEDVind vs. peakVO2 (r = 0.52, p = 0.001); LV SVind vs. peakVO2 (r = 0.47,p = 0.005). There was no correlation between the right ventricular status and exercise capacity. Conclusions: In adults with Ebstein anomaly the size of left ventricle is reduced, right ventricle is enlarged; the function of both is impaired. Abnormal exercise capacity is associated with left ventricular status. Ventricular interdependence probably plays a role in heart failure pathomechanism.
MeSH term(s)	Adult ; Case-Control Studies ; Ebstein Anomaly/diagnostic imaging ; Female ; Heart Failure/complications ; Heart Failure/diagnostic imaging ; Heart Ventricles/diagnostic imaging ; Humans ; Magnetic Resonance Spectroscopy ; Male ; Middle Aged ; Stroke Volume ; Ventricular Function, Right
Language	English
Publishing date	2022-04-26
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2022.04.066
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Article ; Online: The impact of left circumflex coronary artery ostium stenosis on outcomes for patients after percutaneous coronary intervention for unprotected left main disease.

Skorupski, Wojciech Jan / Kałużna-Oleksy, Marta / Mitkowski, Przemysław / Araszkiewicz, Aleksander / Skorupski, Włodzimierz / Grajek, Stefan / Pyda, Małgorzata / Lesiak, Maciej / Grygier, Marek

Kardiologia polska

2023 Volume 81, Issue 9, Page(s) 903–908

Abstract: Background: The impact of left circumflex coronary artery (LCX) ostium atherosclerosis in left main coronary artery (LM) bifurcation disease is not well-known.: Aim: The study aimed to assess whether the involvement of LCX ostium carries prognostic ... ...

Abstract	Background: The impact of left circumflex coronary artery (LCX) ostium atherosclerosis in left main coronary artery (LM) bifurcation disease is not well-known. Aim: The study aimed to assess whether the involvement of LCX ostium carries prognostic implications in patients undergoing unprotected LM percutaneous coronary intervention (PCI). Methods: Consecutive 564 patients with unprotected LM (ULMCA) disease who underwent LM PCI between January 2015 and February 2021, with at least 1 year of available follow-up were included in the study. The first group was composed of 145 patients with ULMCA disease with LCX ostium stenosis, and the second group consisted of 419 patients with ULMCA disease without LCX ostium stenosis. Results: Patients in the group with ULMCA disease with LCX ostium stenosis were significantly older and had more comorbidities. The two-stent technique was used more often in the group with LCX ostium stenosis (62.8% vs. 14.6%; P <0.001). During 7-year follow-up, all-cause mortality did not differ significantly between groups with and without LCX ostium stenosis (P = 0.50). The use of one-stent or two-stent technique also did not impact mortality in patients with LCX ostial lesions (P = 0.75). Long-term mortality subanalysis for three groups of patients: (1) patients with LM plus LCX ostium stenosis; (2) LM plus left anterior descending artery (LAD) ostium stenosis; (3) LM plus LCX ostium plus LAD ostium stenosis also did not differ significantly (P = 0.63). Conclusions: LCX ostium involvement in LM disease PCI is not associated with adverse long-term outcomes, which is highly beneficial for the Heart Team's decision-making process.
MeSH term(s)	Humans ; Coronary Artery Disease/complications ; Coronary Artery Disease/surgery ; Coronary Vessels/surgery ; Percutaneous Coronary Intervention/adverse effects ; Constriction, Pathologic/etiology ; Constriction, Pathologic/pathology ; Coronary Angiography ; Treatment Outcome ; Drug-Eluting Stents ; Coronary Stenosis/surgery ; Coronary Stenosis/etiology
Language	English
Publishing date	2023-07-25
Publishing country	Poland
Document type	Journal Article
ZDB-ID	411492-9
ISSN	1897-4279 ; 0022-9032
ISSN (online)	1897-4279
ISSN	0022-9032
DOI	10.33963/KP.a2023.0156
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Article ; Online: The tip of the iceberg: cardiac magnetic resonance imaging findings in patients with myocardial infarction with non-obstructive coronary arteries: preliminary data from the Polish single-centre registry.

Gościniak, Piotr / Baron, Tomasz / Józwa, Robert / Pyda, Małgorzata

Kardiologia polska

2019 Volume 77, Issue 3, Page(s) 389–392

MeSH term(s)	Coronary Angiography/methods ; Coronary Vessels/diagnostic imaging ; Female ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Myocardial Infarction/diagnostic imaging ; Myocardial Infarction/pathology ; Myocardial Infarction/physiopathology ; Myocardium/pathology ; Poland ; Risk Factors
Language	English
Publishing date	2019-01-03
Publishing country	Poland
Document type	Journal Article
ZDB-ID	411492-9
ISSN	1897-4279 ; 0022-9032
ISSN (online)	1897-4279
ISSN	0022-9032
DOI	10.5603/KP.a2019.0001
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Article: A Twenty-Year Follow-Up of Adults with Ebstein Anomaly with Special Focus on Supraventricular Arrhythmias, Supraventricular Arrhythmias and Effectiveness of Catheter Ablation in 20-Year Follow-Up of Adults with Ebstein Anomaly.

Nartowicz, Sonia Alicja / Ciepłucha, Aleksandra / Waśniewski, Michał / Miechowicz, Izabela / Rajewska-Tabor, Justyna / Bartczak-Rutkowska, Agnieszka / Lesiak, Maciej / Pyda, Małgorzata / Trojnarska, Olga

Journal of clinical medicine

2024 Volume 13, Issue 7

Abstract: ... ...

Abstract	Background
Language	English
Publishing date	2024-04-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13072039
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Article ; Online: Changing appearance of lipomatous hypertrophy of the interatrial septum on positron emission tomography scan.

Siminiak, Natalia / Rajewska-Tabor, Justyna / Pyda, Małgorzata / Czepczyński, Rafał / Ruchała, Marek

Kardiologia polska

2021 Volume 79, Issue 9, Page(s) 1032–1033

MeSH term(s)	Atrial Septum/diagnostic imaging ; Heart Neoplasms/diagnostic imaging ; Humans ; Hypertrophy/diagnostic imaging ; Lipomatosis/diagnostic imaging ; Positron-Emission Tomography
Language	English
Publishing date	2021-06-24
Publishing country	Poland
Document type	Journal Article
ZDB-ID	411492-9
ISSN	1897-4279 ; 0022-9032
ISSN (online)	1897-4279
ISSN	0022-9032
DOI	10.33963/KP.a2021.0046
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