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Article ; Online: Characteristics of the traditional Liu-Wei-Di-Huang prescription reassessed in modern pharmacology.

Cheng, Xiao-Rui / Qi, Chun-Hui / Wang, Tong-Xing / Zhou, Wen-Xia / Zhang, Yong-Xiang

2019 Volume 17, Issue 2, Page(s) 103–121

Abstract: Liu-Wei-Di-Huang (LW) is a Yin nourishing and kidney tonifying prescription in traditional Chinese medicine with promising pharmacological characteristics that can be further exploited and developed in modern medicine. We provide a comprehensive and ... ...

Abstract	Liu-Wei-Di-Huang (LW) is a Yin nourishing and kidney tonifying prescription in traditional Chinese medicine with promising pharmacological characteristics that can be further exploited and developed in modern medicine. We provide a comprehensive and detailed literature report on the clinical and experimental pharmacology of LW, including its quality control parameters, phytochemistry, pharmacokinetics, and toxicology. Our literature review indicates that the LW prescription possesses a unique combination of pharmacological characteristics that can be safely used for treating very different diseases. Quality control and pharmacokinetic parameters of LW are mostly based on its major bioactive phytochemical constituents. We postulate that modulating or rebalancing the neuroendocrine immunomodulation network in the body is the underlying mechanism of the multiple pharmacological activities displayed by LW.
MeSH term(s)	Animals ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Kidney/drug effects ; Medicine, Chinese Traditional ; Neuroimmunomodulation/drug effects ; Phytochemicals/chemistry ; Phytochemicals/pharmacology ; Phytochemicals/therapeutic use ; Quality Control ; Yin Deficiency/drug therapy
Chemical Substances	Drugs, Chinese Herbal ; Liuwei Dihuang Decoction ; Phytochemicals
Language	English
Publishing date	2019-02-22
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	2192577-X
ISSN	1875-5364 ; 2095-6975 ; 1672-3651
ISSN (online)	1875-5364
ISSN	2095-6975 ; 1672-3651
DOI	10.1016/S1875-5364(19)30013-5
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Article: Characteristics of the traditional Liu-Wei-Di-Huang prescription reassessed in modern pharmacology

CHENG, Xiao-Rui / QI, Chun-Hui / WANG, Tong-Xing / ZHANG, Yong-Xiang / ZHOU, Wen-Xia

Chinese journal of natural medicines. 2019 Feb., v. 17, no. 2

2019

Abstract	Liu-Wei-Di-Huang (LW) is a Yin nourishing and kidney tonifying prescription in traditional Chinese medicine with promising pharmacological characteristics that can be further exploited and developed in modern medicine. We provide a comprehensive and detailed literature report on the clinical and experimental pharmacology of LW, including its quality control parameters, phytochemistry, pharmacokinetics, and toxicology. Our literature review indicates that the LW prescription possesses a unique combination of pharmacological characteristics that can be safely used for treating very different diseases. Quality control and pharmacokinetic parameters of LW are mostly based on its major bioactive phytochemical constituents. We postulate that modulating or rebalancing the neuroendocrine immunomodulation network in the body is the underlying mechanism of the multiple pharmacological activities displayed by LW.
Keywords	chemical constituents of plants ; immunomodulation ; kidneys ; medicinal properties ; Oriental traditional medicine ; pharmacokinetics ; quality control ; toxicology
Language	English
Dates of publication	2019-02
Size	p. 103-121.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2192577-X
ISSN	1875-5364 ; 2095-6975 ; 1672-3651
ISSN (online)	1875-5364
ISSN	2095-6975 ; 1672-3651
DOI	10.1016/S1875-5364(19)30013-5
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Article ; Online: Efficacy of alemtuzumab and natalizumab in the treatment of different stages of multiple sclerosis patients.

Wang, Li / Qi, Chun-Hui / Zhong, Ren / Yuan, Chao / Zhong, Qiu-Yue

Medicine

2018 Volume 97, Issue 8, Page(s) e9908

Abstract: Background: Multiple sclerosis (MS) is an autoimmune disease, in which the insulating covers of nerve cells in the brain and spinal cord are demyelinated. This study was conducted to compare the efficacy of alemtuzumab and natalizumab in the treatment ... ...

Abstract	Background: Multiple sclerosis (MS) is an autoimmune disease, in which the insulating covers of nerve cells in the brain and spinal cord are demyelinated. This study was conducted to compare the efficacy of alemtuzumab and natalizumab in the treatment of different stages of MS patients. Methods: A total of 585 patients diagnosed with MS and hospitalized were included and analyzed after which they were divided into the primary progressive MS A and B groups, the relapsing-remitting MS (RRMS) C and D groups, and the secondary progressive MS E and F groups. Patients in A, C, and E groups were administered alemtuzumab while those in B, D, and F groups were administered natalizumab for the treatment. The expanded disability status scale (EDSS) scores and the EDSS difference were calculated before and after treatment. The number of head magnetic resonance imaging enhanced lesions in the patients, recurrence time and recurrence rate were measured before and after treatment. Results: The EDSS score of the RRMS group was significantly lower than that of the primary progressive MS group and the secondary progressive MS group. After 12 months of treatment, the EDSS score of RRMS patients treated with natalizumab was significantly lower compared with the patients with alemtuzumab, and the difference before and after treatment was significantly higher than alemtuzumab. The recurrence rate of the RRMS-D group was significantly lower than the RRMS-C group. After 12 months of treatment, compared with the RRMS-C group, a significant reduction was observed in the number of head magnetic resonance imaging enhanced lesions and longer recurrence time in the RRMS-D group. Conclusion: The efficacy of natalizumab was better than alemtuzumab in the treatment of patients in the RRMS group, while there was no significant difference among other stages of MS patients, which provided the theoretical basis and clinical guidance for the treatment of different stages of MS.
MeSH term(s)	Adult ; Alemtuzumab/therapeutic use ; Female ; Humans ; Immunologic Factors/therapeutic use ; Magnetic Resonance Imaging ; Male ; Multiple Sclerosis, Chronic Progressive/diagnostic imaging ; Multiple Sclerosis, Chronic Progressive/drug therapy ; Multiple Sclerosis, Relapsing-Remitting/diagnostic imaging ; Multiple Sclerosis, Relapsing-Remitting/drug therapy ; Natalizumab/therapeutic use ; Treatment Outcome ; Young Adult
Chemical Substances	Immunologic Factors ; Natalizumab ; Alemtuzumab (3A189DH42V)
Language	English
Publishing date	2018-02-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000009908
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Article ; Online: Baicalin ameliorates cigarette smoke-induced airway inflammation in rats by modulating HDAC2/NF-κB/PAI-1 signalling.

Zhang, Hu / Liu, Baojun / Jiang, Shan / Wu, Jin-Feng / Qi, Chun-Hui / Mohammadtursun, Nabijan / Li, Qiuping / Li, Lulu / Zhang, Hongying / Sun, Jing / Dong, Jing-Cheng

Pulmonary pharmacology & therapeutics

2021 Volume 70, Page(s) 102061

Abstract: Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease distinguished by airway remodelling and progressive inflammation. PAI-1 is an important regulator of fibrosis. Recent studies have shown that PAI-1 seems to be involved in ... ...

Abstract	Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease distinguished by airway remodelling and progressive inflammation. PAI-1 is an important regulator of fibrosis. Recent studies have shown that PAI-1 seems to be involved in COPD progression. Elevated levels of PAI-1 have been found in the lungs of patients with acute inflammation. PAI-1 has been shown to regulate the levels of proinflammatory cytokines in the lungs, such as tumour necrosis factor (TNF)-α and interleukin (IL)-6, indicating that PAI-1 may play a fundamental role during inflammation. In the present study, we investigated the anti-inflammatory role of baicalin, the main active component of Scutellaria baicalensis, against cigarette smoke (extract) (CS/CSE)-induced airway inflammation in vivo and in vitro. For the in vivo study, SD rats were exposed to CS for 1 h/day, 6 days/week, for 24 weeks and treated with baicalin (40, 80 and 160 mg/kg) or budesonide (0.2 mg/kg). For this study, HBE cells were pretreated with baicalin (10, 20, 40 μM) or dexamethasone (10
MeSH term(s)	Animals ; Flavonoids ; Histone Deacetylase 2 ; Humans ; Inflammation ; NF-kappa B ; Plasminogen Activator Inhibitor 1 ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Rats ; Rats, Sprague-Dawley ; Smoke/adverse effects ; Smoking/adverse effects
Chemical Substances	Flavonoids ; NF-kappa B ; Plasminogen Activator Inhibitor 1 ; Smoke ; baicalin (347Q89U4M5) ; HDAC2 protein, human (EC 3.5.1.98) ; Hdac2 protein, rat (EC 3.5.1.98) ; Histone Deacetylase 2 (EC 3.5.1.98)
Language	English
Publishing date	2021-07-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1399707-5
ISSN	1522-9629 ; 1094-5539
ISSN (online)	1522-9629
ISSN	1094-5539
DOI	10.1016/j.pupt.2021.102061
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Article ; Online: Lycium barbarum polysaccharide LBPF4-OL may be a new Toll-like receptor 4/MD2-MAPK signaling pathway activator and inducer.

Zhang, Xiao-rui / Qi, Chun-hui / Cheng, Jun-ping / Liu, Gang / Huang, Lin-juan / Wang, Zhong-fu / Zhou, Wen-xia / Zhang, Yong-xiang

International immunopharmacology

2014 Volume 19, Issue 1, Page(s) 132–141

Abstract: Recognition of the utility of the traditional Chinese medicine Lycium barbarum L. has been gradually increasing in Europe and the Americas. Many immunoregulation and antitumor effects of L. barbarum polysaccharides (LBP) have been reported, but its ... ...

Abstract	Recognition of the utility of the traditional Chinese medicine Lycium barbarum L. has been gradually increasing in Europe and the Americas. Many immunoregulation and antitumor effects of L. barbarum polysaccharides (LBP) have been reported, but its molecular mechanism is not yet clear. In this study, we reported that the activity of the polysaccharide LBPF4-OL, which was purified from LBP, is closely associated with the TLR4-MAPK signaling pathway. We found that LBPF4-OL can significantly induce TNF-α and IL-1β production in peritoneal macrophages isolated from wild-type (C3H/HeN) but not TLR4-deficient mice (C3H/HeJ). We also determined that the proliferation of LBPF4-OL-stimulated lymphocytes from C3H/HeJ mice is significantly weaker than that of lymphocytes from C3H/HeN mice. Furthermore, through a bio-layer interferometry assay, we found that LPS but not LBPF4-OL can directly associate with the TLR4/MD2 molecular complex. Flow cytometry analysis indicated that LBPF4-OL markedly upregulates TLR4/MD2 expression in both peritoneal macrophages and Raw264.7 cells. As its mechanism of action, LBPF4-OL increases the phosphorylation of p38-MAPK and inhibits the phosphorylation of JNK and ERK1/2, as was observed through Western blot analysis. These data suggest that the L. barbarum polysaccharide LBPF4-OL is a new Toll-like receptor 4/MD2-MAPK signaling pathway activator and inducer.
MeSH term(s)	Animals ; Cell Line ; Cell Proliferation/drug effects ; Drugs, Chinese Herbal/pharmacology ; Female ; Interleukin-1beta/metabolism ; Lymphocytes/cytology ; Lymphocytes/drug effects ; Macrophages, Peritoneal/drug effects ; Macrophages, Peritoneal/metabolism ; Membrane Glycoproteins/genetics ; Membrane Glycoproteins/metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C3H ; Mice, Knockout ; Mitogen-Activated Protein Kinases/metabolism ; Receptors, Cell Surface/genetics ; Receptors, Cell Surface/metabolism ; Signal Transduction/drug effects ; Spleen/cytology ; Tumor Necrosis Factor-alpha/metabolism
Chemical Substances	Drugs, Chinese Herbal ; Interleukin-1beta ; Membrane Glycoproteins ; Receptors, Cell Surface ; TLR4-MD2 protein complex, mouse ; Tumor Necrosis Factor-alpha ; lycium barbarum polysaccharide ; Mitogen-Activated Protein Kinases (EC 2.7.11.24)
Language	English
Publishing date	2014-03
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2014.01.010
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Article ; Online: Macrophages, rather than T and B cells are principal immunostimulatory target cells of Lycium barbarum L. polysaccharide LBPF4-OL.

Zhang, Xiao Rui / Zhou, Wen Xia / Zhang, Yong Xiang / Qi, Chun Hui / Yan, Huanga / Wang, Zhong Fu / Wang, Bo

Journal of ethnopharmacology

2011 Volume 136, Issue 3, Page(s) 465–472

Abstract: Aim of the study: Lycium barbarum L. is a renowned Yin strengthening agent in traditional Chinese medicine. Lycium barbarum L. polysaccharide-protein complex is well-known for its immunoregulatory and antitumor effects. LBPF4-OL is the glycan part of ... ...

Abstract	Aim of the study: Lycium barbarum L. is a renowned Yin strengthening agent in traditional Chinese medicine. Lycium barbarum L. polysaccharide-protein complex is well-known for its immunoregulatory and antitumor effects. LBPF4-OL is the glycan part of Lycium barbarum L. polysaccharide-protein complex fraction 4 (LBPF4). LBPF4-OL's active contribution in LBPF4 is still blank. In the study, we enrich the polysaccharide part of Lycium barbarum L. polysaccharide-protein complex, and investigate its immunostimulatory effects on mouse spleen cells, T cells, B cells and macrophages. Materials and methods: Balb/C mice were used in vitro and in vivo studies. In in vitro study, lymphocyte proliferations were analyzed with (3)H-TdR incorporation method. Miltenyi MicroBeads were used in the purification of lymphocytes. Activation of T and B cells was analyzed by flow cytometry. In order to obtain the peritoneal macrophages, mice were injected i.p. with 1mL of sodium thioglycollate 3 days prior to killing. Spleen cells were stimulated with LBPF4-OL and cytokine concentrations in the supernatants were determined by multiplex bead analysis. In in vivo study, mice were injected i.p. with 1 mL of normal saline or 100 μg/mL LBPF4-OL daily for 6 days. Peritoneal macrophage functions were analyzed by enzyme-linked immunosorbent assay and flow cytometry assay. Results: Spleen cells and lymphocyte proliferation assay indicated that LBPF4-OL markedly induced the spleen cell proliferation, but could not induce proliferation of purified T and B lymphocytes. Further research revealed that B cell proliferation took place in the presence of activated macrophages or LPS. Multiplex bead analysis showed that LBPF4-OL can obviously induce IL-6, IL-8, IL-10 and TNF-α production of the spleen cells in a concentration-dependent manner. Flow cytometric analysis showed that LBPF4-OL (i.p.) prompts CD86 and MHC-II molecules expression on macrophages. ELISA assay showed that LBPF4-OL can greatly strengthen macrophage releasing of TNF-α and IL-1β. Conclusion: These results suggested that glycan LBPF4-OL plays an important role in the immunopharmacological activity of Lycium barbarum L. polysaccharide-protein complex, and primary mouse macrophages, rather than T and B cells, are the principal target cells of it.
MeSH term(s)	Adjuvants, Immunologic/pharmacology ; Animals ; B-Lymphocytes/drug effects ; B7-2 Antigen/metabolism ; Cell Proliferation/drug effects ; Cytokines/metabolism ; Dose-Response Relationship, Drug ; Drugs, Chinese Herbal/pharmacology ; Female ; Fruit ; Lipopolysaccharides ; Lycium/chemistry ; Lymphocyte Activation/drug effects ; Macrophages/drug effects ; Macrophages/immunology ; Major Histocompatibility Complex/physiology ; Mice ; Mice, Inbred BALB C ; Polysaccharides/pharmacology ; Spleen/cytology ; Spleen/drug effects ; T-Lymphocytes/drug effects
Chemical Substances	Adjuvants, Immunologic ; B7-2 Antigen ; Cytokines ; Drugs, Chinese Herbal ; Lipopolysaccharides ; Polysaccharides ; lycium barbarum polysaccharide
Language	English
Publishing date	2011-07-14
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2011.04.054
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Article: Macrophages, rather than T and B cells are principal immunostimulatory target cells of Lycium barbarum L. polysaccharide LBPF4-OL

Zhang, Xiao Rui / Zhou, Wen Xia / Zhang, Yong Xiang / Qi, Chun Hui / Yan, Huanga / Wang, Zhong Fu / Wang, Bo

Journal of ethnopharmacology. 2011 July 14, v. 136, no. 3

2011

Abstract	Aim of the study: Lycium barbarum L. is a renowned Yin strengthening agent in traditional Chinese medicine. Lycium barbarum L. polysaccharide-protein complex is well-known for its immunoregulatory and antitumor effects. LBPF4-OL is the glycan part of Lycium barbarum L. polysaccharide-protein complex fraction 4 (LBPF4). LBPF4-OL's active contribution in LBPF4 is still blank. In the study, we enrich the polysaccharide part of Lycium barbarum L. polysaccharide-protein complex, and investigate its immunostimulatory effects on mouse spleen cells, T cells, B cells and macrophages. Materials and methods: Balb/C mice were used in vitro and in vivo studies. In in vitro study, lymphocyte proliferations were analyzed with ³H-TdR incorporation method. Miltenyi MicroBeads were used in the purification of lymphocytes. Activation of T and B cells was analyzed by flow cytometry. In order to obtain the peritoneal macrophages, mice were injected i.p. with 1mL of sodium thioglycollate 3 days prior to killing. Spleen cells were stimulated with LBPF4-OL and cytokine concentrations in the supernatants were determined by multiplex bead analysis. In in vivo study, mice were injected i.p. with 1mL of normal saline or 100μg/mL LBPF4-OL daily for 6 days. Peritoneal macrophage functions were analyzed by enzyme-linked immunosorbent assay and flow cytometry assay. Results: Spleen cells and lymphocyte proliferation assay indicated that LBPF4-OL markedly induced the spleen cell proliferation, but could not induce proliferation of purified T and B lymphocytes. Further research revealed that B cell proliferation took place in the presence of activated macrophages or LPS. Multiplex bead analysis showed that LBPF4-OL can obviously induce IL-6, IL-8, IL-10 and TNF-α production of the spleen cells in a concentration-dependent manner. Flow cytometric analysis showed that LBPF4-OL (i.p.) prompts CD86 and MHC-II molecules expression on macrophages. ELISA assay showed that LBPF4-OL can greatly strengthen macrophage releasing of TNF-α and IL-1β. Conclusion: These results suggested that glycan LBPF4-OL plays an important role in the immunopharmacological activity of Lycium barbarum L. polysaccharide-protein complex, and primary mouse macrophages, rather than T and B cells, are the principal target cells of it.
Keywords	Lycium barbarum ; T-lymphocytes ; cell proliferation ; enzyme-linked immunosorbent assay ; flow cytometry ; in vitro studies ; in vivo studies ; lymphocyte proliferation ; macrophages ; mice ; splenocytes ; traditional medicine
Language	English
Dates of publication	2011-0714
Size	p. 465-472.
Publishing place	Amsterdam; New York: Elsevier
Document type	Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2011.04.054
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