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  1. Article ; Online: Prospective observational studies to provide confidence in the protection conferred by newer generation, inactivated oral cholera vaccines: a proposal.

    Clemens, John / Deen, Jacqueline / Qadri, Firdausi

    EClinicalMedicine

    2023  Volume 67, Page(s) 102389

    Abstract: Inactivated oral cholera vaccines (OCVs) are a cornerstone of international efforts to control cholera, and are currently deployed from a global stockpile for the control of epidemics and endemic hotspots, as well as for humanitarian emergencies. One ... ...

    Abstract Inactivated oral cholera vaccines (OCVs) are a cornerstone of international efforts to control cholera, and are currently deployed from a global stockpile for the control of epidemics and endemic hotspots, as well as for humanitarian emergencies. One inactivated OCV (with tradenames Shanchol™ and Euvichol-Plus™) is used in the stockpile, but the number of available doses is inadequate to meet the rapidly rising demand for OCVs from countries affected by cholera. Newer, simplified inactivated OCVs under development offer the possibilities of lower expense and higher production yields, and could expand the stockpile. However, their clinical development is made complex because placebo-controlled randomised trials of OCV efficacy are no longer ethically permissible and because the serum vibriocidal antibodies used to measure OCV responses are not correlates of OCV protection against cholera. Here, we propose an observational study design with features to enhance methodological rigor to provide credible evidence of protection against cholera by these newer vaccines.
    Language English
    Publishing date 2023-12-22
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2589-5370
    ISSN (online) 2589-5370
    DOI 10.1016/j.eclinm.2023.102389
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  2. Article ; Online: Cholera: resurgence of fatal yet preventable disease.

    Bhuiyan, Taufiqur Rahman / Qadri, Firdausi / Chowdhury, Fahima

    BMJ (Clinical research ed.)

    2023  Volume 382, Page(s) 1831

    MeSH term(s) Humans ; Cholera/epidemiology ; Cholera/prevention & control ; Disease Outbreaks/prevention & control
    Language English
    Publishing date 2023-08-14
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.p1831
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  3. Article ; Online: Use of the typhoid conjugate vaccine in endemic settings.

    Khanam, Farhana / Qadri, Firdausi

    The Lancet. Global health

    2021  Volume 9, Issue 8, Page(s) e1047–e1048

    MeSH term(s) Humans ; Typhoid Fever/epidemiology ; Typhoid Fever/prevention & control ; Typhoid-Paratyphoid Vaccines ; Vaccination ; Vaccines, Conjugate
    Chemical Substances Typhoid-Paratyphoid Vaccines ; Vaccines, Conjugate
    Language English
    Publishing date 2021-07-22
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2723488-5
    ISSN 2214-109X ; 2214-109X
    ISSN (online) 2214-109X
    ISSN 2214-109X
    DOI 10.1016/S2214-109X(21)00308-9
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  4. Article ; Online: Adapting existing tools to control and eliminate protracted epidemics and pandemics.

    Bwire, Godfrey / Chowdhury, Fahima / Khan, Ashraful Islam / Wamala, Joseph Francis / Orach, Christopher Garimoi / Qadri, Firdausi

    The Lancet. Global health

    2024  Volume 12, Issue 5, Page(s) e725–e726

    MeSH term(s) Humans ; Pandemics/prevention & control
    Language English
    Publishing date 2024-04-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2723488-5
    ISSN 2214-109X ; 2214-109X
    ISSN (online) 2214-109X
    ISSN 2214-109X
    DOI 10.1016/S2214-109X(24)00096-2
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  5. Article ; Online: Life-Course Approach to Vaccination in Bangladesh for Meeting the Health and Health-Related Sustainable Development Goals: A Commentary.

    Bhuiyan, Taufiqur Rahman / Islam, Taufiqul / Qadri, Firdausi

    The Journal of infectious diseases

    2021  Volume 224, Issue 12 Suppl 2, Page(s) S749–S753

    Abstract: Bangladesh is entering from low-income to lower-middle-income status in 2020, and this will be completed in the next 5 years. With gross national income growing, vaccines will need to be procured through private market for the Expanded Program on ... ...

    Abstract Bangladesh is entering from low-income to lower-middle-income status in 2020, and this will be completed in the next 5 years. With gross national income growing, vaccines will need to be procured through private market for the Expanded Program on Immunization. A cost-benefit analysis is needed to evaluate vaccine demand in different socioeconomic groups in the country, to inform this procurement. Moreover, disease burden studies and awareness of importance of specific vaccines are needed as we move forward. A life-course approach to vaccination may enable whole society to realize the full potential of vaccination and address most significant threats to its success over time.
    MeSH term(s) Bangladesh ; Cholera/prevention & control ; Cholera Vaccines/administration & dosage ; Communicable Diseases, Emerging/prevention & control ; Humans ; Immunization Programs ; Sustainable Development ; Vaccination
    Chemical Substances Cholera Vaccines
    Language English
    Publishing date 2021-09-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiab455
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  6. Article ; Online: Emerging Infectious Diseases - Learning from the Past and Looking to the Future.

    Elias, Christopher / Nkengasong, John N / Qadri, Firdausi

    The New England journal of medicine

    2021  Volume 384, Issue 13, Page(s) 1181–1184

    MeSH term(s) COVID-19 ; Communicable Disease Control/history ; Communicable Disease Control/organization & administration ; Communicable Diseases, Emerging/epidemiology ; Communicable Diseases, Emerging/history ; Communicable Diseases, Emerging/prevention & control ; Global Health ; Health Planning/organization & administration ; Hemorrhagic Fever, Ebola/history ; Hemorrhagic Fever, Ebola/prevention & control ; History, 20th Century ; History, 21st Century ; Humans ; Information Dissemination
    Language English
    Publishing date 2021-03-27
    Publishing country United States
    Document type Historical Article ; Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMp2034517
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  7. Article ; Online: Vaccine value profile for Salmonella enterica serovar Paratyphi A.

    Martin, Laura B / Khanam, Farhana / Qadri, Firdausi / Khalil, Ibrahim / Sikorski, Michael J / Baker, Stephen

    Vaccine

    2023  Volume 41 Suppl 2, Page(s) S114–S133

    Abstract: In Asia, there are an estimated 12 million annual cases of enteric fever, a potentially fatal systemic bacterial infection caused by Salmonella enterica serovars Typhi (STy) and Paratyphi A (SPA). The recent availability of typhoid conjugate vaccines ( ... ...

    Abstract In Asia, there are an estimated 12 million annual cases of enteric fever, a potentially fatal systemic bacterial infection caused by Salmonella enterica serovars Typhi (STy) and Paratyphi A (SPA). The recent availability of typhoid conjugate vaccines (TCV), an increasing incidence of disease caused by SPA and growing antimicrobial resistance (AMR) across the genus Salmonella makes a bivalent STy/SPA vaccine a useful public health proposition. The uptake of a stand-alone paratyphoid vaccine is likely low thus, there is a pipeline of bivalent STy/SPA candidate vaccines. Several candidates are close to entering clinical trials, which if successful should facilitate a more comprehensive approach for enteric fever control. Additionally, the World Health Organization (WHO) has made advancing the development of vaccines that protect young children and working aged adults against both agents of enteric fever a priority objective. This "Vaccine Value Profile" (VVP) addresses information related predominantly to invasive disease caused by SPA prevalent in Asia. Information is included on stand-alone SPA candidate vaccines and candidate vaccines targeting SPA combined with STy. Out of scope for the first version of this VVP is a wider discussion on the development of a universal Salmonella combination candidate vaccine, addressing both enteric fever and invasive non-typhoidal Salmonella disease, for use globally. This VVP is a detailed, high-level assessment of existing, publicly available information to inform and contextualize the public health, economic, and societal potential of pipeline vaccines and vaccine-like products for SPA. Future versions of this VVP will be updated to reflect ongoing activities such as vaccine development strategies and "Full Vaccine Value Assessment" that will inform the value proposition of an SPA vaccine. This VVP was developed by an expert working group from academia, non-profit organizations, public-private partnerships, and multi-lateral organizations as well as in collaboration with stakeholders from the WHO South-East Asian Region. All contributors have extensive expertise on various elements of the VVP for SPA and collectively aimed to identify current research and knowledge gaps.
    MeSH term(s) Adult ; Child ; Humans ; Child, Preschool ; Middle Aged ; Typhoid Fever ; Salmonella paratyphi A ; Paratyphoid Fever/prevention & control ; Paratyphoid Fever/epidemiology ; Paratyphoid Fever/microbiology ; Salmonella typhi ; Typhoid-Paratyphoid Vaccines ; Salmonella Vaccines
    Chemical Substances Typhoid-Paratyphoid Vaccines ; Salmonella Vaccines
    Language English
    Publishing date 2023-10-06
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2023.01.054
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  8. Article ; Online: Outbreak of diarrheal diseases causes mortality in different geographical locations of Bangladesh during the 2021 COVID-19 era.

    Khan, Ashraful Islam / Islam, Md Taufiqul / Amin, Mohammad Ashraful / Khan, Zahid Hasan / Qadri, Firdausi

    Frontiers in public health

    2023  Volume 11, Page(s) 1103518

    Abstract: Objectives: Diarrhea is a major public health problem in low- and middle-income countries, including Bangladesh. Of the different spectrums of diarrheal diseases, cholera occurs every year, causing outbreaks and epidemics following a biannual seasonal ... ...

    Abstract Objectives: Diarrhea is a major public health problem in low- and middle-income countries, including Bangladesh. Of the different spectrums of diarrheal diseases, cholera occurs every year, causing outbreaks and epidemics following a biannual seasonal pattern. Due to the COVID-19 pandemic, hospitalization for diarrheal diseases decreased in 2020 compared to the previous years. However, in 2021, massive outbreaks occurred in different geographical locations of the country. We described that an outbreak of diarrheal diseases causes mortality in different geographical locations in Bangladesh.
    Method: In this study, we present a report of diarrhea outbreaks that were reported in 2018-2021 in different parts of Bangladesh, and data have been captured from different sources such as print and electronic media as well as from a nationwide surveillance system.
    Results: Among these locations, districts of Barisal Division, Kishorganj, Noakhali, Gopalganj, Bandarban, and Chattogram were the major hotspots of the outbreaks where high morbidity due to acute watery diarrhea and even mortality, which is usually low in Bangladesh, were recorded.
    Conclusion: Early detection and prevention and strengthening of the surveillance system are needed to combat the diarrheal upsurge, take immediate control, and adopt preventive strategies.
    MeSH term(s) Humans ; Bangladesh/epidemiology ; Pandemics ; COVID-19/epidemiology ; Diarrhea/epidemiology ; Disease Outbreaks
    Language English
    Publishing date 2023-01-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2023.1103518
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  9. Article ; Online: The future of the global clinical trial ecosystem: a vision from the first WHO Global Clinical Trials Forum.

    Moorthy, Vasee / Abubakar, Ibrahim / Qadri, Firdausi / Ogutu, Bernhards / Zhang, Wei / Reeder, John / Farrar, Jeremy

    Lancet (London, England)

    2023  Volume 403, Issue 10422, Page(s) 124–126

    MeSH term(s) Humans ; World Health Organization ; Clinical Trials as Topic
    Language English
    Publishing date 2023-12-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(23)02798-8
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  10. Article: Typhoid Control in an Era of Antimicrobial Resistance: Challenges and Opportunities.

    Vanderslott, Samantha / Kumar, Supriya / Adu-Sarkodie, Yaw / Qadri, Firdausi / Zellweger, Raphaël M

    Open forum infectious diseases

    2023  Volume 10, Issue Suppl 1, Page(s) S47–S52

    Abstract: Historically, typhoid control has been achieved with water and sanitation interventions. Today, in an era of rising antimicrobial resistance (AMR), two World Health Organization-prequalified vaccines are available to accelerate control in the shorter ... ...

    Abstract Historically, typhoid control has been achieved with water and sanitation interventions. Today, in an era of rising antimicrobial resistance (AMR), two World Health Organization-prequalified vaccines are available to accelerate control in the shorter term. Meanwhile, water and sanitation interventions could be implemented in the longer term to sustainably prevent typhoid in low- and middle-income countries. This article first approaches typhoid control from a historical perspective, subsequently presents how vaccination could complement water and sanitation activities, and finally discusses the challenges and opportunities for impactful control of typhoid infection. It also addresses data blind spots and knowledge gaps to focus on for typhoid control and to ultimately progress towards elimination. This article presents a synthesis of discussions held in December 2021 during a roundtable session at the "12th International Conference on Typhoid and Other Invasive Salmonelloses".
    Language English
    Publishing date 2023-06-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofad135
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