Article ; Online: Comparison Of Two Definitions (P-Rifle And Kdigo) For Prevalence Of Acute Kidney Injury And In Hospital Mortality In A Paediatric Intensive Care Unit Of Pakistan.
Journal of Ayub Medical College, Abbottabad : JAMC
2022 Volume 34, Issue 1, Page(s) 112–117
Abstract: Background: To compare the Paediatric RIFLE (p-RIFLE) and Kidney Disease Improving Global Outcomes (KDIGO) definitions of acute kidney injury (AKI) for frequency of (AKI) and in-hospital mortality in critically ill children.: Methods: Retrospective ... ...
| Abstract | Background: To compare the Paediatric RIFLE (p-RIFLE) and Kidney Disease Improving Global Outcomes (KDIGO) definitions of acute kidney injury (AKI) for frequency of (AKI) and in-hospital mortality in critically ill children. Methods: Retrospective review of medical records of all patients (aged 1 month - 16 years) admitted in Paediatric Intensive Care Unit from January 2015-December 2016, with length of stay >48 hours, was done. Patients with chronic kidney disease were excluded. Receiver operating characteristic (ROC) curves were used to evaluate the performance of the p-RIFLE and KDIGO criteria to predict the AKI related mortality. Logistic regression analysis was done to determine the association of different variables with mortality in AKI patient based on p-RIFLE, KDIGO. A p-value of <0.05 was considered significant. Results: Out of total 823 patients admitted during the study period, 562 patients were included in the study. Median age was 2 years (Interquartile range 8 years). Acute kidney injury frequency according to p-RIFLE and KDIGO were 391 (70%), and 372 (66%) respectively. Overall, 106/823 (12.8%) children died during study period, 78 (19.9%) in AKI by p-RIFLE and 76 (20.4%) in AKI by KDIGO died. The area-under- curve for in-hospital mortality for p-RIFLE and KDIGO criteria were 0.525 (p=0.427), and 0.534 (p=0.276), respectively. Conclusions: P-RIFLE is more sensitive compared to KDIGO in diagnosing AKI in critically ill children; identifying a greater number of moderate staged AKI cases. Greater AKI severity is associated with higher mortality in critically ill children. |
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| MeSH term(s) | Acute Kidney Injury/diagnosis ; Acute Kidney Injury/epidemiology ; Child ; Critical Illness ; Female ; Hospital Mortality ; Humans ; Intensive Care Units ; Intensive Care Units, Pediatric ; Male ; Pakistan/epidemiology ; Prevalence ; Retrospective Studies | |||||
| Language | English | |||||
| Publishing date | 2022-04-07 | |||||
| Publishing country | Pakistan | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 2192473-9 | |||||
| ISSN | 1819-2718 ; 1025-9589 | |||||
| ISSN (online) | 1819-2718 | |||||
| ISSN | 1025-9589 | |||||
| DOI | 10.55519/JAMC-01-9147 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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