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  1. Article: Improved method for stress detection using bio-sensor technology and machine learning algorithms.

    Nazeer, Mohd / Salagrama, Shailaja / Kumar, Pardeep / Sharma, Kanhaiya / Parashar, Deepak / Qayyum, Mohammed / Patil, Gouri

    MethodsX

    2024  Volume 12, Page(s) 102581

    Abstract: Maintaining an optimal stress level is vital in our lives, yet many individuals struggle to identify the sources of their stress. As emotional stability and mental awareness become increasingly important, wearable medical technology has gained popularity ...

    Abstract Maintaining an optimal stress level is vital in our lives, yet many individuals struggle to identify the sources of their stress. As emotional stability and mental awareness become increasingly important, wearable medical technology has gained popularity in recent years. This technology enables real-time monitoring, providing medical professionals with crucial physiological data to enhance patient care. Current stress-detection methods, such as ECG, BVP, and body movement analysis, are limited by their rigidity and susceptibility to noise interference. To overcome these limitations, we introduce STRESS-CARE, a versatile stress detection sensor employing a hybrid approach. This innovative system utilizes a sweat sensor, cutting-edge context identification methods, and machine learning algorithms. STRESS-CARE processes sensor data and models environmental fluctuations using an XG Boost classifier. By combining these advanced techniques, we aim to revolutionize stress detection, offering a more adaptive and robust solution for improved stress management and overall well-being.•In the proposed method, we introduce a state-of-the-art stress detection device with Galvanic Skin Response (GSR) sweat sensors, outperforming traditional Electrocardiogram (ECG) methods while remaining non-invasive•Integrating machine learning, particularly XG-Boost algorithms, enhances detection accuracy and reliability.•This study sheds light on noise context comprehension for various wearable devices, offering crucial guidance for optimizing stress detection in multiple contexts and applications.
    Language English
    Publishing date 2024-01-23
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2830212-6
    ISSN 2215-0161
    ISSN 2215-0161
    DOI 10.1016/j.mex.2024.102581
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Mesenchymal stem cell injection induces cardiac nerve sprouting and increased tenascin expression in a Swine model of myocardial infarction.

    Pak, Hui-Nam / Qayyum, Mohammed / Kim, Dave T / Hamabe, Akira / Miyauchi, Yasushi / Lill, Michael C / Frantzen, Malkar / Takizawa, Kaname / Chen, Lan S / Fishbein, Michael C / Sharifi, Behrooz G / Chen, Peng-Sheng / Makkar, Raj

    Journal of cardiovascular electrophysiology

    2003  Volume 14, Issue 8, Page(s) 841–848

    Abstract: Unlabelled: Stem Cell Induces Cardiac Nerve Sprouting.: Introduction: Mesenchymal stem cell (MSC) transplantation is a promising technique to improve cardiac function. Whether MSC can increase cardiac nerve density and contribute to the improved ... ...

    Abstract Unlabelled: Stem Cell Induces Cardiac Nerve Sprouting.
    Introduction: Mesenchymal stem cell (MSC) transplantation is a promising technique to improve cardiac function. Whether MSC can increase cardiac nerve density and contribute to the improved cardiac function is unclear.
    Methods and results: Anterior wall myocardial infarction was created in 16 swine. One month later, 6 swine were given MSC and fresh bone marrow (BM) into infarcted myocardium (MSC group). Four swine were given fresh BM only (BM group), and 6 swine were given culture media (MI-only group). The swine were sacrificed 95.8 +/- 3.5 days after MI. Six normal swine were used as control. Immunocytochemical staining was performed using antibodies against growth-associated protein 43 (GAP43), tyrosine hydroxylase (TH), and three subtypes of tenascin (R, C, and X). Five fields per slide were counted for nerve density. The results show the following. (1). There were more GAP43-positive nerves in the MSC group than in the BM, MI-only, or Control group (P < 0.0001). TH staining showed higher nerve densities in the MSC group than in the MI-only (P < 0.01) or Control group (P < 0.0001) in the atria. (2). There were more sympathetic (TH-positive) nerves in myocardium distant from infarct than in the peri-infarct area (P < 0.05). (3). Optical intensity and color analyses showed significantly higher tenascin R and tenascin C expression in the MSC and BM groups than in the MI-only or Control group (P < 0.01).
    Conclusion: MSC injected with BM into swine infarct results in overexpression of cardiac tenascin, increased the magnitude of cardiac nerve sprouting in both atria and ventricles, and increased the magnitude of atrial sympathetic hyperinnervation 2 months after injection.
    MeSH term(s) Animals ; Cardiac Surgical Procedures/methods ; Heart/growth & development ; Heart/innervation ; Heart Atria/innervation ; Heart Atria/metabolism ; Heart Atria/pathology ; Heart Atria/surgery ; Heart Ventricles/innervation ; Heart Ventricles/metabolism ; Heart Ventricles/pathology ; Mesenchymal Stem Cell Transplantation/methods ; Models, Animal ; Myocardial Infarction/metabolism ; Myocardial Infarction/pathology ; Myocardial Infarction/surgery ; Myocardium/metabolism ; Myocardium/pathology ; Nerve Regeneration ; Swine ; Sympathetic Nervous System/growth & development ; Sympathetic Nervous System/pathology ; Tenascin/metabolism
    Chemical Substances Tenascin
    Language English
    Publishing date 2003-08
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1025989-2
    ISSN 1540-8167 ; 1045-3873
    ISSN (online) 1540-8167
    ISSN 1045-3873
    DOI 10.1046/j.1540-8167.2003.03124.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Effect of Heart Failure and Physical Training on the Acute Ventilatory Response to Hypoxia at Rest and during Exercise

    Barlow, Clifford W. / Qayyum, Mohammed S. / Davey, Patrick P. / Paterson, David J. / Robbins, Peter A.

    Respiration - International Journal of Thoracic Medicine

    1997  Volume 64, Issue 2, Page(s) 131–137

    Abstract: We studied the acute ventilatory response to hypoxia (AHVR) in 10 patients with chronic heart failure (CHF) and in 10 subjects with normal left ventricular function (NLVF) before and after 8 weeks of home-based physical training. Subjects were studied at ...

    Abstract We studied the acute ventilatory response to hypoxia (AHVR) in 10 patients with chronic heart failure (CHF) and in 10 subjects with normal left ventricular function (NLVF) before and after 8 weeks of home-based physical training. Subjects were studied at rest and during constant cycle exercise at a work rate equivalent to 40% of their maximum oxygen consumption. The AHVR was not significantly different between the patients with CHF and those with NLVF either at rest (1.32 ± 0.19 vs. 1.63 ± 0.20 litres/min/% arterial desaturation; mean ± SE) or during constant light exercise (2.37 ± 0.48 vs. 2.86 ± 0.55 litres/min/% arterial desaturation). Both groups showed evidence of improved physical fitness after training with increases in maximum oxygen consumption of 11 ± 2.7% (p < 0.01) for the group with NLVF and of 8 ± 3.2% (p < 0.05) for the group with CHF. Values for the AHVR in the trained state were not significantly different between the patients with CHF and those with NLVF either at rest (1.23 ± 0.24 vs. 1.63 ± 0.22 litres/min/% arterial desaturation) or during constant light exercise (2.52 ± 0.69 vs. 2.24 ± 0.37 litres/min/% arterial desaturation). Moreover, these responses did not differ from those in the untrained state (see above). The AHVR increased during exercise compared with rest in both groups (p < 0.05). The AHVR is not substantially altered in patients with CHF compared to subjects with NLVF. Physical training may reduce ventilation during exercise, but it has relatively little or no effect on the AHVR. However, exercise increases the AHVR in patients with CHF, as it does in normals.
    Keywords Hypoxia ; Hypoxic sensitivity ; Ventilation ; Exercise ; Exercise therapy ; Heart failure
    Language English
    Publisher S. Karger AG
    Publishing place Basel
    Publishing country Switzerland
    Document type Article ; Online
    ZDB-ID 206674-9
    ISSN 1423-0356 ; 0025-7931 ; 0025-7931
    ISSN (online) 1423-0356
    ISSN 0025-7931
    DOI 10.1159/000196657
    Database Karger publisher's database

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  4. Article: Intramyocardial injection of allogenic bone marrow-derived mesenchymal stem cells without immunosuppression preserves cardiac function in a porcine model of myocardial infarction.

    Makkar, Raj R / Price, Matthew J / Lill, Michael / Frantzen, Malka / Takizawa, Kaname / Kleisli, Thomas / Zheng, Jie / Kar, Saibal / McClelan, Robert / Miyamota, Takeshi / Bick-Forrester, Justin / Fishbein, Michael C / Shah, Prediman K / Forrester, James S / Sharifi, Behrooz / Chen, Peng-Sheng / Qayyum, Mohammed

    Journal of cardiovascular pharmacology and therapeutics

    2005  Volume 10, Issue 4, Page(s) 225–233

    Abstract: Background: We investigated the efficacy of directly injected allogenic bone marrow-derived mesenchymal stem cells in improving left ventricular function in a porcine model of myocardial infarction.: Methods: Left ventricular infarction was created ... ...

    Abstract Background: We investigated the efficacy of directly injected allogenic bone marrow-derived mesenchymal stem cells in improving left ventricular function in a porcine model of myocardial infarction.
    Methods: Left ventricular infarction was created in 16 adult Yorkshire pigs by coil embolization and thrombotic occlusion distal to the second diagonal artery. One month after myocardial infarction was induced, the animals were randomized to either direct injection of allogenic mesenchymal stem cells or sham treatment (culture medium). Allogenic bromodeoxyuridine-labeled mesenchymal stem cells (2 +/- 0.1 x 10(8)) were directly injected into the infarct and peri-infarct areas during an open chest procedure. No immunosuppressive therapy was used. The left ventricular function was measured using serial biplane left ventricular angiography at baseline, 30, 60, and 90 days before sacrifice. Mesenchymal stem cells were localized using bromodeoxyuridine, and differentiation of mesenchymal stem cells was assessed by confocal microscopic colocalization of bromodeoxyuridine with immunofluorescent antibodies specific for cardiomyocytes (troponin I and MF-20) and endothelial cells (von Willebrand factor).
    Results: Mesenchymal stem cells labeled with bromodeoxyuridine engrafted the peri-infarct zone and colocalized with both cardiomyocyte-specific and endothelial cell-specific immunofluorescence. No intramyocardial bromodeoxyuridine was observed in sham-treated animals. At the time of the mesenchymal stem cell injection 30 days after myocardial infarction, the left ventricular ejection fraction (LVEF) was 58% +/- 3% in mesenchymal stem cell-treated pigs and 56% +/- 2% in sham-treated pigs (P = NS). LVEF deteriorated progressively thereafter in untreated pigs (8.5% and 10.5% decline at 60 days and 90 days after myocardial infarction, respectively), but was preserved in mesenchymal stem cell-treated pigs (2.1% increase and -2.0% decline at 60 and 90 days post-MI respectively) (P < .05).
    Conclusions: Direct intramyocardial injection of mesenchymal stem cells results in successful intramyocardial engraftment and differentiation into cardiomyocytes and endothelial cells and preserves left ventricular function after myocardial infarction in pigs.
    MeSH term(s) Animals ; Antigens, Differentiation ; Cell Differentiation ; Disease Models, Animal ; Endothelial Cells ; Immunohistochemistry ; Mesenchymal Stem Cell Transplantation ; Mesenchymal Stromal Cells/cytology ; Myocardial Infarction/physiopathology ; Myocardial Infarction/therapy ; Myocytes, Cardiac ; Stroke Volume ; Swine ; Time Factors ; Transplantation, Homologous ; Ventricular Dysfunction, Left/physiopathology ; Ventricular Dysfunction, Left/therapy
    Chemical Substances Antigens, Differentiation
    Language English
    Publishing date 2005-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1329372-2
    ISSN 1074-2484
    ISSN 1074-2484
    DOI 10.1177/107424840501000403
    Database MEDical Literature Analysis and Retrieval System OnLINE

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