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  1. Book ; Online: Chapter Introduction : Cooperative development among the South China Sea coastal States

    Qi, Huaigao / Xue, Song

    2020  

    Keywords Politics & government ; International relations ; international cooperation ; South China Sea
    Size 1 electronic resource (17 pages)
    Publisher Taylor and Francis
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021028047
    ISBN 9780367529680 ; 0367529688
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Desmosterol-driven atypical macrophage polarization regulates podocyte dynamics in diabetic nephropathy.

    Qi, Huiying

    Molecular biology reports

    2024  Volume 51, Issue 1, Page(s) 213

    Abstract: Background: Diabetic nephropathy (DN) stands as a leading diabetes complication, with macrophages intricately involved in its evolution. While glucose metabolism's impact on macrophage activity is well-established, cholesterol metabolism's contributions ...

    Abstract Background: Diabetic nephropathy (DN) stands as a leading diabetes complication, with macrophages intricately involved in its evolution. While glucose metabolism's impact on macrophage activity is well-established, cholesterol metabolism's contributions remain less explored. Our study seeks to elucidate this association.
    Methods and results: Methods and Results: Gene expression analysis of monocytes from the blood of both normal and diabetic patients was conducted using public databases, showing that cholesterol metabolism pathways, especially Bloch and Kandutsch-Russell, were more altered in diabetic monocytes/macrophages than glucose-responsive pathways. When bone marrow-derived macrophages (BMDMs) were subjected to desmosterol, they exhibited an unconventional polarization. These BMDMs displayed heightened levels of both M1-related pro-inflammatory cytokines and M2-linked anti-inflammatory factors. Further, in co-culture, desmosterol-conditioned BMDMs paralleled M2 macrophages in augmenting Ki-67 + podocyte populations while mimicking M1 macrophages in elevating TUNEL + apoptotic podocytes. Comparable outcomes on podocytes were obtained using conditioned media from the respective BMDMs.
    Conclusions: Our data underscores the pivotal role of cholesterol metabolism, particularly via desmosterol, in steering macrophages toward an unconventional polarization marked by both inflammatory and regulatory traits. Such unique macrophage behavior concurrently impacts podocyte proliferation and apoptosis, shedding fresh light on DN pathogenesis and hinting at potential therapeutic interventions.
    MeSH term(s) Humans ; Diabetic Nephropathies/metabolism ; Podocytes/metabolism ; Desmosterol/metabolism ; Macrophages/metabolism ; Glucose/metabolism ; Diabetes Mellitus/metabolism
    Chemical Substances Desmosterol (313-04-2) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2024-01-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-023-09198-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1140: Show issues Location:
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  3. Book ; Online: Cooperative Development in the South China Sea: : Policies, Obstacles, and Prospects

    Qi, Huaigao / Xue, Song

    2020  

    Keywords Politics & government ; International relations ; international cooperation ; South China Sea
    Size 1 Online-Ressource
    Publisher Taylor and Francis
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021026922
    ISBN 9780367529680 ; 0367529688
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Role and research progress of hematological markers in laryngeal squamous cell carcinoma.

    Qi, Hui

    Diagnostic pathology

    2023  Volume 18, Issue 1, Page(s) 50

    Abstract: Laryngeal cancer is one of the most common malignant tumors of the head and neck, accounting for about 20%. Due to its high disability rate, the diagnosis and treatment of laryngeal cancer have always been the focus and difficulty of head and neck ... ...

    Abstract Laryngeal cancer is one of the most common malignant tumors of the head and neck, accounting for about 20%. Due to its high disability rate, the diagnosis and treatment of laryngeal cancer have always been the focus and difficulty of head and neck surgery. The outcome of cancer is affected not only by tumor-related factors but also by host-related factors, especially systemic inflammation, this is usually reflected by a variety of hematological markers. Studies have confirmed that there is a significant correlation between hematological markers and the occurrence, development, and prognosis of laryngeal squamous cell carcinoma (LSCC), and has a certain value in auxiliary diagnosis and prognosis prediction of LSCC. We reviewed various hematological markers related to LSCC aim to summarize the role and research progress of hematological markers in LSCC.
    MeSH term(s) Humans ; Squamous Cell Carcinoma of Head and Neck ; Laryngeal Neoplasms/diagnosis ; Laryngeal Neoplasms/pathology ; Head and Neck Neoplasms ; Carcinoma, Squamous Cell/diagnosis ; Carcinoma, Squamous Cell/pathology ; Prognosis
    Language English
    Publishing date 2023-04-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2210518-9
    ISSN 1746-1596 ; 1746-1596
    ISSN (online) 1746-1596
    ISSN 1746-1596
    DOI 10.1186/s13000-023-01335-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Neuroimmunology: reviews and perspectives on recent advances.

    Qi, Hai

    Cellular & molecular immunology

    2023  Volume 20, Issue 11, Page(s) 1257–1258

    MeSH term(s) Neuroimmunomodulation
    Language English
    Publishing date 2023-10-24
    Publishing country China
    Document type Editorial
    ZDB-ID 2435097-7
    ISSN 2042-0226 ; 1672-7681
    ISSN (online) 2042-0226
    ISSN 1672-7681
    DOI 10.1038/s41423-023-01092-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6681: Show issues Location:
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  6. Article ; Online: New twists in humoral immune regulation by SLAM family receptors.

    Qi, Hai

    The Journal of experimental medicine

    2021  Volume 218, Issue 3

    Abstract: SLAM family receptors are involved in humoral immune regulation. In this issue of JEM, Zhong et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20200756) provide evidence that these receptors collectively suppress germinal center reaction but promote ... ...

    Abstract SLAM family receptors are involved in humoral immune regulation. In this issue of JEM, Zhong et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20200756) provide evidence that these receptors collectively suppress germinal center reaction but promote production of antigen-specific antibodies.
    MeSH term(s) Germinal Center ; Signaling Lymphocytic Activation Molecule Family
    Chemical Substances Signaling Lymphocytic Activation Molecule Family
    Language English
    Publishing date 2021-01-14
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20202300
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The EMICS Tool to Design Mixed-methods Studies in Epidemiology.

    Houghton, Lauren C / Qi, Hanfei

    Epidemiology (Cambridge, Mass.)

    2024  Volume 35, Issue 3, Page(s) e10–e12

    MeSH term(s) Humans ; Research Design ; Epidemiology
    Language English
    Publishing date 2024-01-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1053263-8
    ISSN 1531-5487 ; 1044-3983
    ISSN (online) 1531-5487
    ISSN 1044-3983
    DOI 10.1097/EDE.0000000000001718
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3121: Show issues Location:
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  8. Article ; Online: Marking true T

    Qi, Hai

    Nature reviews. Immunology

    2020  Volume 20, Issue 3, Page(s) 139

    Language English
    Publishing date 2020-01-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/s41577-020-0273-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5565: Show issues Location:
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  9. Article ; Online: MRI radiomics predicts the efficacy of EGFR-TKI in EGFR-mutant non-small-cell lung cancer with brain metastasis.

    Qi, H / Hou, Y / Zheng, Z / Zheng, M / Sun, X / Xing, L

    Clinical radiology

    2024  

    Abstract: Aim: To develop and validate models based on magnetic resonance imaging (MRI) radiomics for predicting the efficacy of epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) in EGFR-mutant non-small-cell lung cancer (NSCLC) patients with ... ...

    Abstract Aim: To develop and validate models based on magnetic resonance imaging (MRI) radiomics for predicting the efficacy of epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) in EGFR-mutant non-small-cell lung cancer (NSCLC) patients with brain metastases.
    Materials and methods: 117 EGFR-mutant NSCLC patients with brain metastases who received EGFR-TKI treatment were included in this study from January 1, 2014 to December 31, 2021. Patients were randomly divided into training and validation cohorts in a ratio of 2:1. Radiomics features extracted from brain MRI were screened by least absolute shrinkage and selection operator (LASSO) algorithm. Logistic regression analysis and Cox proportional hazard regression analysis were used to screen clinical risk factors. Clinical (C), radiomics (R), and combined (C + R) nomograms were constructed in models predicting short-term efficacy and intracranial progression-free survival (iPFS), respectively. Calibration curves, Harrell's concordance index (C-index), and decision curve analysis (DCA) were used to evaluate the performance of models.
    Results: Overall response rate (ORR) was 57.3% and median iPFS was 12.67 months. The C + R nomograms were more effective. In the short-term efficacy model, the C-indexes of C + R nomograms in training cohort and validation cohort were 0.860 (0.820-0.901, 95%CI) and 0.843 (0.783-0.904, 95%CI). In iPFS model, the C-indexes of C + R nomograms in training cohort and validation cohort were 0.837 (0.751-0.923, 95%CI) and 0.850 (0.763-0.937, 95%CI).
    Conclusion: The C + R nomograms were more effective in predicting EGFR-TKI efficacy of EGFR-mutant NSCLC patients with brain metastases than single clinical or radiomics nomograms.
    Language English
    Publishing date 2024-03-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 391227-9
    ISSN 1365-229X ; 0009-9260
    ISSN (online) 1365-229X
    ISSN 0009-9260
    DOI 10.1016/j.crad.2024.02.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ue I Zs.201: Show issues Location:
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  10. Article: A comparison between the therapeutic effects of Conbercept combined with panretinal photocoagulation and panretinal photocoagulation monotherapy for high-risk proliferative diabetic retinopathy.

    Sun, Yaoyao / Qi, Huijun

    Frontiers in endocrinology

    2023  Volume 13, Page(s) 1038757

    Abstract: Objective: To compare the therapeutic effects of the administration of intravitreal Conbercept (IVC) plus panretinal photocoagulation (PRP) to that of PRP monotherapy in patients with high-risk proliferative diabetic retinopathy (PDR).: Methods: In ... ...

    Abstract Objective: To compare the therapeutic effects of the administration of intravitreal Conbercept (IVC) plus panretinal photocoagulation (PRP) to that of PRP monotherapy in patients with high-risk proliferative diabetic retinopathy (PDR).
    Methods: In this retrospective consecutive case series, we analyzed the data on high-risk PDR patients followed up for 12 months. Patients were divided into two groups: the IVC+PRP group and the PRP monotherapy group. Patients in the IVC+PRP group were initially administered 3 IVC injections and PRP, while patients in the PRP monotherapy group received PRP only. Depending on the grouping criteria, patients in both groups were administered either IVC+PRP or PRP only if the neovascularization (NV) did not regress. From the initiation to month 12 of treatment, we recorded and compared the data on the NV regression rate, improvement in best-corrected visual acuity (BCVA), laser spots, changes in central macular thickness (CMT), complications, and the need for vitrectomy for all patients.
    Results: In this study, 79 eyes of 58 patients in the IVC+PRP group and 86 eyes of 60 patients in the PRP monotherapy group were included. During the follow-up of 12 months, the number of eyes with complete regression, partial regression, and no regression or increase in NV were 56 (70.88%), 23 (29.12%), and 0 (0%) in the IVC+PRP group and 13 (15.12%), 50 (58.14%), and 23 (26.74%) in the PRP group (
    Conclusion: High-risk PDR patients treated with IVC + PRP showed a higher rate of NV regression, more effective improvement in the BCVA, and lower vitrectomy rate compared to those who were administered PRP monotherapy.
    MeSH term(s) Humans ; Diabetic Retinopathy/drug therapy ; Diabetic Retinopathy/surgery ; Angiogenesis Inhibitors/therapeutic use ; Retrospective Studies ; Laser Coagulation ; Neovascularization, Pathologic/drug therapy ; Diabetes Mellitus/drug therapy
    Chemical Substances KH902 fusion protein (1P05PW62F3) ; Angiogenesis Inhibitors
    Language English
    Publishing date 2023-01-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2022.1038757
    Database MEDical Literature Analysis and Retrieval System OnLINE

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