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  1. Article: A syndrome differentiation model of TCM based on multi-label deep forest using biomedical text mining.

    Gong, Lejun / Jiang, Jindou / Chen, Shiqi / Qi, Mingming

    Frontiers in genetics

    2023  Volume 14, Page(s) 1272016

    Abstract: Syndrome differentiation and treatment is the basic principle of traditional Chinese medicine (TCM) to recognize and treat diseases. Accurate syndrome differentiation can provide a reliable basis for treatment, therefore, establishing a scientific ... ...

    Abstract Syndrome differentiation and treatment is the basic principle of traditional Chinese medicine (TCM) to recognize and treat diseases. Accurate syndrome differentiation can provide a reliable basis for treatment, therefore, establishing a scientific intelligent syndrome differentiation method is of great significance to the modernization of TCM. With the development of biomdical text mining technology, TCM has entered the era of intelligence that based on data, and model training increasingly relies on the large-scale labeled data. However, it is difficult to form a large standard data set in the field of TCM due to the low degree of standardization of TCM data collection and the privacy protection of patients' medical records. To solve the above problem, a multi-label deep forest model based on an improved multi-label ReliefF feature selection algorithm, ML-PRDF, is proposed to enhance the representativeness of features within the model, express the original information with fewer features, and achieve optimal classification accuracy, while alleviating the problem of high data processing cost of deep forest models and achieving effective TCM discriminative analysis under small samples. The results show that the proposed model finally outperforms other multi-label classification models in terms of multi-label evaluation criteria, and has higher accuracy in the TCM syndrome differentiation problem compared with the traditional multi-label deep forest, and the comparative study shows that the use of PCC-MLRF algorithm for feature selection can better select representative features.
    Language English
    Publishing date 2023-10-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2023.1272016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The effect of chronic academic stress on intentional forgetting.

    Qi, Mingming / Gai, Ru / Gao, Heming

    Quarterly journal of experimental psychology (2006)

    2023  Volume 77, Issue 2, Page(s) 433–445

    Abstract: This study investigated whether chronic academic stress could affect the directed forgetting (DF) process. Both the stress group (undergoing preparation for a major academic examination) and the control group performed a DF task. A forgetting cue was ... ...

    Abstract This study investigated whether chronic academic stress could affect the directed forgetting (DF) process. Both the stress group (undergoing preparation for a major academic examination) and the control group performed a DF task. A forgetting cue was presented after a to-be-forgotten (TBF) word, whereas no cue appeared after a to-be-remembered (TBR) item in the study phase. An old/new recognition test was used in the test phase. The results showed that (1) the stress group showed a higher level of self-reported stress, state anxiety, negative affect, and decreased cortisol awakening response (CAR) compared with the control group, suggesting a higher level of stress for the stress group. (2) Both groups showed superior recognition performance of TBR than TBF items, suggesting a DF effect. (3) The stress group showed inferior recognition performance of TBF items and an enhanced DF effect compared with the control group. These results demonstrated that the intentional memory control process might be enhanced under chronic academic stress.
    MeSH term(s) Humans ; Electroencephalography ; Evoked Potentials/physiology ; Memory/physiology ; Recognition, Psychology/physiology ; Mental Recall/physiology ; Cues
    Language English
    Publishing date 2023-05-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 219170-2
    ISSN 1747-0226 ; 0033-555X ; 1747-0218
    ISSN (online) 1747-0226
    ISSN 0033-555X ; 1747-0218
    DOI 10.1177/17470218231171481
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Left dorsolateral prefrontal cortex activation can accelerate stress recovery: A repetitive transcranial stimulation study.

    Wang, Yuanyuan / Gao, Heming / Qi, Mingming

    Psychophysiology

    2023  Volume 60, Issue 10, Page(s) e14352

    Abstract: In this study, a single high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) session was applied over the left dorsolateral prefrontal cortex (DLPFC) after a moderate-to-intense stressor to investigate whether left DLPFC stimulation ... ...

    Abstract In this study, a single high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) session was applied over the left dorsolateral prefrontal cortex (DLPFC) after a moderate-to-intense stressor to investigate whether left DLPFC stimulation could regulate cortisol concentration after stress induction. Participants were randomly divided into three groups (stress-TMS, stress, and placebo-stress). Stress was induced in both the stress-TMS and stress groups using the Trier Social Stress Test (TSST). The placebo-stress group received a placebo TSST. In the stress-TMS group, a single HF-rTMS session was applied over the left DLPFC after TSST. Cortisol was measured across the different groups, and each group's responses to the stress-related questionnaire were recorded. After TSST, both the stress-TMS and stress groups reported increased self-reported stress, state anxiety, negative affect, and cortisol concentration compared with the placebo-stress group, indicating that TSST successfully induced a stress response. Compared with the stress group, the stress-TMS group exhibited reduced cortisol levels at 0, 15, 30, and 45 min after HF-rTMS. These results suggest that left DLPFC stimulation after stress induction might accelerate the stress recovery.
    MeSH term(s) Humans ; Dorsolateral Prefrontal Cortex ; Prefrontal Cortex/physiology ; Hydrocortisone ; Transcranial Magnetic Stimulation/methods ; Anxiety
    Chemical Substances Hydrocortisone (WI4X0X7BPJ)
    Language English
    Publishing date 2023-05-23
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209486-1
    ISSN 1540-5958 ; 0048-5772
    ISSN (online) 1540-5958
    ISSN 0048-5772
    DOI 10.1111/psyp.14352
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Curcumin: a natural organic component that plays a multi-faceted role in ovarian cancer.

    Liu, Xiaoping / Qi, Mingming / Li, Xidie / Wang, Jingjin / Wang, Mingyuan

    Journal of ovarian research

    2023  Volume 16, Issue 1, Page(s) 47

    Abstract: Curcumin, a natural organic component obtained from Curcuma longa's rhizomes, shows abundant anti-tumor, antioxidant and anti-inflammatory pharmacological activities, among others. Notably the anti-tumor activity has aroused widespread attention from ... ...

    Abstract Curcumin, a natural organic component obtained from Curcuma longa's rhizomes, shows abundant anti-tumor, antioxidant and anti-inflammatory pharmacological activities, among others. Notably the anti-tumor activity has aroused widespread attention from scholars worldwide. Numerous studies have reported that curcumin can delay ovarian cancer (OC), increase its sensitivity to chemotherapy, and reduce chemotherapy drugs' side effects. It has been shown considerable anticancer potential by promoting cell apoptosis, suppressing cell cycle progression, inducing autophagy, inhibiting tumor metastasis, and regulating enzyme activity. With an in-depth study of curcumin's anti-OC mechanism, its clinical application will have broader prospects. This review summarizes the latest studies on curcumin's anti-OC activities, and discusses the specific mechanism, hoping to provide references for further research and applications.
    MeSH term(s) Female ; Humans ; Curcumin ; Ovarian Neoplasms ; Antioxidants ; Apoptosis ; Autophagy ; Drug-Related Side Effects and Adverse Reactions
    Chemical Substances Curcumin (IT942ZTH98) ; Antioxidants
    Language English
    Publishing date 2023-03-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2455679-8
    ISSN 1757-2215 ; 1757-2215
    ISSN (online) 1757-2215
    ISSN 1757-2215
    DOI 10.1186/s13048-023-01120-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Shenghong liquid combined with nanosilver accelerates healing of foot ulcers in diabetic rats by inhibiting inflammation and increasing angiogenesis.

    Xie, Xiaolan / Zhou, Xiaoping / Deng, Chun / Qi, Mingming / Tan, Yurong

    Archives of dermatological research

    2023  Volume 316, Issue 1, Page(s) 18

    MeSH term(s) Rats ; Animals ; Diabetic Foot/drug therapy ; Diabetes Mellitus, Experimental/complications ; Wound Healing ; Inflammation/drug therapy ; Angiogenesis
    Language English
    Publishing date 2023-12-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 130131-7
    ISSN 1432-069X ; 0340-3696
    ISSN (online) 1432-069X
    ISSN 0340-3696
    DOI 10.1007/s00403-023-02748-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A functional near-infrared spectroscopy investigation of item-method directed forgetting.

    Jing, Jingyan / Qi, Mingming / Gao, Heming

    Neuroscience research

    2022  Volume 185, Page(s) 11–19

    Abstract: Whether directed forgetting is passive or active remains debated. Using functional near-infrared spectroscopy (fNIRS), blood-oxygen level-dependent responses of intentional forgetting were investigated in the item-method directed forgetting (DF) paradigm. ...

    Abstract Whether directed forgetting is passive or active remains debated. Using functional near-infrared spectroscopy (fNIRS), blood-oxygen level-dependent responses of intentional forgetting were investigated in the item-method directed forgetting (DF) paradigm. During the study phase, each word was followed by a random remembering or forgetting cue indicating whether the word is to be remembered (TBR) or to be forgotten (TBF). A recognition test was used in the test phase and four cue-response conditions were obtained: remembering/forgetting cues associated with the subsequently remembered (TBR-r/TBF-r) or forgotten (TBR-f/TBF-f) words. Data from 16 healthy adult participants showed a DF effect. The fNIRS data revealed that, during the 5-9 s time window, the oxygenate hemoglobin (oxy-Hb) levels were higher during intentional forgetting compared to intentional remembering in the left inferior frontal (TBF-f vs. TBR-f) and right superior frontal gyrus (TBF-r vs. TBR-r), indicating more frontal inhibition involved during intentional forgetting. During the 9-11 s time window, the oxy-Hb level in the frontal and parietal gyrus was higher for forgetting than remembering cues, indicating that the TBF words might be automatically encoded. In sum, the TBF words might receive inhibition control triggered by forgetting cues and then be automatically encoded with the increase of the post-cue interval.
    MeSH term(s) Adult ; Humans ; Evoked Potentials/physiology ; Recognition, Psychology/physiology ; Electroencephalography ; Spectroscopy, Near-Infrared ; Mental Recall/physiology ; Cues
    Language English
    Publishing date 2022-09-06
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 605842-5
    ISSN 1872-8111 ; 0168-0102 ; 0921-8696
    ISSN (online) 1872-8111
    ISSN 0168-0102 ; 0921-8696
    DOI 10.1016/j.neures.2022.09.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The ERP correlates of color-based center-surround inhibition in working memory.

    Shi, Rui / Qi, Mingming / Gao, Heming

    International journal of psychophysiology : official journal of the International Organization of Psychophysiology

    2022  Volume 181, Page(s) 160–169

    Abstract: The color-based center-surround inhibition (CSI) in working memory (WM) refers to that remembering a color inhibits the memory of similar colors but not of distinct colors. This study aimed to investigate the neural activity of color-based CSI in WM. Two ...

    Abstract The color-based center-surround inhibition (CSI) in working memory (WM) refers to that remembering a color inhibits the memory of similar colors but not of distinct colors. This study aimed to investigate the neural activity of color-based CSI in WM. Two WM items (distance 0°, 10°, 20°, 30°, 40°, 50°, or 60° in color space) were displayed sequentially, then one of them was retrieved to compare with a later probe. Behavioral results revealed that participants showed longer RTs for distances 20° and 30° than distances 0° and 40°, suggesting a CSI between similar items. ERP results revealed that: 1) WM item-induced late positive component (LPC) was more positive for distance 30° than the other distances, suggesting an enhanced resource allocation process for encoding similar items; 2) Cue-induced LPC was more positive for distances 20° and 30° than distances 0° and 60°, suggesting a greater difficulty for retrieving similar items; Cue-induced contingent negative variation was less negative for distance 20° than distances 40°, 50°, and 60°, suggesting a reduced response preparation process during retrieving similar items; 3) Probe-induced LPC was more positive for distances 20° and 30° than distances 50° and 60°, suggesting a greater effort for comparing probe with one item retrieved from two similar items. These results revealed a colored-based CSI during WM encoding and retrieval processes. An enhanced top-down control might be required to resolve the greater interference between similar items than identical or distinct items conditions.
    MeSH term(s) Humans ; Inhibition, Psychological ; Memory, Short-Term/physiology ; Mental Recall
    Language English
    Publishing date 2022-09-19
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605645-3
    ISSN 1872-7697 ; 0167-8760
    ISSN (online) 1872-7697
    ISSN 0167-8760
    DOI 10.1016/j.ijpsycho.2022.09.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Acute psychological stress promotes general alertness and attentional control processes: An ERP study.

    Qi, Mingming / Gao, Heming

    Psychophysiology

    2020  Volume 57, Issue 4, Page(s) e13521

    Abstract: The current study investigated the influence of acute psychological stress on selective attention processes. After an acute stressor or a control condition, 20 participants performed an arrow-based version of the Eriksen flanker task, while ERPs (N1, N2, ...

    Abstract The current study investigated the influence of acute psychological stress on selective attention processes. After an acute stressor or a control condition, 20 participants performed an arrow-based version of the Eriksen flanker task, while ERPs (N1, N2, P3), reaction times, accuracy, subjective stress, and electrocardiogram signal were measured. Results showed elevated self-report stress, negative affect, state anxiety, heart rate, and reduced high-frequency heart rate variability in the stress block than in the control block, indicating that the flanker task was performed in a stressful situation. In the flanker task, faster response and larger flanker effect of accuracy were observed for the stress block relative to the control block, indicating increased arousal level and improved conflict detection under stress. Event-related potentials locked to target stimuli in the flanker task revealed that (a) frontal N1 was amplified in the stress block than in the control block, indicating elevated vigilance level under stress; (b) frontal N2 was increased in the stress block than in the control block for both congruent and incongruent trials, indicating more intensive attention control under stress; and (c) Increased P3 in the stress block than in the control block may reflect more allocation of neural resources as a consequence of improved attentional control under stress. These findings suggest that acute psychological stress increases general alertness and promotes attentional control in selective attention processes.
    MeSH term(s) Adult ; Anticipation, Psychological/physiology ; Attention/physiology ; Cerebral Cortex/physiology ; Electrocardiography ; Electroencephalography ; Event-Related Potentials, P300/physiology ; Evoked Potentials/physiology ; Executive Function/physiology ; Female ; Humans ; Male ; Probability Learning ; Psychomotor Performance/physiology ; Reward ; Stress, Psychological/physiopathology ; Young Adult
    Language English
    Publishing date 2020-01-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209486-1
    ISSN 1540-5958 ; 0048-5772
    ISSN (online) 1540-5958
    ISSN 0048-5772
    DOI 10.1111/psyp.13521
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: MLLT11-TRIL complex promotes the progression of endometrial cancer through PI3K/AKT/mTOR signaling pathway.

    Liao, Jingnan / Chen, Huan / Qi, Mingming / Wang, Jinjin / Wang, Mingyuan

    Cancer biology & therapy

    2022  Volume 23, Issue 1, Page(s) 211–224

    Abstract: Endometrial cancer (EC) is a gynecological malignant tumor characterized by high incidence. EC occurrence and development are regulated by numerous molecules and signal pathways. There is a need to explore key regulatory molecules to identify potential ... ...

    Abstract Endometrial cancer (EC) is a gynecological malignant tumor characterized by high incidence. EC occurrence and development are regulated by numerous molecules and signal pathways. There is a need to explore key regulatory molecules to identify potential therapeutic targets to reduce the incidence of EC. Treatment by targeting a single molecule is characterized by poor efficacy owing to the development of resistance and significant side effects. The current study explored potential candidates in EC by integrating bioinformatics analysis and in vivo and in vitro experimental validation to circumvent the limitation of low efficacy of currently used molecules. Molecular dynamics simulations provide details at the molecular level of intermolecular regulation. In the current study, MLLT11 and TRIL were identified as important regulatory molecules in EC. The two molecules formed a heteromultimer by binding to AKT protein, which induced its phosphorylation of threonine at position 308. Ultimately, the complex stimulates PI3K/AKT/mTOR signaling pathway, a pivotal pathway in tumors. The findings of the current study show a novel complex, MLLT11-TRIL, which can act as AKT protein agonist, thus inducing activity of PI3K/AKT/mTOR signaling pathway. Targeting MLLT11 and TRIL simultaneously, or blocking the formation of the MLLT11-TRIL complex, can abrogate progression of EC.
    MeSH term(s) Cell Proliferation ; Endometrial Neoplasms/pathology ; Female ; Humans ; Neoplasm Proteins/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism
    Chemical Substances MLLT11 protein, human ; Neoplasm Proteins ; Proto-Oncogene Proteins ; MTOR protein, human (EC 2.7.1.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; TOR Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2022-03-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2146305-0
    ISSN 1555-8576 ; 1538-4047
    ISSN (online) 1555-8576
    ISSN 1538-4047
    DOI 10.1080/15384047.2022.2046450
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The fronto-central N2 but not parietal P3 reflects response inhibition in the count/no-count task.

    Jing, Jingyan / Zhang, Zhuyun / Qi, Mingming / Gao, Heming

    Psychological research

    2021  Volume 86, Issue 4, Page(s) 1122–1131

    Abstract: This study aimed to investigate whether the N2 or P3 component in the count/no-count task reflects response inhibition. The participants were asked to count/withhold counting the number of O/X letters in the count/no-count task, and to calculate the sum ... ...

    Abstract This study aimed to investigate whether the N2 or P3 component in the count/no-count task reflects response inhibition. The participants were asked to count/withhold counting the number of O/X letters in the count/no-count task, and to calculate the sum of all digits (i.e., 1/0) in the digital accumulation task. Therefore, four conditions were obtained in this study: count, no-count, Add 1, and Add 0. In the count and Add 1 conditions, the counting/calculation number need to be updated. In both no-count and Add 0 conditions, the memory of counting/calculation number need not to be updated; a No-go (withhold) instruction was given in the no-count condition, but a Go instruction was given in the Add 0 condition. Results showed that an enhanced fronto-central N2 was evoked in the no-count than in the Add 0 condition, indicating that a stronger response conflict or stronger inhibition might be triggered in the No-count condition. The frontocentral P3 showed no differences between no-count and Add 0 conditions, however, an enhanced centro-parietal P3 component was observed for the count relative to the no-count condition and for the Add 1 relative to the Add 0 condition, indicating that a greater amount of attentional resources might be consumed during memory updating process. Taken together, in the count/no-count task, the fronto-central N2 might reflect response inhibition or conflict and the parietal P3 might reflect attentional resource allocation but not response inhibition.
    MeSH term(s) Attention/physiology ; Electroencephalography/methods ; Evoked Potentials/physiology ; Humans ; Inhibition, Psychological ; Reaction Time/physiology
    Language English
    Publishing date 2021-08-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1463034-5
    ISSN 1430-2772 ; 0340-0727
    ISSN (online) 1430-2772
    ISSN 0340-0727
    DOI 10.1007/s00426-021-01571-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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