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  1. AU="Qi, Nan"
  2. AU="Pinto, Daniel"
  3. AU="M Serrano-Martin"
  4. AU="Stefano Cacciaguerra"
  5. AU=Ochs Matthias
  6. AU="Ownby, Raymond L"
  7. AU="Belhouchat, Khadidja"
  8. AU="Hulsman, J"
  9. AU="Hadoke, Patrick W F"
  10. AU="Isermann, Philipp"
  11. AU="Polishchuk, Ilya"
  12. AU=Jalali Rostam
  13. AU="Baek, Kyoung Eun"
  14. AU="Gordon, Jay E"
  15. AU="Huang, Mingsheng"
  16. AU="Karkowski, L"
  17. AU="Rana, Punam"
  18. AU=Kawasaki Shunsuke
  19. AU="Oliveira-Júnior, Gersiel"
  20. AU="Alvarado-Aguilar, Pablo"
  21. AU="Kyrin R. Hanning" AU="Kyrin R. Hanning"
  22. AU="Teixidor, Francesc"
  23. AU=Minhas Jasmit
  24. AU="Poe, Alyssa"
  25. AU="Ni, Bo"
  26. AU="Vemuri, Kiranmayi"
  27. AU="Hernández-Wolters, Benjamin"
  28. AU="Chobanova, Veronika"
  29. AU="Otten, Gisela"
  30. AU="Elhence, Anshuman"
  31. AU="Tinneberg, H-R"
  32. AU="Puro, Neeraj"
  33. AU=Yang Chi-Fu Jeffrey
  34. AU="Oliveira, Giuliana S"
  35. AU="Maria Cecilia Jocson"
  36. AU="Tollman, Stephen"
  37. AU="Cherry, Katie E."
  38. AU="Nazet, Ute"
  39. AU="Kranzer, K"
  40. AU="Avelino, Samuel"
  41. AU="Sun, Xiang-Dong"
  42. AU="Vogl, Thomas J."
  43. AU="Johnson, C R"
  44. AU="Gil-Pérez, Pablo"
  45. AU="Donno, Federica"
  46. AU="Vom Saal, Frederick S."
  47. AU="Gazzana, S"
  48. AU="Viswanadha, Vijaya P"
  49. AU="Anastasi, G A"
  50. AU="Romerosa, Antonio"
  51. AU=Gupta Gaorav P
  52. AU="Fernández-Susavila, Héctor"

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  1. Artikel: Editorial: Tumor metabolism and programmed cell death.

    Pu, Dan-Lan / Wu, Qi-Nan

    Frontiers in endocrinology

    2024  Band 15, Seite(n) 1368737

    Mesh-Begriff(e) Humans ; Neoplasms ; Apoptosis
    Sprache Englisch
    Erscheinungsdatum 2024-01-25
    Erscheinungsland Switzerland
    Dokumenttyp Editorial
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2024.1368737
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  2. Artikel: Numerical study of critical straight, frown, and chevron incisions in small incision cataract surgery.

    Han, Yang / Qi, Nan

    Frontiers in bioengineering and biotechnology

    2023  Band 11, Seite(n) 1283293

    Abstract: Introduction: ...

    Abstract Introduction:
    Sprache Englisch
    Erscheinungsdatum 2023-10-20
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2023.1283293
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Seizure prediction based on improved vision transformer model for EEG channel optimization.

    Qi, Nan / Piao, Yan / Zhang, Hao / Wang, Qi / Wang, Yue

    Computer methods in biomechanics and biomedical engineering

    2024  , Seite(n) 1–12

    Abstract: Epileptic seizures are unpredictable events caused by abnormal discharges of a patient's brain cells. Extensive research has been conducted to develop seizure prediction algorithms based on long-term continuous electroencephalogram (EEG) signals. This ... ...

    Abstract Epileptic seizures are unpredictable events caused by abnormal discharges of a patient's brain cells. Extensive research has been conducted to develop seizure prediction algorithms based on long-term continuous electroencephalogram (EEG) signals. This paper describes a patient-specific seizure prediction method that can serve as a basis for the design of lightweight, wearable and effective seizure-prediction devices. We aim to achieve two objectives using this method. The first aim is to extract robust feature representations from multichannel EEG signals, and the second aim is to reduce the number of channels used for prediction by selecting an optimal set of channels from multichannel EEG signals while ensuring good prediction performance. We design a seizure-prediction algorithm based on a vision transformer (ViT) model. The algorithm selects channels that play a key role in seizure prediction from 22 channels of EEG signals. First, we perform a time-frequency analysis of processed time-series signals to obtain EEG spectrograms. We then segment the spectrograms of multiple channels into many non-overlapping patches of the same size, which are input into the channel selection layer of the proposed model, named Sel-JPM-ViT, enabling it to select channels. Application of the Sel-JPM-ViT model to the Boston Children's Hospital-Massachusetts Institute of Technology scalp EEG dataset yields results using only three to six channels of EEG signals that are slightly better that the results obtained using 22 channels of EEG signals. Overall, the Sel-JPM-ViT model exhibits an average classification accuracy of 93.65%, an average sensitivity of 94.70% and an average specificity of 92.78%.
    Sprache Englisch
    Erscheinungsdatum 2024-03-06
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2071764-7
    ISSN 1476-8259 ; 1025-5842
    ISSN (online) 1476-8259
    ISSN 1025-5842
    DOI 10.1080/10255842.2024.2326097
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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 6374: Hefte anzeigen Standort:
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  4. Artikel ; Online: Predicting epileptic seizures based on EEG signals using spatial depth features of a 3D-2D hybrid CNN.

    Qi, Nan / Piao, Yan / Yu, Peng / Tan, Baolin

    Medical & biological engineering & computing

    2023  Band 61, Heft 7, Seite(n) 1845–1856

    Abstract: Epilepsy is a recurrent chronic brain disease that affects nearly 75 million people around the world. Therefore, the ability to reliably predict epileptic seizures would be instrumental for implementing interventions to reduce brain injury and improve ... ...

    Abstract Epilepsy is a recurrent chronic brain disease that affects nearly 75 million people around the world. Therefore, the ability to reliably predict epileptic seizures would be instrumental for implementing interventions to reduce brain injury and improve patients' quality of life. In addition to classical machine learning algorithms and feature engineering methods, the use of electroencephalography (EEG) to predict seizures has gradually become a mainstream trend. Here, we propose a patient-specific method to predict epileptic seizures based on EEG data acquired using spatial depth features of a three-dimensional-two-dimensional hybrid convolutional neural network (3D-2D HyCNN) model. This method facilitates the acquisition of abundant and reliable deep features from multi-channel EEG signals. We first developed a reliable data preprocessing method to reconstruct time-series EEG signals into 3D feature images. Then, the 3D-2D HyCNN model was used to extract correlation features between multiple channels of EEG signals, which are automatically exploited by the network to improve seizure prediction. The method achieved accuracy of 98.43% and 93.11%, sensitivity of 98.58% and 90.98%, and specificity of 96.86% and 92.39% on the CHB-MIT Scalp EEG dataset and the American Epilepsy Society Epilepsy Prediction Challenge dataset, respectively. The results revealed that the new algorithm is reliable. Graphical Abstract A new patient-specific epilepsy prediction approach.
    Mesh-Begriff(e) Humans ; Quality of Life ; Seizures/diagnosis ; Epilepsy/diagnosis ; Neural Networks, Computer ; Algorithms ; Electroencephalography/methods
    Sprache Englisch
    Erscheinungsdatum 2023-03-23
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 282327-5
    ISSN 1741-0444 ; 0025-696X ; 0140-0118
    ISSN (online) 1741-0444
    ISSN 0025-696X ; 0140-0118
    DOI 10.1007/s11517-023-02792-4
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 294: Hefte anzeigen Standort:
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  5. Artikel ; Online: Autophagic dysfunction of β cell dysfunction in type 2 diabetes, a double-edged sword.

    Yao, Ding / GangYi, Yang / QiNan, Wu

    Genes & diseases

    2020  Band 8, Heft 4, Seite(n) 438–447

    Abstract: Diabetes is an age-related disease, most of which is type 2 diabetes, and islet β cell dysfunction and insulin resistance are the main mechanisms of type 2 diabetes. Recent studies have revealed that autophagy plays an important role in maintaining the ... ...

    Abstract Diabetes is an age-related disease, most of which is type 2 diabetes, and islet β cell dysfunction and insulin resistance are the main mechanisms of type 2 diabetes. Recent studies have revealed that autophagy plays an important role in maintaining the structure and function of islet beta cells and inhibiting insulin resistance and apoptosis induced by oxidative stress. In this review, we discussed the positive and negative effects of autophagy and its dysfunction on type 2 diabetes mellitus, which is the so-called double-edged sword, analysed its possible mechanism, and identified possible research hot spots.
    Sprache Englisch
    Erscheinungsdatum 2020-03-19
    Erscheinungsland China
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2821806-1
    ISSN 2352-3042 ; 2352-3042
    ISSN (online) 2352-3042
    ISSN 2352-3042
    DOI 10.1016/j.gendis.2020.03.003
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  6. Artikel ; Online: Autophagic dysfunction of β cell dysfunction in type 2 diabetes, a double-edged sword

    Ding Yao / Yang GangYi / Wu QiNan

    Genes and Diseases, Vol 8, Iss 4, Pp 438-

    2021  Band 447

    Abstract: Diabetes is an age-related disease, most of which is type 2 diabetes, and islet β cell dysfunction and insulin resistance are the main mechanisms of type 2 diabetes. Recent studies have revealed that autophagy plays an important role in maintaining the ... ...

    Abstract Diabetes is an age-related disease, most of which is type 2 diabetes, and islet β cell dysfunction and insulin resistance are the main mechanisms of type 2 diabetes. Recent studies have revealed that autophagy plays an important role in maintaining the structure and function of islet beta cells and inhibiting insulin resistance and apoptosis induced by oxidative stress. In this review, we discussed the positive and negative effects of autophagy and its dysfunction on type 2 diabetes mellitus, which is the so-called double-edged sword, analysed its possible mechanism, and identified possible research hot spots.
    Schlagwörter Apoptosis ; Autophagic dysfunction ; Insulin resistance ; Islet beta cell dysfunction ; Type 2 diabetes mellitus ; Medicine (General) ; R5-920 ; Genetics ; QH426-470
    Sprache Englisch
    Erscheinungsdatum 2021-07-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Study on Collection Performance of Hydraulic Polymetallic Nodule Collector Based on Solid–Liquid Two-Phase Flow Numerical Simulation

    Pin-Jian Wang / Li Li / Qi-Nan Wei / Jia-Bin Wu

    Applied Sciences, Vol 13, Iss 23, p

    2023  Band 12729

    Abstract: The hydraulic collector is an important device for collecting seafloor polymetallic nodules. In this study, a hydraulic polymetallic nodule collector with two acquisition nozzles and one transmission nozzle is described. The numerical model of the ... ...

    Abstract The hydraulic collector is an important device for collecting seafloor polymetallic nodules. In this study, a hydraulic polymetallic nodule collector with two acquisition nozzles and one transmission nozzle is described. The numerical model of the hydraulic collector is established based on the solid–liquid two-phase flow method, and it is verified by experimental tests. On this basis, the collection mechanism of the hydraulic collector is analyzed, and the effects of structural parameters and working parameters on its collection performance are explored. The results show that the collection height and slant angle of the acquisition nozzle are key factors for collection efficiency, with optimal heights below 150 mm and angles between 45 and 49 <semantics> ∘ </semantics> . The recommended range for the center distance between the two acquisition confluence tubes is 650–730 mm. Excessive acquisition and transmission flow rates make a negligible contribution to improving the collection efficiency, but can also cause a significant increase in energy consumption. Therefore, the recommended ranges for acquisition and transmission flow rates are 140–160 m <semantics> 3 </semantics> /h and less than 80 m <semantics> 3 </semantics> /h, respectively. All of the results indicated that the parameters of the developed hydraulic collector were set reasonably, which thus ensured a balance between the collection efficiency and energy consumption.
    Schlagwörter polymetallic nodule ; solid–liquid two-phase flow ; hydraulic collector ; collection efficiency ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 670
    Sprache Englisch
    Erscheinungsdatum 2023-11-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Characterizing key aroma‐active compounds of stewed mutton using gas chromatography‐olfactometry‐mass spectrometry coupled with odour activity value

    Qi, Nan / Liu, Ruijia / Sun, Jie / Chen, Haitao / Zhang, Ning

    Flavour and Fragrance Journal. 2023 July, v. 38, no. 4 p.263-273

    2023  

    Abstract: Stewed mutton is popular for its nutritional and special flavour qualities. To determine the key aroma‐active compounds of stewed mutton in different parts, six experimental groups (sheep fat, sheep bone, sheep brisket, sheep loin, sheep rib and sheep ... ...

    Abstract Stewed mutton is popular for its nutritional and special flavour qualities. To determine the key aroma‐active compounds of stewed mutton in different parts, six experimental groups (sheep fat, sheep bone, sheep brisket, sheep loin, sheep rib and sheep leg) were investigated by gas chromatography‐olfactometry‐mass spectrometry (GC‐O‐MS). Totally, 57 volatile compounds in mutton soup were identified. Of these, 22 aroma‐active compounds were identified as key aroma compounds with odour activity values (OAVs) >1. The partial least squares regression (PLSR) results indicated that sheep fat (SF) was greatly related to most variables of sensory attributes, thus presented richer aroma. Among all samples, 3‐hydroxy‐2‐butanone and (E)‐2‐nonenal were the major aromatic compounds they shared. There were 22 unique key aromatic compounds, including 3‐methylthiopropana, (E)‐2‐decenal, γ‐decalactone, (E)‐2‐octenal and hydroxyacetone, and the differences in these compounds contributed to the flavour profiles of mutton soup. Our research extends the knowledge into the flavour characteristics of different parts of mutton and provides powerful information for improving the flavour of mutton products.
    Schlagwörter flavor ; mutton ; odors ; sheep ; soups ; spectroscopy
    Sprache Englisch
    Erscheinungsverlauf 2023-07
    Umfang p. 263-273.
    Erscheinungsort John Wiley & Sons, Ltd
    Dokumenttyp Artikel ; Online
    Anmerkung JOURNAL ARTICLE
    ZDB-ID 54356-1
    ISSN 0882-5734
    ISSN 0882-5734
    DOI 10.1002/ffj.3745
    Datenquelle NAL Katalog (AGRICOLA)

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  9. Artikel: [Identification and analysis of terpene synthase (TPS) gene family in Schizonepeta tenuifolia].

    Jia, Cong-Ling / Shu, Juan / Dang, Jing-Jie / Wang, Xue / Wu, Qi-Nan / Liu, Chan-Chan

    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

    2023  Band 48, Heft 22, Seite(n) 6039–6050

    Abstract: Terpenoids are important secondary metabolites of plants that possess both pharmacological activity and economic value. Terpene synthases(TPSs) are key enzymes in the synthesis process of terpenoids. In order to investigate the TPS gene family members ... ...

    Abstract Terpenoids are important secondary metabolites of plants that possess both pharmacological activity and economic value. Terpene synthases(TPSs) are key enzymes in the synthesis process of terpenoids. In order to investigate the TPS gene family members and their potential functions in Schizonepeta tenuifolia, this study conducted a systematic analysis of the TPS gene family of S. tenuifolia based on the whole genome data of S. tenuifolia using bioinformatics methods. The results revealed 57 StTPS members identified from the genome database of S. tenuifolia. The StTPS family members encoded 285-819 amino acids, with protein molecular weights ranging from 32.75 to 94.11 kDa, all of which were hydrophilic proteins. The StTPS family members were mainly distributed in the cytoplasm and chloroplasts, exhibiting a random and uneven physical localization pattern. Phylogenetic analysis showed that the StTPS genes family were divided into six subgroups, mainly belonging to the TPS-a and TPS-b subfamilies. Promoter analysis predicted that the TPS gene family members could respond to various stressors such as light, abscisic acid, and methyl jasmonate(MeJA). Transcriptome data analysis revealed that most of the TPS genes were expressed in the roots of S. tenuifolia, and qRT-PCR analysis was conducted on genes with high expression in leaves and low expression in roots. Through the analysis of the TPS gene family of S. tenuifolia, this study identified StTPS5, StTPS18, StTPS32, and StTPS45 as potential genes involved in sesquiterpene synthesis of S. tenuifolia. StTPS45 was cloned for the construction of an prokaryotic expression vector, providing a reference for further investigation of the function and role of the TPS gene family in sesquiterpene synthesis.
    Mesh-Begriff(e) Phylogeny ; Terpenes/metabolism ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Lamiaceae/genetics ; Sesquiterpenes
    Chemische Substanzen terpene synthase (EC 2.5.1.-) ; Terpenes ; Plant Proteins ; Sesquiterpenes
    Sprache Chinesisch
    Erscheinungsdatum 2023-12-19
    Erscheinungsland China
    Dokumenttyp English Abstract ; Journal Article
    ZDB-ID 1004649-5
    ISSN 1001-5302 ; 0254-0029
    ISSN 1001-5302 ; 0254-0029
    DOI 10.19540/j.cnki.cjcmm.20230712.101
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Estimations of Critical Clear Corneal Incisions Required for Lens Insertion in Cataract Surgery: A Mathematical Aspect.

    Qi, Nan / Lockington, David / Wang, Lei / Ramaesh, Kanna / Luo, Xiaoyu

    Frontiers in physiology

    2022  Band 13, Seite(n) 834214

    Abstract: In a routine cataract operation cornea tissue may be damaged when an intra-ocular lens (IOL) injector of diameter between 1.467 and 2.011 mm is inserted through an empirically designed 2.2 mm corneal incision. We aimed to model and estimate the minimal ... ...

    Abstract In a routine cataract operation cornea tissue may be damaged when an intra-ocular lens (IOL) injector of diameter between 1.467 and 2.011 mm is inserted through an empirically designed 2.2 mm corneal incision. We aimed to model and estimate the minimal length of the incision required to avoid wound tear. It was assumed that the damage was caused by tissue fracture at the tips of the incision, and this fracture could be studied using damage and fracture mechanics. The criterion of the damage was caused by a tear governed by the critical energy release rate (ERR)
    Sprache Englisch
    Erscheinungsdatum 2022-04-08
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.834214
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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