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  1. Article: Comprehensive molecular expression profiling of SARS-CoV-associated factors in the endometrium across the menstrual cycle and elevated susceptibility in women with recurrent pregnancy loss.

    Qi, Ruofan / Guan, Rui / Cai, Shengyun / Xu, Mingjuan / Yang, Wen-Jui / Wang, Chi Chiu

    Frontiers in genetics

    2023  Volume 14, Page(s) 1246725

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2023-10-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2023.1246725
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Association of angiotensin II and receptors in peri-implantation endometrium with microvessel density and pregnancy outcomes of women with recurrent implantation failure after embryo transfer.

    Qi, Ruofan / Zhang, Tao / Zhang, Yingying / Chung, Jacqueline Pui Wah / Yang, Wen-Jui / Wang, Chi Chiu

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1206326

    Abstract: Purpose: Investigate whether local angiotensin II (AngII) and its AngII type 1 and 2 receptors (AT1R, AT2R) in the endometrium are different and correlate with microvessel density in women with reproductive failure and pregnancy outcomes.: Methods: ... ...

    Abstract Purpose: Investigate whether local angiotensin II (AngII) and its AngII type 1 and 2 receptors (AT1R, AT2R) in the endometrium are different and correlate with microvessel density in women with reproductive failure and pregnancy outcomes.
    Methods: Endometrium during the window of implantation from 40 women with recurrent miscarriage (RM) and 40 with recurrent implantation failure (RIF) were compared with 27 fertile women. Peri-implantation endometrium from 54 women prior to euploid embryo transfer were collected and compared in women with successful pregnancy and unsuccessful pregnancy.
    Results: Compared with fertile women, expression of AT2R was significantly lower, while AT1R/AT2R expression ratio was significantly higher in the stroma of the RIF group. Endometrium arteriole MVD was significantly lower and negatively correlated with the AT1R/AT2R expression ratio in the stroma of the RIF group. No significant differences and correlations were found in the RM group. Compared with the pregnancy group, expression of AT1R and AT2R were significantly lower in all compartments, but only AT1R/AT2R ratio was significantly higher in the stroma of the non-pregnancy group. Similarly, endometrium arteriole MVD was also significantly lower and negatively correlated with the AT1R/AT2R ratio in the stroma of the non-pregnancy group.
    Conclusion: Local renin-angiotensin system is dysregulated in peri-implantation endometrium and associated with abnormal angiogenesis in RIF and poor implantation outcome after embryo transfer.
    MeSH term(s) Pregnancy ; Female ; Humans ; Angiotensin II ; Microvascular Density ; Pregnancy Outcome ; Abortion, Habitual ; Embryo Transfer ; Endometrium ; Peptide Hormones
    Chemical Substances Angiotensin II (11128-99-7) ; Peptide Hormones
    Language English
    Publishing date 2023-08-29
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1206326
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The role of the renin-angiotensin system in regulating endometrial neovascularization during the peri-implantation period: literature review and preliminary data.

    Qi, Ruofan / Li, Tin Chiu / Chen, Xiaoyan

    Therapeutic advances in endocrinology and metabolism

    2020  Volume 11, Page(s) 2042018820920560

    Abstract: Background: Implantation is initiated when the blastocyst attaches to the endometrium during the peri-implantation period, and appropriate neovascularization is a prerequisite for the success of the subsequent process. The role of the renin-angiotensin ... ...

    Abstract Background: Implantation is initiated when the blastocyst attaches to the endometrium during the peri-implantation period, and appropriate neovascularization is a prerequisite for the success of the subsequent process. The role of the renin-angiotensin system (RAS) in regulation of blood pressure and hydro-electrolyte balance has long been recognized, while its role in the peri-implantation endometrium remains unclear. This manuscript discusses endometrial RAS and its possible pathways in regulating endometrial angiogenesis and its influence on subsequent pregnancy outcomes.
    Methods: A comprehensive search of electronic databases was carried out to identify relevant published articles, and a literature review was then performed. Using immunohistochemistry, we also performed a pilot study to examine expression of angiotensin II receptors, including angiotensin II type 1 (AT1) receptor (AT1-R) and angiotensin II type 2 (AT2) receptor (AT2-R) in the human endometrium around the time of implantation.
    Results: The results of the pilot study showed expression of AT1-R and AT2-R in all endometrial compartments (luminal epithelium, glandular epithelium, stroma cells, and blood vessels), and altered expression was witnessed in women with recurrent miscarriage when compared with fertile control women from our preliminary result.
    Conclusion: Altered vasculature of the endometrium in the peri-implantation period is detrimental to implantation and may lead to recurrent miscarriage. Being an angiogenic mediators, endometrial RAS may play a role around the time of embryo implantation, affecting subsequent pregnancy outcomes.
    Language English
    Publishing date 2020-05-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2554822-0
    ISSN 2042-0196 ; 2042-0188
    ISSN (online) 2042-0196
    ISSN 2042-0188
    DOI 10.1177/2042018820920560
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Aberrant Overexpression of RNA-Editing Enzyme ADAR1 Promotes the Progression of Endometriosis.

    Li, Zhe / Qi, Ruofan / Wang, Qingde / Li, Hongyu / Hu, Jijun / Sun, Lijun

    Reproductive sciences (Thousand Oaks, Calif.)

    2020  Volume 27, Issue 2, Page(s) 575–584

    Abstract: Considerable efforts have been invested to elucidate the potential mechanisms involved in the physiopathology of endometriosis. However, to date, prior research has not been conclusive. This research has examined one particular mechanism, i.e., the ... ...

    Abstract Considerable efforts have been invested to elucidate the potential mechanisms involved in the physiopathology of endometriosis. However, to date, prior research has not been conclusive. This research has examined one particular mechanism, i.e., the effect of ADAR1 on endometriosis lesions. Eutopic endometrium was collected from women with (n = 25) and without endometriosis (n = 25), respectively. The expression of ADAR1 mRNA was measured based on quantitative real-time polymerase chain reactions (RT-qPCR). Both Western blot and immunohistochemistry were performed to establish ADAR1 protein expression levels. The results indicated that ADAR1 mRNA and proteins were significantly greater in the eutopic endometrium of the women with endometriosis, compared to the women without (P < 0.05). The Cell Counting Kit-8 (CCK-8) and EdU method were conducted to examine the effect of ADAR1 on cell viability and proliferation in eutopic endometriosis cells. A transwell assay was also used to detect the role of ADAR1 in the invasion of endometrial cells. The results obtained showed that ADAR1 promoted endometrial cell viability, proliferation, and invasion (P < 0.05). This informed our conclusion that the ADAR1 gene is upregulated in endometriosis, potentially paying a pivotal role in the physiopathology of endometriosis.
    MeSH term(s) Adenosine Deaminase/metabolism ; Adult ; Cell Survival ; Cells, Cultured ; Disease Progression ; Endometriosis/enzymology ; Endometriosis/pathology ; Endometrium/enzymology ; Female ; Humans ; Middle Aged ; RNA, Messenger/metabolism ; RNA-Binding Proteins/metabolism ; Up-Regulation
    Chemical Substances RNA, Messenger ; RNA-Binding Proteins ; ADAR protein, human (EC 3.5.4.37) ; Adenosine Deaminase (EC 3.5.4.4)
    Language English
    Publishing date 2020-01-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2276411-2
    ISSN 1933-7205 ; 1933-7191
    ISSN (online) 1933-7205
    ISSN 1933-7191
    DOI 10.1007/s43032-019-00057-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4113: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: RNA Editing, ADAR1, and the Innate Immune Response.

    Wang, Qingde / Li, Xiaoni / Qi, Ruofan / Billiar, Timothy

    Genes

    2017  Volume 8, Issue 1

    Abstract: RNA editing, particularly A-to-I RNA editing, has been shown to play an essential role in mammalian embryonic development and tissue homeostasis, and is implicated in the pathogenesis of many diseases including skin pigmentation disorder, autoimmune and ... ...

    Abstract RNA editing, particularly A-to-I RNA editing, has been shown to play an essential role in mammalian embryonic development and tissue homeostasis, and is implicated in the pathogenesis of many diseases including skin pigmentation disorder, autoimmune and inflammatory tissue injury, neuron degeneration, and various malignancies. A-to-I RNA editing is carried out by a small group of enzymes, the adenosine deaminase acting on RNAs (ADARs). Only three members of this protein family, ADAR1-3, exist in mammalian cells. ADAR3 is a catalytically null enzyme and the most significant function of ADAR2 was found to be in editing on the neuron receptor GluR-B mRNA. ADAR1, however, has been shown to play more significant roles in biological and pathological conditions. Although there remains much that is not known about how ADAR1 regulates cellular function, recent findings point to regulation of the innate immune response as an important function of ADAR1. Without appropriate RNA editing by ADAR1, endogenous RNA transcripts stimulate cytosolic RNA sensing receptors and therefore activate the IFN-inducing signaling pathways. Overactivation of innate immune pathways can lead to tissue injury and dysfunction. However, obvious gaps in our knowledge persist as to how ADAR1 regulates innate immune responses through RNA editing. Here, we review critical findings from ADAR1 mechanistic studies focusing on its regulatory function in innate immune responses and identify some of the important unanswered questions in the field.
    Language English
    Publishing date 2017-01-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527218-4
    ISSN 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes8010041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Association between chronic endometritis and uterine natural killer cell density in women with recurrent miscarriage: clinical implications.

    Chen, Xiaoyan / Liu, Yingyu / Zhao, Yiwei / Cheung, Wing Ching / Zhang, Tao / Qi, Ruofan / Chung, Jacqueline Pui Wah / Wang, Chi Chiu / Li, Tin Chiu

    The journal of obstetrics and gynaecology research

    2020  Volume 46, Issue 6, Page(s) 858–863

    Abstract: Aim: This aim of this study was to determine the association between uterine natural killer (uNK) cell density and chronic endometritis (CE).: Methods: Endometrial biopsies from 135 women with recurrent miscarriage were obtained precisely 7 days ... ...

    Abstract Aim: This aim of this study was to determine the association between uterine natural killer (uNK) cell density and chronic endometritis (CE).
    Methods: Endometrial biopsies from 135 women with recurrent miscarriage were obtained precisely 7 days after luteinizing hormone surge in natural cycles. Endometrial sections were immunostained for CD56 for uNK cells and CD138 for plasma cells, respectively. Uterine NK cell counting was performed according to a standardized protocol and results were expressed as percentage of CD56+ cells/ total stromal cells. High uNK cell density was defined as >4.5% and CE was diagnosed when the plasma cell density > 5.15 cells/ 10 mm
    Results: The uNK cells density in women with CE (median, 5.1%; range, 3.4-8.8%) was significantly (P < 0.05) higher than that of those without CE (median, 3.8%; range, 1.2%-7.3%). The prevalence of high uNK cell density in women with CE (11/29, 37.9%) was significantly (P < 0.05) higher than that of women without CE (8/106, 7.5%).
    Conclusion: To conclude, there was a significant association between high uNK cell density and CE. In women with high uNK cell density, plasma cell should be examined to determine if the underlying cause is associated with CE.
    MeSH term(s) Abortion, Habitual/immunology ; Adult ; Case-Control Studies ; Endometritis/pathology ; Endometrium/metabolism ; Female ; Humans ; Killer Cells, Natural/immunology ; Lymphocyte Count ; Pregnancy ; Uterus/immunology
    Language English
    Publishing date 2020-03-18
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1327307-3
    ISSN 1447-0756 ; 1341-8076
    ISSN (online) 1447-0756
    ISSN 1341-8076
    DOI 10.1111/jog.14250
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1810: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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